Amikacin may be administered once or twice a day but must be given by the intravenous or intramuscular route. There is no oral form available. Dosage must be adjusted in people with kidney failure.
Arbekacin
Arbekacin (INN) is a semisynthetic aminoglycoside antibiotic. It is primarily used for the treatment of infections caused by multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA).[1][2] Arbekacin was originally synthesized from dibekacin in 1973. It has been registered and marketed in Japan since 1990 under the trade name Habekacin.[3] Arbekacin is no longer covered by patent and generic versions of the drug are also available under such trade names as Decontasin and Blubatosine.
Gentamicin
Gentamicin is an aminoglycoside antibiotic, used to treat many types of bacterial infections, particularly those caused by Gram-negative bacteria. However, gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain gram negative organisms).
Kanamycin
Kanamycin sulfate is an aminoglycoside antibiotic, available in both oral and intravenous forms, and used to treat a wide variety of infections. Kanamycin is isolated from Streptomyces kanamyceticus[1].... Kanamycin is not given to humans often because of its fairly toxic side-effects.
Neomycin
Neomycin is an aminoglycoside antibiotic that is found in many topical medications such as creams, ointments and eyedrops.... It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.[1]
Netilmicin
Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.
Paromomycin sulfate (synonyms: monomycin, aminosidine[1]; brand name Humatin) is an aminoglycoside antibiotic, first isolated from Streptomyces krestomuceticus in 1950s.[2] It is an antibiotic designed to fight intestinal infections such as cryptosporidiosis,[3] amoebiasis,[4] and leishmaniasis.[5] The route of administration is intramuscular injection.
Strptomycin
Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic[3]. Streptomycin cannot be given orally, but must be administered by regular intramuscular injection. An adverse effect of this medicine is ototoxicity, which can lead to temporary hearing loss.
Actually the point I was alluding too is the protection would work both ways, a lubricant with an Aminoglycoside would work as well as a lubricant for the woman's use or for a condom lubricant, the active ingredient would be on both sides of the condom, thus offering some protection to both.
We've been using the turn-on antibiotics for quite a while. Neomycin is one of them it's OTC so if it turns us into Neanderthals we would have noticed it by now.
In this case, their hack could be a-likened to a custom program that executes an executable past the incorrect limitation. Ironically the software not only works correctly, as desired, but it also doesn't conflict with updates in the rest of the software. (I'm sure they'll find some bugs though... I wonder how a human fetus would develop with this code enabled from the start?)
Someone teach me. Going ogling didn't help.:(
In this work, we reveal that, upon correction of the premature termination codon in theta-defensin pseudogenes, human myeloid cells produce cyclic, antiviral peptides (which we have termed "retrocyclins"), indicating that the cells retain the intact machinery to make cyclic peptides. Furthermore, we exploited the ability of aminoglycoside antibiotics to read-through the premature termination codon within retrocyclin transcripts to produce functional peptides that are active against HIV-1. Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1
So they are turning on the intrupted gene
An aminoglycoside is a molecule composed of a sugar group and an amino group.[1]
Several aminoglycosides function as antibiotics that are effective against certain types of bacteria. They include amikacin, arbekacin, gentamicin, kanamycin, neomycin, netilmicin, paromomycin, rhodostreptomycin[2], streptomycin, tobramycin, and apramycin. Aminoglycoside
Potentially with common antibacterial ointments
Given that the endogenous production of retrocyclins could also be restored in human cervicovaginal tissues, we propose that aminoglycoside-based topical microbicides might be useful in preventing sexual transmission of HIV-1.
that could be added to sexual/surgical lubricants like KY jelly; pretty impressive. I don't see where this would effect a fetus anymore than using neomycin ointment would.
The LD50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5-1.0 mg/kg can be a lethal dosage for adult humans.[2][3] Nicotine therefore has a high toxicity in comparison to many other alkaloids such as cocaine, which in mice has an LD50 of 95.1 mg/kg. It is impossible however to overdose on nicotine through smoking alone (though a person can overdose on nicotine through a combination of nicotine patches, nicotine gum, and/or tobacco smoking at the same time.) [4] [5] Spilling an extremely high concentration of nicotine onto the skin can result in intoxication or even death since nicotine readily passes into the bloodstream from dermal contact.Nicotine poisoning
Well... quadriplegics don't get that! Lucky bastards.
Are you sure, quads get phantom limb pain, so I assume phantom limb itching is also likely; imagine an itch that can't be scratched. I burned my hand a few years ago, at the burn clinic they, in a teaching hospital, aways ask about pain, never about itching. Finally one Dr. from another hospital casually mentioned that benedryl would stop the itching. Imagine the gritty itch from a bad sunburn lasting for 3 months, God bless that Dr.
Physics is getting very statistical nowadays too; sometimes you have too squint your eyes and tilt your head just right to see some of the results from high-energy physics as well.
Why fine the company? The science was very probably accurate;
Michael Platt, the president of DesignWrite, wrote that the company âoehas not, and will not, participate in the publication of any material in which it does not have complete confidence in the scientific validity of the content, based upon the best available data.â
of course they left out that the content glorified the reduction of trivial symptoms and the consideration of potentially fatal side effects were beyond the scope of the paper part. A PR/ghostwriting company can't get published if a respected clinician doesn't sign-on as an author, the real answer is to tell someone like Dr. Gloria Bachmann, she's not going to be published anymore for being a drug company's whore.
Yes it does seem possible and you might even get away with it in real life, but the idea of running a 48VDC pair that also uses a 100VAC ring signal right beside your ethernet pairs is scary. Also every time the telephone rings it would induce a hellacious amount of electrical noise into the data pairs; it would probably shut down any data packets on the network and possibly blow out your ethernet cards. If another technician was faninng the wires and happened puncture his skin with them the jolt from the 48VDC would probably make you number ten thousand dirty rotten SOB, a 100VAC ring signal would definitely make you number ten thousand dirty rotten SOB. Telephone and ethernet really don't play well together.
This thing is supposed tp go through 60m of 5000psi reinforced concrete, then explode. In a room full of gas centrifuges spinning at over 100K rpm the explosion would be redundant.
I just don't see a solar panel being able to produce enough power to keep a car cool except in the most optimal of conditions. Sitting idle in traffic is far from ideal.
I thought the solar cells were used to run a vent fan not the AC on the Pirus.
What isn't reasonable is for the electric company to use a fee such as this as a profit center. If they truly are doing this to be equitable to their users they should implement a reasonable fee, but lower their per kWH rate that users pay so the average non-solar user sees no increase in their current bill.
The electric industry is pretty unique, it's the only industry that considers labor a fixed expense, five people can generate 100MW or can generate nothing. Their biggest expense is actually equipment depreciation followed by fuel. Additionally since their profits are generally fixed at 10%, the higher their expenses are, the higher their profits!
A neighbor of mine is a power station operator at a paper plant, they burn ligin, a waste product to generate electricity for the plant, DTE charges the plant something like 75% what the electricity would cost just to have the sub-station to the grid for backup if the plants power station goes down. As a result the plant's power-station generates mainly during peak-load times because off-peak charges are less than the cost of generating their own electricity plus the conectivity charges!
MobileReference, the publisher in question, formats and sells public domain books on Amazon. The only problem is that George Orwell's Animal Farm and 1984 are not yet in the public domain, at least not in the US. According to Amazon's statement to Ars Technica, "These books were added to our catalog using our self-service platform by a third-party who did not have the rights to the books." When the publisher informed Amazon of this, Amazon moved to rectify the situation. The two books are no longer listed on MobleReference's website, either. http://arstechnica.com/tech-policy/news/2009/07/amazon-sold-pirated-books-raided-some-kindles.ars
and they were really between a rock and a hard place on this one.
Apparently when Amazon has to remove a title from sale on kindle, it removes it from their server. The kindle seems to download the work as needed rather than downloading in one shot.
Hacking laws on the books make it illegal to add, modify, or delete data on another person's computer without their consent. I believe it carries a pretty stiff sentence too, because it is a federal statute.
I am pretty sure that Amazon has no consent from anyone when they used their DRM to kill the book, so they could be in some deep water.
Also, since it was an an actual person that punched the enter key when it came time to revoke the DRM license, I wonder if they could be hit with the criminal hacking charge. The fact that invoking DRM controls could land you in the federal pen for 20 years might be a great way get corps to knock that shit off.
MobileReference, the publisher in question, formats and sells public domain books on Amazon. The only problem is that George Orwell's Animal Farm and 1984 are not yet in the public domain, at least not in the US. According to Amazon's statement to Ars Technica, "These books were added to our catalog using our self-service platform by a third-party who did not have the rights to the books." When the publisher informed Amazon of this, Amazon moved to rectify the situation. The two books are no longer listed on MobleReference's website, either.
But does Amazon's Terms of Service even allow for this kind of "rectification"? Peter Kafka examined the ToS and believes that there is no backing for this move. The ToS makes it sound as if all sales are final:
Upon your payment of the applicable fees set by Amazon, Amazon grants you the non-exclusive right to keep a permanent copy of the applicable Digital Content and to view, use, and display such Digital Content an unlimited number of times, solely on the Device or as authorized by Amazon as part of the Service and solely for your personal, non-commercial use. Digital Content will be deemed licensed to you by Amazon under this Agreement unless otherwise expressly provided by Amazon.
One possible loophole would be in the licensing: Amazon cannot license to you something for which it has no rights to license. Also, we suspect that some indemnification clauses in the third party contracts also put the publisher, not Amazon, on the hook for possible infringement problems.
So why would Amazon remove the books? It appears as though Amazon's purchasing system does this automatically. The company told Ars that they are "changing [Amazon's] systems so that in the future we will not remove books from customers' devices in these circumstances." Why Amazon went Big Brother on some Kindle e-books
The purchaser has no obligation to assume that a company that sells books in the normal course of their business might not have the legal rights to sell the book. If you purchase new books out of the trunk of someones car at half the cover price, you are required by law to assume they might be stolen, if you purchase them for a book seller at half price you don't. Returning the money doesn't un-rob the bank, deleting the book doesn't un-distribute it, but it does admit wrong-doing and the rights-holder can still seek damages from Amazon.
The law is actually clear, if you purchase something from a business that is in their normal line of business, you can assume the purchase was legal. I watched a court case where a sign company purchased a boat through barter from a marina. The Marina failed to pay the bank for the boat which they had purchased for resale on a revolving line of credit from the bank. The bank sued the sign company, the judge ruled that the sign company was not liable for the price of the boat because the marina sells boat in their normal course of business and the bank would have to sue the marina for their money. Like-wise the purchase of the book, purchasing the book from Amazon, a book seller should be able to assume that the book was purchased legally and the rights-holders should recover their royalties from Amazon. Amazon deleting the book from the purchaser attempted to void their illegal distribution, however distributing the book and deleting it is still distributing it; if you robbed a bank then later returned the money, the bank was still robbed. Amazon's deletion of the illegally distributed book is actually a confession of wrongdoing. Amazon now not only owes the purchaser for the price of the book and co-incidental damages caused by deletion of the book to the purchaser, but now also owes the rights-holders for royalties and civil penalties for the illegal distribution.
One would think that amazon's legal dept would be much sharper than what they just displayed.
Slashdot Mirror
Amikacin
Amikacin may be administered once or twice a day but must be given by the intravenous or intramuscular route. There is no oral form available. Dosage must be adjusted in people with kidney failure.
Arbekacin
Arbekacin (INN) is a semisynthetic aminoglycoside antibiotic. It is primarily used for the treatment of infections caused by multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA).[1][2] Arbekacin was originally synthesized from dibekacin in 1973. It has been registered and marketed in Japan since 1990 under the trade name Habekacin.[3] Arbekacin is no longer covered by patent and generic versions of the drug are also available under such trade names as Decontasin and Blubatosine.
Gentamicin
Gentamicin is an aminoglycoside antibiotic, used to treat many types of bacterial infections, particularly those caused by Gram-negative bacteria. However, gentamicin is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain gram negative organisms).
Kanamycin
Kanamycin sulfate is an aminoglycoside antibiotic, available in both oral and intravenous forms, and used to treat a wide variety of infections. Kanamycin is isolated from Streptomyces kanamyceticus[1]. ... Kanamycin is not given to humans often because of its fairly toxic side-effects.
Neomycin
Neomycin is an aminoglycoside antibiotic that is found in many topical medications such as creams, ointments and eyedrops. ... It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.[1]
Netilmicin
Netilmicin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.
Paromomycin sulfate (synonyms: monomycin, aminosidine[1]; brand name Humatin) is an aminoglycoside antibiotic, first isolated from Streptomyces krestomuceticus in 1950s.[2]
It is an antibiotic designed to fight intestinal infections such as cryptosporidiosis,[3] amoebiasis,[4] and leishmaniasis.[5]
The route of administration is intramuscular injection.
Strptomycin
Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic[3]. Streptomycin cannot be given orally, but must be administered by regular intramuscular injection. An adverse effect of this medicine is ototoxicity, which can lead to temporary hearing loss.
Actually the point I was alluding too is the protection would work both ways, a lubricant with an Aminoglycoside would work as well as a lubricant for the woman's use or for a condom lubricant, the active ingredient would be on both sides of the condom, thus offering some protection to both.
We've been using the turn-on antibiotics for quite a while. Neomycin is one of them it's OTC so if it turns us into Neanderthals we would have noticed it by now.
two words, condom lubricant
Dude, using triple antibiotic ointment turns the gene on, just peace-out.
In this case, their hack could be a-likened to a custom program that executes an executable past the incorrect limitation. Ironically the software not only works correctly, as desired, but it also doesn't conflict with updates in the rest of the software. (I'm sure they'll find some bugs though... I wonder how a human fetus would develop with this code enabled from the start?)
Someone teach me. Going ogling didn't help. :(
So they are turning on the intrupted gene
Potentially with common antibacterial ointments
that could be added to sexual/surgical lubricants like KY jelly; pretty impressive. I don't see where this would effect a fetus anymore than using neomycin ointment would.
I'd call that pretty toxic.
When the thought "Wow I'm not screaming like a school girl" runs through your mind, you know your really fucked up.
Well... quadriplegics don't get that! Lucky bastards.
Are you sure, quads get phantom limb pain, so I assume phantom limb itching is also likely; imagine an itch that can't be scratched. I burned my hand a few years ago, at the burn clinic they, in a teaching hospital, aways ask about pain, never about itching. Finally one Dr. from another hospital casually mentioned that benedryl would stop the itching. Imagine the gritty itch from a bad sunburn lasting for 3 months, God bless that Dr.
Physics is getting very statistical nowadays too; sometimes you have too squint your eyes and tilt your head just right to see some of the results from high-energy physics as well.
Why fine the company? The science was very probably accurate;
of course they left out that the content glorified the reduction of trivial symptoms and the consideration of potentially fatal side effects were beyond the scope of the paper part. A PR/ghostwriting company can't get published if a respected clinician doesn't sign-on as an author, the real answer is to tell someone like Dr. Gloria Bachmann, she's not going to be published anymore for being a drug company's whore.
Yes it does seem possible and you might even get away with it in real life, but the idea of running a 48VDC pair that also uses a 100VAC ring signal right beside your ethernet pairs is scary. Also every time the telephone rings it would induce a hellacious amount of electrical noise into the data pairs; it would probably shut down any data packets on the network and possibly blow out your ethernet cards. If another technician was faninng the wires and happened puncture his skin with them the jolt from the 48VDC would probably make you number ten thousand dirty rotten SOB, a 100VAC ring signal would definitely make you number ten thousand dirty rotten SOB. Telephone and ethernet really don't play well together.
This thing is supposed tp go through 60m of 5000psi reinforced concrete, then explode. In a room full of gas centrifuges spinning at over 100K rpm the explosion would be redundant.
I wouldn't brag about have a car that Mexican drug runners wouldn't drive.
Like what we do with BBQ propane tanks now. I haven't actually refilled one of those for years; you just switch them out.
Yeah you pay twice as much and receive a tank that's so beat to hell you expect it to explode any second.
I just don't see a solar panel being able to produce enough power to keep a car cool except in the most optimal of conditions. Sitting idle in traffic is far from ideal.
I thought the solar cells were used to run a vent fan not the AC on the Pirus.
What isn't reasonable is for the electric company to use a fee such as this as a profit center. If they truly are doing this to be equitable to their users they should implement a reasonable fee, but lower their per kWH rate that users pay so the average non-solar user sees no increase in their current bill.
The electric industry is pretty unique, it's the only industry that considers labor a fixed expense, five people can generate 100MW or can generate nothing. Their biggest expense is actually equipment depreciation followed by fuel. Additionally since their profits are generally fixed at 10%, the higher their expenses are, the higher their profits!
A neighbor of mine is a power station operator at a paper plant, they burn ligin, a waste product to generate electricity for the plant, DTE charges the plant something like 75% what the electricity would cost just to have the sub-station to the grid for backup if the plants power station goes down. As a result the plant's power-station generates mainly during peak-load times because off-peak charges are less than the cost of generating their own electricity plus the conectivity charges!
and they were really between a rock and a hard place on this one.
Apparently when Amazon has to remove a title from sale on kindle, it removes it from their server. The kindle seems to download the work as needed rather than downloading in one shot.
Hacking laws on the books make it illegal to add, modify, or delete data on another person's computer without their consent. I believe it carries a pretty stiff sentence too, because it is a federal statute.
I am pretty sure that Amazon has no consent from anyone when they used their DRM to kill the book, so they could be in some deep water.
Also, since it was an an actual person that punched the enter key when it came time to revoke the DRM license, I wonder if they could be hit with the criminal hacking charge. The fact that invoking DRM controls could land you in the federal pen for 20 years might be a great way get corps to knock that shit off.
Perhaps no one pushed the enter key!
Fahrenheit 451 would be flushed down the memory-hole, they would cause the batteries to burst into flames instead.
The purchaser has no obligation to assume that a company that sells books in the normal course of their business might not have the legal rights to sell the book. If you purchase new books out of the trunk of someones car at half the cover price, you are required by law to assume they might be stolen, if you purchase them for a book seller at half price you don't. Returning the money doesn't un-rob the bank, deleting the book doesn't un-distribute it, but it does admit wrong-doing and the rights-holder can still seek damages from Amazon.
The law is actually clear, if you purchase something from a business that is in their normal line of business, you can assume the purchase was legal. I watched a court case where a sign company purchased a boat through barter from a marina. The Marina failed to pay the bank for the boat which they had purchased for resale on a revolving line of credit from the bank. The bank sued the sign company, the judge ruled that the sign company was not liable for the price of the boat because the marina sells boat in their normal course of business and the bank would have to sue the marina for their money. Like-wise the purchase of the book, purchasing the book from Amazon, a book seller should be able to assume that the book was purchased legally and the rights-holders should recover their royalties from Amazon. Amazon deleting the book from the purchaser attempted to void their illegal distribution, however distributing the book and deleting it is still distributing it; if you robbed a bank then later returned the money, the bank was still robbed. Amazon's deletion of the illegally distributed book is actually a confession of wrongdoing. Amazon now not only owes the purchaser for the price of the book and co-incidental damages caused by deletion of the book to the purchaser, but now also owes the rights-holders for royalties and civil penalties for the illegal distribution.
One would think that amazon's legal dept would be much sharper than what they just displayed.
The legality depends on the country, this work is public domain in some countries, but still under copyright in the US.