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This is just a ten second selection, if you take your time you will find hundreds if not thousands of apps capable of handling PDF files. Im fairly sure you will find an application that suits your needs if you just lift a couple of rocks. Start by collecting a bunch of PDF files to test the different apps on.

Online:
http://www.sanface.com/webpdfviewer.html
http://view.samurajdata.se/
Windows:
http://www.hsinlin.com/software/pdf.html
http://www.foxitsoftware.com/
http://www.cadkas.de/downengpdf5.php
http://www.freewarehome.com/Business_and_Productiv ity/Word_Processing/PDF_t.html
http://www.tucows.com/downloads/Windows/DesignTool s/PDFTools/

• A standard (or oversized) keyboard with a guidance grid (key-/finger-sized holes) mounted a few mm above the keys. Hand and fingers can rest and tremble until the correct key(hole) is found and pressed. Inhibits accidentally pressing the wrong key and is comparatively cheap. Hazardous for finger joints for people with too forceful tremor or spastic jerks, though. See e.g. http://www.keytools.com/keyboards/guarded.asp (found trough google). Decreasing or disabling autotype/repeat will help here as will anti-repetition keyboard drivers.
  
  
• Input systems where you select the key with buttons, laserpointer, shouts, etc. like http://www.keytools.com/keyboards/lucy_comms.asp (google again). A famous example is the text2sound machine Stephen Hawking is using. Not cheap if done in hardware.
  
  
• Maybe just try as first "zero-investment" help: switch the mouse driver to low response and no (ZERO) acceleration. Then let her use a virtual keyboard with a size she can work with (small enough to be fast, big enough to be jitter-resistant), see e.g. http://www.freewarehome.com/System_Utilities/Tools _For_Disabled_p.html, http://www.lakefolks.org/cnt/ or even the builtin
  
  
• Similar to above - but useful even if her tremors are too high for moused usage: Get a joystick/gamepad she can handle - or re-build one from a cheap gamepad (to be dissected - keep the electronics, dump the mechanics) and low-injury (light-/emergency) switches where she does not scratch herself on the edges. Set her PC to use the microsoft virtual keyboard click/select mode mode http://www.microsoft.com/enable/training/windowsxp /usingkeyboard.aspx
  
  
• If her tremors are even to high for that, set the virtual keyboard to scanning mode and give her one single trigger (from the gamepad/joystick you built before). Select a trigger/switch she can control best (finger, hand, foot, head, shoulder, tongue, breathing, ...
  

Lots of sites still use frames, though 99% of those that do are more irritating than useful. The best use of frames I've seen is at http://www.freewarehome.com/

The worst ones are the ones that display content from another site in the right-hand frame making it look like their own content. Naughty, naughty!

A few desktop prank programs, especially the gems from LizardWorks, are always fun. SneakyIcons is particularly amusing, methinks :)
Unfortunately, I have no clue if they'll run on XP.

Yet I can still find Windows freeware around sometimes. (It's mostly older stuff.)

I'm sure you do realize that mozilla and IE save bookmarks/favorites differently. IE uses individual files for each favorite, where as mozilla uses one file that is basically a webpage itself to hold all of your favorite website needs. There just isn't a practical way for mozilla to use IE's bookmarks if you consider how many profiles mozilla is run on that DON'T have IE.

With that said, you can still find some free wizards to in various places.

If you use the Luna * theme for Mozilla Firebird, run some special customizations with the UI, it'll look EXACTLY like IE (put the location bar in it's own dialog, add a go button, get rid of the search bar, switch the stop and refresh buttons, add the bookmarks and history button, and you've almost got yourself a direct copy (without the sponsored media button and a search button -- but you already have a search bar that you got rid of))

Making toolbars moveable has been slated for AFTER Mozilla Firebird 1.0, so at least you know they are on it. But there are so many programs that don't have moveable toolbars that your argument is invalid anyway.

Regarding making a non-Microsoft Internet Explorer, I think that is a horrible idea. If you can't get used to the Options dialog in Mozilla Firebird, then you don't deserve to be called a teckie. I know some pretty slow people that fell right into that, and away from IE's checkbox heaven.

*Luna does not yet run under MF 0.7. It does run under 0.6, though.

Free Ware Home is a website full of software and components dedicated to just this concept. And here by free he means:

1. No crippleware
2. No demoware
3. No restrictions.

Great site and a lot of really good stuff.