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New US Experiments Aim To Create Gene-Edited Human Embryos (npr.org)

An anonymous reader quotes a report from NPR: A scientist in New York is conducting experiments designed to modify DNA in human embryos as a step toward someday preventing inherited diseases, NPR has learned. For now, the work is confined to a laboratory. But the research, if successful, would mark another step toward turning CRISPR, a powerful form of gene editing, into a tool for medical treatment. Dieter Egli, a developmental biologist at Columbia University, says he is conducting his experiments "for research purposes." He wants to determine whether CRISPR can safely repair mutations in human embryos to prevent genetic diseases from being passed down for generations. So far, Egli has stopped any modified embryos from developing beyond one day so he can study them. "Right now we are not trying to make babies. None of these cells will go into the womb of a person," he says. But if the approach is successful, Egli would likely allow edited embryos to develop further to continue his research. Egli's research is reviewed in advance and overseen by a panel of other scientists and bioethicists at Columbia. Specifically, Egli is trying to fix one of the genetic defects that cause retinitis pigmentosa, an inherited form of blindness. "If it works, the hope is that the approach could help blind people carrying the mutation have genetically related children whose vision is normal," reports NPR.

8 of 87 comments (clear)

  1. Re:Hmmmm yes, pure genetics by Aighearach · · Score: 4, Insightful

    Purity, in the context of genetics, means very badly inbred.

  2. Re:So where does society draw the line? by mentil · · Score: 2

    You say 'line', I say 'goalpost'. In either case it'll keep being moved, and no legion of pearl-clutchers will stop that, for better or worse.

    --
    Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
  3. Re: So where does society draw the line? by ShanghaiBill · · Score: 2

    Why should "society" (i.e.: government) be drawing the line?

    Why shouldn't individuals be allowed to make their own reproductive decisions?

    Keep your laws off my body.

  4. Someone doesn't like this. by grep+-v+'.*'+* · · Score: 4, Informative

    as a step toward someday preventing inherited diseases

    "the hope is that the approach could help blind people carrying the mutation have genetically related children whose vision is normal"

    Very surprisingly to me, this is generally NOT an immediate accepted topic / action / result. IT'S GONE NOW -- I read it and was shocked. I immediately thought of Ender's Game book 3? where the ?antagonist? -- who had to start and follow wood grain lines until the gods were satisfied -- didn't want to be cured, but also couldn't disrespect her father, so was cured against her will.

    There was an article (actually, an opinion piece) that was (not any more!) at: https://www.pluralist.com/post....

    It said: A prominent disabilities activist spoke against the use of genetic editing to eliminate diseases from birth because it would be tantamount to a "genocide" against the culture of the disabled.

    Link. Other link Discussion

    We're talking about removal of diseases," she said. "That's forever. That's a change -- a modification -- that will be passed on to future generations. So that's actually genocide. It's a form of eugenics where certain lived experiences are seen as undesirable and unimaginable."

    ... argued that disabled people are a community unto themselves and that eliminating their conditions means erasing the potential future of their culture. She asked, "Where is the line between what society perceives to be a horrible genetic mutation and someone's culture?"

    The Eye of the Beholder

    I'm like: DO IT. And do it AGAIN just to make sure. And if you're bored, check to see if you need to do it AGAIN. If you want to be deaf, you can always stick bananas in your ears. Or your eyes. Or any other random orifices.

    --
    If the universe is someone's simulation -- does that mean the stars are just stuck pixels?
    1. Re:Someone doesn't like this. by djinn6 · · Score: 2

      I have the same response to people trying to save mosquitoes from genetically engineered extinction.

      There's 600,000 people on one side of the trolley track, a swarm of annoying bloodsuckers on the other, and we keep letting the trolley run over the people.

  5. Re: We all know the cure for this.. by Anonymous Coward · · Score: 2, Insightful

    The point is that thanks to CRISPR, we might be able to do eugenics without sterilization. Since most people with some bad genes also carry a lot of good genes, this is not only more humane, but also good for genetic diversity.

  6. Re: So where does society draw the line? by djinn6 · · Score: 2

    Technically not your body, but your kids. And yes, the government has some say because your kids' problems will eventually be society's problems.

  7. Re:Hidden Danger by djinn6 · · Score: 2, Insightful

    A bug introduced by early 21st century technology will be trivial to fix with 22nd century technology.