Slashdot Mirror
Mutation Creates SuperKid
Tzarius writes "It's not exactly regular Slashdot fare, but the NYTimes has a story about a kid in Berlin (now 4 years old) who was born with naturally massive muscles. It's not a new condition, but it apparently hasn't been recorded in humans before. It also looks like the cause is a suppression of the myostatin protein, which could be reproducible." Reader Spazmasta adds "A gene that blocks production of a muscle-limiting protein (called myostatin) has been found in a abnormally muscular German baby. This news comes apparently 7 years after researchers at Johns Hopkins created 'mighty mice' through a related approach, turning off the gene that produces the muscle-limiting protein. I, for one, welcome our new myostatin-free overlords."
Courtesy of Yahoo here.
Bush Lies On the Record.
Muscle doubling in cattle with the same gene was publishedin 1997, with extraordinary photos of a Belgian Blue bull: HERE
Products that claim to regulate myostatin are already used by many athletes and bodybuilders.These guys are always ahead of the game.
Think like a man of action, act like a man of thought.
The cover story in the July Scientific American is about genetic enhancements of muscle. (They havent put the article online free yet.) The thrust is finding an inhibitor for the muscle-growth inhibitor called myostatin. In the article is a picture of a bovine lacking the myostatin gene. It is so bulked up, that it looks like a cylinder of meat with a nose and four hooves sticking out.
The downside is that your skeletal structure has to be strong enough to support the extra weight, your circulatory system and lungs need to be able to pump enough blood and supply enough oxygen to all that extra tissue and you need to ingest a hell of a lot more food to provide enough energy to grow and sustain your body mass, which in turn requires your digestive system can process the amount of food you'll need to eat.
Think of it as being obese, but with muscle instead of fat. Why would that be an advantage?
Agreed, as a graduate student in the biological sciences, I know that there may be numerous complications from this muscle growth. It depends on the exact function of myostatin, but some problems could be:
enlarged heart - much like someone suffering from chronic ostructive pulmonary disease (COPD). This causes the heart to work more and eventually fail
pseudo neuronal degeneration - failure of the nervous system to keep rewiring itself to accomodate the new muscles. This would lead to all sorts of failure in motor control, and eventual paralysis
These are just two that I can think of off of the top of my head. There may be other, unforeseen consequences. Of course, he could live a "normal" healthy life and get about 20 gold medals in weight lifting.
"Me fail English, that's unpossible." --Ralphie
A few years ago I managed a retail health/nutrition shop. Shortly before I left there was lots of commotion over new research involving certain myostatin inhibitors. Once such product was made from a special marine algae. You can read a review about it here.
Unfortunately, I left the position before I had a chance to discuss with any first-hand users of these things, but it looks like they're still being sold at various web sites, so somebody must think they're working.
The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems
Photo Here.
Life is the leading cause of death in America.
Googling for 'myostatin mutation' finds this, which seems to be an account of another person who has this condition, so you're probably right.
According to the Medical College of Georgia, it weakens ligaments.
From this MSNBC article:
The boy has two copies. He could (absent an extremely unlikely second identical mutation on the other copy of the same gene) only get one from his mother. The other had to come from his father. The mutation is very rare. The mother has four male relatives with one copy of the mutation. The identity of the father has not been disclosed.
Anyone care to connect the dots?
I'm not pointing this out to be cruel or catty; I'm pointing it put because it's a good example of what's called the "founder's effect", a mechanism by which mutations -- by definition unique or nearly unique events -- became part of a general population.
Since this child has two copies of the mutation, not only are phenotypic effects greater -- he's even more muscular than his mother who has a single copy -- but all of his children will have at least a single copy, like his mother.
Were the conditions for founder's effect stronger -- that is, if he were a member of a smaller and more isolated population than modern Germany -- one can easily see how inbreeding could result in the mutation becoming common throughout that population.
When two persons with a single copy of the mutation breed, one-quarter of their offspring (on average) will have, like the child being studied, two copies of the mutated form (or allele) of the gene (and no copies of the gene's normal allele), one-quarter will have two copies of the normal allele, and one-half of the offspring will have, like the mother, one mutated allele and one "normal" allele.
But when a person with two copies breeds with a person with a single copy, one-half the offspring (on average) will have two copies of the mutation, and one-half will have one copy of it.
So if there's any preferential benefit to having the mutation -- if those with the mutation do better and so have more offspring -- and if there's the in-breeding of founder's effect, the mutation should become common in the founder population.
Indeed, it's likely that founder's effect, along with environmental conditions, explains why Germans and other Europeans, despite being descended from Africans 40,000 years ago, are white rather than black: being white is bad under the Africa sun, as, unprotected, it will lead to skin cancer and death by about age twelve. But being black in the weaker sunlight of Europe prevents the metabolization of vitamin D, leading to the weakened bones of rickets. In Africa, mutations that lead to less melanin production and whiteness also lead to death -- but in Europe it allowed a longer, better life.
But how did lessened melanin production and "whiteness" spread in Europe? Likely through founder's effect in small and isolated inbreeding populations -- but certainly not because of any "Aryan" superiority.
Opinions on the Twiddler2 hand-held keyboard?
There's normally a reason for having a tight regulation of muscle growth in animals, as there's a reason for regulating cell divisions and changes that lead to growth and proliferation overall in all sorts of multicellular organisms (otherwise you'd be just a big blob of tumour).
So, taking out that regulatory protein myostatin will not perhaps be the healthies thing to do if you want to increase muscle size, as you'll just probably end up getting a heart-attack and all sorts of other nasty muscular problems with the most essential muscle tissues you have (heart and intestine at least). This sort of issues occur in GM-modified cattle with the similar myostatin mutation very regularly, and human as another not-too-distant mammal will probably not be any more safe from these problems.
I remember reading somewhere a reason why some topics in bad movies, like really giant insects, apes, humans, or to the other direction, very tiny humans (think in Giant's Land) [are unrealistic] and [it] was related to body architecture and strength of materials.
You're thinking of the cube-square law: surface area increases according to the square of the length, but volume increases according to the cube of the length. As mass correlates with volume, thus the thin legs of insects suffice to carry their weight, but elephants need thick stumpy legs.
But this has a number of biological consequences: not only would miniature elephants be (proportionally) super-strong and giant insects unable to support their own weight, but cells in the greater volume of larger animals require food and oxygen.
In an organism with a small volume to surface area ratio, all the cells are close enough to the organism's periphery to obtain their food and oxygen more or less directly from the environment. In "large" organisms, the internal cells must be supplied by the organism itself, so lungs and circulatory systems are needed.
(Indeed, the lungs -- and the intestines -- are designed to pack a lot of surface area, surfaces at which gases can be exchanged or nutrients absorbed, into a small volume, by means of foldings and branchings.)
In "medium-sized" (but still microscopic) organisms, primitive "lungs" -- as simple as a large hollow internal area lined with cells -- and "circulatory systems" -- such as an undifferentiated internal "soup" of nutrients -- can suffice.
Opinions on the Twiddler2 hand-held keyboard?
I've never heard of Richard Sandrak before; here is an interesting link. I swear, some of those photos look fake. Jeez that kid is flexible!!
Send/track messages to 100K people: www.xPressAlert.com
A picture from a Danish newspaper. He is 7 months old at this picture.
Actually, you are incorrect about the health implications.
- Muscle actually helps circulation by pushing veinous blood back towards the heart. The reason big powerlifters and Olympic lifters have problems is all the fat they have in addition to the muscle. Do leg presses and squats with light to medium weight for a few months and then walk up five flights of stairs. You will be considerably less winded than you would have been before you built those leg muscles.
- Endurance sports that don't involve long term steady activity are actually easier for muscular people. This kid may have as tough a time jogging 10 miles as someone the same weight and much fatter, but in football he'll probably catch his breath much more quickly between plays than anyone less fit.
- Bodybuilders who haven't ruined their flexibility with constant short range motions, joint damage from improper use of explosive motion exercises, and tendon damage from dangerous anabolic supplements can be extremely flexible. John Grimek, one of the greatest bodybuilders of the 20th century, could stand with his legs straight and rest his forearms on the ground. Casey Viator could touch his elbows together behind his head.
"Almah" is used 10 tens in the Hebrew scriptures to denote a young unmarried woman. Young unmarried women in ancient Hebrew society would be assumed to be virgins.
Also, the Greek translation called the Septuagint where "parthenos" is used predates Christianity by over 200 years.
In other words. Yes, "bethulah" always means virgin, "almah" implies a virgin.
There is in fact a major disadvantage that you may not be aware of.
There is a finite number of times each cell in your body can replicate itself. Excessive muscle growth WILL limit the maximum lifespan of a life form, and it limits the lifespan of humans as well.
This is part of how limiting caloric intake increases lifespan, it literally reduces the overall cellular growth of a lifeform.
I don't read or respond to AC posts