Honestly, it almost seems as if the insulin market is just too lucrative to allow a real cure for Type 1 diabetes.
Novo Nordisk insulin is available from Walmart at a heavy discount, and biosimilar versions (generic, more or less) will be on the market soon. The insulin market isn't going to be very lucrative for much longer, at least when it isn't attached to a proprietary delivery system.
Over the past four decades, we've seen squat in the form of treatment for diabetes other than improving the delivery of insulin delivery for diabetics, which has been around since the 1920s.
Lots of drugs have been developed for type II and there are always plenty more in development. Pharmas like money and there is always plenty of it for a new diabetes drug.
The other improvement is in the algorithm used to calculate glucose levels and hormone dosages. For one thing, it allows the user to input information about the meals they are about to eat.
It's not click bait; it's the results of the first outpatient trial.
Among the adults, the mean plasma glucose level over the 5-day bionic-pancreas period was 138 mg per deciliter (7.7 mmol per liter), and the mean percentage of time with a low glucose level (less than 70 mg per deciliter [3.9 mmol per liter]) was 4.8%. After 1 day of automatic adaptation by the bionic pancreas, the mean (±SD) glucose level on continuous monitoring was lower than the mean level during the control period (133±13 vs. 159±30 mg per deciliter [7.4±0.7 vs. 8.8±1.7 mmol per liter], P less than 0.001) and the percentage of time with a low glucose reading was lower (4.1% vs. 7.3%, P=0.01). Among the adolescents, the mean plasma glucose level was also lower during the bionic-pancreas period than during the control period (138±18 vs. 157±27 mg per deciliter [7.7±1.0 vs. 8.7±1.5 mmol per liter], P=0.004), but the percentage of time with a low plasma glucose reading was similar during the two periods (6.1% and 7.6%, respectively; P=0.23). The mean frequency of interventions for hypoglycemia among the adolescents was lower during the bionic-pancreas period than during the control period (one per 1.6 days vs. one per 0.8 days, P less than 0.001).
This is the first trial of an experimental device. It's years away from the market. So far:
The developers tested the device over five days in two groups of patients, 20 adults and 32 adolescents, comparing the results with readings obtained with conventional insulin pumps that the participants were using.
The artificial pancreas performed better than the conventional pump on several measures. Among the adolescents, the average number of interventions for hypoglycemia was 0.8 a day with the experimental pump, compared with 1.6 a day with the insulin pumps. Among adults, the device significantly reduced the amount of time that glucose levels fell too low.
HP has a long history of OS, CPU, and other types of tech design, but they lost a lot of that when they spun off Agilent. Since then HP's budget for research, not to mention the researchers/departments themselves, have been slashed. They are not down to Dell levels of R&D yet, but that seems to be the trend.
No a lancer evolution comes from the factory with 300 horsepower and 300ft/lbs of torque from as low as 3000rpm. That's V8 grunt. Except the engine a 2.0 liter 4 cylinder with a massive turbocharger breathing 23psi. In Europe the same car is available with up to 440 horsepower and 415ft/lbs of torque from the same 2.0 liter engine. It's called the FQ440. They also sell 400hp/360hp/330hp/ and in America only the 300hp version.
All of which is housed in the body of a Lancer, which is what the police see unless you're a leadfoot.
I'll only be in town for like 2 or 3 days yet I'll be harassed by cops, have them randomly floor their cars screeching their tires while riding next to me then slam on the breaks and then speed back up next to me and stare at me.
For no reason besides that I drive an Evo which is a very fast Turbo AWD rally car. I'll just be cruising and instantly get all sorts of harassment.... I saw him coming down the road and suddenly he noticed my sports car....
You're driving a Mitsubishi compact sedan or hatchback. Unless you've tarted it up with bric-a-brac (spoilers, coffee can exhaust, stickers, etc) or you're a leadfoot the police think you're driving a Mitsubishi compact sedan or hatchback.
Unions have less political influence now than at any time since WWII. Taxi drivers will certainly complain about the new services, but without significant campaign/PAC funds to contribute they won't be calling the shots. Taxi owners (the ones with medallions that allow others to drive their cabs) are the ones with 7 to 9 figure investments at risk, and they will be the ones lobbying and suing to preserve the status quo.
Some states limit the ride sharing designation to non-profits. The difference in the case you pose is 1, frequency - how often does your friend get paid to transport people? Should the municipality spend time and money enforcing statutes against one offs or instead prioritize habitual offenders? 2, insurance: if you and your friend got in an accident and he told his insurance company he was actually being paid to transport you they wouldn't pay the claim.
Unions aren't the problem, it's the capitalists who invested upwards of $1M per taxi medallion. Specifically the lawsuits they will file against the cities/states if they change laws so as to devalue those medallions.
It's not clear that it's safe for UberX drivers in either situation. If the driver causes an accident UberX will cover their liability costs only. Their own costs they will have to pay out of pocket unless they get commercial insurance, since their personal insurance won't cover them.
yes and no
We need to secure the border or more people will continue to break the law and come in here
If he had the border secure, we would not have to worry about amnesty as there wouldnt be people here who dont belong here
Except for everyone who overstays visas, etc. If you are serious about illegal immigration, make it simple, fast, and cheap to verify a worker's eligibility and back it up with massive fines for employers that don't do it for every new hire.
Why should the taxpayer foot the bill for helping a private organization decide who -won't- run in the general election. All it does is reduce the number of options for the voter. They should ALL be running in the general election. Let them debate it out and fight it out.
Primaries don't benefit anybody except the incumbents.
A single winner take all election benefits incumbents most of all. All they have to do is maintain their hardcore supporters (25-30% of the vote) and the dozen challengers will split the rest of the vote in so many directions that none have a chance. A primary gives a single challenger a chance against an entrenched incumbent - and the primary doesn't have to be party based.
Is that the country with strict gun laws that just had a mass shooting where the killer was at large for several days?
But no, such an event in a country with strict gun laws doesn't fit the narrative you want to hear, now does it?
Canada? The country with 1/4 the firearm related death rate and 1/7 the firearm related homicide rate as the USA? Is that the narrative you were looking for? Obviously they need more guns up there for self defense against mass killers.
Violent crime is down, way down. Why ask, let alone assume, whether law enforcement is purchasing this kind of equipment for practical rather than political reasons?
Safety through obscurity: Encrypt the time capsule and put it in a virus. One that is targeted at, say, machines in Southern China running Windows XP. Do the same with the key. The viruses do absolutely nothing until the targeted time/date, after which their only function is to attempt to send the encrypted data and the key to the gatekeeper and the keymaster or whoever is supposed to get them. Meanwhile, two things you can bet on: 1. There will be a few machines still running XP in southern China 10 years from now. 2. No one will be searching or subpoenaing those machines for your time capsule.
The uploader is the only infringer - unless the powers that be decide that downloading/streaming qualifies as contributory infringement, since the viewer has requested a website to "make a copy" and "distribute" it. How do you feel about the current SCOTUS deciding what "make a copy", "make available", and "distribute" mean on the internet these days?
It would give them twin business models: subscriptions for the people willing to pay, infringement shakedowns for the people who aren't willing to pay.
What I'd like to know is if:
The court ruled that "on-screen copies and the cached copies made by an end-user in the course of viewing a website satisfy the conditions" of infringement exemptions spelled out in the EU Copyright Directive.
We don't consider influenza a serious disease, like we do Polio or Measles however so it's generally not discussed as a "disease", but an infection/illness/sickness/ailment.
There are still ~5,000-50,000 influenza associated deaths per year in the US and quite a few more hospitalizations. It's definitely a serious disease for the elderly, for whom vaccination is often partially effective at best. What does work: vaccinating kids, so they don't give their grandparents the flu:
http://www.medscape.com/viewarticle/737711
Conclusion: Vaccination of children against influenza may induce herd immunity against influenza for older adults and has the potential to be more beneficial to older adults than the existing policy of preventing influenza by vaccinating older adults themselves.
Anti-vaxxer is a choice, but anti-vaxxer is an opinion, not a medical record, especially considering most of them were vaccinated as kids. Staying unvaccinated frequently isn't a choice, or rather, it's the choice of the anti-vaxxer parents, not the choice of the minor himself or herself.
Slashdot Mirror
Honestly, it almost seems as if the insulin market is just too lucrative to allow a real cure for Type 1 diabetes.
Novo Nordisk insulin is available from Walmart at a heavy discount, and biosimilar versions (generic, more or less) will be on the market soon. The insulin market isn't going to be very lucrative for much longer, at least when it isn't attached to a proprietary delivery system.
Over the past four decades, we've seen squat in the form of treatment for diabetes other than improving the delivery of insulin delivery for diabetics, which has been around since the 1920s.
Lots of drugs have been developed for type II and there are always plenty more in development. Pharmas like money and there is always plenty of it for a new diabetes drug.
http://www.nejm.org/doi/full/10.1056/NEJMoa1314474#Results=&t=articleResults
Among the adults, the mean plasma glucose level over the 5-day bionic-pancreas period was 138 mg per deciliter (7.7 mmol per liter), and the mean percentage of time with a low glucose level (less than 70 mg per deciliter [3.9 mmol per liter]) was 4.8%. After 1 day of automatic adaptation by the bionic pancreas, the mean (±SD) glucose level on continuous monitoring was lower than the mean level during the control period (133±13 vs. 159±30 mg per deciliter [7.4±0.7 vs. 8.8±1.7 mmol per liter], P less than 0.001) and the percentage of time with a low glucose reading was lower (4.1% vs. 7.3%, P=0.01). Among the adolescents, the mean plasma glucose level was also lower during the bionic-pancreas period than during the control period (138±18 vs. 157±27 mg per deciliter [7.7±1.0 vs. 8.7±1.5 mmol per liter], P=0.004), but the percentage of time with a low plasma glucose reading was similar during the two periods (6.1% and 7.6%, respectively; P=0.23). The mean frequency of interventions for hypoglycemia among the adolescents was lower during the bionic-pancreas period than during the control period (one per 1.6 days vs. one per 0.8 days, P less than 0.001).
How about implants of pancreatic cells encased so as to be protected from the immune system?
The developers tested the device over five days in two groups of patients, 20 adults and 32 adolescents, comparing the results with readings obtained with conventional insulin pumps that the participants were using.
The artificial pancreas performed better than the conventional pump on several measures. Among the adolescents, the average number of interventions for hypoglycemia was 0.8 a day with the experimental pump, compared with 1.6 a day with the insulin pumps. Among adults, the device significantly reduced the amount of time that glucose levels fell too low.
HP has a long history of OS, CPU, and other types of tech design, but they lost a lot of that when they spun off Agilent. Since then HP's budget for research, not to mention the researchers/departments themselves, have been slashed. They are not down to Dell levels of R&D yet, but that seems to be the trend.
No a lancer evolution comes from the factory with 300 horsepower and 300ft/lbs of torque from as low as 3000rpm. That's V8 grunt. Except the engine a 2.0 liter 4 cylinder with a massive turbocharger breathing 23psi. In Europe the same car is available with up to 440 horsepower and 415ft/lbs of torque from the same 2.0 liter engine. It's called the FQ440. They also sell 400hp/360hp/330hp/ and in America only the 300hp version.
All of which is housed in the body of a Lancer, which is what the police see unless you're a leadfoot.
I'll only be in town for like 2 or 3 days yet I'll be harassed by cops, have them randomly floor their cars screeching their tires while riding next to me then slam on the breaks and then speed back up next to me and stare at me.
For no reason besides that I drive an Evo which is a very fast Turbo AWD rally car. I'll just be cruising and instantly get all sorts of harassment. ... I saw him coming down the road and suddenly he noticed my sports car. ...
You're driving a Mitsubishi compact sedan or hatchback. Unless you've tarted it up with bric-a-brac (spoilers, coffee can exhaust, stickers, etc) or you're a leadfoot the police think you're driving a Mitsubishi compact sedan or hatchback.
Unions have less political influence now than at any time since WWII. Taxi drivers will certainly complain about the new services, but without significant campaign/PAC funds to contribute they won't be calling the shots. Taxi owners (the ones with medallions that allow others to drive their cabs) are the ones with 7 to 9 figure investments at risk, and they will be the ones lobbying and suing to preserve the status quo.
Some states limit the ride sharing designation to non-profits. The difference in the case you pose is 1, frequency - how often does your friend get paid to transport people? Should the municipality spend time and money enforcing statutes against one offs or instead prioritize habitual offenders? 2, insurance: if you and your friend got in an accident and he told his insurance company he was actually being paid to transport you they wouldn't pay the claim.
Unions aren't the problem, it's the capitalists who invested upwards of $1M per taxi medallion. Specifically the lawsuits they will file against the cities/states if they change laws so as to devalue those medallions.
It's not clear that it's safe for UberX drivers in either situation. If the driver causes an accident UberX will cover their liability costs only. Their own costs they will have to pay out of pocket unless they get commercial insurance, since their personal insurance won't cover them.
Yup
yes and no We need to secure the border or more people will continue to break the law and come in here If he had the border secure, we would not have to worry about amnesty as there wouldnt be people here who dont belong here
Except for everyone who overstays visas, etc. If you are serious about illegal immigration, make it simple, fast, and cheap to verify a worker's eligibility and back it up with massive fines for employers that don't do it for every new hire.
Why should the taxpayer foot the bill for helping a private organization decide who -won't- run in the general election. All it does is reduce the number of options for the voter. They should ALL be running in the general election. Let them debate it out and fight it out.
Primaries don't benefit anybody except the incumbents.
A single winner take all election benefits incumbents most of all. All they have to do is maintain their hardcore supporters (25-30% of the vote) and the dozen challengers will split the rest of the vote in so many directions that none have a chance. A primary gives a single challenger a chance against an entrenched incumbent - and the primary doesn't have to be party based.
Especially since Republicans have been advocating using this technique against the Democrats for years.
Canada?
Is that the country with strict gun laws that just had a mass shooting where the killer was at large for several days?
But no, such an event in a country with strict gun laws doesn't fit the narrative you want to hear, now does it?
Canada? The country with 1/4 the firearm related death rate and 1/7 the firearm related homicide rate as the USA? Is that the narrative you were looking for? Obviously they need more guns up there for self defense against mass killers.
Violent crime is down, way down. Why ask, let alone assume, whether law enforcement is purchasing this kind of equipment for practical rather than political reasons?
Safety through obscurity: Encrypt the time capsule and put it in a virus. One that is targeted at, say, machines in Southern China running Windows XP. Do the same with the key. The viruses do absolutely nothing until the targeted time/date, after which their only function is to attempt to send the encrypted data and the key to the gatekeeper and the keymaster or whoever is supposed to get them. Meanwhile, two things you can bet on: 1. There will be a few machines still running XP in southern China 10 years from now. 2. No one will be searching or subpoenaing those machines for your time capsule.
The uploader is the only infringer - unless the powers that be decide that downloading/streaming qualifies as contributory infringement, since the viewer has requested a website to "make a copy" and "distribute" it. How do you feel about the current SCOTUS deciding what "make a copy", "make available", and "distribute" mean on the internet these days?
http://www.washingtonian.com/blogs/capitalcomment/local-news/virginia-dmv-tells-uber-and-lyft-to-stop-operating.php
It would give them twin business models: subscriptions for the people willing to pay, infringement shakedowns for the people who aren't willing to pay.
What I'd like to know is if:
The court ruled that "on-screen copies and the cached copies made by an end-user in the course of viewing a website satisfy the conditions" of infringement exemptions spelled out in the EU Copyright Directive.
applies to streaming video websites as well.
We don't consider influenza a serious disease, like we do Polio or Measles however so it's generally not discussed as a "disease", but an infection/illness/sickness/ailment.
There are still ~5,000-50,000 influenza associated deaths per year in the US and quite a few more hospitalizations. It's definitely a serious disease for the elderly, for whom vaccination is often partially effective at best. What does work: vaccinating kids, so they don't give their grandparents the flu:
http://www.medscape.com/viewarticle/737711
Conclusion: Vaccination of children against influenza may induce herd immunity against influenza for older adults and has the potential to be more beneficial to older adults than the existing policy of preventing influenza by vaccinating older adults themselves.
Anti-vaxxer is a choice, but anti-vaxxer is an opinion, not a medical record, especially considering most of them were vaccinated as kids. Staying unvaccinated frequently isn't a choice, or rather, it's the choice of the anti-vaxxer parents, not the choice of the minor himself or herself.
How the US is doing:
http://www.cdc.gov/nchs/fastat...
Percent of children 19-35 months old receiving vaccinations for:
Diphtheria, Tetanus, Pertussis (4+ doses DTP, DT, or DTaP): 83%
Polio (3+ doses): 93%
Measles, Mumps, Rubella (MMR) (1+ doses): 91%
Haemophilus influenzae type b (Hib) (primary series + booster dose): 81%
Hepatitis B (Hep B) (3+ doses): 90%
Chickenpox (Varicella) (1+ doses): 90%
Pneumococcal conjugate vaccine (PCV) (4+doses): 82%
Percent of children 6 months to 17 years who received an influenza vaccination during the past 12 months: 45.2%
Percent of adults 18-49 years who received an influenza vaccination during the past 12 months: 26.3%
Percent of adults 50-64 years who received an influenza vaccination during the past 12 months: 42.7%
Percent of adults 65 years and over who received an influenza vaccination during the past 12 months: 66.5%