Uplink Creators Surreal It Up With Darwinia
Thanks to DIY Games for its story noting that Introversion Software, "creator of the critically acclaimed hacker sim Uplink", has announced its next game: Darwinia, a "...monstrously fast [PC] shoot-'em-up, influenced by Cannon Fodder and Syndicate", according to PC Gamer UK. There's a very basic official site with the first screenshots, but fansite Darwinia Warfront has some further information on the early-in-development title, quoting PC Gamer as explaining you'll be "playing as a gamer, inserted into the network of retro videogame consoles... you're shooting sprites, stick men, and space-invaders - objets d'art from the annals of videogame history."
It'll only be a matter of time, I think, before the major publishers perk up and start to realize that these indie games are setting the trend, not them
In terms of graphic design aspects of, well, anything, I think this has been true for a long time. I first started seeing games that used photograps as sprites in the indie world long before Mortal Kombat and the like came out. Fashion trends always follow some subculture, && I've seen a lot of graphic styles used by demosceners make their way onto TV over time.