I was there while on vacation a few summers ago. There's not really much in the way of computers, mostly knockoff Chinese 'Nik(e acute)' and 'Adidus' and 'Sonie' items. On the other hand, it does (or did) have 27 places to buy funnel cakes. It was... odd. Vaguely depressing. Kind of like the Salvation Army + run down circus + Cuban refugees looking for food + gaily dressed overweight tourists. Anyway, don't get your hopes up if you visit. If you want computers/electronics, try a Hamfest. If you want to be vaguely nauseated at the human race, go for the swap shop.
1) I was under the impression that Celera's technique involved finding a protien and following it back to the gene, then sequencing. It was supposed to "Only sequence 'Real Genes (tm)' and not all that filler".
2) 3n at a time. As in, n codons at a time (DNA is meaningless other wise). I was trying to suggest that genes have both a location and an offset, so we should sequence a given series of codons 3 times, with different offsets. Yes, it's more work, but certain features of viri suggest that the same stretch of DNA can do multiple protiens.
3) Actually, more than 90% of DNA is non coding in any given cell. All cells will sequence the Citric acid cycle for instance, but only a few will sequence seratonin. You MUST sequence (and compile the protien) for the whole genome. Then, look at another type of cell to see what you missed. Mishapen protien fragments that seem to be "junk" may shape polymorphic protiens as they fold. A sequence lacking its acton may suddenly have one when other "junk" is removed in an intermediate step. Just because a gene is nonexpressed or seemingly non-expressable does not mean it has no function.
Because of the way that Celera (and, AFAIK the HGP) identify genes, I feel that we are going to be seeing this soft of announcement increasingly often. Celera has been using imprinted cells as a base for their sequencing. Imprinted cell have many genes hidden or 'turned off' by interceptor protiens. What needs to be done, but could take many years, and more bio-chemistry than we have now, is to 'walk' the genome. Take the base pairs 3n at a time, and sequence, ala Folding@Home. Actual protien sequences overlap, in a sort of bio-chemical data compression. If you offset the "start here" tag by one base pair you don't always end up with a garbage protien. This is why Celera's claim of such large quantitys of 'junk' DNA was scoffed at by many in the scienfific community.
Actually, as per the Space.com article linked to elsewhere, thare are no O-rings on the Buran. Buran uses liquid fueled throttleable boosters, while the US Shuttle uses stacked cylinders of aluminum powder, oxidizer and goo (it's like rubber cement). The O-rings you're thinking of, from the Challenger are between segments of solid fuel, and are VERY dangerous in cold weather. They shrink and make gaps. Buran could not use this technology, so the Soviets (1980s) invented cold weather launch technologies. Cryogenic liquid fuel is about the best cold weather launch technology I can think of, eh?
It seems to me that an enzyme set would be ideally suited to building N-length nanotubes. Additionally, you could glue them together with that indestructable stuff barnacles use to cling to stuff. It's got huge compression strengths, while nanotubes have awesome tensional strength. Bio-composites anyone?
Really...
How long do you think it'll take for some student to publish his/er own Howto? Or, what usually happens is that the university, tired of dealing w/ freshmen will post explicit instructions on their webpage. Nice though, that now you can sit in a comfy chair and surf, or, God forbid, get some sun.
"The yellow eye! She burns ussssss....."
Slashdot Mirror
Adobe _has_ a .pdf reader for Palm/visor. Try http://www.adobe.com/products/acrobat/readerforpal m.html (but remove the spaces). It even does images.
Although, it does use Acrobat 5's content control. Anybody know where I can get a ghostscript workalike for my Visor?
I was there while on vacation a few summers ago. There's not really much in the way of computers, mostly knockoff Chinese 'Nik(e acute)' and 'Adidus' and 'Sonie' items. On the other hand, it does (or did) have 27 places to buy funnel cakes. It was... odd. Vaguely depressing. Kind of like the Salvation Army + run down circus + Cuban refugees looking for food + gaily dressed overweight tourists. Anyway, don't get your hopes up if you visit. If you want computers/electronics, try a Hamfest. If you want to be vaguely nauseated at the human race, go for the swap shop.
1) I was under the impression that Celera's technique involved finding a protien and following it back to the gene, then sequencing. It was supposed to "Only sequence 'Real Genes (tm)' and not all that filler".
2) 3n at a time. As in, n codons at a time (DNA is meaningless other wise). I was trying to suggest that genes have both a location and an offset, so we should sequence a given series of codons 3 times, with different offsets. Yes, it's more work, but certain features of viri suggest that the same stretch of DNA can do multiple protiens.
3) Actually, more than 90% of DNA is non coding in any given cell. All cells will sequence the Citric acid cycle for instance, but only a few will sequence seratonin. You MUST sequence (and compile the protien) for the whole genome. Then, look at another type of cell to see what you missed. Mishapen protien fragments that seem to be "junk" may shape polymorphic protiens as they fold. A sequence lacking its acton may suddenly have one when other "junk" is removed in an intermediate step. Just because a gene is nonexpressed or seemingly non-expressable does not mean it has no function.
Because of the way that Celera (and, AFAIK the HGP) identify genes, I feel that we are going to be seeing this soft of announcement increasingly often. Celera has been using imprinted cells as a base for their sequencing. Imprinted cell have many genes hidden or 'turned off' by interceptor protiens. What needs to be done, but could take many years, and more bio-chemistry than we have now, is to 'walk' the genome. Take the base pairs 3n at a time, and sequence, ala Folding@Home. Actual protien sequences overlap, in a sort of bio-chemical data compression. If you offset the "start here" tag by one base pair you don't always end up with a garbage protien. This is why Celera's claim of such large quantitys of 'junk' DNA was scoffed at by many in the scienfific community.
But I'm rambling. Time to go home.
Actually, as per the Space.com article linked to elsewhere, thare are no O-rings on the Buran. Buran uses liquid fueled throttleable boosters, while the US Shuttle uses stacked cylinders of aluminum powder, oxidizer and goo (it's like rubber cement). The O-rings you're thinking of, from the Challenger are between segments of solid fuel, and are VERY dangerous in cold weather. They shrink and make gaps. Buran could not use this technology, so the Soviets (1980s) invented cold weather launch technologies. Cryogenic liquid fuel is about the best cold weather launch technology I can think of, eh?
It seems to me that an enzyme set would be ideally suited to building N-length nanotubes. Additionally, you could glue them together with that indestructable stuff barnacles use to cling to stuff. It's got huge compression strengths, while nanotubes have awesome tensional strength. Bio-composites anyone?
How is this different from ->
2 22 9
http://slashdot.org/article.pl?sid=01/03/16/145
?
Really... How long do you think it'll take for some student to publish his/er own Howto? Or, what usually happens is that the university, tired of dealing w/ freshmen will post explicit instructions on their webpage. Nice though, that now you can sit in a comfy chair and surf, or, God forbid, get some sun. "The yellow eye! She burns ussssss....."
Is anyone else getting constant rebuffers/signal drops? I think we're taking down C-SPAN!
Shouldn't this one be sued first? www.firstgov.gov
Better images are available from the Chandra Photo Album @ http://chandra.harvard.edu/photo/cycle1/1220/index .html