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Superflu Being Brewed in the Lab

Genial Generalist writes "Superflu is being brewed in the lab, an article by Michael Le Page, describes some of the ongoing efforts to genetically modify the different strains of flu, specifically CDC modification of bird flu for the purpose of developing new vaccines."

19 of 332 comments (clear)

  1. Bosh by shystershep · · Score: 5, Interesting

    This make anyone else think of Stephen King's The Stand ?

    That said, I think the dangers of this are exaggerated. No doubt it would be a catastrophe if it were to escape the lab, but life is a lot more resilient than it is usually given credit for. Creating "a virus that could kill tens of millions if it got out of the lab" is a catchy line in an article (or a cheesy plot for a movie), but there is absolutely no basis for it. I think any benefit that comes from this sort of research far outweighs the hypothetical dangers.

    --
    The bigotry of the nonbeliever is for me nearly as funny as the bigotry of the believer. - Albert Einstein
    1. Re:Bosh by stratjakt · · Score: 2, Interesting

      Umm, I think the use of "Superflu" in the headline was a direct reference to The Stand.

      Would it be a catastrophe if it escaped the lab, or is this just run of the mill New Scientist fear mongering?

      There are plenty of lethal strains of the flu, and other nasty bugs out in the open. Yet, humanity survives.

      --
      I don't need no instructions to know how to rock!!!!
    2. Re:Bosh by michael_cain · · Score: 4, Interesting
      That said, I think the dangers of this are exaggerated. No doubt it would be a catastrophe if it were to escape the lab, but life is a lot more resilient than it is usually given credit for. Creating "a virus that could kill tens of millions if it got out of the lab" is a catchy line in an article (or a cheesy plot for a movie), but there is absolutely no basis for it. I think any benefit that comes from this sort of research far outweighs the hypothetical dangers.

      Life may be resilient, and even human life may be resilient, but civilization is somewhat more fragile. Postulate a death rate from an engineered organism similar to the Black Death in Europe: one-third of the population killed in five years. In the US, that's almost 100M deaths, 20M per year. The current US death rate is about 2.4M per year. Disposing of the bodies is going to be a large, but probably managable, task. How much of the rest of the infrastructure will we be able to keep going? Or at least, at what level will we keep it going?

      Here's another scenario that you might consider. Suppose it's just the US that gets hit. The US economy would have BIG dislocations -- consider what happens in the housing industry as an example. New construction essentially halts, since we would have an enormous oversupply. Some number (probably large) of banks and other holders of mortgages would fail, since a third or so of their mortgages are now worthless. The fallout is not just domestic. At the present time, US consumption of goods and services is driving the world economy (the Economist bemoans this situation on a regular basis). If the US suffers an epidemic that kills a third of the population, US consumption falls drastically, probably by an even bigger factor. The result would be a world-wide depression as enormous numbers of workers whose jobs depend on sales in the US become unemployed.

      Taking a long view, engineered bioweapons scare me more than nukes do. Today building such a bug is still a difficult task, but it's getting easier. At the current rate of progress, how hard/expensive will it be in 20 years? Will a lunatic with the resources of a small country (even a poor one) at his/her disposal be able to do it? There are still going to be a lot of poor countries in 20 years, many with a grudge against the rich countries, and at least a few controlled by lunatics. OTOH, I don't lose sleep over the issue, since (a) there's not much I can do about the risk and (b) the options for trying to protect myself (say by becoming an isolated subsistence farmer somewhere) are unpalatable.

    3. Re:Bosh by JASegler · · Score: 5, Interesting

      Guess you don't read much history do you.

      The Pandemic flu of 1918-1919 - 10-25% exposed died, 25-37 million victims. They think it was a mutated swine flu.

      Bubonic plague (bacteria actually but just to point out a very deadly NATURAL biological agent) - ~90% exposed died, ~137 million victims.

      When europeans came to the US the diseases they brought wiped out about 90% of the Native American population simply because they didn't have the resistances the Europeans had.

      So you think a genetically engineered flu like what was in The Stand isn't possible?
      That it couldn't have a kill rate as high as 90+%?

      Genetic engineering of this kind is far worse than radiation. At least radiation will decay and disappear in 50,000 years or so.

      Biological agents mutate and get stronger through the standard darwinian evolutionary processes.

      They only reason we got rid of smallpox was there was a global effort to vaccinate everyone on the planet for decades. Colds and flu strains are so numerous that we haven't been able to devise a way to get rid of the ones we know of..

      And they want to build super versions of something we can't irradicate now?

      To paraphase from memory The Stand:
      This is how the world ends, not with a bang but a wimper.

      -Jerry

  2. Re:Good morning, Captain by Anonymous Coward · · Score: 2, Interesting

    Writing from Boulder, the average house here is $483,000. Things are really different than when King lived here. Of course, when the population dies off, you can move in anywhere. My house is pretty nice, with a view of the mountains, a couple of NeXTs and SparcStations, and 3Mb braodband.

    "The Stand" was the first thing that I thought of upon seeing the article, too.

    Right now, the world could be dying off around me, and I wouldn't know it for weeks. Why? Because I live in the world of ONS-Torlan in UnrealTournament2004, on Linux, OS X and Win32. mmmmm, raptors.....

  3. Fear psychosis? by aacool · · Score: 5, Interesting
    Stories of this nature tend to bring out alarmists, Cassandras, and 'the sky is falling' types as well as rationalists and 'it-couldnt-happen-here' types.

    The tendency of the human race to both improve it's awareness of the world while at the same time endangering itself has been the cause of grief and happiness.

    This though, seems to be of little benefit to anyone, unless it guarantees a cure for the common cold!

  4. old news ... by tazanator · · Score: 5, Interesting

    sorry but the USSR plan was nukes and a "virus cocktail". They would hit major cites with nukes and lay waste there, however the fields that made crops had to be saved (we ship most of the grain they live on to them). They planned to release biological weapons on the great plains, not just a little problem stuff but things like anthraz and small pox or malaria and eboloa. By mixing the virus it becomes harder to trace what antibody the hospital needs, and the next year they can vacinate some people against what was spread in the area to allow farming to resume, 2 winters later the dieases would have died.

    --
    I'm told you are what you eat, does that mean I can be you by tomorrow with some A1?
  5. It's only a matter of time... by hoggoth · · Score: 4, Interesting

    It's only a matter of time, perhaps 10 or 20 years, until a grad student or third world scientist will be able to easily engineer his own deadly plague virus.

    Human nature is not going to change. We are petty and short sighted, driven by emotion. These things WILL be made, eventually. It is likely sooner or later something really bad will get loose.

    I am afraid for the whole Human Race. How do we prepare for this or prevent this?

    --
    - For the complete works of Shakespeare: cat /dev/random (may take some time)
    1. Re:It's only a matter of time... by EchoMirage · · Score: 2, Interesting

      It's only a matter of time, perhaps 10 or 20 years, until a grad student or third world scientist will be able to easily engineer his own deadly plague virus.

      You forget that by that time a grad student or third world scientist will be able to easily engineer the cure, too. And advanced medicine in a first world country even moreso.

      Look, I understand that people want to be all doomsday to knock some sense into people, but really no human invention except the atomic bomb and television has actually had the ability to cause mass casualities that could be considered on a 'doomsday' scale.

    2. Re:It's only a matter of time... by Simonetta · · Score: 2, Interesting

      It's only a matter of time, perhaps 10 or 20 years, until a grad student or third world scientist will be able to easily engineer his own deadly plague virus.

      I wouldn't sell the scientific community short on this. Scientists are well aware of the consequences of their reasearch and the ethical foundations of said research. They are also aware of the various techniques that politicians use to force them into to unethical research and development and how to fight this coersion.

      Scientists are not soldiers: they just don't train any street-gang psychopath into their advanced knowledge and tactics. It is expected to be able to demostrate high moral character and a deep and fundamental understanding of ethics before being trained to do genocidal or omnicidal (technology that would destroy all human life) research.

      That is one of the reasons why the Soviet Union fell: scientists realized that THEY could not control the research that the paranoid WWII veteren Communist leaders were forcing them to do. So they worked behind the scenes to pull the plug on this dangerous and unpredictable government.

      Give the scientists some credit. Just because no one else takes ethics seriously doesn't mean they don't.

  6. Human Evolution by Lord_Frederick · · Score: 5, Interesting

    I've read that human evolution has stopped, because modern medicine has eliminated most of the diseases that cause death prior to being mature enough to reproduce.

    If one of these superviruses was released, could it be viewed as a way of pushing along evolution, since only those strong enough and with the genetics to survive the virus would live to reproduce?

    1. Re:Human Evolution by 77Punker · · Score: 3, Interesting

      Evolution still continues, in a Planet of the Apes sort of way. Assorted rich/socially skilled/muscular dumbasses are still more likely to reproduce than a typical high IQ'd geek.

    2. Re:Human Evolution by Anonymous Coward · · Score: 1, Interesting

      Actually; I've wondered about that for awhile. The typical thing for a rich/muscular dumbass to do, is marry a trophy wife; one not noted for brains. So in theory, after many generations of successive breeding (like, say, the last 400 years or so), would that make the rich population dumber on average? IANAGeneticist/Biologist, so please excuse my ignorance.

    3. Re:Human Evolution by 77Punker · · Score: 1, Interesting

      That's why it's Planet of the Apes. Promiscuous people are causing us to go down. These are the people that don't have the capability for abstract thought. They get drunk, fuck, live on welfare (or the rich buy a wife), fuck some more. Now we have a bunch of kids who might be genetically as bad as their parents. Our only hope is that those kids might turn out to be rebels and marry somebody intelligent and not have tons of kids and crowd the Earth.

  7. This reminds me of some of the Animaniacs sketches by Darken_Everseek · · Score: 5, Interesting

    Good Idea: Studying naturally occuring flu viruses to learn how to prevent future pandemic outbreaks.

    Bad Idea: Deliberately creating new versions of the flu, to learn how to prevent future outbreaks.

    The frightening thought is that they aren't using the highest grade of quarantine level. I suppose though, when it does get out, they'll know how they made it, and theoretically, also how to fight it. At least until it mutates naturally.

  8. Re:How about 100 million? 200 million? by gc8005 · · Score: 2, Interesting

    Here's a great read on the 1918 Flu outbreak:

    Flu : The Story Of The Great Influenza Pandemic by Gina Kolata.

    http://www.amazon.com/exec/obidos/tg/detail/-/07 43 203984/qid=1077900610//ref=pd_ka_1/103-9029329-360 3017?v=glance&s=books&n=507846

    The book covers much of the 1918 outbreak. It also details recent effort by two teams to exhume 1918 flu victims from permafrost to study the 1918 flu virus. IIRC, the conclusion was that today's flu is genetically similar to the 1918 strain, but that it doesn't have the same epidemic effect today since 1918 survivors passed on the genetics to fight this strain. In other words, those humans that were genetically susceptible to the 1918 flu strain have all died off.

  9. Re:Oh NO! Worldwide Outbreak!!! by geoffspear · · Score: 4, Interesting

    Nearly all books are published by corporations, too, so I guess we can't respect them, either.

    --
    Don't blame me; I'm never given mod points.
  10. Virii and toxins by miketo · · Score: 5, Interesting

    IANAS, but if I recall correctly, the problem with biological agents like virii are that it's very difficult to create a highly contagious, high-mortality virus. Virii need a living host to reproduce, mutate, and pass on their modified genes to the descendants. Airborne virii need to be extremely hardy to survive outside their ideal breeding conditions (read: human host). And a virus that is so virulent it kills its host almost immediately won't live for very many more generations -- it's an unsuccessful mutation.

    That being said, it's still possible to balance all the factors so you have a fairly lethal virus, relatively contagious, that mutates quickly and successfully. It's just not as likely to end up as a Captain Tripps, or even an Ebola.

    Toxins, on the other hand, are better for short-term, near-instantaneous death, and are more likely to be "controllable" through judicious application. Again, there are contraindications such as method of application, weather, &tc. that would warrant not using them.

    The various death merchants will keep experimenting anyway, but it's nice to know that we're far more likely to be wiped out as a species by a giant asteroid than from a little critter built in a lab.

  11. Natural viruses not as deadly as man-made ones by tehanu · · Score: 4, Interesting

    But Nature also seems to be good at counter-balancing its viruses so that they don't wipe out everything (thus ending up killing the virus as well - it needs something to spread to).

    For example many of the most deadly viruses which you have practically no chance of surviving such as Ebola are not airborne. Syphilis used to be much more deadly but gradually evolved into a less potent form.

    Also you forget that a lot of the diseases we survive (as in the population in general not individual people) because people gradually develop immunity to them especially due to proximity to animals. For example smallpox. For examples of what happens when people are suddenly exposed to diseases just look at aboriginal populations like the Australian Aborigines, the South American or North American Indians.

    So a man-made virus:
    (1) While a natural virus's main aim is to survive and hence not kill everything in sight, thus either is either difficult to spread (anything that doesn't involve airbourne or a simple touch) or is simply not instantly deadly, a man-made virus does not need to fill this condition and thus can be both deadly and easy to spread. In fact these are the sort of mutations they are working on in the experiments.
    (2) The virus escapes suddenly into a population which has none or practically no immunity to it.

    So a man-made virus could very well be something that nature has never produced and is not likely to produce - a virus as deadly as Ebola (99% death rate), as easy to spread as the cold (airbourne and touch) released suddenly into a population which has even less immunity to it than the American Indians to smallpox.