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Artificial Prion Created

jabberjaw writes "Nature is reporting that researchers at the University of California San Diego have created a synthetic prion which, when injected into mice will bring about symptoms similar to those displayed by cattle suffering from bovine spongiform encephalopathy, aka mad cow disease. The researchers first crafted healthy prion proteins using bacteria. They then shook these proteins until they resembled the tangled structure of an unhealthy prion. Afterwords, these prions were injected into the brains of mice who fell ill two years later. Perhaps someone who is more familiar with this field of research would care to fill us in on the details as the article was rather light."

26 of 496 comments (clear)

  1. whoo hoo? by grasshoppa · · Score: 5, Funny

    We gave mice mad cow disease! Yay!

    This is the first step, I'm sure, to giving it to politicians.

    On perhaps a bit more serious of a note, what does this do for us? Is this highlighting that we now know HOW the disease is created, so we can start developing a cure? Or am I wrong. Again. :)

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    1. Re:whoo hoo? by bcrowell · · Score: 5, Funny

      We gave mice mad cow disease! Yay!
      The lesson is clear. If someone comes at you with a big long needle, and wants to stick it in your brain, don't let him!

    2. Re:whoo hoo? by Anonymous Coward · · Score: 1, Funny

      No, no. It's more like, "If someone comes at you with a mouse sandwich, don't eat it!"

    3. Re:whoo hoo? by Anonymous Coward · · Score: 1, Funny

      um... artificial MS

      Must. Resist. Microsoft joke...

    4. Re:whoo hoo? by MarkGriz · · Score: 2, Funny

      Meanwhile, Tom has sworn off mouse sandwiches and has become a vegetarian. He and Jerry are quite good pals now.

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  2. the bottom line by Anonymous Coward · · Score: 5, Funny

    Don't eat the beef that comes from those experimental mice.

  3. mandatory by captnitro · · Score: 1, Funny

    If I had unhealthy prions injected into me, I'd be pretty pissed too.

  4. Ugh by Anonymous Coward · · Score: 1, Funny

    Why did I first read that as "Artificial Pron" now ? My eyes !

  5. two years?? by Anonymous Coward · · Score: 5, Funny

    they should get an award just for keeping mice alive for two years. When I was a kid my pet mice lasted like two months and I kept good care of them too. I'm not as interested in the mad cow/mice disease as I am in the mouse longevity.

    1. Re:two years?? by Motherfucking+Shit · · Score: 2, Funny
      I'm not as interested in the mad cow/mice disease as I am in the mouse longevity.
      Your spam filter must be set too high, I've been getting M.o-USsC-Le L0-N.G.eEVi-T.yY offers via email for several years now...
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  6. Artificial Beef Patties? by Billobob · · Score: 2, Funny

    1. Turn mice into gigantic mad cows 2. ??? 3. Profit!!

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  7. You do realize what this means... by Anonymous Coward · · Score: 1, Funny

    If we shake up a prion, it morphs into the type that causes mad cow disease.

    If we shake up a pop singer, it morphs into the type that causes property damage.

    Connection, anyone?

  8. Only nukes are true WMDs by tepples · · Score: 5, Funny

    Great, now we have yet another form of weapon of mass destruction.

    Artificial prions are chemical weapons, just like VX, sarin, and other nerve agents. Unlike nuclear weapons, chemical weapons are technically not weapons of mass destruction because only a nuclear reaction can destroy mass.

  9. A solution ... by Anonymous Coward · · Score: 2, Funny

    If you'd just stop felching them they would live longer. "ARMAGEDDON!"

  10. Zombie Proteins by silentbozo · · Score: 4, Funny

    The analogy I like to use is that prions are the protein version of "The Living Dead". One zombie protein will convert any healthy proteins it comes into contact with, those newly created zombie proteins will convert other ones, etc., until there aren't any healthy proteins left. It doesn't hurt that the analogy involves brains...

  11. Re:Shaking by Maljin+Jolt · · Score: 3, Funny

    Very thanks for the explanation! Now I have a really scientific reason to avoid dancing, action sports and other non-geek activities: shaking is so dangerous to mental health...

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  12. More fun way to make prions.... by servognome · · Score: 2, Funny

    Inject the protein into the mice first, then shake them until they become twisted.
    Hmm anybody want to fund my experiment, just need $80 for some mice, a paint can, and a paint mixer.

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  13. anybody else read 'Artificial prison created'? by silence535 · · Score: 2, Funny

    and I thought: Wow! But how do they keep the people there?

    -silence

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  14. Re:Explanation by Dachannien · · Score: 3, Funny

    Actually, prions are more like reality television. Normally, you have regular functioning TV shows being produced constantly by your big networks. However, the introduction of reality TV is dangerous because, due to its very low cost of production (you don't have to pay your actors anymore, since they are now "contestants"), it starts changing every other show on TV into a reality TV show. Over time, these reality shows aggregate throughout prime-time until eventually you have nothing but a hideous brain-destroying mass of crap.

  15. Re:WMD by BrokenHalo · · Score: 2, Funny
    Great, now we have yet another form of weapon of mass destruction. Terrorists could cook up a batch of prions and dump it in a water or food supply, thus killing off lots of people a short period of time later.

    Probably quicker to just grab a few mice and chuck them into the hopper at a McDonald's factory. After all, it's not as if anyone would notice the difference in taste... :-)

  16. Ok... by cdemon6 · · Score: 2, Funny

    Everybody (else) who read "pr0n" instead of prion, please sit down and think about what's going on in your life...

  17. Re:Mad cow acceptable level of risk to big busines by Speed+Racer · · Score: 2, Funny

    For example, most cheese is made with animal-based rennet.

    I hear that they sometimes use animal-based milk as well.

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  18. Artificial Pr0n? by ntr0py · · Score: 3, Funny

    The only reason I clicked through to the comments is because I thought the headline said, "Artificial Pron Created"

  19. Re:You Sir by Profane+MuthaFucka · · Score: 3, Funny

    I've seen worse ways to die than CJD. Yes, I read Stile Project and Consumption Junction.

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  20. Re:Ah, the mandatory fscking stupid conspiracy the by SydShamino · · Score: 4, Funny

    >> You know what? There's a medical name for that. It's called "Paranoia".

    There are treatments for paranoia, but I know the world government is keeping the best of them hidden from us... ;p

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  21. Re:You Sir by gid-goo · · Score: 3, Funny

    I have done some personal MDMA neurotoxicity experiments which have demonstrated that it gets me incredibly high. And my jaw hurts the next day.