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Bacterial Printing Press

juushin writes "New Scientist has reported that scientists at Harvard University have created a bacterial printing press that can be reconfigured to print complex patterns of bacteria. The technology is reported to have applications in studying biofilms, communication between bacteria (and colonies of bacteria), and the interaction of bacteria and surfaces. Of medical interest, these applications may lead to a better understanding of how to prevent bacterial infections."

49 of 90 comments (clear)

  1. The possibilities... by Albinofrenchy · · Score: 1

    It would be kind neat to have bathroom tiles that grow into flowers.

    --
    "A man is but the product of his thoughts what he thinks, he becomes." -Mahatma Gandhi
    1. Re:The possibilities... by CaptainPotato · · Score: 1

      ... if you live in the 1970s perhaps. Most people I know pull off the horrendous flower bathroom (and kitchen) tiles that were the bane of bad 1970s home renovations (in Australia, that is...)

      Or were you thinking of tiles that you could plant after they have served their official life spans as tiles?

      --
      I heard that your library burnt down and destroyed your only two books - and one was not even coloured in yet.
    2. Re:The possibilities... by Mancat · · Score: 1

      I knew you were kidding when you said "neat."

      --
      hello dear sirs my name is jamesh i are india (bihar) can u guide me install red had linux 9?
  2. Hmm. by FireballX301 · · Score: 2, Interesting

    I actually did RTFA. This basically seems like a neater way to make a Petri dish.

    He uses bacteria as 'ink', and presses the bacterial mold onto a sheet to produce a bacteria pattern.

    I'm not exactly sure why this is better or worse than simply pipetting bacteria into a large petri dish, though.

    1. Re:Hmm. by palndrumm · · Score: 1

      I'm not exactly sure why this is better or worse than simply pipetting bacteria into a large petri dish, though.

      It's better because it allows much more detailed and accurate patterns of bacteria to be deposited - using a pipette pretty much all you can do is stick a blob of gunk on a bit of glass.

  3. stamping rather than ink-jet based... by blackcoot · · Score: 3, Funny

    it's a neat process. before i read the article i'd pictured an inkjet-esque approach. probably a good thing they didn't go that way --- can you imagine how much consumables would cost? to say nothing of issues related to poor quality drivers...

    1. Re:stamping rather than ink-jet based... by drgonzo59 · · Score: 1

      Actually ink can be a good bacterial growth medium. Especially polygraph ink (for Grass polygraphs, we use them at the lab). It even comes with a warning that bacteria will grow rappidly in it and to make sure to clean it up. So yeah, I can see sprinking some of that ink to 'seed' a pattern that baceria will further grow and develop, even on someone's skin...

  4. Quite ingenious by Dancin_Santa · · Score: 3, Insightful

    He takes a tip from the silicon chip makers and uses the same type of technology to etch a pattern in a wafer. Then he creates a mold (like a mask, not like the stuff growing in the crotches of slashbots) which he can use repeatedly as a printing template.

    Since a lot of bacteria grow resistant to antibiotics, it makes sense to use this kind of "printing press" to study how they create their protective biofilm. As a species, we are slowly succumbing to our own success at killing off bacteria. However the rise of super-bacteria that are immune to our medicines is a huge worry. If this type of research can shine some light on why these bacteria are so resistant and how we can control them to be less dangerous to us, then we will be able to hold off our extinction for a few more years.

    1. Re:Quite ingenious by MAdMaxOr · · Score: 2, Insightful

      >> then we will be able to hold off our extinction for a few more years.

      We're not in danger of becoming extinct from bacteria resistance. We adapt too.

    2. Re:Quite ingenious by Anonymous Coward · · Score: 1, Insightful

      Since a lot of bacteria grow resistant to antibiotics, it makes sense to use this kind of "printing press" to study how they create their protective biofilm.

      Antibiotics resistance usually has little to do with biofilm structures, more with genetic adaptations that alter the original target of the antibiotic, making the bacteria resistant to it. When a bacterium happens to combine a series of those adaptations, it becomes multiple drug resistant, which is where the actual problem lies that we're starting to face today.

  5. old news by helfen · · Score: 3, Insightful

    Stanislaw Lem predicts it about 20-30 years ago in some of his novel.

    1. Re:old news by kfg · · Score: 1

      And now, with a bacterial printing press, they can read it. Just what we need, literate bacteria.

      KFG

  6. Yay Finally by inflex · · Score: 2, Funny

    Now I can get my [fake mail order] University Degree /and/ real [bacterial] culture diversity all on the same certificate.... just like if I had gone to Univeristy and dorm-hopped, or eaten cafeteria food.

  7. Oh-Oh by kabz · · Score: 2, Funny

    Lets hope this doesn't get combined with the http://slashdot.org/article.pl?sid=05/02/03/033023 8sushi printing cartridge ...

    With hilarious consequences.

    --
    -- "It's not stalking if you're married!" My Wife.
  8. Re:How to tell if you are a linux fanatic. by Albinofrenchy · · Score: 2, Funny

    Sit the fuck down and shut the fuck up.

    The radical group you are trying to piss off happens to have the same idiotic arguments as you, but is on the other side of the spectrum. And both groups are morons.

    I'm tired of this trendy shit in \. where at the drop of a fucking hat people start categorizing people as either a Linux Zealot or a M$ Luvers. Technology is not meant to be worshiped, it is meant to be used to accomplish a goal, and you should use whatever best fits that goal, windows, linux or a fucking ti83. It's a minority that occupies these radical areas, albeit a vocal one. And I would like to say to both groups:

    SHUT THE FUCK UP.

    --
    "A man is but the product of his thoughts what he thinks, he becomes." -Mahatma Gandhi
  9. Now I can..... by there_can_be_only_on · · Score: 1

    Really play the game of Life!!!!

    1. Re:Now I can..... by Alien+Being · · Score: 1

      Would you have died of loneliness?

  10. bacterial computation by carcosa30 · · Score: 5, Informative

    This sounds like a good way to study computational properties of bacterial colonies. By printing them like this, perhaps they would be able to get them to behave in ways that would perform useful information processing. It might also end up acting as some sort of "interface" to DNA computation.

    Whether we'd be able to get them to behave in reproducible ways would be the question.

    Here are some links. The first has some interesting photos of bacterial colonies-- similar to cellular automata, because hey! They are! And the second is a link to an article on bacterial colony computation. Or maybe they're both to Goatse. You won't know until you click.

    http://alnk.org/dankwish
    http://alnk.org/nearseal

    --
    Intolerance for ambiguity is the mark of the authoritarian personality.
    1. Re:bacterial computation by nandu_prahlad · · Score: 1

      Dude thanks for the links.
      Quite an eye opener!

      Are you working in this field? Could you direct me to more material on bacterial computation? I'd love to know more.

    2. Re:bacterial computation by carcosa30 · · Score: 1

      No, I'm not. I'm just an amateur real interested in artificial life.

      It's so much more interesting than real life.

      http://online.itp.ucsb.edu/online/pattern_c03/p_be njacob/

      --
      Intolerance for ambiguity is the mark of the authoritarian personality.
    3. Re:bacterial computation by nandu_prahlad · · Score: 1

      Fantastic art! BTW I'm an amateur scientist as well ;-)

    4. Re:bacterial computation by juushin · · Score: 1

      for the most interesting stuff, see: Drew Endy or Tom Knight (MIT) James Collins (Boston University) Michael Elowitz (Princeton) Stanislas Leibler (Rockefeller University)

  11. Sounds familar... by __aaclcg7560 · · Score: 3, Funny

    Just remember not to use anti-bacterial soap on your bacterial printer. Otherwise, you will void the warrantry.

  12. Here... by UniXY · · Score: 2, Funny

    have a copy of my latest research on flesh eating bacteria. Be sure to note the texture!

  13. Tommorow's Paper by Valcoramizer · · Score: 1

    Even as you are reading this, you are being infected by...

    --
    We raise our slide-rules high.
  14. Game of Life by Craig+Ringer · · Score: 3, Insightful

    I can't possibly be the only one who immediately thought "game of life" ... can I?

    Too bad it'd never work - not unless you could find some REALLY weird bacteria, anyway.

    1. Re:Game of Life by richie2000 · · Score: 1
      I can't possibly be the only one who immediately thought "game of life" ... can I?

      No, you could not.

      --
      Money for nothing, pix for free
    2. Re:Game of Life by FirienFirien · · Score: 1

      I thought it straight away too ;)

      Too bad it'd never work - not unless you could find some REALLY weird bacteria, anyway.

      For the 'standard' rules of the Game of Life, this is probably true. Remember though that the rules are changeable; with most real bacteria you've just got a higher chance of survival at higher densities, or some form of lifespan - each point lasting longer than a single turn, with the state of each turn also affecting the lifetime left and spread per unit.

      David Brin's Glory Season takes the Game of Life a step further - proper competition. You line up your array on your side of the board, and your opponent on theirs; after the Go, no more changes can be made, and the winner is the one who has the most live cells on their side when stability is reached.

      With bacteria, this would need a fair amount of adaptation, and might be hindered by the tendency to clump, but I'm sure that various things like a trigger on overdensity that released a short-lived poison onto the board... clusters that had detached from the main would be more likely to survive this, etc etc.

      You've also got elements of 3D being introduced... thick bacteria, thin bacteria, air transfer rather than direct contact with the next cell... could be restricted by laying the single sheet between two slides...

      It certainly requires a fair bit more innovation than the simple 2D board, but that's only to be expected. It is at least a fun thought experiment; rather than the Game of Life being unlikely, just consider this as simply being a heck of a lot more complicated >:)

      --
      Browsing with +2 to insightful posts and a higher threshold makes the average post seen seem a lot more ingenious
  15. Neural experimentation kit? by mattr · · Score: 1

    I'd like to see a 2-D equivalent of a habitrail, where you have wells connected by thin tubes, with wires dunked in all over the place. Fill a well with neurons (or stem cells???) and start up a circuit you've programmed before to send specific analog or digital pulses to different wires. Then let it grow throughout the network with the circuit running. Would this not be an interesting way to learn about brain organization and also organic computing? Maybe you could even heat the wells differently or otherwise treat them? Give them a way to output to your circuit and create feedback?

  16. Spatial Properties by putko · · Score: 2, Interesting

    It seems a lot of interesting science happens at the spatial/topological/geometrical level.

    E.g. those bioplaques can be real killers. Models of bacteria that assume they are all evenly distributed in 2-space or 3-space really don't cut it.

    Same thing with blood vessels. They aren't solid tubes, like the plumbing in your house. There's all sorts of transverse stuff happening that doctors fail to model and take into consideration.

    Or materials science -- all the "edge effects" that people like to ignore, because they are necessarily messy.

    If this advance allows them to study different geometries of bacteria cheaply, that will be a big step -- they'll be able to run big batches of simulations of different layouts. Hopefully they'll get their models right and do better work.

    --
    http://www.thebricktestament.com/the_law/when_to_s tone_your_children/dt21_18a.html
  17. Novel application of existing technology by StateOfTheUnion · · Score: 2, Informative
    I like the novel application of existing technologies. He's using agarose medium, pipetting, and casting into a photolithographic mold.

    One thing in the article that is a bit deceptive is that the article says that one can print with details as small as one micrometer . . . the size of a single bacterium. This may technically be true, but I doubt that controlling which individual bacterium are transferred (printed) or not is possible. And the neither the technique of pipetting bacteria nor regrowing bacteria on the agarose media is likely to have a resolution of one micrometer. Though the postulated one micrometer resolution may be possible, it is for all practical purposes impossible.

    1. Re:Novel application of existing technology by juushin · · Score: 1

      if you read the article (Langmuir) and then read what new scientist wrote, you can see that they screwed up by writing that it is possible to pattern single bacteria. the article hints that this might be the direction that the scientists are moving, but that they aren't at this level yet.

  18. Well that allows... by rcbarnes · · Score: 1

    Censorship via penicillin! "My dog ate my homework" replaced by "my mom's medicine ate my homework" would be good fun, too...

    --
    "Fight for lost causes. You may discover they weren't."
  19. Yeah, well... by Black+Parrot · · Score: 1


    I've dripped cheese on my printer a time or two as well, but it never seemed suitable for a Slashdot headline.

    --
    Sheesh, evil *and* a jerk. -- Jade
  20. Re:How to tell if you are a linux fanatic. by calculadoru · · Score: 1

    Wish I had points to mod you back up. (Even though it is offtopic)

    --
    The power of accurate observation is commonly called cynicism by those who have not got it. -- G.B. Shaw
  21. Re:How to tell if you are a linux fanatic. by natrius · · Score: 1

    I'm tired of this trendy shit in \. where at the drop of a fucking hat people start categorizing people as either a Linux Zealot or a M$ Luvers.Technology is not meant to be worshiped, it is meant to be used to accomplish a goal, and you should use whatever best fits that goal, windows, linux or a fucking ti83.

    Backslashdot? BACKSLASHDOT?! You... you... M$ LUVER!!!

    Now excuse me while I port Linux to my TI83.

  22. Only on way to explain that adolecent rant... by TapeCutter · · Score: 1


    You finally got an interview with that oh-so-fuckable headhunter at the agency, didn't-ja.

    Then she told you it takes more than "installing a distro on mum's PC" to get a $100K blow ...err... dream job.

    You ran off home to mum's basement, had a wank (staring the headhunter), got stoned and started posting.

    --
    And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  23. Transfers by iamdrscience · · Score: 1

    I was thinking about how I could maybe use these printers to make a bacteria t-shirt transfer but I ultimately decided to just sneeze on my shirt instead.

  24. Obligitory simpsons. by TapeCutter · · Score: 1



    Homer at sushi bar - "What is number 23? I haven't had that one yet".

    Waiter - "Number 23 is Poison Fish".

    Homer - "Poision!!"

    Waiter - "Do not be concerned about eating poison fish it is the head chef's speciality, also there is a map to the hospital on the back of your menu."

    --
    And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  25. Oh great... by Spacejock · · Score: 1

    A printer which is full of bugs by design.

  26. My first thought was plumbing. by TapeCutter · · Score: 1

    Most water supplies have a scummy film that grows on the inside of the pipes (even copper pipes), the film is impervious to chlorinated water. Water companies want a simple way to remove it.

    --
    And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  27. Re:Next generation of computer viruses? by Chris+Daniel · · Score: 1

    Do you just read headlines or what?

    --
    Don't blame me -- I voted for Roslin.
  28. Bacterial Printing press? by StarCharter · · Score: 1

    Why is this a good thing? I mean, how much can bacteria read anyway?

  29. Real Life by clickety6 · · Score: 1

    Perhaps we can print some bacterial colonies in classic LIFE patterson then let thenm breed and see how well it replciates the old computer game :-)

    --
    ----------------------------------- My Other Sig Is Hilarious -----------------------------------
  30. Well this is going to make Snail Mail by crovira · · Score: 2, Informative

    a thing of the past. You already have to watch out when opening hand addressed mail for anthrax and shit like that but you have just lowered the bar for spreading viri.

    Now it doesn't have to come by an email either.

    Send something that looks like junk mail to a congressman's home in the winter and you can just see the trail of death and destruction because the ink itself could kill you. (ebola 'flavoured' ink anyone?)

    I don't think this is too smart but the cat's out of the bag now. Pretty soon we're going to need transparent exo-skins to do anything. (Think about it.)

    --
    MSBPodcast.com The opinions expressed here are my own. If you don't like 'em... Think up your own stuff.
  31. The killer "I'm Sorry" card... by IronChefMorimoto · · Score: 2, Funny

    "Lisa, look -- I'm really sorry I've been sleeping with my secretary at work. I never thought you'd come looking for me in the janitorial closet at 2am on a Sunday morning."

    "Harold -- there's no excuse for this -- I want a divorce, and I'm taking EVERYTHING! INCLUDING THE DOG!"

    "But, Lisa -- I really want to apologize -- this card says it all..."

    "Card? What? How pathetic...oh...wait...what a wonderful photo from our wedding, Harold..."

    "Yeah -- I made it myself with a new printer we got at the labs at the office..."

    [wife reads card -- eyes tear up -- lip trembles]

    "Oh, Harold...I love you so much...I accept your apology..."

    [wife tries to kiss husband]

    "Wait -- I'm not worthy of that kind of love just yet...give it time...so you know it's real again..."

    "You're right, Harold. I'll read this card over and over and remember that you're going to make an effort to be better and more faithful..."

    [28 days later]

    "Well, Harold -- it's the weirdest thing..."

    "What's that, doc?"

    "I have no idea how your wife got a case of bubonic plague. Did you guys have rats in your house?"

    "Nope. Really odd. Oh, well."

    "It's a mystery to me, Harold. She died such a painful death."

    "Yes...she did... Well, I'm off for an appointment. Gotta pick up my secretary. See ya doc!"

    IronChefMorimoto

  32. Re:Good work but by juushin · · Score: 1

    yup. is there shame in slashdotting yourself? i read slashdot and i do science.

  33. Please. This has been done for years! by writermike · · Score: 1

    I worked in printing for 11 years and have seen the various sores and cuts on many a pressman. Believe me, they've been printing bacteria for a long, long time.

    Pathogens, too!

    And diseases.

    Oh, and don't forget syndromes...

    --
    If Nalgene water bottles are outlawed, only outlaws will have Nalgene water bottles.
  34. Muppet Labs! by SuperBanana · · Score: 1
    to say nothing of issues related to poor quality drivers...

    "Okay Beaker, print out a test page now!"
    "Meep"

    [Whiirrrr zip whirrrrr zip whirrr]

    "RAWWWWR!"
    "Mee...meee...MEEEP MEEEP MEEEEEEP!"
    "Good job, Beaker! Now we know that is definitely too much biological ink!"

    (with apologies to the writers of Muppet Island).