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Distributed Computing Attacking SARS
fwc writes "D2OL has added a SARS Target to it's distributed computing project which locates potential drug candidates for several viruses. At this point, I've replaced SETI@Home at least temporarily on all of my Boxen. There are clients available for Linux, Solaris, Mac OS X, and of course Windows."
Unfortunately, finding a target binding site for a potential drug is years away from actually having a useful cure...
Except that seti@home does not analyse signals in real time, they've got a huge evergrowing database of signals recieved and we're analyzing that... we aren't going to miss a signal, we're just going to find it few hours later.
AFAIK.
Actually, the way SETI works allows for any workload over an extended period of time. The samples that your computer is analysing have been around for quite some time; they are transmitted from regions that are light years away! In addition, it is only once every year or so that they have a real chance to look for anything interesting that they find. As far as a cure for SARS goes, I have an elderly grandmother who was rushed to the hospital for unrelated reasons shortly after the start of the SARS scare in Ontario. She was taken into an ambulance by men and women wearing full environmental suits. She has since been released, quite possibly too early (they still don't know what was wrong with her), so I'm anxious for the world to just deal with SARS. This is a prime example of the Fear Consumption Model brought to us by Marilyn Manson and Michael Moore. The more we fear, the more we consume. As a whole our society has seen millions of dollars spent on research on a disease that has only killed 295 people out of over six billion. When diseases were feared in the past it was worth fearing them: Justinian's Plague (541-544AD) killed 40% of the population of Constantinople; In the 14th Century we saw as many as 800 people a day dying of the Bubonic Plague -- 30% of Normandy's population was decimated. By comparison, SARS has managed to destroy less than 0.0000005% of the world's population, infecting a mere 0.000077% of the population.
In order to be immortal you must be organize
There won't be any Nobel prize to win in this case. There nothing innovative about trying to find a binding target for a potential drug on the nucleic acid or one of the preoteins of a virus. It would be like rewarding "brute force" as an intelligent way of breaking code. But frankly, I don't care if we get rid of this thing intelligently or not!
Download the SARS genetic sequence here.
I've heard you can run it under wine but can't be bothered messing with it.
At risk of sounding ignorant, isn't smallpox well and truly beaten? (Apart from the lab samples?)
I saw a report yesterday, either BBC or CNN, that WHO now believes the fatality rate of SARS will be about 10-15%. Much higher than previously believed (this was after China went public with their info)
Je ne parle pas francais.
The fact that it is New is exactly why it is so dangerous. The population has almost Zero natural immunity to it. This can cause massive propagation of the virus and when it spreads through under-developed regions of the planet, it will be a plague.
If we don't throw everything we can at it now, millions of people will die. It's just that simple.
The illness has of yet been isolated to a few regions with moderately decent health care systems in place. Imagine a small town of 200 people infected with this disease. Weeks of lost productivity will not only cause immediate harm to those infected but the means of that town will loose the ability to support itself. Can you say famine?
Personally I understand that new bugs come on the scene on a (on a big picture scale) frequent basis, and its natures way of population control and generating a healthier species. But if it were my daughter in a hospital bed, coughing and vomiting, I would want to know that I did everything possible to help, even if it were just a few idle clock cycles.
--
Make up your mind. Never mind, I'll do it. The SARS virus is a coronavirus, a family that includes infectious bronchitis. Colds are typically caused by paramyxoviridae, which includes things like mumps, measles and pneumoviruses.
World Health Organization issued a travel advisory
(another article
on Yahoo.)
To be honest with you, I have not taken the TTC (subways or buses) for a long time now so I do not know if there are many people wearing masks there, but on the streets I have only seen two people in the last month actually wearing surgical masks. On the radio (CFRB 1010) there was a discussion of a baseball game from where shots were broadcasted widely displaying a person wearing a mask, with headlines like "In Toronto, Fear Strikes Out ". The host from the radio was on that game and he only saw one (1) person wearing a mask out of thousands of people there. The camera-man concentrated his attention on that person.
Have you seen the shots from Baghdad, where supposedly thousands of Iraqi people were cheering while the US Marines took down Saddams statue? Later in the news they actually showed wide shots of that scene, and it became clear there were only a handfull of people in the area.
This is the same tactics used by the news crews for the single purpose of maintaining attention of millions of people on something that is not that newsworthy but something that can be blown out of the proportions and something that will boost news channels' ratings.
I live in Toronto and I swear to you there is no uncontrolably spread disease here, the offices are not closing, the restaurants and hotels are not closing business is as usual, people are not staying home out of fear but there are a few thousand people on quarantine, most of which will never show any symptoms.
Since last week there was no new cases of SARS in Toronto and the only deaths that occured (19 I think) can be attributed to SARS striking on the older people with some other health problems.
The only thing that WHO achieved was creating massive desinformation and boosting cnn and bbc audiences for the past month and costing Toronto travel industry hundreds of millions of dollars in damage. Really, last year, about 2000 people died in Toronto from flue, but we did not hear about this on cnn.
There are over 5000000 people in Toronto area and there are about 200 people that have SARS, that is 1/50000 of 1 percent. 19 of the sick people died. So far this means about 10% mortality rate for a disease that is statistically so rare, that anyone will have better chances of been killed by a lightning bolt than getting it. Hell, there are more chances of been violently murdered somewhere in Texas than getting SARS in Toronto. Maybe WHO should post a travel advisory about that.
You can't handle the truth.
What benighted fool came up with "Severe Acute Respiratory Syndrome"? Severe and acute mean the same thing.
Not in that context. In the medical community, when a disease is categorized as 'acute' it means the disease has a rapid onset and becomes a problem quickly, as opposed to a 'chronic' disease, which implies a long duration.
Mod down people who tell people how to mod in their sigs
Ebola usually requires some kind of bodily fluid/tissues swap with an infected person.
There's also a reason why "hemorrhagic fever" bugs like Ebola tend to burn themselves out... they are extraordinarily lethal, and quickly kill their host; Ebola has a 90% mortality (compared to 6-12% for SARS). When a virus is too hard on its host, it lessens the opportunity to spread itself.
AIDS is a good example of a successful high-mortality bug... but you can stay alive and asymptomatic for so very long, that spread is virtually assured if you are uncautious.
SARS looks so much like the common cold, that even experienced clinicians have difficulty differentiating it from other bugs. That is, of course, until it's too late. SARS could be a real problem... significant mortality rate, easy to spread, poorly understood, and, like West Nile, NO treatment (well, some advocate treating West Nile with interferons... but the side effects of those drugs are terribly unpleasant; the treatment is almost worse than the disease).
It's nice that they're taking this thing seriously; any money spent on containment is probably well-spent indeed. If they can determine that this bug has no animal reservoir, it could even be eradicated. Till then, public panic serves no one, but public caution is NOT a bad thing.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
No, it`s not.
Acute= Having a rapid onset and following a short but severe course: acute disease.
Afflicted by a disease exhibiting a rapid onset followed by a short, severe course: acute patients.
Severe=Causing great discomfort, damage, or distress: a severe pain; a severe storm.
Very dangerous or harmful; grave or grievous: severe mental illness.
sorry but you are not even pedantic.
(This is from http://www.reenhead.com/comments.php?93238396 )
"It is not clear yet whether the SARS virus will be similar to corona virus in these respects, but it is highly likely.
So, the top 5 reasons SARS is here with us forever.
1. The corona virus envelope lacks immunogenicity. On average you get sick with corona virus every 2-4 years, but there are only two types of virus, hence 80% of infections represent re-infections with a type you have already fought off. So, the immune response to corona virus is not permanent like those for chicken-pox or measles (which are only near permanent, you can get reactivations and the vaccines wear off over a decade or so).
2. It is a cold, colds spread via small particles of aerosolized spit or mucus from sneezing, coughing, breathing etc. The spread is unlikely to be contained considering this.
3. It also represents a fusion with some kind of animal virus, making an animal reservoir highly likely, although so far it only appears to infect humans.
4. A vaccine could conceivably be developed, but because the coronavirus is typically resistant to normal immune responses illicited by the viral envelope or whatever your body targets, it is likely we will have to use a much more experimental type of vaccine. Such as plasmid vaccines which express a chosen protein from the virus, or a vaccine that infuses a particularly wierd epitope of the virus that is not mutable, and your body doesn't ordinarily recognize.
5. Finally, it is unlikely we will resolve this anytime soon because our government, and the government of China have not taken this seriously. The CDC took it seriously, and I'm sure in a decade we'll here about how they fought the administration for more attention, money, manpower etc., but it was denied just like with HIV. The second this was detected we should have taken far more drastic measures. Now the fatality rate approaches 10%, and the virus even kills young healthy people.
So, we're screwed. Just sit back and wait for the people to start dropping like flies.
Dr. Strangelove 04/25/03 05:56pm"
The point about SARS is not how many people it has killed relative to something like your example of murders in Texas. Murders in Texas are not particularly contagious.
The purpose of WHO's advisories is to limit the spread of a contagious disease. It's not really targeted at individuals to tell them that they may be in danger if they go to Toronto - the point is to stop the spread of the disease. However, the disease is ultimately spread by individuals, and to stop it spreading, you ultimately need to prevent individuals from acting as vectors for the disease. That means issuing advisories telling them not to travel to certain regions, and it means quarantining people who may be infected, even though you know that most of them are not.
Unfortunately, individuals aren't very good at recognizing and respecting risks to a global population, and they tend to want to personalize it - which leads to the faulty logic that since the SARS risk to an individual travelling to Toronto is low, it is therefore OK to travel to Toronto.
This is a little like saying that since my personal taxes are small relative to my country's total tax revenues, that I don't need to pay them. The point is that disease containment, like taxes, only works if everyone complies.
BTW, the truth about Toronto specifically, as I understand it, is that its quarantine practices originally weren't up to scratch, and it allowed e.g. exposed health care workers to wander freely amongst the population - attending church, for example. It's at least partially these lapses in containment procedure that have led Toronto to have one of the largest SARS-infected populations on the planet, which is why it was slapped with a WHO warning. The warning is the result of Toronto's health care system and government not originally taking the problem seriously enough.
It's hard to say for sure, but SARS simply doesn't seem that deadly. With worse hygiene and containment certainly far more people would be infected, but it's unlikely such a huge percentage of them would die. Currently fatality rates are in the 2-4% range. Even if that'd double to 4-8% without modern medical care, that's still not near 40%
The Spanish Flu of 1918-1919 had a mortality rate of about 4% which is similar to what we're seeing with SARS. It infected a fifth of the world's population. The U.S. was one of the countries least devastated by the pandemic. But even here 20,000,000 Americans came down with the flu, with 850,000 deaths resulting. Which means that flu killed more Americans than died in all the wars of the twentieth century.
Like SARS, this one originated in China as well. It started as a virus passed from birds to pigs. (They know because in 1997 someone exhumed the body of a soldier who died of it in 1918 and sequenced some of the virus from his lungs.)
Check out http://folding.stanford.edu/. They aren't researching SARS, but other, IMHO more important problems such as Altzheimer's, BSE (mad cow disease) and general protein research. Also, since it's run by a university, their data is public domain (although they'll probably take credit for your CPU cycles ;) ). Go fold!
Mod me down, and I will become more powerful than you can possibly imagine!
i wget'd it to a sf account before downloading from there, so there's an unofficial mirror at http://sealsystem.sf.net/bgp/ until i get around to deleting it.