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Scourge: The Once and Future Threat of Smallpox

Stella Daily writes: "Had Jonathan Tucker's Scourge: The Once and Future Threat of Smallpox been released just a few months ago, it might have been of interest only to a few outside of the world of epidemiology, but now that anthrax scares have reawakened public interest in biowarfare, it's hardly surprising that Scourge has been flying off the shelves." Read on for the rest of her review of this sobering non-fiction technothriller. Scourge: The Once and Future Threat of Smallpox author Jonathan B. Tucker pages 291 publisher Atlantic Monthly Press rating 9 reviewer Stella Daily ISBN 0-87113-830-1 summary The history and potential horrors of a vanquished killer

Tucker clearly wrote the book believing that the use of smallpox as a biological weapon was a worrisome, but not especially likely, threat, and on September 10th, most of us would not only have concurred, but would probably never have thought that such a thing could happen; after all, smallpox remains the only infectious disease to have been eradicated by humans. After reading Scourge, you will be grateful that the mysterious sender of anthrax-laced mail doesn't have the power of this infinitely worse pestilence in his or her hands.

The smallpox virus, or variola, is a biscuit-shaped bundle of DNA and protein casing, so tiny it can only be viewed with an electron microscope, yet devastating to the human body. The disease kills up to thirty percent of its victims and leaves the rest permanently scarred after battling fever, nausea, and boils so painful that thirsty patients often refused water, unable to swallow without excruciating hurt. Perhaps to be merciful, Tucker has included no photographs of suffering victims covered in the gruesome pustules of the disease, but should you have a morbid curiosity to see one, visit the Polio Eradication Photo Gallery.

Scourge is not a story about a virus, however; it is a story about people. Tucker tells of the history of smallpox and civilizations, how political machinations combined with idealism to bring about the global cooperation that removed smallpox from the earth, and the elaborate subterfuge used by the Soviet Union to hide its research on smallpox as a potential biological weapon. Fans of Laurie Garrett's (The Coming Plague, Betrayal of Trust) journalistic style will appreciate Tucker's treatment; the major figures in the history of smallpox are presented in terms of their personalities and personal struggles, rather than in simple obituary-style listings of what they did.

In describing the early history of the disease, Scourge is fascinating. You may have known that smallpox helped Hernando Cortes conquer the Aztecs in the sixteenth century, but perhaps you didn't know that smallpox may have been the Athenian epidemic Thucydides describes in his account of the Peloponnesian war. The superstitions that existed prior to the germ theory of disease - and, in some areas, long enough to hinder the last stages of the smallpox eradication campaign in the late 1970s - seem truly impossible now, but such was belief prior to the germ theory of disease.

The conquering of smallpox remains one of the great triumphs of mankind - the only infectious disease successfully eradicated by humans. The history of the eradication campaign is one of cooperation between nations and between scientists, but it is also a story of obstacles placed in the way by reluctant governments, the rapid spread of disease due to world travel, and the stubbornness of the superstitious. Here, you will meet such figures as D.A. Henderson, the reluctant leader of the World Health Organization campaign, and Viktor Zhdanov, the man who first proposed a global eradication campaign to the WHO in 1958, then, ironically, became the first chairman of the Soviet council that oversaw the secret biowarfare program beginning in the 1970s.

The clash between the traditional openness of the scientific community, where information is shared relatively freely, and the secretiveness of bureaucracies, where being in the know is a mark of power, is a recurring theme. Often, you'll find yourself rooting for the researchers, who frequently had to reason with government officials who knew nothing about science, but you may be surprised to find yourself agreeing with the government - specifically, the Department of Defense - a time or two.

The story of the Soviet Union's successful cover-up of its research into the use of smallpox as a biological weapon is unsettling, to say the least. Do you find the aftermath of a nuclear bomb impressive? Imagine that bomb followed by an ICBM bearing smallpox - a disease that kills nearly a third of its victims in a normal situation, but would be attacking survivors of a nuclear attack, whose immune systems would be severely compromised by radiation damage. Lest you think that earlier vaccinations might have helped, the smallpox vaccine is effective for only about ten years before revaccination is required, and the United States had stopped mandatory vaccinations long before the last known case of naturally occurring smallpox was diagnosed in 1978. Such a warhead was one of the foci of the Soviet program, even as facilities were carefully disguised so as to give the appearance of compliance with the Biological Weapons Convention treaty. Western governments did not learn of the full scope of the Soviet effort until 1989, and kept the information classified until former Soviet smallpox research scientist Ken Alibek (ne Kanatjan Alibekov) told the story to the American press in 1998.

Although, officially, the last remaining stores of variola virus are kept in Moscow and at the Center for Disease Control in Atlanta, Tucker raises the possibility that other governments - particularly Iraq - may have retained secret stores of smallpox virus, citing enough circumstantial evidence to keep his speculation from being easily discounted. He also brings up the possibility that a government might, to avoid the certain retaliation that would come from launching a smallpox attack, supply the virus to a group like al-Qaeda, then deny responsibility when the terrorists release the disease. Tucker finished documenting these speculations well before the September 11th attacks; now, one hopes they aren't prophetic.

In the case of smallpox, the truth is as morbidly fascinating as any fiction could possibly be, and Tucker tells the story of those who fought to end the scourge and those who would have preserved it as a weapon with equal aplomb, yet from the perspective of a world where smallpox was a piece of history and sophisticated biological attack a back-burner phenomenon. Now that fears of biological warfare are all too real, Scourge is exceptionally relevant - and hopefully not a prediction of what is to come.

You can purchase this book at Fatbrain.

18 of 248 comments (clear)

  1. And next... by Orkin · · Score: 2, Interesting

    Chicken soup books will start selling again because people are going to be scared of getting chicken pox.

    Sheesh! There's no more of a biological terror threat than there was 15 years ago. People are so paranoid.

  2. Possibilities... by Neon+Spiral+Injector · · Score: 2, Interesting

    Slightly off topic, the anthrax attacks.

    Does anyone else wonder why they just seem to have stopped all of a sudden.

    Did the person(s) sending the letters run out of anthrax? Or perhaps was this just a first phase? Just a small scale experiment to see how a controlled release of antrax spreads.

    I just wish the whole small pox idea was never brought up. But I guess with this book having been released even before the initial attacks, the thought was on someone's mind. I just feel now every time someone talks about small pox being used in a biological attack it increases the chances of it happening (I guess I'm not helping any).

  3. Fear and Unity by under_score · · Score: 4, Interesting

    When I read something like this review, I experience twinges of fear. Smallpox sounds like it is truly terrible. And yet, somehow, we, the people of this world, did manage to get rid of it. For the future of the world, we need to recognize that we are one people first, and citizens of a nation second. This doesn't mean we all need to believe the same things, etc. This is about unity in diversity. And unity isn't abstract: its about action. Getting rid of smallpox was an example of unity in diversity. The people of the world got rid of it. Now, can we get rid of AIDS? Can we get rid of Malaria? What about our physical environment? What about nuclear weapons? What about poverty? These are things that can only be solved with unity of action.

  4. Scary stuff by Tsar · · Score: 3, Interesting
    From another site that mentions Tucker's work...
    How vulnerable are we? In June, a two-day simulation exercise called Dark Winter was held at Andrews Air Force Base in Washington, D.C. It began with a fictional scenario depicting a covert smallpox attack by Iraq that left 24 infected in Oklahoma. After an imaginary two weeks, decisions by the assembled politicians coupled with the quick exhaustion of the stockpiled vaccine would have resulted in 16,000 people infected in 25 states and 1,000 dead, 10 other countries reporting cases and the grim prediction that within three weeks there would be 300,000 victims, a third of whom would die.
    Very scary stuff. I think I'll sign up for that Mars mission now.
    1. Re:Scary stuff by fireduck · · Score: 2, Interesting

      The Dark Winter scenario apparently was based on some screwy statistics regarding rates of infection. Steven Milloy of Junkscience fame wrote an editorial on the subject.

      Dark Winter assumed every infected person would infect 10 additional people. This was based on a couple of statistically abnormal infection events. A more reasonable infection rate of 2 people is what the CDC believes more likely. This obviously would reduce the catastrophic victims exponentially.

  5. coincidental... by ravrazor · · Score: 4, Interesting

    There was a episode of Nova about the very same topic last night on our local PBS affiliate. Quite disturbing, especially in regards to the experiments of the Soviet Union even after global treaties had been signed.
    The pictures of smallpox victims were even more disturbing.
    Check out the schedule, maybe it's on again, for those interested.

  6. George Carlin (Offtopic) by scott1853 · · Score: 4, Interesting

    I know this is slightly offtopic, but I downloaded a Carlin MP3 from an HBO show from 1999 that I never saw or heard before. The first ten minutes he talked about terrorists and how they're not going to be stupid enough to use a bomb, but they'll take knives and dozens of other weapons that the airlines would let you take on board. He then went into talking about how we'd all be afraid of anthrax in our drinking water.

    I know it's just comedy, but he's a smart guy and that was just a little creepy hearing about this stuff from a 2 year old recording.

  7. And it gets worse.. genetically modified mousepox by Anonymous Coward · · Score: 1, Interesting

    Australians scientists found that by adding a single gene to mousepox they can create a 100% lethal virus (even to resistant mice), with the effect of vaccines being greatly reduced. It is thought that the gene placed in smallpox would have a similarly devastating effect on humans. heres an article and another.

  8. More important than that... by Orkin · · Score: 2, Interesting

    It is far more important that we, as the only superpower in the world, work NOT on additional countermeasures to combat terrorism and biological attacks, but on making such attacks irrelevant.

    You're absolutely right in pointing to our hopeless foreign policy as the instigator of this entire ordeal.

    If our military forces are used only in accordance with their constitutionally aligned duties, this paradigm would not exist, and terrorist attacks would be a non-issue.

  9. Suggested Reading about Chemical and Biowarfare by anzha · · Score: 3, Interesting

    I would strongly suggest looking up the book of _A Higher Form of Killing_ (iirc, by Harris and Paxman). It's a sobering book. I found it in our high school library in Los Alamos. I'd be curious to see if it is still there...

    --
    Do you know why the road less traveled by is littered with the bones of the unwary?
  10. Re:Demon in the Freezer by hoggoth · · Score: 4, Interesting

    > Demon in the Freezer
    Excellent read! Terrifying stuff.

    The article talks a lot about delivery mechanisms, from ICBMS that explode smallpox in the air, to microchip based aerators that spray live smallpox into the air and could fill an airport in a few hours.

    But based on our recent experiences with suicide terrorists, has anyone thought about the simplest method of hiding, importing, and distributing the virus?

    A suicide terrorist could EAT the virus, and go on vacation in the US, visiting as many places as possible, breathing on as many people as possible.
    F*** this is scary! All he would have to do is visit a McDonalds in every big city!
    He would have two weeks before he shows symptoms.

    I almost hate even SAYING this, spreading the idea. But I'm sure they can think of it on their own.

    --
    - For the complete works of Shakespeare: cat /dev/random (may take some time)
  11. Re:Dont StockPile Vaccine by hobbs · · Score: 2, Interesting
    I see that you have a sensitivity towards solving the current AIDs problems, but smallpox was a major epidemic. According to this article about stockpiling vaccine in Canada, it states:
    Smallpox claimed around one billion lives before being declared eradicated in 1980.
    That's not a small number, which is indicative of how dangerous it can be. Also in the same article, it notes that it would cost less than CAD$400 million (~US$250mil) to stockpile for Canada. The US could presumably make it cheaper for the enormous scale.

    Then you have to think like a taxpayer. Do I spend my equiv US$8 for my dose of smallpox vaccine against a potential epidemic, or do I spend it on people I'll never see in Africa? Then remember that a large population of the States lives in what's termed the "Bible Belt" ...

  12. Re:Biopreparat by SpinyNorman · · Score: 2, Interesting

    Journal of Historical Review

    Biowarfare in the 20th Century

    Biohazard (Alibek) review

    It's hard to imagine anyone much better placed than Alibek to know the truth.

  13. ah, but its worse... by hamburger+lady · · Score: 3, Interesting
    smallpox isn't that bad, as has been posted before, its only contagious when symptoms are showing, etc etc.

    what really scares the bejeezus outta me is modified smallpox.

    to summarize the article, some guys in australia discovered by genetically modifying mousepox (pretty weak, like chicken pox) that they could turn it into a far, far deadlier virus which was pretty much immune to vaccines (!).

    now, this kind of genetic modification isn't easy. but a vaccine-resistant strain of smallpox which kills somewhere up to 90% or so of people infected would really suck.

    then again, maybe such a modification wouldn't work on smallpox like it does for mousepox. i hope.

    --

    ---
    Is this the MPAA? Is this the RIAA? Is this the DMCA? I thought it was the USA!
    1. Re:ah, but its worse... by meldroc · · Score: 3, Interesting

      The Soviet Union created some ghastly genengineered diseases. Off the top of my head, they genengineered the smallpox virus by adding genes from the Marburg virus (similar to Ebola). The result was a virus nicknamed Blackpox or Ebolapox that is airbone & contagious like smallpox, but caused a nasty bleeding-out-your-pores hemorrhagic fever with a near 100% fatality rate like Ebola. They also added the gene for myelin (the coating around nerve cells) to a plague bacteria. Treatment is simple enough, give antibiotics, and the bacteria goes away. But when the immune system sees the myelin proteins in the bacteria, it attacks anything with myelin, such as nerve cells. The result is a multiple sclerosis type of illness that results in a lingering death.

      --

      Meldroc, Waster of Electrons
  14. Small Pox Vaccine Allergies? by carping · · Score: 3, Interesting

    How does one come to realize that one is allergic to the small pox vaccine?

    -E

  15. Re:An interesting philosophical question... by dublin · · Score: 3, Interesting

    MHO, there is only one solution to this, and a lot of pro-Corporate people are not going to like, or understand, it. We have to take care of what we have - people, fauna, flora, habitats, EVERYTHING - as well as, or better than, ourselves.

    One can only assume by your rant that you believe we should enforce a uniform standard of living for ll people everywhere. The Soviet Union tried that, and it's a great means of ensuring that everyone (but the truly elite - we really hardly have such a thing in this country relative to the Poilitburo or royalty of old) winds up equally ppor and miserable.

    We have nations for a reason, and we haven't outgrown them, nor are we likely to in this millenium.

    The people of those countries CAN and SHOULD change their own national governments to ensure that they act responsibly and in the best interest of the people of that nation. The US BY FAR the most generous benefactor nation in the entire history of the world. The superiority of our economic system generates a bountiful surplus that has allowed us to do so. While the US should encourage the formation of republics wherever it can, it is NOT our job or duty to try to sort out the internal politics of every corrupt regime on the planet.

    In fact, the experiences of this century have clearly shown the futility of attempting to "install" free governments in countries where the people are not sufficiently motivated to fight in their own self-interest.

    Obviously, you've fallen for the flawed logic of your leftist college professors. Following your course of action would result in the destruction of any means by which the US might be able to provide aid. We should encourage freedom, but the people of foreign nations must have some skin in the game. Welfare works even less well for nations than it does for individuals, sapping their desire and any initiative to get up and work for thier own benefit.

    Our goal (the only truly compassionate one) should be to help these countries generate their own wealth, rather than being dependent on ours. (The US has a long and successful history of doing this, even for our enemies...)

    --
    "The future's good and the present is nothing to sneeze at." - Roblimo's last ./ post
  16. Airborn ebola virus could be the apocolypse by Suicyco · · Score: 2, Interesting


    Anybody ever read Hotzone? The airborn version of ebola (Hemmoraghic fever) that was discovered in a washington suburb a decade ago LUCKILY only infected monkeys. Normally ebola infects both humans and monkeys, but luckily is only transmissible via contact with bodily fluids. An airborn version was discovered and since this disease is 90% fatal, if a strain is found that can infect humans and has the structure to live in aerosol form, would be FAR FAR worse then smallpox. Most people have no idea how close we came to global oblivion of over 90% of the human race during that infection at the monkey quarantine house. Scary stuff. Stephen King wrote that Hotzone was the scariest book he had ever read. Its terrifying. And all it would take is one guy to walk into an international airport with an airborn version of the virus. 36 hours later the world is in deep doo doo.