Rich Muller has been a self-important [you fill in the rest] IMHO since I first espied him in the late '70s. No one ever said he wasn't smart, or a fine experimentalist, but what did he bring to the table that wasn't already there? Did he have a real argument here, or did he want to be a denier? Is Climate Change "just a theory" until Freeman Dyson capitulates too?
The technology deposits DNA fragments, many copies of a single fragment, in each of millions of wells on a chip. A, G, C, or T are flooded over the chip sequentially, and if one is incorporated by the polymerase, the reaction, not the chip, emits a proton and the sensor beneath each well picks up the change in voltage. The cycle is repeated hundreds of times, until the end of the fragment is reached or the quality of the reads falls off. Lets say you get a few million fragments of a few hundred basepairs, you get close to 1B bp per chip.
One of Jonathan Rothberg's insights was that the large, well funded core labs with the largest most expensive instruments, could not give the individual investigator the turnaround time she needed. So, he sought to deliver the solution in a low cost instrument that allows the investigator to decouple herself from the core labs. I've heard him say that Ion has the largest installed base of any sequencer, and I've heard from many investigators that what appeals to them is this very independence.
Sorry to be fawning, but your message should be rated 5. Regrettably, it's an analogy that's being used "everywhere", as if Gordon invented the exponential. He invented lots of things, but e^x is not on the list.
Re:Political showpieces and $$ for supporters
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Big Screen for NYPD
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I worked for 3 years in the display industry where it was generally accepted that such large visualization systems were feel good systems either for senior management or for customers, but not for the people sitting in front of them.
For displays of laptop sizes and larger, a very good manufacturer can produce a display with drivers at a manufacturing cost of $2.50 to $3.00 per square inch, assuming the volume is high. Gradual cost reductions come into play, but those are countered by higher resolution and larger dimensions. So, for a 19" display in 16:9, you have $400 or so tied up in the display itself. $1000 street price sounds like a deal.
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Rich Muller has been a self-important [you fill in the rest] IMHO since I first espied him in the late '70s. No one ever said he wasn't smart, or a fine experimentalist, but what did he bring to the table that wasn't already there? Did he have a real argument here, or did he want to be a denier? Is Climate Change "just a theory" until Freeman Dyson capitulates too?
The technology deposits DNA fragments, many copies of a single fragment, in each of millions of wells on a chip. A, G, C, or T are flooded over the chip sequentially, and if one is incorporated by the polymerase, the reaction, not the chip, emits a proton and the sensor beneath each well picks up the change in voltage. The cycle is repeated hundreds of times, until the end of the fragment is reached or the quality of the reads falls off. Lets say you get a few million fragments of a few hundred basepairs, you get close to 1B bp per chip. One of Jonathan Rothberg's insights was that the large, well funded core labs with the largest most expensive instruments, could not give the individual investigator the turnaround time she needed. So, he sought to deliver the solution in a low cost instrument that allows the investigator to decouple herself from the core labs. I've heard him say that Ion has the largest installed base of any sequencer, and I've heard from many investigators that what appeals to them is this very independence.
Sorry to be fawning, but your message should be rated 5. Regrettably, it's an analogy that's being used "everywhere", as if Gordon invented the exponential. He invented lots of things, but e^x is not on the list.
I worked for 3 years in the display industry where it was generally accepted that such large visualization systems were feel good systems either for senior management or for customers, but not for the people sitting in front of them.
For displays of laptop sizes and larger, a very good manufacturer can produce a display with drivers at a manufacturing cost of $2.50 to $3.00 per square inch, assuming the volume is high. Gradual cost reductions come into play, but those are countered by higher resolution and larger dimensions. So, for a 19" display in 16:9, you have $400 or so tied up in the display itself. $1000 street price sounds like a deal.