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Alzheimer's Disease Affects 'Twice As Many People' As Experts Thought (nypost.com)

schwit1 shares a report from the New York Post: In the U.S., 5.8 million people are living with the debilitating condition, according to the Alzheimer's Association, and that number is projected to rise to nearly 14 million by 2050. Scientists at the Mayo Clinic in Minnesota believe, however, that many more people are probably already living with it without having a formal diagnosis. They've been using brain imaging to give a definite answer as to how many people are affected. Tests on 2,500 people have shown that double the number of people have telltale signs of protein plaques and tangles in the brain -- markers of Alzheimer's disease -- even if they're not experiencing dementia. "The prevalence of Alzheimer's disease is all based on clinical assessment. It's just based on the question 'Do you have dementia?'" Dr. Jack Clifford, the Alexander Family professor of Alzheimer's disease research at the Mayo Clinic, told The Telegraph. "Classically defined Alzheimer's undercounts people who have the pathology but do not have symptoms. A lot more people have the disease but do not have symptoms, just like a lot more people have hypertension than have had a stroke, or a lot more people have diabetes than people who have gone blind."

60 comments

  1. makes sense by Anonymous Coward · · Score: 0

    What? How could they make a mistake like that, sounds like the experts have Alzheimerâ(TM)s too.

  2. Biological markers by manu0601 · · Score: 3, Interesting

    If you can live with the disease biological marker and without the disease, it means the biological marker does not tells us much about the disease.

    1. Re:Biological markers by sjames · · Score: 3, Insightful

      Not necessarily. Some diseases show few signs at first until the suffer suddenly decompensates. That is, it appears to come on suddenly when it's actually been at a slow boil for some time, then it crosses a threshold.

    2. Re:Biological markers by Ol+Olsoc · · Score: 1

      If you can live with the disease biological marker and without the disease, it means the biological marker does not tells us much about the disease.

      Asymptomatic Alzheimer's - what will they think of next?

      This whole thing smacks of an effort to get more funding. The ads will be frantically telling everyone that Alzheimer's is epidemic even through we don't always know we have it.

      Reminds me of the autism epidemic, where they were trying to shoehorn more and more people into the spectrum.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    3. Re:Biological markers by Ol+Olsoc · · Score: 1

      Not necessarily. Some diseases show few signs at first until the suffer suddenly decompensates. That is, it appears to come on suddenly when it's actually been at a slow boil for some time, then it crosses a threshold.

      Well, having had some family experience with Alzheimer's, the symptoms never came on suddenly. At first the decline was so slow that it was only in retrospect that we knew that the person was in the beginning stages of dementia.

      Even then, when it was obvious that the person was having trouble, it was not a fast onset, merely a long, slow goodbye.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    4. Re:Biological markers by Megol · · Score: 2

      Ever wondered if maybe it's you that have difficulty understanding the world rather than there being conspiracies everywhere?

    5. Re: Biological markers by Code+Herder · · Score: 1

      Cant say Iâ(TM)m agaisnt more funding for a cure or mitigation treatment. I saw a few people die of it and man itâ(TM)s not pretty in the last fee years. I mean its ok for a while but at some point if it was me Iâ(TM)d whish someone would pull the plug its just a farce.

      We have legal medically assisted suicide here but you have to prove youâ(TM)re sound of mind so itâ(TM)s pretty much out of the window if you want to check out late and you cant ask for it in advance in a will or something. The lawâ(TM)s still new and people are fighting to change it but thereâ(TM)s a lot of logistic to build are making sure people dont bring relatives to have them killed to get their money.

    6. Re:Biological markers by Anonymous Coward · · Score: 0

      I think the idea is to get treated before the symptoms manifest themselves.

    7. Re: Biological markers by Ol+Olsoc · · Score: 1

      Cant say Iâ(TM)m agaisnt more funding for a cure or mitigation treatment. I saw a few people die of it and man itâ(TM)s not pretty in the last fee years. I mean its ok for a while but at some point if it was me Iâ(TM)d whish someone would pull the plug its just a farce. We have legal medically assisted suicide here but you have to prove youâ(TM)re sound of mind so itâ(TM)s pretty much out of the window if you want to check out late and you cant ask for it in advance in a will or something. The lawâ(TM)s still new and people are fighting to change it but thereâ(TM)s a lot of logistic to build are making sure people dont bring relatives to have them killed to get their money.

      In the USA, the scheme is to insure that your money is extracted before you die. So they will treat you with drugs that draw out the cognitive decline as much as possible. Then (conjecture here) when you have no more money to give the nursing home, they allow you to die.

      Having seen the process firsthand with some family members, my hope is that if I come down with that, I can check out myself during the early stages. Getting to watch a loved one take 10 years to die, the last several as just a mindless money source for the death industry, I gotta say that is several orders of magnitude more stressful on a family than a quick exit. I figure I'll be doing my family a favor both emotionally and financially that way.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    8. Re:Biological markers by Ol+Olsoc · · Score: 0

      Ever wondered if maybe it's you that have difficulty understanding the world rather than there being conspiracies everywhere?

      You win the non-sequitur prize this morning for interpreting what I wrote as a conspiracy theory. It's just the economics of the medical industry in the US.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    9. Re:Biological markers by Ol+Olsoc · · Score: 1

      I think the idea is to get treated before the symptoms manifest themselves.

      And what would that treatment be?

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    10. Re:Biological markers by jma05 · · Score: 1

      Why do you feel that Alzheimer's Association is an industry organization?
      https://en.wikipedia.org/wiki/...

      Not saying it is or isn't - I don't know anything about it; just wanted to know why you think it is.

    11. Re:Biological markers by Ol+Olsoc · · Score: 1

      Why do you feel that Alzheimer's Association is an industry organization? https://en.wikipedia.org/wiki/...

      Not saying it is or isn't - I don't know anything about it; just wanted to know why you think it is.

      I don't think it is an industry association. But if they can suddenly claim that asymptomatic people are suffering from Alzheimer's, research money can be demanded. The issue is that Alzheimer's is invariably fatal. The medicines used to treat it simply extend the inevitble timeline. This is like extending the timeline of incurable incendiary cancer. Live a few more months in terrible pain, allow your family to suffer as they see you suffer.

      Ever see a lot of people with Alzheimer's? While some are happy, most are crying, miserable for the times they aren't asleep. So in addition to the drugs that merely slow the progression, they are miserable for that much longer. Fear not though, as other drugs can be administered that might take a little bit of the edge off that misery. This isn't like insulin. This is people who are already demented having the length of their dementia extended. And that means maybe another year on some mighty expensive drugs.

      It doesn't have anything specific that is the fault of any association, it is the pharmaceutical industry, and the nursing industry that can realize increased profits the longer an Alzheimer's patient lives. Another year of life, and they can realize a hundred K or even much much more. The goal is to extract the patient's wealth, then after they are destitute, for them to die. I've seen it with family members. The last two years of my Mother in law's life cost $675,000 dollars for care, without the meds. With the meds, it was edging toward a million. There's a lot of money to be made by having people be ready to die, but extending that as long as possible.

      While some folks seem to think I'm talking about a conspiracy, this is not. It is simply a successful and rather cruel business model that I have been though a few times. I dunno if any of y'all have gone through the US death business. Your retirement account is emptied, then any real estate you might have is sold and the proceeds go toward more upkeep. When you are finally destitute, the socialized medicine takes over, but it simply isn't as profitable as the rates they charge you while you have money. When they can, and if you appear to have afew more years in you, the for profit industry will ship you off to the county home. Your socialized medicine bed can be much more profitably filled with someone who still can pay full price.

      There are a fair number of couples who divorce so that the interred person will be destitute and won't destroy the estate. That however, takes special conditions, where the patient is ill but still of sound mind, which is not the case for dementia.

      And now, we have the real reason that single payer medicine is vehemently fought by one of the political parties in the US. There's too much money in it, and plenty of bribes to be made, and profit to be had.

      --
      The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
    12. Re: Biological markers by DigressivePoser · · Score: 1

      In the USA, the scheme is to insure that your money is extracted before you die. So they will treat you with drugs that draw out the cognitive decline as much as possible. Then (conjecture here) when you have no more money to give the nursing home, they allow you to die.

      Sorry you had to go through the long goodbye with a family member. Your bleak assessment has not been my experience with my Dad's decline though. His doctor and nursing home are not in cahoots to drain money. Whether to use drugs that may improve his memory or to alleviate other health issues has been the family's decision. The only time the nursing home chimed in was to control aggression.

      As far as myself getting the disease, man I'm with you. Get out while you still know how. Otherwise, at some point, you'll be wearing Depends because you can't remember where the toilet is or how to use it.

    13. Re:Biological markers by Anonymous Coward · · Score: 0

      I live in and out of US. Love the country and medical research, but the healthcare costs scare the hell out of me.

    14. Re:Biological markers by sjames · · Score: 1

      And likewise, someone with the biological markers may be affected at a level that won't be noticed as symptome except perhaps in retrospect.

  3. news? by Anonymous Coward · · Score: 0

    not really

  4. JUST WOW by Anonymous Coward · · Score: 0

    Thr thought that has never occurred to anyone ever. Lack of diagnosis. YEEEAAAAH.

  5. Heh by Anonymous Coward · · Score: 0

    Next "story" plz

  6. Re: Another fine piece of fake news... by Anonymous Coward · · Score: 0, Insightful

    if you literally can't be bothered to get a diagnosis now, why would the doctor care later?

  7. Wait what? by Anonymous Coward · · Score: 0

    Why are alzheimers and dementia being conflated here?

    1. Re: Wait what? by Anonymous Coward · · Score: 0

      Because they're calling one not the other that's why. Enough. Dementia is worse than Alzheimer's clearly.

    2. Re: Wait what? by Anonymous Coward · · Score: 0

      They're not being conflated. Alzheimers is a disease. Dementia is a symptom. Many different diseases have dementia as a symton. Alzheimers has several symptons, and dementia is one of those symptoms. Dementia is much more easy to observe than the other symptoms, but it apears late in the progression of Alzheimers. What this study did was lok for a particular early symptom.
      The reason we previoulsy were not aware of the previously undetected early symptom is that we did not look for it.
      The other thing is that many people who have undetected Alzheimers in the earlier stages have other health problems because they are old. They may die from heart trouble or kidney disease before dementia becomes obvious.

    3. Re: Wait what? by Anonymous Coward · · Score: 0

      I apologize for all the typos. I'm using an Ipad while driving on Atlanta's I-285.

    4. Re: Wait what? by Anonymous Coward · · Score: 0

      I apologize for all the typos. I'm using an Ipad while driving on Atlanta's I-285.

      That'll reduce your chance of dying from Alzheimer's.

  8. SAD - Standard American Diet by no-body · · Score: 1

    and insulin resistance are main factors for causing this disease. Has the US society any defense against this onslaught of care cases?
    Nope!

    1. Re: SAD - Standard American Diet by Anonymous Coward · · Score: 0

      At least I don't have gangrene anymore although I tend to forget from time to time. That's good enough or at least I thought it was. I forgot.

    2. Re:SAD - Standard American Diet by religionofpeas · · Score: 1

      Right, it's also called diabetes type 3. Cutting down carbs (especially refined) should be first step in treatment and avoidance.

    3. Re:SAD - Standard American Diet by Megol · · Score: 1

      Nice that you have the cause of and solution to one of this disease, have you published your scientific findings yet? We're all waiting. /s

    4. Re:SAD - Standard American Diet by no-body · · Score: 1

      Nice that you have the cause of and solution to one of this disease, have you published your scientific findings yet? We're all waiting. /s</p></quote>

      Steven Masley "The better brain solution"

      The knowledge is there, is something changing?

      Here is another one for you:

      Over 20 years ago, a book "The heat is on" was written by Ross Gelbspan about global warming and the denial about it.
      In this book, it was outlined that the warming itself is not so much the issue but the increased energy in the system causing more dynamic and extremes - storms, floods droughts etc.

      The knowledge is there, is something changing?

      I'd say system failure, red light flashing - ooonk ooonk oonk,
      somewhere in the basement....

    5. Re:SAD - Standard American Diet by no-body · · Score: 1

      Nice that you have the cause of and solution to one of this disease, have you published your scientific findings yet? We're all waiting. /s</p></quote>

      Another one:

      Have you experienced a person close to you going through this until the very end, and what that does that to you?

      Me thinks this would drive the smart-assy-ness right out of you!

  9. Smoke and mirrors by Anonymous Coward · · Score: 0

    Uh ... I can say for a fact that clinical assessment of dementia is not based on asking people "do you have dementia?" No one does that and you'd lose your license for doing that. Prevalence might be estimated sometimes that way but not in any rigorous studies.

    There's a continuum of functioning from mild cognitive difficulties to full-blown advanced neurodegenerative disease. This is one reason why major and mild NCI was introduced into the DSM-5, although it doesn't solve the issue completely.

    Setting up and taking down a strawman is what this sounds like.

    1. Re:Smoke and mirrors by Dayze!Confused · · Score: 2

      I don't think they meant literally asking them "Do you have dementia?" But going from the question, "Do you have dementia?" and answering it by asking the other questions which would say "Yes you do." or "No you don't." But that line of questioning wouldn't catch those without symptoms, but with the pathology. The idea is to examine those without the symptoms to find if they have the pathology. This could help to find how early the disease begins to develop before any symptoms show up.

      --
      "All tyranny needs to gain a foothold is for people of good conscience to remain silent." [Thomas Jefferson]
    2. Re:Smoke and mirrors by Anonymous Coward · · Score: 0

      But Alzheimer's disease is defined as a dementia. So if you have plaques and are otherwise asymptomatic, you don't have Alzheimer's, nor does it "affect" you in any evident way as the inaccurate title suggests. There is no 100% link between dementia and plaque, nor is there a plausible model of how it works. For example whatever causes Alzheimer's could also be one cause for plaque, but not the only one. Redefining the disease to include people without signs of dementia would only obscure these open questions.

  10. I'd read this too. by Anonymous Coward · · Score: 0

    Only defense is to reduce carb intake to about 30%, which is half what so-called "healthy" Americans eat. Most obese people probably ate 80% carbs to get there. I did.

    Going below 30% carbs for more than a year could be unhealthy for some people. Just look at Bob Harper; heart attack at age 52. He was doing the low carb, plenty of protein diet before. Now he's doing the low carb, plant-based diet with poultry, fish and eggs for protein. No red meat. He also reduced the extreme intensity of his crossfit workouts. He still does crossfit.

    Of course, there are always exceptions for every advice/diet. I know obese people who have been obese since childhood who eat carbs only from normal veggies and avoid it from grains, rice, and starches, so there are some people for which avoiding carbs doesn't help.

    OTOH, if I keep all carbs below 30%, I loose a little weight every week and my mind seems much sharper. Since switching to mostly plant-based diet, limited carbs, I'm never hungry and still get to choose when I eat, just like people on a keto diet. I know my mind feeling sharper isn't related to caffeine, since I stopped using that drug over a decade ago.

  11. I thought I had heard something about that by Crashmarik · · Score: 1

    But I couldn't be sure

  12. Real fake news? by Anonymous Coward · · Score: 0

    It's only news if we make them all President.

  13. Re: Another fine piece of fake news... by Rockoon · · Score: 1

    Seems to me if a theorized-to-be telltale sign of Alzheimer's isnt present in a staggering number of people that are specifically not diagnosed with Alzheimer's, then maybe it isnt such a telltale sign after all.

    --
    "His name was James Damore."
  14. Breaking news by Hognoxious · · Score: 1

    [fiddles with earpiece]

    Source of error found: it seems they counted them, forgot they'd done it, and then counted them again.

    --
    Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  15. This is actually the long tail of CJD. by Anonymous Coward · · Score: 0

    When the satanic Thatcher came to power in the UK, one of her first deeds was to reverse farming protocols that Humanity had followed for THOUSANDS of years. This evil slag thusly gave the world 'mad cow' disease- moving a deadly prion into much of the Earth's beef livestock.

    CJD/mad cow got a lot of publicity early on, since a tiny number of young people had unfortunate genetics that meant they suffered massive prion brain deterioration from eating beef. This caused massive concern amongst the scientific community - thinking that this was the beginning of an epidemic. Twenty years later the people tracking this problem concluded the general Human population had a genetic make-up that delayed the brain damaging effect of the prion until 'old age'. But once enough time had elapsed, there would be a massive increase in 'dementia' type events in Humans in their 60s and older- the long tail of Thatcher's mad cow 'gift' to Humanity.

    As you may know, the prion infection can only be confirmed by a post mortem- the brain damage caused by the prion in the elderly is rarely as 'extreme' as those early cases of CJD in the young. This serves the governments of the Earth perfectly, since their plan was to fold CJD cases into pre-existing forms of senility, and to allow the sheeple to come to an erroneous conclusion- namely that their brain damaged elderly relative is suffering from any condition BUT CJD.

    Why? Because CJD implies (correctly) horrific malfeasnce by governments and their agencies that are supposed to protect us. And today the same governments are saying "trust us" over issues of population mass drugging policies, and Thatcher like policies of changing farming protocols in the name of 'modern genetic science'.

    Just like Slashdot commands you to 'trust' the mainstream news outlets that all co-ordinated WMD in Iraq lies on behalf of Humanity's worst living war criminal- Tony Blair.

    At least the cause of mad cow was not covered up, unlike the similar story of AIDS (caused when vaccination protocols were ignored, and an oral polio vaccine was created from monkeys, moving the virus the monkeys had carried for thousands of years into the Human population of much of Africa). Heaven and earth has been moved to cover up the scientific disaster that caused AIDS. All in the name of keeping the sheeple 'trusting' the vaccination 'experts'.

    Of course before the OPV in Africa spread AIDS, vaccinations had been responsible for explosions of various forms of cancer- because it was originally impossible to filter out cancer cause viruses from vaccinations used up until the 1960s.

    When governments or their 'experts' say "trust us", that is exactly the moment to withdraw any and all trust.

    And it NEVER stops. Food agencies in the UK were supposed to be the most advanced on the planet- monitoring the quality of ALL meat sold for Human consumption with sophisticated lab tests. And then it was revealed that most processed 'beef' in the UK was actually HORSE meat- the state-of-the-art government labs just hadn't noticed.

    Why do you think foul outlets like Slashdot work so hard pushing the statist message that govenments and their agencies are more trustworth than any other source? Liars, cheats and monsters need their cheerleaders.

    1. Re:This is actually the long tail of CJD. by Megol · · Score: 1

      No U.

  16. Re:Stewpeed story by Anonymous Coward · · Score: 0

    Alzheimer's Disease affects twice as many Presidents as experts thought.

  17. sounds like a good bussiness idea by Anonymous Coward · · Score: 0

    Hook up people on crap food inducing diabetes, obesity and lowering mental performance, ensuring you remain the top doggie in doggie eat doggie land. Keep normal food overpriced so 'little people' can't buy it. Hmm, this sounds awfully familiar. Where could it be?

  18. that does explain a lot of what is happening today by Anonymous Coward · · Score: 0

    "Scientists at the Mayo Clinic in Minnesota believe, however, that many more people are probably ALREADY LIVING with it without having a formal diagnosis."

  19. Re: Another fine piece of fake news... by MrKaos · · Score: 1

    Seems to me if a theorized-to-be telltale sign of Alzheimer's isnt present in a staggering number of people that are specifically not diagnosed with Alzheimer's,

    then it maybe a physical manifestation of the cognitive by-products of personality disorders from the production of peptides in the brain.

    --
    My ism, it's full of beliefs.
  20. Donald Trump by Anonymous Coward · · Score: 0

    When Donald Trump kept talking about the "oranges" of the Mueller report (instead of origins), that seems like classic dementia to me. Trump chose a word which sounded like the correct word, but which did not make sense at all in the context of what he was trying to say. Because of the context, what Trump said came across as humorous.

    This fits a lot with the friends I have had who were stricken with dementia. They would say things like that all the time. I would correct them, and they would realize the mistake.

    Dementia could also explain why Trump keeps saying his father was born in Germany when it was really his grandfather who was born there. One of my friends kept a list in his wallet of all the major years of his life. So when I would ask him when he graduated from college, he would pull out the list and tell me. People with dementia get basic facts from their life wrong, which would not happen with people who do not have dementia.

    1. Re: Donald Trump by Anonymous Coward · · Score: 0

      I am almost 70, and the fact that Trump is senile jumped out at me in the Trump-Hillary debates. It is very very obvious if you just read the transcripts, and like me have seen it progress in my peer group.

    2. Re: Donald Trump by Anonymous Coward · · Score: 0

      Full disclosure: I am the almost 70 AC, a lifelong Republican, and I voted for him for the simple reason that I have a large income and I wanted the tax cut I got. I will not vote to reelect him.

  21. You can do better than that WindBourne by Anonymous Coward · · Score: 0

    You getting lazy?

  22. One manifestation of Alzheimer's develops from STD by Anonymous Coward · · Score: 0

    One manifestation of Alzheimer's develops from Spirochaete infection of the brain.

    READ THIS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139345/

  23. Re:that does explain a lot of what is happening to by Anonymous Coward · · Score: 0

    Well, Mayo Clinic in Minnesota is in Rochester and is surrounded by a minimum of 100 miles in every direction by farm country.

    And believe me, it's not a surprise that twice as many of those old farmers have Alzheimer's even if it hasn't been formally diagnosed than previously thought.