Posted by
timothy
on from the no-two-cats-are-alike dept.
bbsguru writes "When Texas A&M researchers announced the first Cloned Kitty about a year ago, everyone expected to see a Multiplicity-style pair of cats by now. Not so! The clone is genetically identical, but in many other ways totally a different cat. This
CNN Story has details."
Re:Nature vs. Nurture
by
Billly+Gates
·
· Score: 4, Interesting
But its not personality.
The coats are different colors. How is this possible?
I know when they cloaned dolly, the clone experienced premature aging. The theory is that when each cell divides it stores the information about the division internally. After so many divides the cells began to not regenerate as much and this causes aging. Perhaps something similiar happened and caused the hairs to not display in full colors due to false information stored from the other cat that was implanted in the egg cell of the clone.
Anyway this is a mystery and alot more research is needed on this.
why on earth would you expect a carbon copy ?
by
psycho_tinman
·
· Score: 4, Interesting
Its been established that nature plays a lesser role than nurture in the personality of a human.. obviously, the same must apply to animals as well..
No matter even if you clone an Einstein, they're not going to pop out spouting theorems, it just doesnt work that way.. from a purely research oriented perspective, though, it might be interesting to have an Einstein clone, simply to see how he may use his innate talents along ANOTHER field of science (or maybe not even a science, he might have been a GREAT musician, for all we know)..
For any person, most things we do are not innate but rather taught.. Would Mozart have started composing from the age of 4 if he hadnt had parents who encouraged him ? I doubt it.. With a clone, the only thing you CAN get is the potential to achieve the same things as the "original" (I hate using that term, but whatever)..
So, finally, in typical Slashdot-style, let me ask.. Is this really news ? (yeah, it is, it probably helped correct a lot of peoples misconceptions about the cloning process, which is GREAT, but it should have been obvious from the start)
I don't get it
by
peterpi
·
· Score: 5, Interesting
I am genetically identical today to how I was yesterday, but I expect I'll do loads of different stuff.
people apparently left out the "nurture" part of the equation entirely.
It seems to me an incredible stretch that people actually believed their pet's behavior/personality was hard-coded in the DNA.... but maybe that's just my studied-the-hard-sciences-all-my-life bias.
Behaviors are very complex things... both genetic tendency and environmental interaction play important roles. Even in psychiatric disorders that have strong genetic links (schizophrenia, bipolar disorder) having both parents (or an identical twin) afflicted will only buy the child or sibling a 50-60% chance (give or take 10%) of developing the disorder.
Yes, genes are the building blocks of our bodies... but you have to give nurture its chance at bat.
-- Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
Scientists and the Public missing the point
by
Nemus
·
· Score: 5, Interesting
Alot of the general public, and unfortunately alot of companys and independent scientists as well, have forgotten what the true purpose and logical extension of cloning is.
Of course there will always be infertile couple who will want use this method to have babies, someday maybe, but otherwise we don't really need cloning to duplicate life forms. We already have a method. Its called sex. And while some arguments can be made for cloning endangered or extinct animals, until we could make a clone that was capable of reproduction, would there really be anything besides a novelty interest in this? I mean sure, yay, you've got a zoo with a thousand pandas. Unfortunately they'll all be dead in x number of years, and you'll have to clone a thousand more. Rather pointless.
The true purpose of cloning is, and should remain, complete and utter mastery of genetics and medical science. This is why the whole stem cell thing is so important, and should not be constarined in the way it is (For those who object to it on moral grounds saying it encourages abortions, it doesn't. The abortion doctor who made sales pitches like that to pregant women would be shot on principle.)
Stem Cell research and the race to human cloning are, objectively, two leaves on the same branch. Both should be refined and mastered to the point where the dream of human immortality is no longer a dream. This should be all about pushing genetics and microbiology to their absolute limits, not trying to make a Bob mark II or Fluffy 3.0 . Cloning a human just for the hell of it though, or trying to bring back to life a dead child or loved one or pet out of hopes for a "replacement" is irresponsible both scientifically, and morally.
So what would be "legitimate" applications of these technologies. Obviously, and one that was a main topic of debate during the stem cell controversy in congress, was the cloning of indivual organs, like hearts and livers. This way, instead of someone having to wait for months or years for a vital heart or liver transplant, a compatible one could be made up on the spot. And, since research into these fields will also yield advances in fields like neurological medicine, the possibility of new arms or legs, or even new eyes or audial organs becomes a possibility.
However, I do disprove of the notion that some people seem to think that we'll be planting out minds into "blank slate" bodies, sometime in the distant future. Thats not just ultra-late term abortion, thats essentially murder, unless something was done to the brain to keep it only restricted to base biological functions, and not the development of a psyche, and even that would be just weird.
And, for the record, I am pro-life, so no flames from pro-lifers on the stem cell stuff like last time.
-- Mod Points: Helping you keep your opinion to yourself.
Re:Impossible to...
by
KDan
·
· Score: 5, Interesting
Depends what you mean by raising the dead. If you mean "oh, make a clone of John, educate it, let it grow up to John's age, and you have John again", then obviously that's never going to work, and there was never really any doubt about that. Unless you can reproduce the exact environment of John's life, down to the quark configuration of the entire universe (every little bit can alter events), it's impossible to get John again through that method.
However, another much better method is this: Make a clone of John, keep its brain blank as you grow it (maybe in an accelerated fashion) to John's size, and then transfer John's thoughts to that clone. Of course that requires very advanced brain knowledge to "read" and "write" a brain - assuming that's even possible.
But that would give you immortality (so long as you keep your brain safe).
Actually, the reason that these coats don't look entirely alike is probably entirely genetic. Although, you're correct, it's not predictable or controllable.
When a female cat is conceived, it begins to grow, duplicating its cells. Each of these cells, however, has two copies of the x-chromosome. Only one of these is useful. So, in a random pattern, the cells will switch off one of the chromosomes by forming Barr bodies that surround it. It's a well understood process called Lyonization for anybody interested in looking into it. However, this only happens for females.
One might then ask whether a male cat's clone would look identical. My guess is again that it would not, although Lyonization would not be an adequate explanation. However, I believe that they would look much more similar than any two cloned calico cats (which are all female and whose coats are formed by this mechanism).
Actually... No
by
Anonymous Coward
·
· Score: 4, Interesting
I think you are confusing breeding with cloning. In breeding, two cats give half of their genes to combine into one set of genes. It would then make sense to say one gene is active and the other gene counterpart is inactive. In cloning, the genes come from the same donor so it is not possible for the clone to have an active gene while the original have not.
The reason why the cats have different fur patterns is the same reason why identical twins do not have identical fingerprints even though they have identical DNA. Don't believe me? Check your twin friends' DNA and compare their fingerprints. The DNA only provides the general blueprint, the cell has some leeway on the implementation... much like our manufacturing industries.:-)
Re:Look at the photo!
by
goodmanj
·
· Score: 5, Interesting
A quibble regarding the excellent post above: The poster says "The other X chromosome is completely inactive", but actually, the deactivated X chromosome reactivates in the ovaries, so that the eggs all end up with functioning X chromosomes.
The really interesting thing about this is that while Cc is genetically a calico, she looks exactly like a white-patched gray tabby. In all probability, she is the only calico cat on the planet with no orange spots.
Even more interesting, she is probably the only gray cat on the planet who can mate with a gray or black male and give birth to orange kittens!
For a "perfectly normal" cat, Cc is actually a pretty strange critter.
Slashdot Mirror
The coats are different colors. How is this possible?
I know when they cloaned dolly, the clone experienced premature aging. The theory is that when each cell divides it stores the information about the division internally. After so many divides the cells began to not regenerate as much and this causes aging. Perhaps something similiar happened and caused the hairs to not display in full colors due to false information stored from the other cat that was implanted in the egg cell of the clone.
Anyway this is a mystery and alot more research is needed on this.
http://saveie6.com/
Its been established that nature plays a lesser role than nurture in the personality of a human.. obviously, the same must apply to animals as well..
No matter even if you clone an Einstein, they're not going to pop out spouting theorems, it just doesnt work that way.. from a purely research oriented perspective, though, it might be interesting to have an Einstein clone, simply to see how he may use his innate talents along ANOTHER field of science (or maybe not even a science, he might have been a GREAT musician, for all we know)..
For any person, most things we do are not innate but rather taught.. Would Mozart have started composing from the age of 4 if he hadnt had parents who encouraged him ? I doubt it.. With a clone, the only thing you CAN get is the potential to achieve the same things as the "original" (I hate using that term, but whatever)..
So, finally, in typical Slashdot-style, let me ask.. Is this really news ? (yeah, it is, it probably helped correct a lot of peoples misconceptions about the cloning process, which is GREAT, but it should have been obvious from the start)
I am genetically identical today to how I was yesterday, but I expect I'll do loads of different stuff.
people apparently left out the "nurture" part of the equation entirely.
It seems to me an incredible stretch that people actually believed their pet's behavior/personality was hard-coded in the DNA.... but maybe that's just my studied-the-hard-sciences-all-my-life bias.
Behaviors are very complex things... both genetic tendency and environmental interaction play important roles. Even in psychiatric disorders that have strong genetic links (schizophrenia, bipolar disorder) having both parents (or an identical twin) afflicted will only buy the child or sibling a 50-60% chance (give or take 10%) of developing the disorder.
Yes, genes are the building blocks of our bodies... but you have to give nurture its chance at bat.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
Of course there will always be infertile couple who will want use this method to have babies, someday maybe, but otherwise we don't really need cloning to duplicate life forms. We already have a method. Its called sex. And while some arguments can be made for cloning endangered or extinct animals, until we could make a clone that was capable of reproduction, would there really be anything besides a novelty interest in this? I mean sure, yay, you've got a zoo with a thousand pandas. Unfortunately they'll all be dead in x number of years, and you'll have to clone a thousand more. Rather pointless.
The true purpose of cloning is, and should remain, complete and utter mastery of genetics and medical science. This is why the whole stem cell thing is so important, and should not be constarined in the way it is (For those who object to it on moral grounds saying it encourages abortions, it doesn't. The abortion doctor who made sales pitches like that to pregant women would be shot on principle.)
Stem Cell research and the race to human cloning are, objectively, two leaves on the same branch. Both should be refined and mastered to the point where the dream of human immortality is no longer a dream. This should be all about pushing genetics and microbiology to their absolute limits, not trying to make a Bob mark II or Fluffy 3.0 . Cloning a human just for the hell of it though, or trying to bring back to life a dead child or loved one or pet out of hopes for a "replacement" is irresponsible both scientifically, and morally.
So what would be "legitimate" applications of these technologies. Obviously, and one that was a main topic of debate during the stem cell controversy in congress, was the cloning of indivual organs, like hearts and livers. This way, instead of someone having to wait for months or years for a vital heart or liver transplant, a compatible one could be made up on the spot. And, since research into these fields will also yield advances in fields like neurological medicine, the possibility of new arms or legs, or even new eyes or audial organs becomes a possibility.
However, I do disprove of the notion that some people seem to think that we'll be planting out minds into "blank slate" bodies, sometime in the distant future. Thats not just ultra-late term abortion, thats essentially murder, unless something was done to the brain to keep it only restricted to base biological functions, and not the development of a psyche, and even that would be just weird.
And, for the record, I am pro-life, so no flames from pro-lifers on the stem cell stuff like last time.
Mod Points: Helping you keep your opinion to yourself.
Depends what you mean by raising the dead. If you mean "oh, make a clone of John, educate it, let it grow up to John's age, and you have John again", then obviously that's never going to work, and there was never really any doubt about that. Unless you can reproduce the exact environment of John's life, down to the quark configuration of the entire universe (every little bit can alter events), it's impossible to get John again through that method.
However, another much better method is this: Make a clone of John, keep its brain blank as you grow it (maybe in an accelerated fashion) to John's size, and then transfer John's thoughts to that clone. Of course that requires very advanced brain knowledge to "read" and "write" a brain - assuming that's even possible.
But that would give you immortality (so long as you keep your brain safe).
Daniel
Carpe Diem
Actually, the reason that these coats don't look entirely alike is probably entirely genetic. Although, you're correct, it's not predictable or controllable. When a female cat is conceived, it begins to grow, duplicating its cells. Each of these cells, however, has two copies of the x-chromosome. Only one of these is useful. So, in a random pattern, the cells will switch off one of the chromosomes by forming Barr bodies that surround it. It's a well understood process called Lyonization for anybody interested in looking into it. However, this only happens for females. One might then ask whether a male cat's clone would look identical. My guess is again that it would not, although Lyonization would not be an adequate explanation. However, I believe that they would look much more similar than any two cloned calico cats (which are all female and whose coats are formed by this mechanism).
I think you are confusing breeding with cloning. In breeding, two cats give half of their genes to combine into one set of genes. It would then make sense to say one gene is active and the other gene counterpart is inactive. In cloning, the genes come from the same donor so it is not possible for the clone to have an active gene while the original have not.
:-)
The reason why the cats have different fur patterns is the same reason why identical twins do not have identical fingerprints even though they have identical DNA. Don't believe me? Check your twin friends' DNA and compare their fingerprints. The DNA only provides the general blueprint, the cell has some leeway on the implementation... much like our manufacturing industries.
The really interesting thing about this is that while Cc is genetically a calico, she looks exactly like a white-patched gray tabby. In all probability, she is the only calico cat on the planet with no orange spots.
Even more interesting, she is probably the only gray cat on the planet who can mate with a gray or black male and give birth to orange kittens!
For a "perfectly normal" cat, Cc is actually a pretty strange critter.