If BPA is found in the urine, it most certainly enters the bloodstream. However, what the GP post's article is suggesting is that it is cleared and excreted very quickly from the bloodstream, therefore it cannot build up in a large enough quantity in the blood to exert any physiological effect on humans.
Thus when they tried to measure blood levels they could only detect the conjugated, presumably inactive form of bisphenol A, which was found in very small quantities and promptly cleared in the urine.
Fuck that. Life is about having some fun too. If I enjoy inhaling toxic smoke, then maybe that is the way I want to have the fun in my life, and if me choosing what I want to do for fun doesn't match your "reason" or Big Brother's "reason" then fuck you both.
I hear this a lot. I don't want to argue with you because I don't believe in being someone else's mother. However, I assure you that the life in your days once you develop emphysema and heart disease is going to be both long AND miserable.
Stimulants (amphetamines, modafinil) can be addictive (or have potential to be--modafinil is Schedule IV), beta-blockers (Inderal, aka propanolol) cannot. There is a huge, huge difference between the two. Beta-blockers have long been indicated for anxiety and are well tolerated in most patients, your grandfather is probably on beta-blockers, I'm not really sure what relevance they have to TFA. I guess the journalist here doesn't know the difference or just doesn't care.
(Not a doctor, not a pharm anything, just an ordinary medical student speaking. Merry Christmas!)
I know you're joking, but I think that might be a valid complaint. What immediately came to my mind, and the article mentions this point, is the recent SCID treatment using a viral vector where a bunch of the patients unexpectedly ended up with leukemia, which you might say is the extreme opposite of immunodeficiency.
Also, it's a Phase I trial with five (5) patients, so while it's encouraging to hear about such a development, don't keep your hopes too high. Call me when Phase II is successful!
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Then read TFA. It's available. Free.
http://jama.ama-assn.org/cgi/content/full/300/11/1303
I should probably clarify that comment.
If BPA is found in the urine, it most certainly enters the bloodstream. However, what the GP post's article is suggesting is that it is cleared and excreted very quickly from the bloodstream, therefore it cannot build up in a large enough quantity in the blood to exert any physiological effect on humans.
Thus when they tried to measure blood levels they could only detect the conjugated, presumably inactive form of bisphenol A, which was found in very small quantities and promptly cleared in the urine.
Hope that makes sense.
A curious statement, since BPA was found at detectable levels in the urine of 92.6% of the population
What part of "excrete" did you not understand?
Fuck that. Life is about having some fun too. If I enjoy inhaling toxic smoke, then maybe that is the way I want to have the fun in my life, and if me choosing what I want to do for fun doesn't match your "reason" or Big Brother's "reason" then fuck you both.
I hear this a lot. I don't want to argue with you because I don't believe in being someone else's mother. However, I assure you that the life in your days once you develop emphysema and heart disease is going to be both long AND miserable.
Disclaimer: I work in a hospital.
Stimulants (amphetamines, modafinil) can be addictive (or have potential to be--modafinil is Schedule IV), beta-blockers (Inderal, aka propanolol) cannot. There is a huge, huge difference between the two. Beta-blockers have long been indicated for anxiety and are well tolerated in most patients, your grandfather is probably on beta-blockers, I'm not really sure what relevance they have to TFA. I guess the journalist here doesn't know the difference or just doesn't care.
(Not a doctor, not a pharm anything, just an ordinary medical student speaking. Merry Christmas!)
I know you're joking, but I think that might be a valid complaint. What immediately came to my mind, and the article mentions this point, is the recent SCID treatment using a viral vector where a bunch of the patients unexpectedly ended up with leukemia, which you might say is the extreme opposite of immunodeficiency.
Also, it's a Phase I trial with five (5) patients, so while it's encouraging to hear about such a development, don't keep your hopes too high. Call me when Phase II is successful!