where is the CD1 mouse infected with the 'synthetic prion'? My guess is that it didn't get disease, so they excluded the data.
It probably didn't get the disease, and the authors probably expected that as well. Here's the text in the summary article accompanying the paper:
"This might also explain why no one has yet accomplished the gold-standard experiment: infecting normal mice, not transgenic ones, with pure prion proteins."
I'm not an expert in the field, but my understanding is that only mice overexpressing the wild-type (not aberrant) MoPrP can be induced to display neurologic disease.
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It probably didn't get the disease, and the authors probably expected that as well. Here's the text in the summary article accompanying the paper:
"This might also explain why no one has yet accomplished the gold-standard experiment: infecting normal mice, not transgenic ones, with pure prion proteins."
I'm not an expert in the field, but my understanding is that only mice overexpressing the wild-type (not aberrant) MoPrP can be induced to display neurologic disease.