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Have Humans Come Close To Extinction?

waytoomuchcoffee writes "According to a new study, our virtually identical DNA indicates humans were close to extinction about 70,000 years ago. Another take on the same study tells how being lactose intolerant in adulthood was normal, and being able to digest lactose became a survival advantage after dairy farming was invented."

64 of 206 comments (clear)

  1. Diversity in a small group by Inexile2002 · · Score: 3, Interesting
    Unlike our close genetic relatives - chimps - all humans have virtually identical DNA. In fact, one group of chimps can have more genetic diversity than all of the six billion humans alive today.
    Something about that struck me. If the natural state of affairs is for a wide genetic diversity even in a small group - such as the chimps, then why wasn't there a similar diversity in the 2000 people who went on to sire the rest of us.

    Think about it. A chimp troop can consist of up to 60-70 chimps for a big troop. Assume all but around 30 troops are killed off leaving around 2000 chimps. If a single troop of those chimps could have more genetic diversity than all of humanity - ie. more than the 2000 people who sired us then 2000 chimps would have around 30 times more diversity. (Or more than that depending on how much more diversity in a chimp troop than there is in humanity.)

    So, either humanity dwindled down by chance to 2000 people who happened to have little genetic diversity, or there was some common genetic trait that selected for those specific people. Or something. But then who knows... maybe chimps are just naturally genetically diverse and we're not... or maybe I just missed something that the writer thought was too technical for the article.

    Still, the numbers bothered me.
    1. Re:Diversity in a small group by Anonymous Coward · · Score: 2, Insightful

      > So, either humanity dwindled down by chance to
      > 2000 people who happened to have little genetic
      > diversity, or there was some common genetic
      > trait that selected for those specific people.
      > Or something. But then who knows... maybe
      > chimps are just naturally genetically diverse
      > and we're not... or maybe I just missed
      > something that the writer thought was too
      > technical for the article.

      Nah, there's no extra explanation needed .. its a well known phenomena, called the 'founder effect' - and the reason why those chimps in that troop are as genetically diverse as they are is because of gene shuffle between groups.

      Think about it; if you are isolated, alone and there is no one else around, the diversity is naturally going to suffer - interbreeding will see to that. However, chimps haven't gone through the same genetic pruning because groups/tribes mate with each other.

    2. Re:Diversity in a small group by zaad · · Score: 5, Insightful

      Something about that struck me. If the natural state of affairs is for a wide genetic diversity even in a small group - such as the chimps, then why wasn't there a similar diversity in the 2000 people who went on to sire the rest of us.

      IANAG(eneticist), but I would say that this is most likely due to a concept known as founder's effect in population genetics. There looks like there's an interesting page curtesy of googlecache.

      Think of it in these terms. Whatever your genetic diversity happens to be, if you reduce a population from two million down for two thousand, you're going to lose a lot of diversity. Further, especially that population reduction was due to some selection pressure (may immunity to some disease), you're going to target a very select subset of the population (known as hard selection). So what happens is that you end up with much less genetic diversity than you would have otherwise (diversity takes time to build up).

      In the case of the chimps, if they've not gone through a recent "extinction" scare, and have had a long, long time for their genome to diverge and mutate, even if you just sample a small group of 60 or so chimps, they're going to exhibit much more diversity simply because they've had so much more time for their genome to wander or drift.

      Does that make more sense?

    3. Re:Diversity in a small group by AllenChristopher · · Score: 2, Interesting
      And moreover, when that little group discovers something like the hatchet, they suddenly outcompete everything that eats the same food as them, but isn't in the tribe and isn't told the secret. Time and again, one tribe wipes out all the tribes nearby with a new weapon or other new technology, thinning the gene pool.

      In the 1300s, there certainly weren't a billion people of European descent. There were more like 50 million. That's barely thirty generations ago. This sort of thing happened in pre-history as well.

    4. Re:Diversity in a small group by aug24 · · Score: 2, Interesting
      What you are missing, I think, is that diversity reduces in small total populations.

      Chimps, can and do change troops, interbreed with other troops, exist as lone males, etc. If they were reduced to 2000 or so then they would not maintain their current level of genetic diversity as, for example, fewer males would have the opportunity of siring offspring.

      Hence it is not a like-for-like comparison. You are comparing pre-small-pool chimps with post-small-pool humans. Although given the state of the world's primates, it won't be long before you can make the comparison fairly :(

      J.

      --
      You're only jealous cos the little penguins are talking to me.
    5. Re:Diversity in a small group by EvilTwinSkippy · · Score: 2, Interesting
      Just look in the Bible. (I'm a secularist myself, but the old testimate is an entertaining folk tale.) How many Son's did Abraham have? You have Lot who had a lot of kids by his daughters. I mean incest, polygamy on a mass scale, all the makings of a really shallow gene pool.

      Then you have Kings from other cultures who would spread their seed wide and far. You see the same behavior in rock stars and sports figures today. How many kids did Jim Morrison sire? How about Wilt Chamberlin? Hell even Ben Franklin got around. In every cult what happens? The cult leader fucks all the groupies.

      Women are drawn to success. Men are drawn to breed with healthy women. In less enlightened times someone Enronized our Gene pool by being really successful and not being dumb enough to die young before they spread.

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
    6. Re:Diversity in a small group by Muad'Dave · · Score: 2, Interesting

      Unlike our close genetic relatives - chimps - all humans have virtually identical DNA. In fact, one group of chimps can have more genetic diversity than all of the six billion humans alive today.

      Why doesn't such impressive genetic diversity in the chimp world translate to more obvious facial/structural diversity as is seen in the wildly differing appearances of humans?

      To put it another way, if they're so genetically diverse, why do they all look alike? I'm sure Jane Goodall, et al, can tell different troops and individuals apart, but I sure can't. Perhaps chimps think we all look the same, huh?

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
    7. Re:Diversity in a small group by jstott · · Score: 2, Insightful
      Something about that struck me. If the natural state of affairs is for a wide genetic diversity even in a small group - such as the chimps, then why wasn't there a similar diversity in the 2000 people who went on to sire the rest of us.

      You need diversity to preserve the diversity. If you have a small population and they start inter-breeding, you'll wipe out most of your diversity in fairly short order because, before long, everyone will have the same common set of ancestors (and thus, a relative lack of genetic diversity). In short, past history is everything in genetics.

      --
      Vanity of vanities, all is vanity...
  2. What a liability for humans! by 1nv4d3r · · Score: 4, Funny

    So do your part to ensure diversity, and make sweet love with someone genetically different (read: hot) under some power lines near a microwave running with the door open. "For the sake of the species" never made a better pick-up line.

    (Just don't give her your name--she might expect you to help raise your special freak).

    1. Re:What a liability for humans! by yarbo · · Score: 2, Interesting

      sounds like the setup for Geek Love. A circus family that intentionally tried to produce freaks for their show. It was an excellent book.

  3. Additional Comments on reflection by Inexile2002 · · Score: 4, Interesting

    Thinking about that, I didn't make myself clear on something. What I was trying to say was that if a single troop of 60 to 70 chimps can have X diversity, shouldn't a group of 60 to 70 humans - a close relative of the chimp - also have X diversity. What struck me about the article is that their implication is that those 2000 people they say sired us had less diversity than 60 to 70 chimps.

    Makes you wonder if it has something to do with human females being fertile year round. If I recall, chimp females are not. Because chimps can only mate at certain times, there is less oppurtunity for one male to sire all the children in a troop. In a human harem type social group, this could be easily accomplished which would cut down the genetic diversity considerably. Do this for a couple of generations and you might end up with a population with a depressed gene pool. Anyway, just arm chair theorizing off the top of my head. (Gotta use that anth degree for something.)

    1. Re:Additional Comments on reflection by zenyu · · Score: 3, Interesting

      Makes you wonder if it has something to do with human females being fertile year round. If I recall, chimp females are not. Because chimps can only mate at certain times, there is less oppurtunity for one male to sire all the children in a troop.

      I think the article isn't specific enough to judge whether sexual practices have anything to do with it. Pygmy Chimps (Bonobos) always look like they are in heat and like humans who never look like they are fertive have sex with anything that moves. But most chimps have a stratified society where only one male at a time has sex with all the females. The females do cheat on him, but I don't know how common those children are. Even the Amish have plenty of out of 'falsely fathered' children so I don't think humans should be less diverse due to sexual exclusivity.

      More likely there where several rounds of near human extinction and just the latest one was sometime in the last 100,000 years. We also have this nasty habit as a species to eat those that aren't 100% human...perhaps our competitors had similar tastes ;) (JK! -- no homo erectus, homo neanderthalis hate mail pls)

    2. Re:Additional Comments on reflection by Inexile2002 · · Score: 3, Insightful

      You're right of course, the article is too vague. It was really just musing onto the keyboard. I'm not advancing a theory or anything. There could be many explanations for the low genetic diversity including subsequent death of lineages, genetic advantages of a sub-group (the whole scikle cell anemia - malaria connection) etc. Also, there was some genetic bottlenecking, where an even smaller group populates most of the world and the remainder stays behind in Africa.

      I remember reading that if you took any world wide sample non-Africans - ANY sample no matter how diverse - and an equal number of randomly sampled Africans from the same villiage, you'd find more genetic diversity in the African villiage. The argument being that there was some genetic bottneck on the way out of Africa and only a tiny minority of the gene pool actually left.

      Oh, and if us Neaderthals were still cheesed about that whole cannibalism thing, we'd let you know. We're over it. We ate you guys too. It's all good.

    3. Re:Additional Comments on reflection by maxume · · Score: 3, Interesting
      One thing that might be a factor that you don't seem to have mentioned is that most chimps are probably under considerably higher environmental pressure than the average human. The genetic makeup of todays typical human doesn't really have all that much to do with the continuation of his genetic line. It seems like the increased pressure for selection in the chimps would cause them to evolve faster than humans do. I don't really mean evolve in the sense of becoming greater as a species, but in the sense of becoming better suited to a particular environment.

      If two sub groups of chimps each evolved under rather disparate conditions, and then crossbred, it would seem that their genetic diversity would increase. Considering that we as humans don't really evolve to any particlar environment anymore(we move around way to much), and we crossbreed pretty much constantly, perhaps the chimps are just doing a good job of playing survival of the fittest?

      --
      Nerd rage is the funniest rage.
    4. Re:Additional Comments on reflection by Madcapjack · · Score: 3, Insightful

      Since evolution is a two step process: first mutation, then selection, we wouldn't expect selection to increase diversity. mutation is responsible for increasing diversity. selection decreases diversity. diversity might be a selective advantageous property of populations, and in some cases there might evolve (by selection) functions that increase diversity. sexual reproduction is one such thing.

    5. Re:Additional Comments on reflection by Martin+Spamer · · Score: 2, Interesting

      Your first post was pretty clear and interesting question.

      A prolonged & extreme selective pressure is a cause of reduced diversity. An obvious candidate must be the last Ice-Age which also fits nicely into the time frame. This issue has recently been covered in a excellent BBC documentary series Walking with Cavemen, which also featured a figure of 2000 females in a significantly reduced human population. I suspect the last programme was based at least partly on this research.

      The programme suggested that until the Ice Age human 'tribes' where extended family size (~12) but survival in the Ice-Age was linked with a strong selective pressure for larger groups (~200). Socialisation allowed specialisation and increased expertise, this allowed food shortages to be more readily smoothed out. Socialisation and Specialisation both required elevated intelligence.

      A idea to consider is that the number of people could have been larger than the 2000 suggested but the genetic heritage of the extras doesn't survive today; consider the effect of evolutionary shock caused by the large group coming into contact with smaller groups, the larger would quickly swamp the genetics of the smaller group. The larger group would be more genetically diverse than the smaller group and more resistant as a group to any diseases pool.

      Also consider the negative impact on genetic diversity of plagues and pandemics, Influenza, Small Pox, Cholera, Black Death, many of these have surely sweep the world before recorded history leaving only immune populations, and reducing diversity.

    6. Re:Additional Comments on reflection by JanneM · · Score: 4, Insightful

      Well, there are other factors as well. Normally, that troop will outbreed quite a lot with other troops, which will keep it diverse and smother out much of the randomness.

      But if there are only on the order of hundreds of individuals available, small random effects will start to have an impact. Not every individual will reproduce equally effectively, even if they are genetically equally viable - due to accidents, and other random effects, you will tend to get an inverse power-law like distribution with small numbers oif individuals. So, in that troupe of 2k individuals, maybe twenty to fifty of them will in reality be the progenitors of the majority of the offspring - others will have caught a disease, or be infertile, or have their children all die early, or have a falling out with their partner or whatever.

      By the time the population is large enough that individual chance is smothered out, the individuals will in practice all stem from a small subpopulation of those that were available at that earlier time.

      --
      Trust the Computer. The Computer is your friend.
    7. Re:Additional Comments on reflection by kmilani2134 · · Score: 2, Interesting
      The interesting thing is that scientists have found that chimps (I believe what I saw was about the Bonobos) have two different types of sperm. Half the sperm actually serve the purpose of forming a sperm "wall" or barrier to keep other monkey's sperm from reaching the females egg.

      I guess it pays to be first.

      --
      Those who trade freedom for security will lose both, and deserve neither" -- Ben Franklin
  4. Close to Extinction? by Sunlighter · · Score: 4, Interesting

    Arguably, in spite of our numbers, we're close to extinction now.

    Hey, good to know we got out of it last time.

    --
    Sunlit World Scheme. Weird and different.
  5. More Info & complete paper by MonkeyBoyo · · Score: 5, Informative

    Here is the abstract from the The American Society of Human Genetics article, and here is Stanford's press release on the story.

    And are the web pages of Marcus W. Feldman and Noah Rosenberg From Rosenberg's research page, here is access to a PDF of the journal article.

  6. Re:Jesus Christ... by DustMagnet · · Score: 2, Informative
    I don't know why this story was news. I've known it since college.

    Anyway, farts is the problem, but indirectly. If you are lactose intolerant, you're body can't break down lactose, so you get few calories from it. The energy is wasted on fart generating bacteria.

    Hey, I never knew you could watch a post drop each time you hit preview!

    --
    'SBEMAIL!' is better than a goat!!
  7. advantages by larry+bagina · · Score: 5, Funny
    being able to digest lactose became a survival advantage after dairy farming was invented."

    But being lactose intolerant was an advantage once fart-lighting was invented.

    --
    Do you even lift?

    These aren't the 'roids you're looking for.

  8. Re:Jesus Christ... by BlackMagi · · Score: 2, Informative

    According to a new study, the old study was right!

    -BM

    --
    http://melbournephilosophy.com/
  9. Not clear by GCP · · Score: 4, Insightful

    The thing that should have bothered you is the utter ambiguity of such a claim. This is just one of those "newspaper statistics" that sound as though they mean something but don't.

    What is the diversity of all humans? Is it more than the diversity between the two most different humans? What is the means of quantifying difference? Is there some standard, or are there lots of standards, or are there just countless ways, each of which yields a different answer?

    What about the diversity in a group of chimps? Is that a family of chimps, or a small group randomly chosen from all chimps, such as one might find at some zoos?

    I'm just not sure how to interpret the comparison of diversity between a small group (of chimps) and a large group (all humans). Size of group wouldn't have been mentioned, presumably, if it weren't part of the equation. What part?

    Unless you know what it is they really mean, I'm not sure it makes much sense to go looking for deeper meaning.

    --
    "Those who have never entered upon scientific pursuits know not a tithe of the poetry by which they are surrounded."
    1. Re:Not clear by Inexile2002 · · Score: 3, Informative

      First off, tits and beer rock. Sports... I can take of leave.

      As for the parent comment, I studied anthropology in school and did a rather large term paper on genetic diversity. Not the topics in the articles exactly, but enough that I do know what I mean, and I think I know what they mean.

      As for the genetic diversity, usually, they mean exactly what the term would imply. The different genotypes that occur in a given sample. In humans, it doesn't mean the difference between the two most genetically different people. The problem with discussing the difference between the two most genetically different people is that it implies a range. That's not the case, there isn't some genetic continuum or between disparate people. There are other people who might not be as genetically different as the two extremes but possess novel genes that the two extremes lack, thus they contribute to the over all diversity.

      Your problem (other than being a contrariam who would rather criticize the discussion than contribute to it) is that you're used to thinking in terms of the quantifiable and the continua. There is a continual, quantifiable spectra of light for example, so you try to apply this thinking to other non-continuous phenomena.

      If geneticists needed to discuss gene diversity in some sort of quantifiable measure, it would eliminate their ability to discuss relevant topics. Unless you are referring to a specific sample of genes, you can't quantify the diversity. So you just call it diversity instead of lamenting the lack of a standardized "Gene-ino" quanta. Just because they haven't sampled every gene of every human doesn't mean they can't make statements about human genetic diversity.

      And another thing, it doesn't really matter which group of chimps they were talking about. The point stands even if it is only true for a single chimp troop out of all the chimp troops in the world. If somewhere out there there are 60 - 70 chimps with more diversity than all of humanity, then chimps possess more diversity, and a scientist will ask why.

  10. invention of dairy farming by alonsoac · · Score: 5, Funny

    being able to digest lactose became a survival advantage after dairy farming was invented.

    So at some point some humans said:

    "Hey lets invent dairy farming!"
    "Hmm, but we're all lactose intolerant..."
    "What the heck, if we take this crap every day we'll eventually mutate and some generations down they will be thanking us."

    Nice long-term thinking there, thanks!

  11. Even better prediction. by Stonent1 · · Score: 4, Funny

    Within the next 50 years, about half of us will be dead!

  12. Alternative Interpretation by Iainuki · · Score: 4, Insightful

    I'm not sure I buy the article's argument that "humans" came close to extinction. I think another possibility is that what they're looking at is a speciation event: that's the point that homo sapiens sapiens branched off from immediate predecessors. If that group had been killed, we wouldn't be here, but I'm not sure the homo genus would have died off.

    1. Re:Alternative Interpretation by Muhammar · · Score: 2, Funny

      The gene study only suggests that we all have common ancestors from a small group (perhaps only few thousand) which was pretty geneticaly homogennous and lived maybe 70 000 years ago.

      There are many possible scenarios: one possibility is that tribes originating from an isolated small group of individuals got lucky for some random reason, while the other prehistoric people did not make it to the current gene pool. But it does not necesserily follow that everybody other must have died at once, exactly around that time. Maybe the other prehistoric people were living happily along for millenia, just thinking that hunting with the handaxe is a good idea and did-not want to have anything to do with those imbred short-sighted teet-seeking inovators with narrow shoulders and concave rib-cage. But the lactose tolerancy incidentaly infered immunity against bad infection outbreak caused by canibalism, which in turn was a result of sudden unability to hunt because of the hand-axe repeated strain injury.

      --
      I doubt that we will ever figure out - and I suspect that even if we did figure out we couldn't do much about it
  13. Actually what they said was... by Inexile2002 · · Score: 4, Funny

    "I dare you to drink that."
    "No, I dare you."
    "Ok, we all dared, so we all drink."

    Then they all got sick except one who not only brained them with a club and sired children with thier wives... After that, he taught his sons how he got all the foxy wives and they went to neighboring villiages...

  14. Dogs by Beryllium+Sphere(tm) · · Score: 3, Interesting

    Robert K. Wayne of UCLA has estimated that we may have domesticated wolves as much as 100,000 years ago.

    What if it was 70,00 years ago? Did our partnership with dogs save our species?

    1. Re:Dogs by Scaba · · Score: 2, Funny

      I think it is, in fact, the wolves who domesticated us; well, domesticated our chimpanzee ancestors. Through careful breeding they were able to create an entirely new species which they called "Aaaaooooooooooooooo!!!!!" (which is also their name for everything else). But they quickly became bored with us, sniffed one another's asses, and then chased down a gazelle for an early supper.

  15. Lactose intolerace by Nice2Cats · · Score: 4, Informative
    The ability to digest milk after puberty is still only widespread in Caucasians and some parts of Africa, as I happen to know because I am one of the Caucasians who is not a mutant and had to give up my ice cream orgies with puberty (puberty did have its compensations). This is why lactase pills (which contain the emzyme required to break down the milk sugar lactose into glucose and (I believe) galactose) are selling like mad.

    The BBC had one of their unevitably brilliant documentations about the rise of mankind a few weeks again on German television where they pointed out that humanity must have been really, really close to the gutter before it exploded. Then this big, black rectangle came and showed them how to use the thigh bone of a pig to kill...oh, never mind...

    1. Re:Lactose intolerace by Martin+Spamer · · Score: 2, Insightful

      how being lactose intolerant in adulthood was normal, and being able to digest lactose became a survival advantage after dairy farming was invented.

      Preceding the domestication of cattle; for lactose intolerant to arrise, it must have offered some survival advantage.

    2. Re:Lactose intolerace by arkane1234 · · Score: 3, Funny

      I'm just trying to imagine how milk was harvested before the domestication of cattle...

      I'm picturing a mass army of hunters, with painted bodies to blend in to the environment, silently stalking the herd of cows. Suddenly, a violent explosion of activity occurs, and thousands of hunters bolt towards the herd with bucket in hand, tackling the slower cows and draining the milk from their teets.

      That, my friend, is Darwin in action =)

      --
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    3. Re:Lactose intolerace by eglamkowski · · Score: 2, Informative

      Milk is not very common or popular in China, and the government there has been making a big push to get the people drinking it for health reasons. But they also had to set up a special hotline to handle all the cases of lactose intolerant people drinking it for the first time. And that'd be most of them.

      http://www.fb.com/issues/analysis/China_Briefing_I ssue19.pdf

      I read the original Wall Street Journal article referenced, but don't have reg at wsj.com so can't link to it. It was quite interesting.

      --
      Government IS the problem.
  16. Noah's ark by DJ+Rubbie · · Score: 4, Interesting

    Could the biblical story of Noah's ark explain this, as a worldwide flood leaving only a single family of eight alive will achieve this effect of everyone having similar genes.

    Before you mod me down into oblivion for sounding like a self-righteous Creationist, do note that other cultures have references to a catastrophical flood (such as the Chinese, apparently the character for ship is that story).

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    1. Re:Noah's ark by MonkeyDluffy · · Score: 3, Interesting

      No.

      There is no evidence whatsoever that there was a worldwide flood - and a disaster of that magnitude would leave lots of evidence. And nobody told the Egyptians and Chinese about it - their civilizations were going strong before, during, and after when the flood supposedly occurred.

      Many cultures have flood stories, because towns are usually located near good water supplies such as lakes and rivers. Which flood on occasion.

      -MDL

      --
      Happy meals fund terrorism
    2. Re: Noah's ark by Black+Parrot · · Score: 4, Insightful


      > Could the biblical story of Noah's ark explain this, as a worldwide flood leaving only a single family of eight alive will achieve this effect of everyone having similar genes.

      No. As others have already pointed out, (a) the biblical flood supposedly happened 4000-5000 years ago, not 70,000 years ago, and (b) geology soundly refutes any and all claims of a global flood (this being realized by the parsons who invented geology, already by 1820), and (c) all animals would also have to have genetic bottlenecks at the same time (or more recent, due to other causes), and (d) there are a very large number of additional problems with the flood yarn, which we can go into if you wish.

      Of course, you could always sweep everything under the rug by claiming that God patched everything up with miracles afterward, to make it look like the flood never happened. But theology is no more capable of investigating such bizarre claims than science is.

      > Before you mod me down into oblivion for sounding like a self-righteous Creationist, do note that other cultures have references to a catastrophical flood

      And lots of cultures have references to multiple gods. Do you put the same weight on those traditions, or do you just pick the ones that you think supports your own position?

      > (such as the Chinese, apparently the character for ship is that story).

      I think that particular claim is that the character is the composition of the characters for "8" and "mouth". Extraordinarily weak evidence for a flood, even if the claim about the symbols is true. Basically someone has noticed that out of all the writing systems in the world they can find one symbol that has a very weak association with one story in their favorite mythology. This is nothing more than a posteriori data scumming.[*] Given the amount of data they have to work with, the only surprise is that they haven't found a better match with the target mythology.

      [*] I use the roguelike term "scumming", since the obvious "data mining" has a very different connotation.

      --
      Sheesh, evil *and* a jerk. -- Jade
    3. Re:Noah's ark by Bowling+Moses · · Score: 3, Informative

      "On a related note, mitochondrial DNA seems to indicate that our common mother (mitochondrial eve) existed ~6000 years ago, less than the 70,000 years proposed here."

      One nit to pick. Going back to the original "Research News" article in Science (vol 279 issue 5347 pg 28-29), we see that instead of this being evidence for a ~6000 year old mitochondrial eve, we have to reconsider some of our beliefs about mitochondrial DNA (mtDNA), or more specifically a region of mtDNA called the D-loop, which comprises only 7% of mtDNA and which most mtDNA studies have used. One of the biggies is that most mtDNA studies use "so-called "noncoding" sequences of the control region of mtDNA, which do not code for gene products and therefore are thought to be free from natural selection." to quote the article. Another is to check and see if we are instead hitting "hotspots," regions with above-average mutation rates; hotspots will have more back- and parallel-mutations which will cloud the picture. A third is that the mutation rate may vary over time. A fourth is to investigate the issue of heteroplasmy--having multiple mtDNA sequences, even though for a given region there should be only one. For a while it was thought to be rare, now 10-20% of the population could be heteroplasmic. All of these issues would need to be addressed by the creationists before it could be considered evidence of a ~6,000 year old mitochondrial eve rather than a problem with the underlying assumptions of the technique. Indeed, with the advancement of our ability to manipulate and sequence DNA, we no longer have to utilize only 7% of the mtDNA--we can sequence the whole thing--all 16,000 or so base pairs of it. A recent study published in Nature (vol 408 pg 708-713, Dec. 2000) using mtDNA--all of it--found that the D-loop (used in most mtDNA studies) does not have a constant mutation rate. The study goes on to show (again using the whole mtDNA sequence) that the date of "mitochondrial eve" is about 170,000 years ago. A more reader-friendly report by the author of the Nature paper can be found here.

    4. Re: Noah's ark by Black+Parrot · · Score: 3, Informative


      > On a related note, mitochondrial DNA seems to indicate that our common mother (mitochondrial eve) existed ~6000 years ago, less than the 70,000 years proposed here. It was originally thought that mitochondrial eve existed ~200-250,000 years ago. However, new research in 1997 (off memory) indicated that mutations in mtDNA occurred far more rapidly than assumed (assumptions were based on evolutionary expectations for mitochondrial eve). This resulted in the new date. Take note: I've had many evolutionists come back and quote the original article saying "See! It says 200,000 years, not the 6,000 creationists quote. Just another example of creationist lies". However, they failed to look at the top of the article which was dated (Again, off memory) 1996, a year before the new research was discovered. I thought I'd mention that to save potential embarrasment.

      Actually, the Loewe and Sherer letter cited by your favorite creationist Web site does not argue for a 6,000 year old mitochondiral eve; they merely mention in passing that that would be the untenable effect of basing a molecular clock on one specific mDNA site that has come under investigation. They spend the rest of their letter proposing ways of understanding the mutation rates that would naively yield the date that they themselves reject.

      If you search for "mitochondrial eve" at PubMed and read the abstracts of more recent papers you will see other papers cautioning the use of mDNA for calibrating biological clocks.

      Also, very recent articles are still dating the y-Adam to 50,000-170,000 years ago. This is somewhat problematic for people who misunderstand "mitochondrial eve" to be the female founder of the species and think she lived a mere 6,000 years ago, as she would have had to get bonked by a 44,000-164,000 year old man. [cite: Howard JM, '"Mitochondrial Eve", "Y Chromosome Adam", testosterone, and human evolution', Riv Biol. 2002 May-Aug;95(2):319-25 - though I have only seen the abstract, which is available on PubMed.]

      --
      Sheesh, evil *and* a jerk. -- Jade
    5. Re: Noah's ark by BCGlorfindel · · Score: 3, Informative

      Actually, the Loewe and Sherer letter cited by your favorite creationist Web site does not argue for a 6,000 year old mitochondiral eve; they merely mention in passing that that would be the untenable effect of basing a molecular clock on one specific mDNA site that has come under investigation. They spend the rest of their letter proposing ways of understanding the mutation rates that would naively yield the date that they themselves reject.

      A little more background on the Parsons paper. Untill the Parsons paper, mutation rates in ALL mtDNA regions were believed to be neutral. The projection made by the creationist site use precisely the same mtDNA clock methods that where used by evloutionary scientists to predict the 100k year MTeve before the high rates were discovered. To that point the mutation rates for the 100k year old MTeve were generated off mutation rates predicted from the divergence between chimp and human mtDNA. Nobody had tried measuring actual mutation rates from human forensic evidence. Parsons was the first to measure observed rates, and discovered a mutation rate 20x higher than the rates predicted by the chimp/human calibration. Parsons rejection of this rate was primarily based on the ridiculously high rate compared to the relatively low differences between chimp and human mtDNA. If mtDNA was neutral and chimp/human diverged ~5ma then the observed mutation rate was impossible. Thus the non-neutrality of mtDNA was proposed.

      If you search for "mitochondrial eve" at PubMed and read the abstracts of more recent papers you will see other papers cautioning the use of mDNA for calibrating biological clocks.

      And most of them have been trying to justify the difference between observed mutation rates in mtDNA with those predicted from chimp/human divergence rates. The explanation has always been that the random observed mutation rate in current studies is different than the fixation rate over millions of years. Selective pressure and hotspots were random mutations cancel each other out are among proposed explanations. The creationist conjecture that the chimp/human divergence assumptions are wrong are rejected out of hand as ridiculous. The coincidental 6k years for MTeve and same approx date from biblical records is merely that, a coincidence. Some people though don't reject that big a coincidence as lightly.

    6. Re: Noah's ark by lovebyte · · Score: 2, Funny

      all animals would also have to have genetic bottlenecks at the same time
      except fish, obviously!

      --

      I'll do it for cheesy poofs.

  17. Wacko Sci-Fi Theory by EvilTwinSkippy · · Score: 2, Interesting
    Perhaps humans haven't always lived here. Think about it, most cultures have an Atlantis-like legend, and a Flood/Migration legend.

    Could it be possible that we are the decendents from a crashed spacecraft? Maybe I played Homeworld too often, but doesn't it seem funny that we are the only primates that can:

    • Swim
    • Choke to death on food (Apes and monkeys can breathe and drink at the same time.)
    • Lose our Virginity.
    • Cry

    (A great site that goes into more detail is: Here.)

    At times we have more anatomically in common with a Seal than an ape. Not enough to make me buy a tinfoil cap, but precisely how does an otherwise aquatic creature "evolve" on an Savanna, and then ddevelop their first civilization in the middle of a desert?

    --
    "Learning is not compulsory... neither is survival."
    --Dr.W.Edwards Deming
    1. Re:Wacko Sci-Fi Theory by Silburn_Luke · · Score: 2, Informative
      Second; The features you mention are (I think) quite well explained be Dessmond Morris's 'Aquatic Ape' hypothesis.

      Actually it was Alister Hardy who first coined the hypothesis. Desmond Morris mentions it in passing in 'The Naked Ape' and it was picked up by Elaine Morgan as an alternative to what she called 'The Mighty Hunter' narrative of human origins in her 1972 pop feminism book 'The Descent Of Woman'. It is Morgan who is the published writer most identified with Aquatic Ape Hypothesis.

      Pro/anti flamefests are a regular occurence on various human origins fora which is probably why the earlier post got moderated as flamebait.

      Regards
      Luke
      --
      #include witty_one_liner.h
    2. Re:Wacko Sci-Fi Theory by EvilTwinSkippy · · Score: 2, Interesting
      Now you have to ask yourself: how?

      I realize that all of these traits are probably dormant in all mammals, and were simply re-expressed in humans through mutation. The enlarged forehead of humans is actually a common feature of infant apes, our forehead simply doesn't receed during maturity. (Though you wouldn't know it looking at the behavior of some people.)

      But there is a big problem. We somehow successfully mutated several major features in our Genome in the blink of an eye. To boot, we did it with a relatively small gene pool. Granted, the two could aggrivate each other.

      Something REALLY wierd happend at some point in our developmental past. In the absence of any records, fossils, or talking ghosts just about any answer is good.

      --
      "Learning is not compulsory... neither is survival."
      --Dr.W.Edwards Deming
    3. Re:Wacko Sci-Fi Theory by OpenSourced · · Score: 2, Interesting
      For a possible (rather reasonable) explanation, read "The descent of woman" by Elaine Morgan. She theorizes that human beings are part acuatic, that part of our evolution happened at sea, or rather at the coast making extensive use of the sea. That explains the biped position (to walk into sea as far as possible), the hairlessness (you drop hair as a thermo insulator and get fat instead if you know what's good for you, when you are at sea), the big nose with downward-pointing holes, the crying (eliminates salt by being more saline than normal fluids), and, although she doesn't mention it, the fact that you cannot run faster than a dog, but sure can you swim faster. She made a convincing argument.

      --
      Rome taught me patience and assiduous application to detail. Virtues which temper the boldness of great, general views.
  18. BBC's writer clearly didn't do his homework by zaad · · Score: 5, Informative

    It's shocking how much better the San Francisco Chronicle article is to the BBC article.

    Clearly both writers had the same source to work with, but the sfgate article was much more researched, thought-out, and nicely tied together. Even when I had only read the BBC article, I was shocked at how poorly structured the article was.

    If you're only going to read one of the two, read the sfgate piece.

  19. Genetic Lactose Intolerance by MonkeyBoyo · · Score: 4, Informative
    What triggered the writeup was the The American Society of Human Genetics journal article. For some reason the SFGate link also discussed the genetics of lactose intolerance, and here I will give some references and discuss how this is relevant to early human evolution and perhaps bottlenecks.

    Genetic lactose intolerance (= hypolactasia = non-production of lactase enzymes past weaning) has a hereditary component (Sahi 1994)
    It is assumed that thousands of years ago all people had hypolactasia in the same way as most mammals do today. At that time in cultures where milk consumption was started after childhood, lactase persistence had a selective advantage. Those people with lactase persistence were healthier and had more children than people with hypolactasia, and the frequency of the lactase persistence gene started to increase.
    The Cambridge World History of Food (2000) has a good article on the science and geography of lactose intolerance. This problem is not caused by the gene that creates lactase but instead by another gene (LAC*R (lactase restriction)) that kicks in later and ramps down the primary gene. (The other allele LAC*P allows lactase production to persist) However that article says:
    it seems most likely that the European and Arabia-Sahara centers of LAC*P prevalence, and the Uganda-Rwanda center (if it in fact exists), arose independently. Population movement and gene flow can be very extensive and, no doubt, have played a substantial role around the centers. Despite the efforts of some authors to find a common origin in the ancient Middle East, it is simpler to suggest independent origins than to postulate gene flow from the Middle East to Scandinavia and to the interior of East Africa. The problem might be resolved in the future if gene sequencing could show that the LAC*P alleles in Sweden and Saudi Arabia are, in fact, the same or are distinct forms of the gene with a similar function.
    â¦
    Finally, the LAC*P and LAC*R genes are interesting far beyond their biomedical significance. Along with linguistics, archaeology, and physical anthropology, further research on lactase genes and other genetic markers will provide clues to the prehistory of peoples, their migrations and interminglings, and the origins and development of major language families.
    However in 2002 the LAC*P gene was identified and sequenced within a Finnish population and was found to be the same as those in the rest of the world. This means that genetic adaptation for adult milk drinking evolved early and all milk-drinkers have ancestors in some early population in the middle-east or Africa.

    The problem with equating lactose intolerance with genetics is that people will see this as an either/or situation â" either you can eat it or you can't. The fact is that most intolerant people can consume small to medium amounts of lactose with no problem. Major milk problems are more often the result of allergies.

    Eventually there is the issue of culture. Fermented milk products (e.g. yoghurt and cheese) may be easier to digest than raw milk. Do the cheese/yoghurt eaters have a cultural advantage? Or have they disadvantaged other cultures?
  20. Don't panic! It can all be explained Mr Gorilla by madmarcel · · Score: 3, Insightful

    (Without reading the article...)

    I don't know much about genetics but....

    IIRC genetic diversity also indicates how
    old a 'species' is.

    Hence, given the widespread genetic diversity in chimpansees and the low genetic diversity in humans, you can deduce that chimpansees have been around much longer than humans.

    The other explanation could be that a single group of humans were so succesfull at some point in the past that we are all descendants of that group.
    (oops, thats the same as coming close to extinction - just phrased a different way :)

    There are groups of people in the world that are very much genetically distinct from the rest of us. (Eh, Read "The Naked Ape" by whatshisname...)
    ( Isolated pockets of genetic diversity...stuff like that )

    Another explanation could be the life span of chimpansees...anyone know how long they life in the wild? Short lifespan? Females are almost constantly pregnant. Now compare that to humans...long lifespan...relatively low pregnancy rate ( welll...) That could also explain the difference in genetic diversity?
    Phrased another way - for an equivalent period of time there might have simply been more generations of chimpansees compared to generations of humans.

    Could that account for the difference in genetic diversity (as well)?

  21. BBC should check it's own archives... by EvilSuggestions · · Score: 5, Interesting

    I don't expect the BBC to do an exhaustive search of all the peer review journals every time they do a science story, but they should at least check their own archives to help explain an curious conundrum like this one.

    The date given for the bottleneck, ~70,000 years ago, coincides perfectly with the largest volcanic explosion in the last half million years. One that spewed thousands of times as much ash as produced in the 1980 Mt. St. Helens eruption.

    The explosion of Toba in Indonedia around 74,000 years ago probably caused a greater than 5 degree drop in average global temperature that lasted over 6 years. 5 degrees may not seem like much but that global average may translate to over a 15C drop in the summertime temperatures in the temperate regions and would have devestating effects on many of the plants we relied on for food.

    Point is that most of what I just mentioned (and much more) can be found in a few articles on their own web site:

    --
    "There is a thin line between ignorance and arrogance, and only I have managed to erase that line." - Dr. Science
  22. Big Volcanic blast ~70K yrs. ago? by budalite · · Score: 3, Interesting

    This "news" is pretty old. There was even a Learning Channel (or Discovery) show a couple of years ago about the idea of "supervolcanoes", one of which could rest beneath Yellowstone and one (Toba) that, they think, blasted ~70K years ago, causing global average temperatures to drop and nearly causing our species to become extinct. Interesting stuff.

  23. That would be the Masai. (admittedly -partly -OT) by SolemnDragon · · Score: 3, Interesting
    And on the subject of the Masai, cattle are sacred to them, a gift from the god(s), and they generally don't kill them. In fact, they gave the USA fourteen cows in the wake of 9/11- a collective donation from many tribes, and (for them) a priceless gift. Our ambassador refused to accept it.

    I don't know what happened to the cows. I do know that the Masai do, indeed, drink blood and milk mixtures. Having lived with a Jewish roommate, i can remember the look of horror on her face as she tried to interpret it into kosher food concepts.

    Lactose Intolerance is not the only intolerance out there... Gluten intolerance hits 7% of the population (including me.) More women than men, mostly northern european descent. Me with my scottish pale skin and my german grey eyes, it's got my grandmum, my mum, my sister, and me. Skipped both brothers.

    Part of my point being - there are genetic variations that are gender specific, there are genetic variations that are region-specific, and there are genetic variations that we're only just discovering. Another part of my point being- Lactose intolerance is unbelievably common. And i miss ice cream and milk. Lactase tablets aren't enough for a lot of people out there, that's how severe we're talking... I think maybe there are a number of changes that happened regionally, and now we're seeing the results as cultures blend. My dentist talked about it all the time, how asian teeth and african teeth and european teeth are similar but jawlines differ, and when you get different genes kicking in for jawbone and teeth it sometimes leads to really good combinations and sometimes leads to surgical correction so that the kid can chew. He said this in a completely nonracist way; he thought it was a great idea to blend genetic and cultural groups together, so he was more than happy to help correct the results of problem combinations, because they could usually be helped and their appearance meant that new combinations were always being created.

    Oh, and about the Masai. Don't mess with a people who kill lions by hand. These are the people from the movie the ghost and the darkness- flushing out lions by shouting and beating the brush...

  24. Toba by 4of12 · · Score: 4, Interesting

    I'm surprised that article didn't pick up on the theory that the bottleneck in the genetic line about 70K years ago might well have been due to the eruption of the Toba supervolcano that was regarded as one of the most significant eruptions in the last 2 million years. That kind of climatic change from such an eruption could well be responsible.

    --
    "Provided by the management for your protection."
  25. Do your bit for genetic diversity! by A55M0NKEY · · Score: 2, Funny

    Wear uranium underwear!

    --

    Eat at Joe's.

  26. Measure of genetic diversity by bobthemuse · · Score: 2, Insightful

    As I remember from high school biology, doesn't only a small percentage of our DNA code for useful information? The reset was just junk that is cut out during protein synthesis (introns? extrons? I forget the terms...) Is this included in the study? Could it be that chimps are also extremely genetically uniform in the areas that matter, but they have more diverse "junk" material than us? Then again, I seem to remember someone saying that the "junk" DNA plays a vital part in evolution? Argh, guess I shouldn't have slept through those classes! Now we'll all become extinct!

    1. Re:Measure of genetic diversity by thomasmd · · Score: 2, Insightful

      they don't mention "junk" DNA, and I couldn't even find the original article (why in the hell wouldn't the BBC reference it?). What is called junk DNA makes up the vast amount of our 3 billion base pairs, but junk DNA is different than intron DNA (and exon), and there is increasing evidence that Junk DNA may actually be very important. As far as diversity, that usually refers to differences within coding DNA, not junk DNA.

    2. Re: Measure of genetic diversity by Black+Parrot · · Score: 2, Funny


      > As I remember from high school biology, doesn't only a small percentage of our DNA code for useful information? The reset was just junk that is cut out during protein synthesis (introns? extrons? I forget the terms...)

      I think they call the junk "enrons".

      --
      Sheesh, evil *and* a jerk. -- Jade
  27. Re:Jesus Christ... by arkane1234 · · Score: 2, Interesting

    Lactose intolerancy is a little bit more than just some farts... it's not like eating chili or something :)

    It can really mess your day up... the major side effect of lactose intolerance is massive gastrointestinal issues stemming from the lactose not being broken down. I have it, and believe me it's not just gas or I could definately handle that.

    --
    -- This space for lease, low setup fee, inquire within!
  28. Swimming by TamMan2000 · · Score: 2, Insightful

    In 1959 Koshima macaque monkeys learned to swim, ever since then the entire group can swim...

    Also in American colonial times the only human swimmers were witches...

    The other arguments are interesting, but the swimming one is weak.

    --
    "I'll have a Guinness, no wait, make that a Coors Light" -Grad student I work with, who shall remain anonymous...
  29. Goats, not cows by Tablizer · · Score: 3, Interesting

    Why didn't they domesticate goats for milk production instead of cows? Goats don't produce lactose in their milk. We can't easily switch now because goat milk tastes too different from cow's milk. We are too used to the taste. Cow milk is kind of like the QWERTY of milk.

  30. you can so quantify diversity!!!! by Anonymous Coward · · Score: 2, Interesting
    If geneticists needed to discuss gene diversity in some sort of quantifiable measure, it would eliminate their ability to discuss relevant topics. Unless you are referring to a specific sample of genes, you can't quantify the diversity.

    Leave it to an anthro major to pull out bullshit like that.

    Meanwhile, in the scientifc world, diversity has a specific technical meaning that can be measured using "H," or entropy, from Claude Shannon's information theory -- which is similar the measure of entroy in physics.

    H(p) = - sum[i=1..X] (pi * log pi)

    Just take Shannon's equation, plug in allele frequencies for the population (maybe use log base 4 for 4 base pairs?) and presto, a quantity of diversity

  31. Goats are Full of Lactose by MonkeyBoyo · · Score: 2, Informative
    Goats don't produce lactose in their milk.

    From the Ontario Goat Milk Producers' Association
    Many people with cow milk allergies can drink goat milk because it contains a different kind of protein. Goat milk has 13% less lactose than cow milk, and 41% less than human milk.
  32. Re:Skin Color by afreniere · · Score: 3, Informative
    Being nice and white, it there any physical advantage for having light skin?

    It seems physically(not trying to get in a social debate) that dark skin would only be advantageous(you don't burn as bad), less skin cancer?

    Ideas either way.

    I believe those with darker skin need more sunlight to produce enough Folic Acid and Vitamin D. Thus the adaptation to lighter skin when we moved North to the Cloudy Continent.

    -Ansel.

    --
    G=C800:5