Funny - I clicked on the link and the rating is a B. No ambiguity about it and not the result of a hasty recent security update (the site was assessed on Sat Mar 07 22:39:37 PST 2015). Where does this headline and summary come from?
Just to clarify. Lab experiences = building recombinant DNA constructs, making transgenic organisms, using $500k microscopes, taking advantage of staffed greenhouses and animal facilities. No amount of online simulation can come anywhere close to replicating time spent in a real research lab.
I teach Biology at a small prestigious liberal arts college. My students do their real learning in the laboratories associated with each course and in their independent research projects. Their research projects often run for more than a year and include full time summer research experiences - it is an apprenticeship. This is where they learn to be Biologists and where they get the value out of the college. No amount of book learning or seminar participation can prepare them for the challenges of actually doing science. Growing living organisms, troubleshooting experimental protocols, interpreting data, and having to write and talk about their results (which are rarely 'clean') gives them the skills to make discoveries which will drive technology forward.
"a human corporation called ISDN retaliates against the boppers by infecting them with a genetically modified organism called chipmold. The artificial disease succeeds in killing off the boppers, but when it infects the boppers' outer coating, a kind of smart plastic known as flickercladding, it creates a new race of intelligent symbiotes known as moldies " - from Rucy Rucker's Ware Tetrology series (http://en.wikipedia.org/wiki/Ware_Tetralogy).
Notably, this set of three books was released free by the author (http://www.rudyrucker.com/wares/).
Note she was cited for speeding and a second violation. Wearing Glass was the third violation on the image of the ticket she posts. Speeding while distracted by a web enabled heads up display - how bad would she have felt if she'd killed someone.....
When Obama was re-elected there was a whole string of articles in the press (and associated Slashdot discussions) of how good the technical team who built his campaign infrastructure was. I keep thinking that it is a shame that he did/could not hire the same people to make the health care marketplace work well. It's nearly as if the same contractors who produced ORCA for Mitt Romney got hired to bring about this fiasco.
So educate me - is the health care marketplace system much more complicated than the election system? And if not was there a compelling reason to go with large contractors vs. the smart guys from the election team with a demonstrated track record?
It always amazes me that people worry so much about moving one or two genes around in plants in a thought out and carefully controlled manner yet they hardly worry about the introduction of whole functional genomes (i.e. invasive species) into ecosystems. Given the clear and deleterious impacts of introduced species (as opposed to those for GMOs which are debatable at best) you would think there would be large organizations of anti-introduced genome activists.
Trust me - benefits cost a lot more than $300 a month.
The benefits that I pay for my $35k entry level employee add up to about $14k per year on top of the salary - and about half of that scales linearly with salary.
Benefits include retirement (10% of salary), health insurance (>$300 a month even for an individual if you're providing decent insurance), contributions to social security and medicare, disability insurance, life insurance, unemployment insurance, and a couple of others that I am sure I'm forgetting right now.
While you're obviously correct that you can buy 'benefit packages', the value of the benefits at a company that treats it's workers (even the entry level ones) well is significant. No doubt you can include these costs in consulting fees, but $300 a month it is not.
Completely true - I did not mean to make light of the storage issues that come along with big genomic data sets.
The point was more that storage issues are easier to address (you can for the most part throw $$ at these issues until you get to really big data sets) than the challenges of analyzing the data which cannot necessarily be solved with brute force approaches.
We're trying to do a good job with the annotation which includes manually curating the gene families we are interested in, characterize splicing isoforms, and we're looking for genes/gene families that may be expanded or unique and provide us with insights into the evolution of the unique morphological structures we study in our critter.
Nope - the bottleneck is largely analysis. While the volume of the data is sometimes annoying in terms of not being able to attach whole data files to emails (19GB for a single 100bp flow cell lane from a HiSeq2000) it is not an intellectually hard problem to solve and it really doesn't contribute significantly to the cost of doing these experiments (compared to people's salaries). The intellectually hard problem has nothing to do with data storage. As the article states "The result is that the ability to determine DNA sequences is starting to outrun the ability of researchers to store, transmit and especially to analyze the data.". We just finished up generating and annotating a de novo transcriptome (sequences of all of the expressed genes in an organism without a reference genome). Sequencing took 5 days and cost ~$1600. Analysis is going on 4 months and has taken at least one man year at this point and there is still plenty of analysis to go.
In our Biology department we have a high end confocal microscope. This is a very expensive, sophisticated and complicated microscope with complex optical, mechanical, and control systems. The technician who services it and keeps it running was a sonar technician in a submarine for many years before he got a job working on microscopes. He is very good - logical, careful, and responsible. Obviously this is a small sample size but if his training in the navy has anything to do with his performance in his current job then this is a nice example of military training actually translating well into a civilian technology position.
$130 million dollars for 8 projects - this is truly a drop in the bucket (if it is even that much).
Consider the fact that the government essentially insures nuclear plants against disasters Price Andersen act. With a disaster (3 in the past 30 years) bound to happen again in this country, and given a possible cost of a nuclear disaster in the trillion dollar range if it occurs close to a major city, $130 million dollars is peanuts.
Consider the direct tax subsidies for oil exploration and extraction - in the billions of dollars per year (oil subsidies).
The sad fact is that the only reason that this kind of funding is news is that our energy policy is so incredibly beholden to entrenched interests that it is a miracle that there is any funding for alternative energy sources.
Press release stories like this should get a special Slashdot category - something like scientific vaporware. While this is potentially an important discovery, none of the information needed to determine if this could ever be an energetically or economically viable way of producing hydrogen is provided. I split water into hydrogen and oxygen every day when I run gels in my lab. The energy you could potentially get from the hydrogen that this electrolysis produces is smaller than the amount of energy it takes to run the gel.
Basic research is cool and all (so cool it's what I do for a living), but without more data I would guess that this discovery is very much on the basic end of the basic-->applied research spectrum. Discoveries like this are made all the time - only a tiny fraction end up being useful in real life.
This is why journalists would be terrible farmers
on
iPad Review
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· Score: 1
That's right - new things take time to shake out. See this recent Obama speech where he makes the same point about health care reform in a pretty darn funny way.
If you read my original post you will see that I stated that "I cannot remember ever having to (directly) use calculus in the last 20 years for any of my research". The word 'directly' was used very purposefully. I do realize that the math that underlies some of the statistical and analytical tools that I use includes calculus. However, I have not had to directly deal with solving problems involving integration or derivatives for a long long time. For example, for some of our PCR based genotyping assays, the data we produce is a melting curve (amount of double stranded DNA measured as fluorescence vs temperature). See Melting curve analysis for a reasonable explanation. To make the data easy to visualize we plot the derivative of the fluorescence vs temperature - this gives us nice peaks centered around the melting temperatures of the PCR products. To get the curves I click a button built into the real time PCR machine software - I never do the math myself. This is not to say that I could not do it (although it would take me a lot longer now than when I was in a math class and practiced this kind of thing on a regular basis).
Just trying not to be preposterous....
Re:If you can't handle calculus, science isnt for
on
Help Me Get My Math Back?
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· Score: 4, Insightful
As a scientist I learned a long time ago not to make general and unsubstantiated claims like "No matter what kind of scientist you plan to be, your knowledge of calculus will be essential." As a practicing molecular geneticist and cell biologist I use statistics quite often. I cannot remember ever having to (directly) use calculus in the last 20 years for any of my research. I really enjoyed all of the calculus (and linear and set theory and...) that I took a long time a ago. When I look back at it what I really got out of all my math classes (and O-Chem too for that matter) was the the knowledge that I could learn anything I really set my mind to - if I have to.
One alternative is to bow out http://web.reed.edu/apply/news_and_articles/college_rankings.html of the rankings game and take a principled stand as Reed College has done. One way of thinking about attending a fine school like this is that you "want to go to a school that isn't interested in selling out its education." Perhaps not surprisingly, US News didn't actually remove Reed from the rankings, they just ranked Reed (lower) with an incomplete data set.
The other alternative could be called 'open source' ranking. The University and College Accountibility Network http://www.ucan-network.org/ ranks colleges in a common format, has useful information, and best of all, you don't have to buy a copy of US News to get the rankings!
"Who hasn't ever had a touchscreen ATM or a touchscreen POS station not register a touch as something unintended? You don't think the ATM is trying to rip you off when it picks "Savings" when you meant "Checking". You just hit cancel and do it again."
Hmmm - let me think - 15+ years of using ATM's and I can't think of a single occurrence where an ATM machine registered the wrong choice when I used it. In fact I can't think of ever discussing this problem with anyone. What this says to me is that the registration/alignment of touch screens can be very reliable. Of course it will raise suspicions if this same technology does not function reliably in a voting machine.
While I don't buy into the vote switching consipracy I do think that it is at best negligent and at worst criminal to choose such an apparently unreliable implementation of this technology for such an important purpose. Why can't the local voting officials make better choices and avoid this embarrasing and unneccesary confusion every time we vote as a country.
Slashdot Mirror
Perhaps Google should focus on making phones that actually work without lag or locking up when you try to take pictures with the camera instead of fancy cases. That would be much more impressive. https://productforums.google.c... https://productforums.google.c... https://productforums.google.c... https://productforums.google.c...
Really? Is this like the blue dress/yellow dress thing? Different people see different things?
Funny - I clicked on the link and the rating is a B. No ambiguity about it and not the result of a hasty recent security update (the site was assessed on Sat Mar 07 22:39:37 PST 2015). Where does this headline and summary come from?
Consumption -> energy use -> global warming -> worse droughts -> desalinization -> energy use ->->-> This is a very poor long term solution
Just to clarify. Lab experiences = building recombinant DNA constructs, making transgenic organisms, using $500k microscopes, taking advantage of staffed greenhouses and animal facilities. No amount of online simulation can come anywhere close to replicating time spent in a real research lab.
I teach Biology at a small prestigious liberal arts college. My students do their real learning in the laboratories associated with each course and in their independent research projects. Their research projects often run for more than a year and include full time summer research experiences - it is an apprenticeship. This is where they learn to be Biologists and where they get the value out of the college. No amount of book learning or seminar participation can prepare them for the challenges of actually doing science. Growing living organisms, troubleshooting experimental protocols, interpreting data, and having to write and talk about their results (which are rarely 'clean') gives them the skills to make discoveries which will drive technology forward.
"a human corporation called ISDN retaliates against the boppers by infecting them with a genetically modified organism called chipmold. The artificial disease succeeds in killing off the boppers, but when it infects the boppers' outer coating, a kind of smart plastic known as flickercladding, it creates a new race of intelligent symbiotes known as moldies " - from Rucy Rucker's Ware Tetrology series (http://en.wikipedia.org/wiki/Ware_Tetralogy). Notably, this set of three books was released free by the author (http://www.rudyrucker.com/wares/).
Note she was cited for speeding and a second violation. Wearing Glass was the third violation on the image of the ticket she posts. Speeding while distracted by a web enabled heads up display - how bad would she have felt if she'd killed someone.....
When Obama was re-elected there was a whole string of articles in the press (and associated Slashdot discussions) of how good the technical team who built his campaign infrastructure was. I keep thinking that it is a shame that he did/could not hire the same people to make the health care marketplace work well. It's nearly as if the same contractors who produced ORCA for Mitt Romney got hired to bring about this fiasco. So educate me - is the health care marketplace system much more complicated than the election system? And if not was there a compelling reason to go with large contractors vs. the smart guys from the election team with a demonstrated track record?
It always amazes me that people worry so much about moving one or two genes around in plants in a thought out and carefully controlled manner yet they hardly worry about the introduction of whole functional genomes (i.e. invasive species) into ecosystems. Given the clear and deleterious impacts of introduced species (as opposed to those for GMOs which are debatable at best) you would think there would be large organizations of anti-introduced genome activists.
Trust me - benefits cost a lot more than $300 a month. The benefits that I pay for my $35k entry level employee add up to about $14k per year on top of the salary - and about half of that scales linearly with salary. Benefits include retirement (10% of salary), health insurance (>$300 a month even for an individual if you're providing decent insurance), contributions to social security and medicare, disability insurance, life insurance, unemployment insurance, and a couple of others that I am sure I'm forgetting right now. While you're obviously correct that you can buy 'benefit packages', the value of the benefits at a company that treats it's workers (even the entry level ones) well is significant. No doubt you can include these costs in consulting fees, but $300 a month it is not.
What do you mean 19 genes - there are only 16.
I'm currently reading 1Q84 and, like all the rest of his books, it is fantastic.
Completely true - I did not mean to make light of the storage issues that come along with big genomic data sets. The point was more that storage issues are easier to address (you can for the most part throw $$ at these issues until you get to really big data sets) than the challenges of analyzing the data which cannot necessarily be solved with brute force approaches.
We're trying to do a good job with the annotation which includes manually curating the gene families we are interested in, characterize splicing isoforms, and we're looking for genes/gene families that may be expanded or unique and provide us with insights into the evolution of the unique morphological structures we study in our critter.
Nope - the bottleneck is largely analysis. While the volume of the data is sometimes annoying in terms of not being able to attach whole data files to emails (19GB for a single 100bp flow cell lane from a HiSeq2000) it is not an intellectually hard problem to solve and it really doesn't contribute significantly to the cost of doing these experiments (compared to people's salaries). The intellectually hard problem has nothing to do with data storage. As the article states "The result is that the ability to determine DNA sequences is starting to outrun the ability of researchers to store, transmit and especially to analyze the data.". We just finished up generating and annotating a de novo transcriptome (sequences of all of the expressed genes in an organism without a reference genome). Sequencing took 5 days and cost ~$1600. Analysis is going on 4 months and has taken at least one man year at this point and there is still plenty of analysis to go.
In our Biology department we have a high end confocal microscope. This is a very expensive, sophisticated and complicated microscope with complex optical, mechanical, and control systems. The technician who services it and keeps it running was a sonar technician in a submarine for many years before he got a job working on microscopes. He is very good - logical, careful, and responsible. Obviously this is a small sample size but if his training in the navy has anything to do with his performance in his current job then this is a nice example of military training actually translating well into a civilian technology position.
$130 million dollars for 8 projects - this is truly a drop in the bucket (if it is even that much). Consider the fact that the government essentially insures nuclear plants against disasters Price Andersen act. With a disaster (3 in the past 30 years) bound to happen again in this country, and given a possible cost of a nuclear disaster in the trillion dollar range if it occurs close to a major city, $130 million dollars is peanuts. Consider the direct tax subsidies for oil exploration and extraction - in the billions of dollars per year (oil subsidies). The sad fact is that the only reason that this kind of funding is news is that our energy policy is so incredibly beholden to entrenched interests that it is a miracle that there is any funding for alternative energy sources.
Press release stories like this should get a special Slashdot category - something like scientific vaporware. While this is potentially an important discovery, none of the information needed to determine if this could ever be an energetically or economically viable way of producing hydrogen is provided. I split water into hydrogen and oxygen every day when I run gels in my lab. The energy you could potentially get from the hydrogen that this electrolysis produces is smaller than the amount of energy it takes to run the gel. Basic research is cool and all (so cool it's what I do for a living), but without more data I would guess that this discovery is very much on the basic end of the basic-->applied research spectrum. Discoveries like this are made all the time - only a tiny fraction end up being useful in real life.
That's right - new things take time to shake out. See this recent Obama speech where he makes the same point about health care reform in a pretty darn funny way.
If you read my original post you will see that I stated that "I cannot remember ever having to (directly) use calculus in the last 20 years for any of my research". The word 'directly' was used very purposefully. I do realize that the math that underlies some of the statistical and analytical tools that I use includes calculus. However, I have not had to directly deal with solving problems involving integration or derivatives for a long long time.
For example, for some of our PCR based genotyping assays, the data we produce is a melting curve (amount of double stranded DNA measured as fluorescence vs temperature). See Melting curve analysis for a reasonable explanation. To make the data easy to visualize we plot the derivative of the fluorescence vs temperature - this gives us nice peaks centered around the melting temperatures of the PCR products. To get the curves I click a button built into the real time PCR machine software - I never do the math myself. This is not to say that I could not do it (although it would take me a lot longer now than when I was in a math class and practiced this kind of thing on a regular basis).
Just trying not to be preposterous....
As a scientist I learned a long time ago not to make general and unsubstantiated claims like "No matter what kind of scientist you plan to be, your knowledge of calculus will be essential." As a practicing molecular geneticist and cell biologist I use statistics quite often. I cannot remember ever having to (directly) use calculus in the last 20 years for any of my research. I really enjoyed all of the calculus (and linear and set theory and ...) that I took a long time a ago. When I look back at it what I really got out of all my math classes (and O-Chem too for that matter) was the the knowledge that I could learn anything I really set my mind to - if I have to.
One alternative is to bow out http://web.reed.edu/apply/news_and_articles/college_rankings.html of the rankings game and take a principled stand as Reed College has done. One way of thinking about attending a fine school like this is that you "want to go to a school that isn't interested in selling out its education." Perhaps not surprisingly, US News didn't actually remove Reed from the rankings, they just ranked Reed (lower) with an incomplete data set. The other alternative could be called 'open source' ranking. The University and College Accountibility Network http://www.ucan-network.org/ ranks colleges in a common format, has useful information, and best of all, you don't have to buy a copy of US News to get the rankings!
"Who hasn't ever had a touchscreen ATM or a touchscreen POS station not register a touch as something unintended? You don't think the ATM is trying to rip you off when it picks "Savings" when you meant "Checking". You just hit cancel and do it again." Hmmm - let me think - 15+ years of using ATM's and I can't think of a single occurrence where an ATM machine registered the wrong choice when I used it. In fact I can't think of ever discussing this problem with anyone. What this says to me is that the registration/alignment of touch screens can be very reliable. Of course it will raise suspicions if this same technology does not function reliably in a voting machine. While I don't buy into the vote switching consipracy I do think that it is at best negligent and at worst criminal to choose such an apparently unreliable implementation of this technology for such an important purpose. Why can't the local voting officials make better choices and avoid this embarrasing and unneccesary confusion every time we vote as a country.
Ahhh - reminds me of my favorite political Google bomb - the single word Santorum. Still numer 1 even after he was voted out of office.