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Engineers Implant Vascularized 3D Muscles

An anonymous reader writes "A big hurdle to creating "replacement parts" for the human body is the lack of an internal, nourishing blood system in engineered tissues. Using a stem cell "cocktail," researchers say they've now overcome that, and successfully implanted engineered muscles in lab animals. Next stop, genuine implantable pecs?"

42 comments

  1. Waiting isn't too hard... by mister_llah · · Score: 2, Insightful

    Well, it'll be nice to be able to graft some muscles on and all that, but I'll do what I do with software releases... I will wait until awhile after the technology is released, so that all the misfortunes occur to the impatiently eager... and then when the technology will not have a chance of leaving me a parapalegic or something, then I'll go for it...

    === ... but this is fun stuff, especially considering the article on cloned brain cells... perhaps this means we are nearing cloned stem cells? ... and then the moral ambiguity of stem cell research is only in cloning issues, one step closer to pleasing everybody!

    Yee haw!

    --
    MoM++ - A Classic Expanded - [Master of Magic 1.5]
    http://mompp.sourceforge.net/
  2. Schwarzenegger upgrade module by ealfert · · Score: 1

    Can't wait until I can order a Schwarzenegger upgrade module. :)

    1. Re:Schwarzenegger upgrade module by Leroy_Brown242 · · Score: 1

      Well, I'm sure early models will be as bad as early breast implants . . . .

    2. Re:Schwarzenegger upgrade module by ealfert · · Score: 1

      "Well, I'm sure early models will be as bad as early breast implants . . . . " Bit your tongue... there are _no_ "bad" breast implants.

    3. Re:Schwarzenegger upgrade module by Leroy_Brown242 · · Score: 1

      Oh, there are some very bad implants.

      If they move, or deflate, or whatever.

      eeeewwww. So gross.

    4. Re:Schwarzenegger upgrade module by TripMaster+Monkey · · Score: 1


      Bit your tongue... there are _no_ "bad" breast implants.

      I beg to differ...

      --
      ____

      ~ |rip/\/\aster /\/\onkey

    5. Re:Schwarzenegger upgrade module by ealfert · · Score: 1

      I stand corrected. I was wrong!

    6. Re:Schwarzenegger upgrade module by Anonymous Coward · · Score: 0

      AARGH!

      A NSFW tag would be appreciated in the future.

    7. Re:Schwarzenegger upgrade module by 19thNervousBreakdown · · Score: 2, Insightful

      OK, normally NSFW tags are nice, but:

      • You're in a discussion about breast implants.
      • The link is to a website called siliconeholocaust.com, that's
        silicone: The things breast implants are made out of. holocaust: Something horrible. .com: A website.
      • The document linked is photos1a.html. There might just be picutures there.

      Given these facts, it would be a pretty good bet that you shouldn't click the link if you're at work, but then again I could see how you would think it's the Cliff Notes for the novelized version of Dawson's Creek.

      --
      <xml><I><am><so><damn>Web 2.0</damn></so></am></I></xml>
  3. Downsides... by RootsLINUX · · Score: 4, Funny

    Now I'm even *less* motivated to exercise than before, which I thought was impossible. Maybe I could get really strong leg muscles implanted (like those of a cheetah) and then I wouldn't need to be stuck in traffic for 30-60 minutes a day. I'd just run to work at 60+ MPH!!! Abusing technology is what American's do best after all.... >_>

    --
    Hero of Allacrost, a FOSS RPG for *NIX/*BSD/OS X/Win
    1. Re:Downsides... by bluGill · · Score: 1

      Considering the relative efficiency of cars vs humans, abusing resources is right. You will need a lot more energy from food than you car burns. That is at a normal aerobic run pace, the Cheeta can to 60 mph, but only for a short anaerobic sprint, which is an order of magnitude less efficient yet.

      Now if you were going to bike to work you might have a chance, so long as you were willing to stick to aerobic speeds. I'm not a doctor, but I suspect that to increase aerobic speeds you need to work on the circulation system first, not muscles. (the heart is a muscle, but only a small part of the system)

      Get a car that runs on ethanol/biodiesel if you don't want to abuse resources - in the end it is more efficient than exercise. (but you won't live as long)

    2. Re:Downsides... by drightler · · Score: 2, Interesting

      Humans are way more energy efficient than cars. Assuming a human could run at 60mph, and assuming gasoline could be comsumed rather than food:

      1 gallon of gasoline contains 33000 kCal (calories).
      A human burns 0.653 kCal (calories) per mile per pound of body weight.
      Assume a 200 pound man.

      200 * .653 * 60 = 7836 kCal (calories). This is about 23.75% of a gallon. About 252.68 miles/gallon.

      --

      blah blah blah....
      drightler@technicalogic.com
    3. Re:Downsides... by drightler · · Score: 1

      Of course I'm sure the efficiecy comes from humans weighing signifcantly less than the average car.

      --

      blah blah blah....
      drightler@technicalogic.com
    4. Re:Downsides... by bluGill · · Score: 1

      Did you account for digestion inefficiencies? As your numbers for aerobic or anaerobic running?

      As you already noted, a car is significantly more mass. In fact VW's 1 liter car has similar efficiencies, despite being a car plus the man.

    5. Re:Downsides... by dmaduram · · Score: 2, Interesting

      Just as a fyi, if you're interested in swapping muscles with a different species, you'd probably be better off using the rat IIb fast-twitch myosin muscle filament, instead of the cheetah.

      There was a great article about gene therapy & interspecies muscle filament switching a few years ago in Scientific American, and they noted that switching muscles with another species could be problematic under duress, because the resultant strain on the quadriceps could physically rip out the hamstring, patella tendon, and tibia bone, eventually causing the quadriceps to shoot up the femur.

      Muscle, Genes and Athletic Performance. Andersen, Jesper L.; Schjerling, Peter; Saltin, Bengt. Scientific American, Sep2000, Vol. 283 Issue 3, p48
    6. Re:Downsides... by NanoGator · · Score: 1

      "Now I'm even *less* motivated to exercise than before, which I thought was impossible.... I'd just run to work at 60+ MPH!!!"

      So.. how are you going to do that and avoid the exercise part?

      --
      "Derp de derp."
    7. Re:Downsides... by BerntB · · Score: 1
      Cool reference! Will go read it.
      that switching muscles with another species could be problematic under duress, because the resultant strain on the quadriceps could physically rip out the hamstring [etc]
      You would obviously have to reengineer tendons and placement of muscle connections, too.

      We might change most animals and plant life the coming few few hundred years. (And not only pets looking like manga people.)

      Maybe the animals in Vance's Dying Earth (and other books) was realistic?!

      Consider what would happen if a later war sends us back to the stone age.

      Any later technological civilization would then start going over the fossils and doing gene comparision... lots of insane researchers!! :-)

      --
      Karma: Excellent (My Karma? I wish...:-( )
    8. Re:Downsides... by BoogieChile · · Score: 1

      As opposed to say, abusing apostrophes.

  4. Adding "new" body parts? by lilmouse · · Score: 1

    If they can get nerves to grow too, then perhaps they can grow things like a tail for a person - a tail that will actually move, wiggle around, twitch, etc...

    Or imagine putting extra rings of muscles in certain orifices, or in certain appendages to give more movement?

    "Body mod" could take on a whole lot of new meanings!

    --LWM

    1. Re:Adding "new" body parts? by Leroy_Brown242 · · Score: 1

      Like being able to scratch your balls your wang?

    2. Re:Adding "new" body parts? by 19thNervousBreakdown · · Score: 1

      God damn fucking furries...

      BTW, the vagina and ass already have lots of muscles, and hitting the G-spot is pretty easy, just have her push her hips up and go in from a low angle. Sex has been around for a long time.

      Unlike fucking furries.

      --
      <xml><I><am><so><damn>Web 2.0</damn></so></am></I></xml>
  5. The link to the article by mister_llah · · Score: 1

    http://www.cnn.com/HEALTH/9804/27/parkinsons.cloni ng/ ... [the cloned cells were bovine, but hey, its a start] ...

    ===

    If the future is going to be a scary place, at least I'll have the muscles to beat it up...

    --
    MoM++ - A Classic Expanded - [Master of Magic 1.5]
    http://mompp.sourceforge.net/
    1. Re:The link to the article by Alsee · · Score: 1

      From your link:
      Researchers at the University of Colorado transplanted cloned bovine brain cells into the brains of rats.

      What are we going to do tonight Brain?
      Same thing we do every night Pinky, stand around eating grass and gazing vacantly into space.

      I for one welcome our new bovine-genius rodent overlords.

      Just imagine a beowoulf cluster of bovine-brained rodents!

      Natalie Portman! Parkinson-petrified and lactating!

      But do these rodent brains run Gncow-Linux?

      In Soviet Russia rats implant bovine brain cells in YOU!

      1) implant bovine brains in rats
      2) ???
      3) PROFIT!

      The Kansas School Board has outlawed the teaching of evolution to hyperintelligent rats.

      My brain is made of bovine brain cells you insensitive clod!

      All your brain are belong to moo.

      Researchers report: bovine brain cells implanted into George W. Bush died of loneliness.

      MPAA lobbies congress to mandate Digital Rights Management flag on all implanted brain cells.

      Brain cells want to be free!

      Why is my mouse is mooing?

      Ok... ok... I'm sorry. I get silly when I haven't slept. My bad.

      -

      --
      - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
  6. Hail your new leader by Anonymous Coward · · Score: 1, Funny

    I for one welcome our new bio-engineered overlords.

  7. Sadly... by mister_llah · · Score: 1

    The brain is organized in a certain way that I am not sure (as I am uneducated in that particular area) that it would work quite as one might hope.

    Much like we need physical therapy to learn to use our muscles after an accident... I'd imagine that you'd need to go through tail therapy to be able to work in the control for those new muscles, if it is possible at all.

    [Hard to say, I do know a bit about the language centers of the mind, and there is a set range of time that they need to be developed in or they can't be extensively developed at all... and I don't know if this is the case for muscle use, so I'm going to shush and just leave it at all of this]

    --
    MoM++ - A Classic Expanded - [Master of Magic 1.5]
    http://mompp.sourceforge.net/
  8. Don't be surprised by marcus · · Score: 1

    These ideas are just the beginning...

    How about, not just mods, but variable, adjustable ones?

    Heading for the tropics? Forget sunscreen, turn your skin black, really.

    Going to do ocean research, in the ocean? Grow yourself a sleek torpdeo shaped body with fins.

    Time to head back to the lab? Grow your body into an eight armed lab 'bot.

    Want to go hiking and backpacking this Summer? Start growing our feet into hooves and an extra pair of legs. Become a centaur for the Summer.

    Having kids and need to watch everything? Grow some more eyes, even in the back of your head.

    --
    Good judgement comes from experience, and experience comes from bad judgement.
    - W. Wriston, former Citibank CEO
  9. Fortunately by lilmouse · · Score: 1

    Did you see the article about the monkey's learning to move the robotic arm? If we can teach monkeys to use a third arm, why not teach people to wiggle their wangs (or tails if you want to be PG13) at will? Same idea!

    Yeah, it'd take some effort, but it's certainly doable, and I expect it will be done.

    --LWM

  10. Indeed by mister_llah · · Score: 1

    There will be all manner of new appendages, I'm sure, might even become a fad to have some new limb added ;) ... good excuse for people to get a personal trainer, too!

    --
    MoM++ - A Classic Expanded - [Master of Magic 1.5]
    http://mompp.sourceforge.net/
    1. Re:Indeed by forkazoo · · Score: 1

      This week only, buy second head, get third arm free. Great place to store your extra half brain!

  11. To the wealthy go the spoils by sithsasquatch · · Score: 2, Funny

    I'm sure it will take a while, but when it is a commercially viable procedure, this stuff will probably cost insane amounts of money.

    This leads to an obvious problem: If the rich and powerful are also physically stronger than us, how are we gonna overthrow them?
    Seriously, muscles harnessed for long toil under the blazing sun won't be able to compete with these cyborg implants!

    We must act now, before the muscles are implanted, and before the damn upper class becomes impervious to our insurrection. To arms, comrades!

    Viva la revolucion!

    --
    With so many ppl on /., how am I supposed to come up with a unique sig?
    1. Re:To the wealthy go the spoils by JofCoRe · · Score: 1

      This leads to an obvious problem: If the rich and powerful are also physically stronger than us, how are we gonna overthrow them?

      Guns. Lots of guns. As they say: "God didn't make all men equal, Samuel Colt did."

      --

      Place sig here.
    2. Re:To the wealthy go the spoils by rbarreira · · Score: 1

      The richer guys would/will also have guns and would/will pay a lot of the weak guys to fight for them...

      --

      The AACS key is NOT 0xF606EEFD628B1CA427BEA93A9CA9773F
  12. No, No, its not about enhancement, augmented... by ElitistWhiner · · Score: 1

    body parts which is all the rage with bio-this, clone-that marketing hype you guys seem to drool over so easily.

    Surgeons most difficult obstacle to success isn't the surgery task but the _re_vascularization of the affected area. Skin grafts, tissue implants and such depend upon a *healthy* supply of bloodflow to nourish the new tissues as a result of surgical intervention.

    The choice now is cut&paste, well scalpel and sew but one area has to sacrifice its vascularity for another area which has lost its vascularizion as a result of surgery.

    This changes outcomes for the positive for surgeon and patient. Wahoo!

  13. Problem: Kids with rich parents all get upgrades by relaxrelax · · Score: 1

    This happens in 5 years...

    Arnold Schwartzanegger: but I'm the real actor, er, I mean the real senator!

    some dude: Ivy league kids tell me that 5 times a day, and they're all exactly the same musculature up to the milimeter. So wait in line like everybody else, mr. terminator!

    P.S.: The exercice programs are dying! )I guess the overlord thing is taken).

    --
    Microsoft is pure dog-ma. FreeBSD is pure cat-ma.
  14. Growable meat by AmicoToni · · Score: 2, Interesting

    Growing muscle tissue on demand actually means growing meat. Which can be edible meat.

    Is the science-fiction scenario of growing meat without farming closer? It sure would represent a whole new source of high-quality, "ethically correct" proteins.

    But would you eat such a thing?

    1. Re:Growable meat by nimblebrain · · Score: 1

      Sumna biach, I'm uninstalling Autoform as soon as I get the chance :)

      I remember a story called "Angel Station" where they had "vat meat". I was pretty enamoured of the concept at the time, really. Hell, I eat and enjoy hot dogs - by-products and all.

      Seriously, though, the search to clone organs has been on for quite some time, and 'vat-grown meat' is very likely to happen at some point in time in the future. It won't happen on its own; some strange enlightened vegan or ex-Microsoft philanthropist will have to get the idea in their heads. There's a need for cloned organs regardless, though, so the longer it takes for someone to do vat meat, the cheaper it will be at the outset.

      The fates of the farm animals of the future might be more up in the air, but it could be for the better. An economy of scale may no longer be required for some of the meat animals - this may push the balance back to smaller farms. It may depend on lobbying and advertising, though - you better believe that big operations, especially for chicken and pork, are going to take every opportunity to denigrate vat meat.

      What would they call vat meat, though? "Vat meat" doesn't sound appealing as a name at all :)

      Another kink in the road is Thermal Depolymerization. One argument against using real animals would be the waste products, but Thermal Depolymerization is proving its worth in trials in turkey processing plants, turning the waste into something useful.

      I leave the actual prognosticating to others :)

      -- Ritchie

      P.S. Sorry for the other post - Autoform pulled that up after I did my preview. Grrr. Fool me twice.

      --
      Binary geeks can count to 1,023 on their fingers :)
  15. Re:A Quick Question by nimblebrain · · Score: 1

    Hear, hear.

    I've been quite surprised at the influx of "odd" observations over the past few years; I certainly wasn't expecting local pancake structures.

    You raise a pretty good point, though, on the structure of disks, large and small, in the first place.

    Plasma physicists jump up and down that the in-vogue theories treat large-scale magnetic fields and currents as non-existent, as though charge must cancel out on the large scale, therefore it has no effect. Sometimes, they make a good point - some of the disk systems do resemble dynamos.

    Some of the papers I've read in passing on "push" gravity theories estimate that the force of gravity is proportional to 1/d**2 locally, but trends to 1/d on the outsides of the galaxy. Otherwise, there's a lot of unseen matter there (and we haven't seen anything resembling the high-velocity clouds gathering on the edges of the galaxy)... or, alternately, we're ignoring a dynamo effect.

    Or... etc. (Assuming we stop before postulating that angels sit on the edge fanning galaxies with their wings ;)

    It's the bank of poorly-explained pieces that will lead us to our next big theoretical breakthrough (or revolution) - but it takes some special vigilance to keep track of what hasn't actually been explained properly, and what's been merely papered over.

    Too many tweaks. They should have realized something was wrong sometime between inflation theory, and dark-energy-requiring ever-increasing-acceleration theory. Plenty of duct tape on things already :)

    By the way, speaking of aether... ;)

    I can understand the establishment position somewhat... it's either duct tape or anarchy. There's got to be a standard to measure against, but if the explanations start stretching thin, they need an exit strategy.

    If that day comes, they will need to exit to something, though. What's out there that can explain the pancakes at multiple scales of the universe and other phenomena as well?

    Perhaps they need to take a page out of other research and development, and apportion some funds to "blue sky" research.

    The biggest dividends will come from research that's reviewed for logic, self-consistency and explanation of phenomena without regard to how well it fits into prior patterns. Pro-Ams and people in fields with more easily measureable results (applied sciences, for one) realize these benefits, but being in a field where so many assumptions have to be made to interpret the results in the first place make this next to impossible for the theoreticians to condone dissent.

    Everybody's MMV :)

    -- Ritchie

    --
    Binary geeks can count to 1,023 on their fingers :)
  16. Neuromancer to become reality? by hcdejong · · Score: 1

    woo hoo! :starts planning to create Molly:

  17. Re:A Quick Question by zero_offset · · Score: 1

    Wow, talk about replying to the wrong post... Admittedly, at first I thought, "Maybe the 'local pancake structure' reference is some kind of complex food-related pun I'm just not getting..."

    And by the way, Hell Yes I would eat vat-grown steaks. In a pinch I will occasionally eat the weird shit McDonald's sells. A little vat veal couldn't be any worse.

    --

    Slashdot quality declines as the number of hot grits posts decreases. - Provolt's Law, Apr-09-2005

  18. Re:A Quick Question by CFTM · · Score: 1

    I seriously doubt that vat-grown steak can cause your liver to fail like the mystery meats over at McDonald's...anyday of the week in my book :)

  19. Yes! by ebuck · · Score: 1

    That would improve my ski-boxing, like, immensely!

  20. I would love to mod you up. by arete · · Score: 1

    I haven't wanted to mod somebody "Funny" so much in a long time. Maybe I'm just as tired : )

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