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Human-Mouse Hybrids?

scientistguy writes "There is a remarkable story by Nicholas Wade in the early morning edition of the New York Times about a discussion to create human-mouse hybrid organisms. One of these techniques involves the introduction of genetically altered mouse embryonic stem (ES) cells (e.g. with genes 'knocked-out' or replaced) into a developing mouse blactocyst to create progeny hybrid organisms. Typically, these progeny organisms are then bred to unaltered mice to see if the genetic alteration has gone germline or is heritable. If heritable, mice can be bred and animals which are homozygous for the altered gene can be phenotypically examined as long as the manipulation is not homozygous lethal or cause sterility in a single copy state. Unless using blastocysts from immunologically crippled mice, there would most likely be a recognition of non-self by murine immune cells not educated (which haven't seen during their development) to the human cells that would wipe them out. Nonetheless, it's amazing that it's being contemplated due to the ethical implications of such an experiment. What if it were viable? What if there were more than just a few human cells? Could it be sacrificed? ... or even experimented on further if part 'human'? Perhaps these types of experiments are best relegated to little known, deserted islands far away from the reaches of civilization (or perhaps regulation) ..."

15 of 409 comments (clear)

  1. Where...? by MrFenty · · Score: 5, Funny
    Perhaps these types of experiments are best relegated to little known, deserted islands far away from the reaches of civilization (or perhaps regulation)

    What - like Australia ?

  2. wow by mrselfdestrukt · · Score: 3, Funny

    Another new input device.
    Why not just stick my mouse to my hand with superglue?

    --
    "I used to have that really cool,funny sig ,but it got stolen."
  3. What are we going to do tonight Brain? by Anonymous Coward · · Score: 3, Funny

    What we do every night, Pinky.

  4. Ehhhhhh by Uruk · · Score: 5, Funny

    blactocyst to create progeny hybrid organisms

    Good god! Don't you understand the implications though? If the digital tri-mode defrobulator gets out of sync with the anticalisthenticator, we could have some serious subdermal anamolous activity!

    Open your eyes man!

    (I just thought the sentence sounded funny the way it was strung together, even if I do have enough biology to know what a blastocyst is and to recognize when it's misspelled)

    --
    -- Truth goes out the door when rumor comes innuendo. -- Groucho Marx
  5. Are you a man or a mouse ? by MosesJones · · Score: 5, Funny


    Oh very freaking funny you insensitive clod!

    --
    An Eye for an Eye will make the whole world blind - Gandhi
  6. Have a heart by Comrade+Pikachu · · Score: 3, Funny

    The next time you visit Disney World, don't pick on the guy in the costume. See what he has to endure?

  7. So potentially, by sawilson · · Score: 5, Funny

    If this research continues, it might only take
    1000 genetically altered monkees 10 years to create
    the collective works of shakespeare. You probably
    wouldn't have to lock them in a room either. They'd
    of course be superior and have 3 asses.

  8. The Secret of NIMH by randomErr · · Score: 3, Funny

    Don Bluth is so pround now.

    --
    You say things that offend me and I can deal with it. Can you?
  9. Can't resist... by TeknoHog · · Score: 5, Funny

    This Human-Mouse hybrid sounds like a great advance in the computer interface design. At least it would remove one bottleneck. Soon we'll outquake even Dustpuppy (he uses a separate mouse).

    --
    Escher was the first MC and Giger invented the HR department.
  10. babelfish by nmg196 · · Score: 4, Funny

    I don't understand. Is there an English copy?

    I shoved that into babelfish but it didn't come up with anything - no matter what language I selected...

  11. Re:I'm horrified... by sawilson · · Score: 4, Funny

    I consider myself open to scientific experimentation

    That's pretty brave. I'm just an organ donor myself.

  12. Re:I'm horrified... by csguy314 · · Score: 3, Funny

    One telling comment though:

    He gave as an extreme example the possibility that a mouse making human sperm might accidentally be allowed to mate with a mouse that had made its eggs from human cells.


    Hey baby, I'd like you to my parents, Squeeky and Whiskers.

    --
    This is left as an exercise for the reader.
  13. You know what this means don't you? by trcooper · · Score: 4, Funny

    They're creating an army of Mouse-men to take over the world. An army of millions that will scurry out of rural corn fields and take over America.

    Fortunately I am almost finished designing a giant trap that will prey on the one weakness they neglected to genetically correct, Sweet, sweet, cheese.

  14. Coming soon.... by sawilson · · Score: 3, Funny

    This page was generated by a barrel of Human-Mouse Hybrids for sawilson.

  15. So how...? by KC7GR · · Score: 3, Funny

    ...do you left-click with one of these hybrids? Heck, are they two or three-button? PS/2 compatible, or just USB?

    For that matter, do they have balls or are they purely optical?

    (There go my karma points...)

    --

    Bruce Lane, KC7GR,

    Blue Feather Technologies