There's a problem with that scheme. The fake dongle says you got from point A to point B in much more time than it took, right? So what happens if, at point B, you're in an accident? The fake dongle won't sent the right data for that, at the right time, and probably witnesses and the other driver will also give the right time (esp. if the other driver has a real dongle).
Also, a car tends to sustain much more damage from a 60 mph impact than a 25 mph impact.
In this case pronouncing the word "disease" is a slack way of dismissing the symptoms of dementia without any futher (sic) thought.
Most people who call dementia a disease do not dismiss the symptoms, especially considering the huge impact those symptoms have on both the patient and those around them.
Also, when you wrote "One girl asked, "Is it true that in your country you send old people off to live alone?", you didn't take into account that the average lifespan in many parts of Africa the life expectancy is below 50, and in some parts (Sierra Leone) it's below 40. The average - a puny 52 years. So when that little girl asked her question, she wasn't referring to "old people", but middle-aged people at best. She probably hasn't even seen an old person with dementia.
Often the elderly are put in homes because their relatives want their money, and distress at being stripped of their freedom and rights is considered proof that they need to be confined.
And for those who are put in homes who have no money or property of their own in the first place? And the millions of seniors below the poverty line? And the ones who have some money, but not enough to pay for living in a home, so others have to make up the difference? They're certainly not put in homes for their money.
Sometimes it's the only safe thing to do. They have better access to doctors, they have nurses on staff 24/7, and if they cannot take care of themselves, what other option is there? None, really. As for forcing them to take drugs, the big problem is to get them to take their meds on schedule - they will insist they already had them or don't need them. Many can't be trusted to manage diseases like diabetes, nor should they be left alone to cope with hypoglycemic/hyperglycemic events.
contact with family is more important that (sic) where you left your keys.
That was not what I wrote. You claimed that less important stuff is lost from memory while more important stuff is preserved:
unimportant memories lose significance and get cycled out
I gave counter-examples, such as remembering where you put your smartphone 15 minutes ago is more important than remembering a stupid joke (watch someone go into panic mode when they can't find their phone), and yet we easily recall stuff that is just not important such as the stupid joke, but not the smartphone, which is more important to the person.
Your attempt to move the goalposts by repositioning the question as "for most people, contact with family is more important that where you left your keys." has zero - nothing whatsoever - to do with my original point.
"Disease" is an unfortunate label because it implies a pathogen and there is none for Alzheimers."
Hate to reply twice, but "disease" covers much more than illnesses caused by pathogens. The various forms of diabetes, for one. Osteoarthritis, glaucoma, cataracts...
Q. "Definition of disease"
A.. disease
noun
a disorder of structure or function in a human, animal, or plant, especially one that produces specific signs or symptoms or that affects a specific location and is not simply a direct result of physical injury.
The real problem with stuff like is is that it brings out your inner child - "Gee, wouldn't it be fun to do some stop-motion animation". Of course, the reality is that it's as tedious as programming.
I think you have cause and effect reversed - mostly people (of all ages) are put in homes because they already require 24-hour supervision and care. If they can't get dressed, go to the bathroom, make their own food, know approximately what time of day, day of the week, and month of the year, and they show increasing bouts of rage, they're a danger to both themselves and those around them. Try taking care of someone and having them accuse you of all sorts of ridiculous stuff, like stealing stuff that a quick search shows they misplaced, or taking a harmless remark or action and twisting it around when they retell it to the whole family. Taking care of someone by yourself under those conditions is hazardous just from a legal perspective.
Also, I would question whether "unimportant memories are routinely deleted." How many times have you forgotten things like passwords, birthdays, where you left your smartphone, wallet, purse, or keys, your own phone number, and yet can clearly recall the punchline of really stupid jokes?
Pepsi did exactly that when Coke introduced New Coke. However, Coke brought back the old coke (renamed Coke Classic) so they shelved making "Savannah Cola".
My wife works with people that have Alzheimer's and dementia. What a terrible way to go.
It's one of the reasons we legalized assisted suicide here (and probably elsewhere in the world). Nobody wants to end up that way. Maybe this will be a second option.
If only that were true - then we could just find ways to get them interest in life again. However, dementia affects people in their 30s and 40s, not just "old people" who have stopped working or have grandkids. Also, we don't know what the human brain's memory capacity is, but we know we're far from "filling it up" at 30, and probably at 100 as well. Just the disease interferes with the replacement of dead synapses, so you lose memory capacity as well as the memories themselves.
Obviously I couldn't put everything in the summary (I provided 4 links) A few points: First, the same protection was observed with higher levels or RBM3 in mice that didn't undergo induced hibernation as with those who underwent induced hibernation:
In the grand finale set of experiments, the researchers bypassed cooling and injected lentiviruses expressing RBM3 directly into the hippocampi of mice early in prion disease. They achieved a threefold overexpression of RBM3 that afforded the mice the same synaptic, behavioral, and survival benefits that early cooling had, and rescued flagging protein synthesis observed in neurons nine weeks post-infection. Boosting RBM3 expression also allowed synapses in both neurodegenerative disease models to recover completely after cooling. Conversely, knocking down expression of RBM3 accelerated disease progression in the prion model, and hastened synapse loss in both models. Synapses and memory even took a hit in normal mice deprived of RBM3 expression, as they lost synapses and did not recognize novel objects as well as control mice. This suggested that the cold-shock protein may play an important physiological role in normal synapse upkeep.
Mallucci hypothesized that RBM3 promotes synaptic plasticity and staves off neurodegeneration by raising levels of protein synthesis in dendrites. “Synapses are so dependent on their key synaptic proteins for assembly and function,” said Mallucci. Because synapses often reside distant from the cell body, local translation at the dendrite is important to ensure a ready supply of such proteins and thus facilitate synaptic recovery, she added.
So we know that RBM3 protects regardless of whether it was produced by hibernation or artificial elevation of just the protein RBM3.
Second we already know cooling of the brain in humans is also protective:
A state of hypothermia is known to protect the brain. People have been survived for hours after a cardiac arrest without brain damage after falling into icy water.
Similiarly, cooling the brains of babies that have suffered a loss of oxygen at birth is also used to protect against brain damage.
"We’ve known for some time that cooling can slow down or even prevent damage to brain cells, but reducing body temperature is rarely feasible in practice: it’s unpleasant and involves risks such as pneumonia and blood clots," said Professor Giovanna Mallucci, who led the research team, at the Medical Research Councils Toxicology Unit at the University of Leicester.
"But, by identifying how cooling activates a process that prevents the loss of brain cells, we can now work towards finding a means to develop drugs that might mimic the protective effects of cold on the brain."
So there is reason to think that the same mechanism might work in other mammals, and not just those who hibernate. We'll only know when human trials commence, but considering what's at stake, there will be literally millions volunteering to be test subjects.
But go on and pretend to live in a free country as you surrender your fundamental liberties for safety, real or imagined.
I don't have to imagine that I live in a free country, as I don't live in the US. Canada, New Zealand, and Switzerland are the only countries in the world ranked "free" (top ranking) in the 2014 Index of Economic Freedom. It also shares the top ranking for the 2014 Press Freedom Index ("good situation"), and again the US is only ranked "satisfactory".
The Economists' Democracy Index for 2012 puts my country way ahead of the US:
The US and the UK remain at the bottom end of the full democracy category. US democracy has been
adversely affected by a deepening of the polarisation of the political scene and political brinkmanship
and paralysis.
By the same argument, if a tree falls in the forest and nobody't there to hear it, it doesn't make noise, which is a load of horse pucky.
The formula for Coca-Cola isn't patented - and a good thing, because the patent would have expired by now. According to your logic, Coca-Cola doesn't exist.
And yes, it's still a trade secret, and anyone who stole it would be culpable.
If you put a bullet in your head but do it in complete secrecy and your body is never found, you're still dead. There's no "sharing" needed to have the event have meaning, even though according to your argument, the event "makes no difference."
Don't sweat the moderation. I've had comments go from +5 informative to -1 flamebait to +4 troll. I'm kind of hoping one day to get the quasi-mythical +5 Troll mod. Just because...
Nice try, but information has no "wants." My original point stands - people who say "information wants to be free" need to quit anthropomorphizing. It's just data.
It's called serendipity. Without the perturbations in Neptune's orbit they wouldn't even have started looking for a "Planet X", so Pluto was indeed found because of perturbations in Neptune's orbit.
"should" is meant in the moral sense here. Are you really that bad at listening comprehension?
There is no "moral sense" that information should be free. "information" has no moral rights of its own. "information" is not suffering if it's not free. And if someone creates something, it is up to them whether to share it or not. You have no moral right to dictate what they should do.
I dont like the scumbags that shoot up chocolate shops and newspaper offices or crash airplanes into buildings or blow up nightclubs but I would rather see 1000 terrorists go free than to see a single innocent person have their privacy, security, civil liberties or constitutional rights violated.
Methinks you need a bit of perspective here.
I don't. He's absolutely right: Freedom and the constitution are more important than safety.
First, like more than 95% of the world, I don't live in the USA. And yes, I like my gun control laws.
Second, the "1000 terrorists go free than see a single innocent person have their privacy, security, civil liberties or constitutional rights violated" line is self-contradictory, because 1,000 free terrorists are sure as heck going to violate the security and civil liberties of a lot more than one person.
You are engaging in "black and white thinking" (aka splitting), which is characteristic of people with orderline personality disorder and/or narcissistic personality disorder. It's a form of cognitive distortion, but the problem is that people who suffer from it don't see it as such, but as a "good thing."
Free software and opensource software are two different things. Also, there's precedent for charging on proprietary platforms since (1) there's no requirement for the author to make their Windows or OSX version free if they're using libraries and code that can be dual-licensed or not licensed under a "you must give the source to anyone who asks" license, and (2) there might be licensing issues with libraries used to build on proprietary platforms, such as a per-unit fee (or even per-user, like dBASE 4 and other programs had, where you had to buy "license packs").
This is slashdot. But look at the good side - you made the front page.
Quickie question - this is on both on your home page and your news page. Can you clarify?
As you will see, the full Android version is sold for 6€ now but the price will have to be adjusted to find the optimal one.
Do you consider Android to be proprietary - just wondering.
Also, I'll email you with a correct translation from the original french - click on my user name and scroll to the bottom (slashdot's css is broken again - the user info that used to be beside the list of recent comments no longer fits because..., well, because this is slashdot:-)
Try the discovery of Pluto, which was predicted from orbital irregularities of Neptune, which as also predicted because of orbital irregularities of Uranus.
What would be interesting would be to see what a polygraph says about their false memories. Can it distinguish between an event that occurred and one that was from a false memory? If not, that would be the final nail in the coffin.
And it's false. Look at how much money and effort goes into determining the laws of the universe - that's information that we're only now starting to get - and may never succeed at, even though it's being actively sought by some of our best minds.
Slashdot Mirror
And the excess damage?
There's a problem with that scheme. The fake dongle says you got from point A to point B in much more time than it took, right? So what happens if, at point B, you're in an accident? The fake dongle won't sent the right data for that, at the right time, and probably witnesses and the other driver will also give the right time (esp. if the other driver has a real dongle).
Also, a car tends to sustain much more damage from a 60 mph impact than a 25 mph impact.
In this case pronouncing the word "disease" is a slack way of dismissing the symptoms of dementia without any futher (sic) thought.
Most people who call dementia a disease do not dismiss the symptoms, especially considering the huge impact those symptoms have on both the patient and those around them.
Also, when you wrote "One girl asked, "Is it true that in your country you send old people off to live alone?", you didn't take into account that the average lifespan in many parts of Africa the life expectancy is below 50, and in some parts (Sierra Leone) it's below 40. The average - a puny 52 years. So when that little girl asked her question, she wasn't referring to "old people", but middle-aged people at best. She probably hasn't even seen an old person with dementia.
Often the elderly are put in homes because their relatives want their money, and distress at being stripped of their freedom and rights is considered proof that they need to be confined.
And for those who are put in homes who have no money or property of their own in the first place? And the millions of seniors below the poverty line? And the ones who have some money, but not enough to pay for living in a home, so others have to make up the difference? They're certainly not put in homes for their money.
Sometimes it's the only safe thing to do. They have better access to doctors, they have nurses on staff 24/7, and if they cannot take care of themselves, what other option is there? None, really. As for forcing them to take drugs, the big problem is to get them to take their meds on schedule - they will insist they already had them or don't need them. Many can't be trusted to manage diseases like diabetes, nor should they be left alone to cope with hypoglycemic/hyperglycemic events.
contact with family is more important that (sic) where you left your keys.
That was not what I wrote. You claimed that less important stuff is lost from memory while more important stuff is preserved:
unimportant memories lose significance and get cycled out
I gave counter-examples, such as remembering where you put your smartphone 15 minutes ago is more important than remembering a stupid joke (watch someone go into panic mode when they can't find their phone), and yet we easily recall stuff that is just not important such as the stupid joke, but not the smartphone, which is more important to the person.
Your attempt to move the goalposts by repositioning the question as "for most people, contact with family is more important that where you left your keys." has zero - nothing whatsoever - to do with my original point.
"Disease" is an unfortunate label because it implies a pathogen and there is none for Alzheimers."
Hate to reply twice, but "disease" covers much more than illnesses caused by pathogens. The various forms of diabetes, for one. Osteoarthritis, glaucoma, cataracts ...
Q. "Definition of disease"
A.. disease
noun
a disorder of structure or function in a human, animal, or plant, especially one that produces specific signs or symptoms or that affects a specific location and is not simply a direct result of physical injury.
The real problem with stuff like is is that it brings out your inner child - "Gee, wouldn't it be fun to do some stop-motion animation". Of course, the reality is that it's as tedious as programming.
I think you have cause and effect reversed - mostly people (of all ages) are put in homes because they already require 24-hour supervision and care. If they can't get dressed, go to the bathroom, make their own food, know approximately what time of day, day of the week, and month of the year, and they show increasing bouts of rage, they're a danger to both themselves and those around them. Try taking care of someone and having them accuse you of all sorts of ridiculous stuff, like stealing stuff that a quick search shows they misplaced, or taking a harmless remark or action and twisting it around when they retell it to the whole family. Taking care of someone by yourself under those conditions is hazardous just from a legal perspective.
Also, I would question whether "unimportant memories are routinely deleted." How many times have you forgotten things like passwords, birthdays, where you left your smartphone, wallet, purse, or keys, your own phone number, and yet can clearly recall the punchline of really stupid jokes?
Pepsi did exactly that when Coke introduced New Coke. However, Coke brought back the old coke (renamed Coke Classic) so they shelved making "Savannah Cola".
True, but the way they're always breaking^Wimproving stuff, there's hope :-)
My wife works with people that have Alzheimer's and dementia. What a terrible way to go.
It's one of the reasons we legalized assisted suicide here (and probably elsewhere in the world). Nobody wants to end up that way. Maybe this will be a second option.
If only that were true - then we could just find ways to get them interest in life again. However, dementia affects people in their 30s and 40s, not just "old people" who have stopped working or have grandkids. Also, we don't know what the human brain's memory capacity is, but we know we're far from "filling it up" at 30, and probably at 100 as well. Just the disease interferes with the replacement of dead synapses, so you lose memory capacity as well as the memories themselves.
Because Alzheimer's doesn't cause "retardation".
Obviously I couldn't put everything in the summary (I provided 4 links) A few points: First, the same protection was observed with higher levels or RBM3 in mice that didn't undergo induced hibernation as with those who underwent induced hibernation:
In the grand finale set of experiments, the researchers bypassed cooling and injected lentiviruses expressing RBM3 directly into the hippocampi of mice early in prion disease. They achieved a threefold overexpression of RBM3 that afforded the mice the same synaptic, behavioral, and survival benefits that early cooling had, and rescued flagging protein synthesis observed in neurons nine weeks post-infection. Boosting RBM3 expression also allowed synapses in both neurodegenerative disease models to recover completely after cooling. Conversely, knocking down expression of RBM3 accelerated disease progression in the prion model, and hastened synapse loss in both models. Synapses and memory even took a hit in normal mice deprived of RBM3 expression, as they lost synapses and did not recognize novel objects as well as control mice. This suggested that the cold-shock protein may play an important physiological role in normal synapse upkeep.
Mallucci hypothesized that RBM3 promotes synaptic plasticity and staves off neurodegeneration by raising levels of protein synthesis in dendrites. “Synapses are so dependent on their key synaptic proteins for assembly and function,” said Mallucci. Because synapses often reside distant from the cell body, local translation at the dendrite is important to ensure a ready supply of such proteins and thus facilitate synaptic recovery, she added.
So we know that RBM3 protects regardless of whether it was produced by hibernation or artificial elevation of just the protein RBM3.
Second we already know cooling of the brain in humans is also protective:
A state of hypothermia is known to protect the brain. People have been survived for hours after a cardiac arrest without brain damage after falling into icy water. Similiarly, cooling the brains of babies that have suffered a loss of oxygen at birth is also used to protect against brain damage.
"We’ve known for some time that cooling can slow down or even prevent damage to brain cells, but reducing body temperature is rarely feasible in practice: it’s unpleasant and involves risks such as pneumonia and blood clots," said Professor Giovanna Mallucci, who led the research team, at the Medical Research Councils Toxicology Unit at the University of Leicester. "But, by identifying how cooling activates a process that prevents the loss of brain cells, we can now work towards finding a means to develop drugs that might mimic the protective effects of cold on the brain."
So there is reason to think that the same mechanism might work in other mammals, and not just those who hibernate. We'll only know when human trials commence, but considering what's at stake, there will be literally millions volunteering to be test subjects.
But go on and pretend to live in a free country as you surrender your fundamental liberties for safety, real or imagined.
I don't have to imagine that I live in a free country, as I don't live in the US. Canada, New Zealand, and Switzerland are the only countries in the world ranked "free" (top ranking) in the 2014 Index of Economic Freedom. It also shares the top ranking for the 2014 Press Freedom Index ("good situation"), and again the US is only ranked "satisfactory".
The Economists' Democracy Index for 2012 puts my country way ahead of the US:
The US and the UK remain at the bottom end of the full democracy category. US democracy has been adversely affected by a deepening of the polarisation of the political scene and political brinkmanship and paralysis.
By the same argument, if a tree falls in the forest and nobody't there to hear it, it doesn't make noise, which is a load of horse pucky.
The formula for Coca-Cola isn't patented - and a good thing, because the patent would have expired by now. According to your logic, Coca-Cola doesn't exist.
And yes, it's still a trade secret, and anyone who stole it would be culpable.
If you put a bullet in your head but do it in complete secrecy and your body is never found, you're still dead. There's no "sharing" needed to have the event have meaning, even though according to your argument, the event "makes no difference."
Don't sweat the moderation. I've had comments go from +5 informative to -1 flamebait to +4 troll. I'm kind of hoping one day to get the quasi-mythical +5 Troll mod. Just because ...
If it's a domestic incident it's already public, just from the screaming and the sounds of stuff being broken and the slamming of doors.
Nice try, but information has no "wants." My original point stands - people who say "information wants to be free" need to quit anthropomorphizing. It's just data.
It's called serendipity. Without the perturbations in Neptune's orbit they wouldn't even have started looking for a "Planet X", so Pluto was indeed found because of perturbations in Neptune's orbit.
"should" is meant in the moral sense here. Are you really that bad at listening comprehension?
There is no "moral sense" that information should be free. "information" has no moral rights of its own. "information" is not suffering if it's not free. And if someone creates something, it is up to them whether to share it or not. You have no moral right to dictate what they should do.
I dont like the scumbags that shoot up chocolate shops and newspaper offices or crash airplanes into buildings or blow up nightclubs but I would rather see 1000 terrorists go free than to see a single innocent person have their privacy, security, civil liberties or constitutional rights violated.
Methinks you need a bit of perspective here.
I don't. He's absolutely right: Freedom and the constitution are more important than safety.
First, like more than 95% of the world, I don't live in the USA. And yes, I like my gun control laws.
Second, the "1000 terrorists go free than see a single innocent person have their privacy, security, civil liberties or constitutional rights violated" line is self-contradictory, because 1,000 free terrorists are sure as heck going to violate the security and civil liberties of a lot more than one person.
You are engaging in "black and white thinking" (aka splitting), which is characteristic of people with orderline personality disorder and/or narcissistic personality disorder. It's a form of cognitive distortion, but the problem is that people who suffer from it don't see it as such, but as a "good thing."
Free Software is also Open Source software.
Free software and opensource software are two different things. Also, there's precedent for charging on proprietary platforms since (1) there's no requirement for the author to make their Windows or OSX version free if they're using libraries and code that can be dual-licensed or not licensed under a "you must give the source to anyone who asks" license, and (2) there might be licensing issues with libraries used to build on proprietary platforms, such as a per-unit fee (or even per-user, like dBASE 4 and other programs had, where you had to buy "license packs").
Quickie question - this is on both on your home page and your news page. Can you clarify?
As you will see, the full Android version is sold for 6€ now but the price will have to be adjusted to find the optimal one.
Do you consider Android to be proprietary - just wondering.
Also, I'll email you with a correct translation from the original french - click on my user name and scroll to the bottom (slashdot's css is broken again - the user info that used to be beside the list of recent comments no longer fits because ..., well, because this is slashdot :-)
Try the discovery of Pluto, which was predicted from orbital irregularities of Neptune, which as also predicted because of orbital irregularities of Uranus.
What would be interesting would be to see what a polygraph says about their false memories. Can it distinguish between an event that occurred and one that was from a false memory? If not, that would be the final nail in the coffin.
And it's false. Look at how much money and effort goes into determining the laws of the universe - that's information that we're only now starting to get - and may never succeed at, even though it's being actively sought by some of our best minds.