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Scientists Create Deadlier TB Strain By Accident

Makarand writes "BBC News is reporting that Scientists at the University of California (Berkeley, U.S.) accidentally created a hyper-virulent form of the Tuberculosis bacterium while trying to alter its genetic structure to make it less deadly. The mutant form of the super-bug could multiply more quickly and also had the unexpected effect of undermining the body's own immune response against Tuberculosis."

46 comments

  1. Hmm.. by Bombcar · · Score: 0, Redundant

    Now we know where the scab-pickin' smallpox terrorists are!

    Get 'em, boys!

    -Ashcroft

  2. Things that make you go by FFFish · · Score: 1

    Hmmmm. Now why would we need an ultra-virulent Tuberculosis?

    --

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    Don't like it? Respond with words, not karma.
    1. Re:Things that make you go by squiggleslash · · Score: 4, Funny

      It's all down to marketing at the end of the day. Who's going to buy a vial of TB marked "Slightly worse than normal TB"? Nobody. You need to make your product stand out.

      --
      You are not alone. This is not normal. None of this is normal.
    2. Re:Things that make you go by andy666 · · Score: 1

      Bah, hypervirulent humbug!

    3. Re:Things that make you go by zhenlin · · Score: 1

      Supertuberculosis -- Insanely Better!
      100% Guaranteed Effective!

      Instructions:
      1 Open Mouth.
      2 Open Vial.
      3 Pour Contents of Vial into Mouth.
      4 Swallow.
      5 Go to 4.
      6 Close Mouth.

  3. One of very few hyper-virulent organisms ever crea by leoaugust · · Score: 4, Funny

    A virulent form of tuberculosis was created in the laboratory by experts trying to alter its genetic structure. The mutant form of the bug multiplied more quickly, and was more lethal than its natural counterpart. "This is one of the very few hyper-virulent organisms ever created," said scientist Dr Lisa Morici.

    I could just picture the glee with which Dr. Lisa Morici must have said that. It reminds me of the smile on the son's face when his dad came to visit him in his lab.

    From

    The father was very proud when his son went off to college. He came to tour the school on Parents' Day and observed his son hard at work in the chemistry lab.

    "What are you working on?" he asked.

    "A universal solvent," explained the son, " a solvent that'll dissolve anything."

    The father whistled, clearly impressed, then wondered aloud, "What'll you keep it in?"

    --
    To see a world in a grain of sand, and then to step back and see the beach where the sand lies ...
  4. don't they know by nuggetman · · Score: 1

    This is how we get really bad sci fi movies. Shit like this.

    --
    ...and that's all there is to it.
  5. Hmmmm by Hanji · · Score: 2, Interesting

    I'm reading Stephen King's The Stand at the moment. 'nuff said.

    --
    A Minesweeper clone that doesn't suck
  6. I, for one, .... by Anonymous Coward · · Score: 0

    would like to read about this and other studies, in the New England Journal of Evil Medicine.

    As an nascent super-villian the only way I can compete with the likes of the entrenched old boy networks like Osama's Al-queda is with better information. The Wall Street Journal is fine for the likes of Halliburton. But I'm far from forming my own sinister cabal and attracting a host of supervillain. I'm still in the garage or development phase like MArtha Stewart and her catering business.

    "Phase 1:" May well be underpants (I've got a lot, and like all slashdot reader's they're huge).

    We all know "Phase 3:" and maybe my "Phase 2:" is "Infecting underpants with hyper-virolent strains of fatal respitory diseases and then repackaging them and secreting them on to the shelves of major retailers (sans skidmarks)." And maybe it isn't. But if I can't get all the information I need, reguarding how to modifiy the bug, how to harden it to survive for extended periods out side of nice warm lung, or even how to get from someone's ass to their respitory system, it doesn't do me much good.

    If you're all ever to live cowering under my dominion, I need better intelligence. Some changes have to be made people. It's almost like you don't even WANT a happy erratic autocrat. I'm not just disappointed in you, I'm much more disappointed for you.

  7. One word. One truth. by Anonymous Coward · · Score: 0

    Sandmonkeys. Just too many of them.

  8. Underlines the problems with genetic manipulation. by pwagland · · Score: 2, Insightful
    First up, don't get me wrong. Genetic research is incredibly useful, and as a tool in the modern medical warchest has paid great dividends. However, from the article "The emergence of these strains should pose no risk to humans, [Dr Morici] said." He goes on to say that these strains probably already exist, or have existed in the wild, but, for whatever reason, they are not viable.

    Now imagine, for sake of argument, that we create a similar problem with wheat or rice, common non-human subjects of genetic manipulation. Further, assume that we don't catch it in the lab. It might not kill us directly, but by wiping out our "natural"* crops it may well starve us to death... * "natural" since farmers have been selectively breeding grains and livestock for many centuries, it is just that recently we have improved on the technique.

  9. Why were they trying in the first place? by Tango42 · · Score: 2, Insightful

    What is the point of trying to make less deadly versions of TB? Are they trying to make a version that will stimulate the production of the same antibodies, but not harm someone, so they can make a live vacine? The article doesn't seem to worry about details like that, i guess the interesting bit is them making a harmless mistake, rather than the useful work they are trying to do...

    1. Re:Why were they trying in the first place? by Tackhead · · Score: 1
      > What is the point of trying to make less deadly versions of TB? Are they trying to make a version that will stimulate the production of the same antibodies, but not harm someone, so they can make a live vacine? The article doesn't seem to worry about details like that, i guess the interesting bit is them making a harmless mistake, rather than the useful work they are trying to do...

      That's possibly it. The other alternative is to let everyone catch it.

      The biggest (IMO overblown) worry about GMO in the food chain is that the UberFish or the MegaTomato will leak into the wild, and outcompete the NatureFish or the RegularTomato due to propensity for high growth rates, etc.

      Turn that around. TB is endemic in certain populations (the homeless, the dirt-poor, prisons). There's a treatment for most strains, but not all. But the treatment is nontrivial in terms of cost, and in terms of the discipline required on the part of the person taking it. Many of the people in the TB-carrying segments of the population lack both the cash for the treatment, and the brains to keep taking the pills for months after they feel better.

      But just spray a low-virulence strain of TB into the lungs of every prisoner you take in, and you've just prevented most of your prison population from spreading antibiotic-resistant strains to their contacts on the outside when they get out in 5-10 years. Cost is nothing, and the prisoner benefits too - better to have the less-virulent strain under medical supervision than to get the regular (or worse, antibiotic-resistant) strain anyways as part of his prison experience.

  10. Kinda frightening by Popadopolis · · Score: 1

    That is a pretty frightening bit 'o news there, given the government's track record for 'misplacing' things.

    1. Re:Kinda frightening by Demolition · · Score: 2, Interesting

      That is a pretty frightening bit 'o news there

      Yes, it is frightening. And, I'm not just agreeing with you because of what could occur in the future if a variant strain of TB was accidentally (or even purposely) released into the general population, but because I've already personally experienced the suffering that it can cause. TB has hit my family particularly hard -- three of my aunts succumbed to it during internment in World War II.

      So, when I hear about researchers fooling about with virulent diseases (diseases which should have been eradicated long ago!) for seemingly superficial or spurious reasons, then I always get an uneasy feeling. Especially when they say that these hyper-virulent strains should, as Dr. Stoker says in the article, "pose no danger to humans". I hope that those aren't the proverbial famous last words.

      D.

    2. Re:Kinda frightening by Popadopolis · · Score: 1
      I agree (though this post is very late and will probably be unnoticed) that it is quite dangerous to fool with viruses. However, I can also see how it can be very helpful. If the scientests were much more careful than in the past, viral research could prevent deaths and such. Of course, that is not considering the fact that viruses mutate seemingly without rhyme or reason, so our friend today would be our enemy tomorrow.

      Anyhow, if I continue right now, I will go in circles and confuse myself.

  11. somewhere far beneath the surface ... by ignatus · · Score: 1

    well, maybe some sicko scientist somewhere down in a military basement accedently will create a non-virulent tuberculosis bacterium while trying to alter its genetic structure to make it hypervirulen.
    The question is: will they publish it or just pile it up their large collection of other deadly virii?

    --
    - Never underestimate the power of human stupidity.
  12. Re:Underlines the problems with genetic manipulati by jamesh · · Score: 5, Funny

    That would be okay though. Industry would step in with a resistant strain of rice which they'd be happy to sell. Unfortunately it's seeds, while tasty, would be sterile, so you'd need to buy from them each time you wanted to plant a crop.

  13. It seems to me... by i_need_no_nick · · Score: 1
    Like all those bioterrorists out there who work in hidden laborotories around the world, fiendishly trying to create super-deadly diseases to wipe out us decadent western scum...

    Should instead just try to create a harmless bug, for laboratory purposes. Every time someone tries that, they end up with something which kills every mouse in the area.

  14. Re:One of very few hyper-virulent organisms ever c by JDWTopGuy · · Score: 1

    Obviously, you keep it in a force field. You can't dissolve energy, right?

    --
    Ron Paul 2012
  15. Obviously... by JDWTopGuy · · Score: 1

    ...it must be a government funded project to screw up that badly.

    --
    Ron Paul 2012
  16. Doesn't anybody read Stephen King? by jetsfandb · · Score: 1

    Sounds like The Stand starting to unfold.

    --
    It is by caffeine alone I set my mind in motion, It is by the beans of Java that thoughts acquire speed, The hands acqui
  17. Re:One of very few hyper-virulent organisms ever c by yourmom16 · · Score: 1

    But matter is energy.

    --
    "We have got to make Stan understand the importance of voting, because he'll definitely vote for our guy." - South Park
  18. Risk Assessment by Wardish · · Score: 3, Insightful

    Actually I'm surprised that there was any report in the news at all. Some enterprising reporter must have been keeping a close eye on minor publications or some such.

    In the scheme of things and to put it into perspective.

    People are going to be doing this sort of work either out in the open or as underground projects. The fact is that we've the best chance to have the skills and technology to deal with the possible accidental and/or bioterror release if we encourage as much work in this area as we can.

    If we clamped down on it then only a small elite group will have access to the knowledge and tools and they will be of lower quality than in a more open scenario.

    Yes I have considered that the "bad" guys will also have the advantage of better tools. Additionally there will be an increased risk of accidental release due to much more research being done. But I think the advantages of having many more people available and speeding up our advances far outweigh the added risk.

    Mmmmm thorazine....

    --
    Ward

    . Silence! Be thankful thy species is unpalatable! .
    1. Re:Risk Assessment by tuxtomas · · Score: 1

      I agree. I remember seeing on the cover of some pop science magazine... something about decoding SARS in five days. I don't remember the specifics, but what if everyone ran some distributed computing to help out? People could use their dsl connections for more besides routing pr0n! Seriously though, it's cat and mouse. Harness the resources.

      --
      Open source- the greatest equalizer mankind has ever seen.
    2. Re:Risk Assessment by jbridge21 · · Score: 1

      As technology gets more and more powerful, the killing power of one man increases more and more (as well as the healing power). The problem comes when one man has the ability to, by himself, decide to wipe out all humans and then carry through with it. However, one could view a species that ends up killing itself as an undesireable one. So really it comes down to, will we kill ourselves or not?

    3. Re:Risk Assessment by nucal · · Score: 1

      The work was published in PNAS - not exactly a minor publication.

  19. The question is: misspelt by jamesh · · Score: 4, Funny

    They will pile it up with their other virii. They now have enough virii to wipe out at least the following creatureii:
    . humanii
    . sheepii
    . cowii
    . catii
    . pigii
    . giraffii
    . dogii

    1. Re:The question is: misspelt by Urkki · · Score: 1
      • creatureii

      I believe you mispelled that, you should leave out the last 'e'. Though I'm not native English speaker, so I could be wrong...
    2. Re:The question is: misspelt by jamesh · · Score: 1

      yes. I spotted that the day after i posted it. Shame on me for making a spelling mistake when making up new words.

  20. Top ten list (abbreviated) by Alsee · · Score: 4, Funny

    .
    .
    .
    5) NASA telemetry station, tracking YetAnotherMarsProbe.
    4) Your barber, giving you a hair cut.
    3) Your daughter, checking a pregnancy test.
    2) A munitions expert, loading nuclear weapons for transport.
    1) A genetic engineer, experimenting on human pathogens.

    Top 10 people you don't want to hear say "Oops".

    -

    --
    - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
    1. Re: Top ten list (abbreviated) by Black+Parrot · · Score: 1


      > Top 10 people you don't want to hear say "Oops".

      You left out the one about circumcision.

      --
      Sheesh, evil *and* a jerk. -- Jade
  21. This implies that all things not killing us... by Anonymous Coward · · Score: 0

    ...are being selected for a less virulent form. I bet a lot of innocuous stuff can be pushed into super-virulent status with similar deletions. Might be bad for those directly infected, but natural flora should naturally select for the less virulent forms even if virulent forms got in the mix.

  22. HA! by Rhinobird · · Score: 1

    They had that gene sequencer in reverse. How silly.

    --
    If Mr. Edison had thought smarter he wouldn't sweat as much. --Nikola Tesla
  23. common practise ... by ignatus · · Score: 1

    Acctually, i don't think this ultra-virulent form was created that 'accidentally'. It's a common practice in dna-modification research to simple fuck up a part of the dna of the bacterium and then look which one has the most peculiar change in its behaviour. Maybe the chance of creating a less virulent bacterium is even smaller than an ultra-virulent one. Nevertheless, in my opinion scientist will stumble on a lot more (and worse) of those freaking creatures of mankind.

    --
    - Never underestimate the power of human stupidity.
  24. And 28 Days Later ... by donbrock · · Score: 1, Funny

    The entire world's population will be reduced to deranged psychos looking for fresh blood.

  25. Tuber culosis? by Black+Parrot · · Score: 1


    Does this mean all our potatos are going to get culosis?

    --
    Sheesh, evil *and* a jerk. -- Jade
  26. Re:Underlines the problems with genetic manipulati by Anonymous Coward · · Score: 0

    arn't you kinda assuming the 'unnatural' crop isn't edible? More important, what on earth could you possibly _mean_ by "a similar problem with wheat or rice". A strain that grows and multiplies voraciously? Oh no! You talking triffids or weeds with a mean streak?

  27. I just wanted to say.. by michaelhood · · Score: 1, Funny

    hey, thanks a lot guys.

  28. smart descision ? by anotherwjt · · Score: 1

    would be to put a warning out on gene modification recipe and make this new variation extinct . The lab would have the only culture in existance , right . u.n.l.e.s.s.o.f.a.m.i.s.s.i.n.g.m.e.d.i.a.g.r.o.w. t.h.p.l.a.t.e

  29. Quick! by metamatic · · Score: 2, Insightful

    Someone call Rumsfeld, I know his friend Saddam is in jail but he might know another murderous dictator we can sell the stuff to.

    --
    GCHQ Quantum Insert installed. If only our tongues were made of glass, how much more careful we would be when we speak
  30. Re: Universal solvent by Anonymous Coward · · Score: 0

    The father whistled, clearly impressed, then wondered aloud, "What'll you keep it in?"

    Secret Squirrel suspended a similar solvent in an airstream.
    He used his helicoptor to transport it by blowing air upwards from the coptor blades.

    Now I know that helicoptors work by blowing air downwards, not upwards, but this was a cartoon for kids; what do you expect?

  31. Re:Underlines the problems with genetic manipulati by drinkypoo · · Score: 1

    Now that's what I call Opening the Door to New Possibilities.

    --
    "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  32. One Step Closer by Viking+Coder · · Score: 1

    Thank God scientists have moved us one step closer to Captain Trips. Oh wait - that marks the END OF THE WORLD.

    Why the hell don't scientists who do something like this write a report for the National Security Council, and then destroy their research and all documentation about how they did it?

    You can yell about "security through obscurity" applying to germ warfare, but until we get better at actually preventing supergerms from killing us all, I'd just as soon not make any new ones. Let's figure out how to patch exploits in the human genome and in basic human biology, before we go discovering (and publishing) new exploits.

    --
    Education is the silver bullet.
  33. MOD PARENT DOWN by Anonymous Coward · · Score: 0

    Honestly, people. How is that "insightful" in any way?