My Mazda 3 manual said the same thing, but a quick search online showed that it was actually a fairly easy and tool-less operation. The manual admonished the owner doing it for some voltage danger nonsense... I think the real reason was that it was a little tricky in the dexterity department. I imagine with a specialized tool it'd be fast, and I imagine it is designed with the initial assembly cost in mind more than the maintenance cost.
Many of the mechanisms that cause aging are anti-cancer, such as shortening telomeres. Disable telomerase (which lengthens telomeres) and you'd be immune to cancer but only live a decade. Permanently switch telomerase on and your cell lines could live forever but you'd have disabled an important anti-cancer function. Maybe if you turned up your killer T cell activity, but then those will make you age by inducing apoptosis in your tissues... and so you see, since cancer is malfunctioning pieces of you, the natural processes that your body uses to control it all involve slowly killing you at a slower rate than killing the cancer. Which is also how chemo works when we try our own anti-cancer interventions.
I'm not sure I follow what you're trying to say. The correct answer is that the epitope being bound is important to whether or not the antigen is inactivated fully. In any case, my point was that you're setting the bar too high when it gets to the point where the technical nuance exceeds your grasp. It'd be like if I decided to declare plate tectonics was false and a geologist tried to set me straight. I'm not going to understand the literature as well as I think I do and eventually may remain unconvinced by him because I don't realize the borders of my own ignorance.
Yes, a neutralization test and an ELISA are measuring different aspects of the antibody action. Your homework question is now: what aspects of antibody/antigen interaction would cause neutralization and antibody titer not to correlate?
Next go read up on avidity.
Oh even something relatively old like ELISA is good enough. Controlling for background cross-reactivity is straightforward. It is one of the first things you do when developing an ELISA.
You see how this conversation has reduced to that between an evolutionary biologist and a creationist? Your barriers to your personal credulity outstrip your ability to understand the answer to your query if it is given with sufficient scientific depth when you're doing your Google research. So you have to be told the cartoon version which doesn't sate you because you recognize it to be diluted. I can't get you a bachelor's degree in biology via Slashdot.
Sure you are, these aren't questions from someone within a biological science field that you're asking, they're layman's questions barely better than "what's the difference between a virus and a bacteria?" The whole bit about not understanding viral mutation in HIV is a pretty big giveaway. An expert might be interested in why the titer drops off at the rate it does that requires boosting, whether it is better to generate IgG versus IgM mediated immunity under difference circumstances, etc etc. I could take a blood draw and tell you what you're immune to and what you need a booster for if needed. Even your physician could. The science is that robust.
You don't have to look at historical data about measles, you can look at epidemiology data where there are outbreaks amongst communities with low vaccination rates. It ought to be pretty understandable for a layman.
In this context, skeptics would be actual scientists publishing contrary research and so on. Jenny McCarthy isn't a skeptic in a scientific sense, for example.
Are there really any of them around any more? I was sticking to topics that are currently controversial among the public but no longer among scientists.
This isn't that, it is actual skeptics wanting cranks called something other than 'skeptics.'
A scientist legitimately skeptical about a prevailing theory gets lumped in with creationists and Fox News anchors, which poisons the dialog.
Creationists, anti-vaxxers, anti-HIV causes AIDS guys, and anti-AGWers can hardly be considered to be utilizing the scientific process honestly, let alone correctly. Hence why actual skeptics want to be distanced from them.
It's all one big long gradient, man, no stages.
If you read about instars in non-metamorphic insects then metamorphosis will begin to make more sense to you. Aside from that, one of the main benefits is that young and adults are not competing for the same resources.
The immune response to disease is the same as that to the vaccine, that's why it works. The only additional response over a killed-virus vaccine you might have would be some T cell response due to having actual infected cells to kill. Incidentally that means that if they missed any cells due to only partial viral replication inside, your chance of getting cancer later in life ticked up a smidge.
I suppose our non-biodegradeable plastics fall along similar lines, not that they are actually an effective carbon sink. Heaps of stuff that can't rot. If nothing else I suppose that geology will eventually recycle them back into oil.
You can use a modified uxtheme.dll to use non-MS themes, which takes no more resources than running luna instead of classic. This doesn't need to be done for flashy looks, there are quite a few minimalist themes out there.
Neowin's forums have a section where lots of themes are posted.
Correct, it isn't society's responsibility. The kid can also purchase a Parental Advisory CD or an R rated movie legally, although the stores often times won't allow that to occur, without any government action required. Why not just ask them to do the same for video games instead of passing needless laws?
Unlike the CD or movie, your computer and console have flexible parental controls, so it is even easier to prevent little Billy from playing violent games than it is preventing him from listening to profane music or reading violent literature.
Cigs and alcohol are not media, its apples and oranges to lump them in.
Slashdot Mirror
Ah, but at that point don't you have to weigh the cost of the bulb versus differences in fuel economy due to boxy utilitarian vs molded shapes?
My Mazda 3 manual said the same thing, but a quick search online showed that it was actually a fairly easy and tool-less operation. The manual admonished the owner doing it for some voltage danger nonsense... I think the real reason was that it was a little tricky in the dexterity department. I imagine with a specialized tool it'd be fast, and I imagine it is designed with the initial assembly cost in mind more than the maintenance cost.
Many of the mechanisms that cause aging are anti-cancer, such as shortening telomeres. Disable telomerase (which lengthens telomeres) and you'd be immune to cancer but only live a decade. Permanently switch telomerase on and your cell lines could live forever but you'd have disabled an important anti-cancer function. Maybe if you turned up your killer T cell activity, but then those will make you age by inducing apoptosis in your tissues... and so you see, since cancer is malfunctioning pieces of you, the natural processes that your body uses to control it all involve slowly killing you at a slower rate than killing the cancer. Which is also how chemo works when we try our own anti-cancer interventions.
I'm not sure I follow what you're trying to say. The correct answer is that the epitope being bound is important to whether or not the antigen is inactivated fully. In any case, my point was that you're setting the bar too high when it gets to the point where the technical nuance exceeds your grasp. It'd be like if I decided to declare plate tectonics was false and a geologist tried to set me straight. I'm not going to understand the literature as well as I think I do and eventually may remain unconvinced by him because I don't realize the borders of my own ignorance.
Yes, a neutralization test and an ELISA are measuring different aspects of the antibody action. Your homework question is now: what aspects of antibody/antigen interaction would cause neutralization and antibody titer not to correlate? Next go read up on avidity.
Oh even something relatively old like ELISA is good enough. Controlling for background cross-reactivity is straightforward. It is one of the first things you do when developing an ELISA. You see how this conversation has reduced to that between an evolutionary biologist and a creationist? Your barriers to your personal credulity outstrip your ability to understand the answer to your query if it is given with sufficient scientific depth when you're doing your Google research. So you have to be told the cartoon version which doesn't sate you because you recognize it to be diluted. I can't get you a bachelor's degree in biology via Slashdot.
Sure you are, these aren't questions from someone within a biological science field that you're asking, they're layman's questions barely better than "what's the difference between a virus and a bacteria?" The whole bit about not understanding viral mutation in HIV is a pretty big giveaway. An expert might be interested in why the titer drops off at the rate it does that requires boosting, whether it is better to generate IgG versus IgM mediated immunity under difference circumstances, etc etc. I could take a blood draw and tell you what you're immune to and what you need a booster for if needed. Even your physician could. The science is that robust.
You don't have to look at historical data about measles, you can look at epidemiology data where there are outbreaks amongst communities with low vaccination rates. It ought to be pretty understandable for a layman.
In this context, skeptics would be actual scientists publishing contrary research and so on. Jenny McCarthy isn't a skeptic in a scientific sense, for example.
Are there really any of them around any more? I was sticking to topics that are currently controversial among the public but no longer among scientists.
This isn't that, it is actual skeptics wanting cranks called something other than 'skeptics.' A scientist legitimately skeptical about a prevailing theory gets lumped in with creationists and Fox News anchors, which poisons the dialog.
Creationists, anti-vaxxers, anti-HIV causes AIDS guys, and anti-AGWers can hardly be considered to be utilizing the scientific process honestly, let alone correctly. Hence why actual skeptics want to be distanced from them.
Slacker is pretty much Netflix for music with the paid plans, you can cache onto an iPod too.
There are plenty of birds that prey on mammals, and while none of them eat people for the most part, plenty of other critters do.
It's all one big long gradient, man, no stages. If you read about instars in non-metamorphic insects then metamorphosis will begin to make more sense to you. Aside from that, one of the main benefits is that young and adults are not competing for the same resources.
A vaccine administered after infection can help sometimes, but yes, if you're far gone then it would be too little too late.
Sort of... without herd immunity, immunocompromised and some unlucky ones where the vaccine didn't take will be swept away as well.
The immune response to disease is the same as that to the vaccine, that's why it works. The only additional response over a killed-virus vaccine you might have would be some T cell response due to having actual infected cells to kill. Incidentally that means that if they missed any cells due to only partial viral replication inside, your chance of getting cancer later in life ticked up a smidge.
I suppose our non-biodegradeable plastics fall along similar lines, not that they are actually an effective carbon sink. Heaps of stuff that can't rot. If nothing else I suppose that geology will eventually recycle them back into oil.
On the other hand, my HDTV takes longer to turn on than the old TV, so perhaps they were expecting the times to move towards one another ;)
Why would you be ordering PPV of a movie if you already had the DVD?
If that is true, how does Eolas have grounds to sue? Shouldn't that be the sole responsibility of the patent owner?
You can use a modified uxtheme.dll to use non-MS themes, which takes no more resources than running luna instead of classic. This doesn't need to be done for flashy looks, there are quite a few minimalist themes out there.
Neowin's forums have a section where lots of themes are posted.
The stores enforce videos and music when they could just try for a buck, I don't know why we shouldn't expect it to be the same for games.
Correct, it isn't society's responsibility. The kid can also purchase a Parental Advisory CD or an R rated movie legally, although the stores often times won't allow that to occur, without any government action required. Why not just ask them to do the same for video games instead of passing needless laws?
Unlike the CD or movie, your computer and console have flexible parental controls, so it is even easier to prevent little Billy from playing violent games than it is preventing him from listening to profane music or reading violent literature.
Cigs and alcohol are not media, its apples and oranges to lump them in.