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Chimps Belong in Human Genus?

Bradley Chapman writes "I found this interesting story from Discovery News about our ties with chimpanzees. Excerpts: 'Chimpanzees share 99.4 percent of functionally important DNA with humans and belong in our genus, Homo, according to a recent genetic study. Scientists analyzed 97 human genes, along with comparable sequences from chimps, gorillas, orangutans and Old World monkeys (a group that includes baboons and macaques). The researchers then took the DNA data and estimated genetic evolution over time. They determined that humans and chimps shared a common ancestor between 4 and 7 million years ago. That ancestor diverged from gorillas 6 to 7 million years ago.'" Genus is the next step up from species, if you recall your taxonomy. Humans are the only living species in genus homo, currently.

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  1. Bogus by inertia187 · · Score: 5, Insightful

    Chimpanzees share 99.4 percent of functionally important DNA with humans and belong in our genus, Homo, according to a recent genetic study. Scientists analyzed 97 human genes, along with comparable sequences from chimps, gorillas, orangutans and Old World monkeys (a group that includes baboons and macaques).

    We've only fully mapped the human genome so far. I bet if we fully mapped the chimp genome, we'd see many many more entries in the diff log than we thought.

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    1. Re:Bogus by John+Hurliman · · Score: 5, Informative

      "The human genome is estimated to have as few as 30-45,000 functional genes" - Imperial College London (http://www.ic.ac.uk/P3509.htm)

      Where did you get your "couple quadzillion" number from?

    2. Re:Bogus by BigBadBri · · Score: 5, Informative
      The New Scientist has a slightly more detailed account of the study here.

      If you read this, you'll see that the analysis is based on 97 'critical' genes where a difference in a single base will produce a change in the amino acid coded for, and hence a change in the protein.

      If the 'junk' DNA is included, there is more likelihood of variation between humans and chimps, but there is a corresponding rise in the variability within the human population which tends to lessen the overall significance of the inter-species variation.

      Other than the fact that evolution would tend to favour the stability of these 97 'critical' genes, I see no problem with this analysis, but think that putting humans and chimps in the same genus is pushing matters slightly.

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    3. Re:Bogus by Michael+Woodhams · · Score: 5, Insightful

      According to my handy textbook*, orangutangs are about twice as diverged from us as chimpanzies. The numbers** here are the number of nucleotide substitutions per 100 sites (i.e. approximately % difference.)

      Human-Chimp: 1.45
      Human-Gorila: 1.51
      Human-Orangutang: 2.98
      Gorilla-Chimp: 1.57

      Standard errors on these numbers are about 0.2, so the human/chimp/gorilla differences are not statistically significant. The evidence is growing that the human/chimp split is more recent than the gorilla split, but as far as I know this hasn't yet been determined beyond reasonable doubt.

      The numbers in the article are only looking at DNA nucliotides in genes, which change much more slowly then the bulk of DNA which is 'junk'. This is because inside a gene, most mutations will be disadvantageous and selected against. The numbers I give above are from non-coding DNA.

      Note that even within genes, not all nucleotide substitutions have any evolutionary effect. There are 4 nucleotides (think letters) which come in groups of 3 (codons, think words) giving 64 possible codons to code for 20 amino acids (plus a little punctuation) so most amino acids have several codons that code for them. Therefore even inside a gene, some nucleotide substitutions will be 'synonymous' - they will not change the protien generated from the gene.

      For the purpose of saying "How different (functionally) are we from chimpanzees", it makes most sense to look at how different the proteins are - non-coding DNA and synonymous changes within coding DNA have no effect on phenotype (the critter that the DNA builds.)

      For the purpose of timing evolutionary branchings, it makes most sense to look at non-coding DNA and synonymous substitutions. This is because the rate at which substitutions/mutations occur at these sites is much less variable than at coding sites. At coding sites, the rate is constrained by evolutionary pressures, and those pressures may not be the same on different lineages.

      Anyway, the story looks like a big yawn to me - this isn't anything we haven't known about for years. There's probably lots of interesting stuff in the details, but not the '99.4%' number. Saying this means were in the same genus is pure sensationalism - the concept of genus is more fuzzy than species, and is fairly arbitrary. There is a fair argument that homo and pan are separate genii(?) only because of parochialism, but this data is not a strong reason to change it.

      * I'm studying up for my new job in molecular phylogentics. It will be something of a challenge, given that my degrees are in physics and astronomy.

      ** Book is Molecular Evolution, Li, 1997. Data is from Li et al 1987.

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  2. IM all for including some chimps in the human cat. by Unknown+Poltroon · · Score: 5, Funny

    But that on the condition that i can downgrade some humans to monkey.

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  3. We share many things in common with chimpanzees by diatonic · · Score: 5, Funny

    Goodman added, "In terms of culture, social behavior, language and other factors, we share many things in common with chimpanzees."

    There was a guy at a nursing home I worked at that would throw poop at the staff.

  4. Classification System Stinks by Superfreaker · · Score: 5, Insightful

    Well, it may not be completely stinky, but it is close.

    Our current system for categorizing the inhabitants of this is long outdated and is based largely on phsycal characteristics of the components on the creature, rather than the stuff it is actually made up of.

    We find we've had to tweak this existing system to make new species fit. We've even had to add new kindoms! Many species bridge, these categories making them all the more harder to classify.

    A better, more accurate, system needs to be devised based on current technologies that classify based on genetic code. The point of a classification system would be to allow us to draw similarities in creatures while studying them based on available data for ones in the same category. A genetic model would be very beneficial for this very reason.

    IMHO.

    1. Re:Classification System Stinks by pyrosoft · · Score: 5, Informative

      Google for phylogeny, or just check out this page for a relatively good introduction. Comparative geneticists use sequence comparisons between species to determine relative evolutionary separation, much like the subject of the article. We haven't gotten rid of the kingdom-phylum-order-class-family-genus-species thing yet, but we're working on it.

      --
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  5. Genetic similarity isn't everything... by valis · · Score: 5, Informative

    For what it is worth, the raw similarity in the genome sequence doesn't need to indicate the same degree of similarity. Transcription is quite complex (much of it we still don't understand) and it is possible that small differences in regulatory regions can cause completely different parts of the sequence to be expressed.

  6. Can't resist by daves · · Score: 5, Funny

    Humans are the only living species in genus homo, currently.

    If we are the only species, that would make us "homo genus".

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  7. Chimps are slackers by doublem · · Score: 5, Funny

    Why not put them in the same Genus as us? They've had just as much time to evolve.

    Clearly, we made better use of that time than they did. They slacked off instead of evolving, so they don't get to be in the same rank.

    I don't get this desire to uplift losers with false titles designed to boost the self esteem of those who fell behind.

    Of course now with Hollywood and TV causing humans to devolve, the Chimps will have a chance to catch up.

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  8. Canis lupus latrans by Kafir · · Score: 5, Informative

    Wolves are not genetically identical to dogs, any more than beagles are genetically identical to rotweilers: the consistent phenotypic differences between dog breeds, and between dogs and wolves, are genetically determined.
    If being genetically identical were the key, each human (or pair of twins) would be a species unto himself.

    But what people mean by species is usually more determined by whether the animals interbreed and produce fertile offspring (this gets fuzzy with plants and is more or less irrelevant to bacteria, but still...).

    Dogs and wolves are close enough to interbreed, successfully and often, and a lot of people would class dogs as a subspecies of wolf (Canis lupus latrans).

    But classification by genus and higher levels is fairly arbitrary, based mostly on what people see as significant differences and similarities (e.g. people are different from apes, cats all kind of look alike). The only important thing is that the basic nesting is right, so that if species A and B have a common ancestor, and C and D are descended from B, then if A and C are in one class, B and D are also in that class.

    It might be more rational to have a system that took each branching into account, but we don't have enough information for that, and it would be inconvenient to deal with.

    To sum up: the argument that no one calls a wolf a dog is incorrect, but there's still no point in calling a chimp a Homo.

  9. Re:Bogus... NOT! by Anonymous Coward · · Score: 5, Informative
    The gemone centers are working on chimp and many other species right now. Chimp will be done soon but only taken to the "draft" stage. You can see the data accumulate at the trace archive at the NIH.

    So far

    total human reads: 23 million

    total chimp reads (Pan troglodytes): over 12 million

    having worked on annotation of a few of the chimp BAC clones, I can assure you the two species range from about 97% to over 99.9% similar at the DNA sequence level.

  10. The Chimps' Spokesman says 'No, thank you!" by budalite · · Score: 5, Funny

    And in other news, the Chimpanzee World Spokesman, uu uu waaa uuu u, says they want no part of any "tree" that has humans in it, thank you very much, and, besides, it's against THEIR religion to believe that humans evolved from Chimps. Especially the ones with fake hair.

  11. Amazingly enough... by CptChipJew · · Score: 5, Funny

    Scientists then discovered that Apes have a 100% DNA match with Vin Diesel.

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