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U.S. Scientists Create Zombie Dogs

Alex_Ionescu writes "U.S. scientists have managed to revive dead dogs to life, by using a technique similar to cryogenation, in which the dogs' blood was drained and replaced by a cold, saline liquid. A couple of hours, their blood was replaced, and an electric shock brought them back to life with no brain damage. The technology will be tested on humans within the next year."

31 of 1,010 comments (clear)

  1. well... by darthpenguin · · Score: 5, Insightful

    The article is somewhat light on facts. From what I recall, during drowning or suffocation, brain damage occurs in humans quite soon (10 minutes?). How is it that this process negates the lack of oxygen to the brain, allowing no damage to occur? Is it the temperature of the liquid used for replacing the blood?

    Also, the article has "Although the animals are clinically dead, their tissues and organs are perfectly preserved." followed immediately by "Damaged blood vessels and tissues can then be repaired via surgery." So, which is it?

    I suppose we'll have to wait for a real scientific journal to publish this before we find out much more.

    Also, another attempt at hibernation, this time in mice, using a different method involving hydrogen sulfide gas.

    1. Re:well... by Binestar · · Score: 5, Informative

      Also, the article has "Although the animals are clinically dead, their tissues and organs are perfectly preserved." followed immediately by "Damaged blood vessels and tissues can then be repaired via surgery." So, which is it?

      They were refering to the use of this in medical emergencies. Put someone into this state, work on the damaged tissue with no bleeding or time crunch, then revive when they are fixed.

      I'm more interested in knowing who the hell is going to volunteer for this procedure...

      --
      Do you Gentoo!?
    2. Re:well... by daniil · · Score: 5, Insightful
      I'm more interested in knowing who the hell is going to volunteer for this procedure...

      A mortally wounded gunshot victim?

      --
      Man is a slave because freedom is difficult, whereas slavery is easy.
    3. Re:well... by Carnildo · · Score: 5, Interesting

      Well, one obvious use is for open-heart surgery -- that goes a whole lot easier if you can stop the heart, and heart-lung machines aren't perfect. I think the first human trials will be volunteers who are additionally undergoing major surgery.

      --
      "They redundantly repeated themselves over and over again incessantly without end ad infinitum" -- ibid.
    4. Re:well... by Rei · · Score: 5, Interesting

      Yep. And the reason that they don't get brain damaged is because their neurons aren't dying. And their neurons aren't dying because they're not metabolizing, and thus needing oxygen. The brain is in hibernation, just like the rest of the body.

      Still, this is ubercreepy. Even the electrical shock at the end bit... sounds like 50s sci-fi. What's next? "The shock required is quite intense, so facilities doing this work will need to affix a lightning rod to their roof and wait for a storm..."?

      --
      What a crazy random happenstance!
    5. Re:well... by Rei · · Score: 5, Funny

      I'm wondering if the US (or other countries) would allow those on death row to volunteer

      So what... they kill them, bring them back to life, and kill them again? That explains the concept of being given multiple sentences of death ;)

      Besides... from what I heard, as soon as the dogs were brought back, they immediately headed to the nearest computer and started incessently sending out bulk email.

      --
      What a crazy random happenstance!
    6. Re:well... by evilpenguin · · Score: 5, Informative

      The Tuskegee airmen and the Tuskegee syphilus study aren't the same thing! (Although both refer to the same place).

      The evil government experiment was the Tuskegee syphilus study. They told residents of Tuskegee that they would receive free syphilus treatment and then treatment was withheld so the effects of syphilus could be scientifically documented and studied.

      I do not know if any of the Tuskegee Airmen (the only black squadron -- or the first, I don't remember -- in WWII) were in the study also, but they are not the same thing at all.

    7. Re:well... by kfg · · Score: 5, Insightful

      Once upon a time, a long, long time ago, I was brought into the hospital for lifesaving surgery. . .but my condition was such that it was deemed I would die from the stress of undergoing surgery.

      This is the sort of person who will volunteer. A person who has nothing to lose if the procedure fails, but everything to gain if it succeeds.

      KFG

      P.S. I got better.

    8. Re:well... by Ungrounded+Lightning · · Score: 5, Informative

      From what I recall, during drowning or suffocation, brain damage occurs in humans quite soon (10 minutes?). How is it that this process negates the lack of oxygen to the brain, allowing no damage to occur?

      The 10 minute limit is for slow suffocation at normal temperatures. Two things happen:

      - First, many of the tiny valves controlling the distribution of blood in the brain capilaries shut, trying to route the remaining oxygen to the neurons controlling things like breathing and heart rate.

      These valves are tiny muscles, which, once contracted, require power (from metabolization) to reopen. Let them be oxygen-starved for too long - about ten minutes - and they get stuck closed. Then, even once oxygen is restored, the blood remains cut off to the areas they control. (It does no good to raise the blood pressure to try to force blood past them: You'll blow the plumbing before they leak. Massive stroke.)

      - Second: As with the muscles, the neurons have continuous chemical reactions going on that cause damage that must be cleaned up by active, powered, systems. Turn down the oxygen while leaving the temperature up and the cleanup systems fail while the damage mechanisms continue. (Firing the nerve uses up additional power, making the problem worse.)

      Let this go on for more than half an hour or so without turning the air back on and the damage gets ahead of the nerve's ability to repair it - causing cell death. That ruptures the cell and releases a glutamate - which tends to force other nearby nerves to fire, consuming their resources and speeding their death, in the "glutamate chain reaction". This easily gets started in regions of the brain fed by still-shut-off plumbing. But with enough glutimate dumped it can spread to nearby areas that have adequate oxygen - because it's not adequate to keep ahead of the massive firing and cell exhaustion.

      The first mechanism sets the normal time limit. But the second is the final catastrophe.

      But diving sets up a condition much like suffocation upon resurfacing: Swimming underwater pressurizes the gas in the lungs, and the organism can remain active for some time before it starts to run out of oxygen. But then it takes time to get back to the surface - and the lowered pressure on the ascent causes oxygen levels in the blood and tissue to crash. Not good.

      Evolution came up with a workaround: The "mamilian diving reflex", so called because it's characteristic of all mamals - happened a LONG time back.

      When the reflex detects a deep dive (cold on the skin - especially on the back of the neck, I think), it modifies the valves' reaction to overall oxygen shortage: Instead of shutting off blood to "unimportant" (for respiration) parts of the brain, it causes ALL the valves to OPEN. Then if they stick they stick open. This risks speeding respiratory failure. But once (if) oxygen is restored, it allows it to reach ALL the brain. Get oxygen back before the cells start dying (after a half hour or so) and they all get the power they nead to clean up and get on with life.

      So if you drown in COLD water you can be breathing-stopped for a half-hour or a bit more and still be restarted with no long-term brain damage.

      This treatment seems to extend on that: Flooding with cold saline will activate the diving reflex, sticking the valves open. Then the rapid oxygen loss will shut down all energy-driven metabolism - both the repair and some of the damage-makers.

      Meanwhile, the deep cooling of the tissue (to essentially refrigerator temperatures) will slow the other damaging chemical reactions, just as refrigeration slows meat spoilage. (It IS slowing meat spoilage! And 7C is about 45F, close to the 40F recommended for refrigerator settings.) This is probably the main factor in getting past the half-hour limit on cold-drowning.

      Separate storage of the blood allows the replacement fluid to be optimized to cool the rest of the body at a more rapid rate than could be accom

      --
      Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
  2. death and taxes by NegativeOneUserID · · Score: 5, Funny

    Ok, looks like taxes are the only sure bet left.

  3. Ralston-Purina has responded by rebug · · Score: 5, Funny

    New Gravy Brains(TM) brand dog food has the brain flavor your zombie dog craves.

    --

    there's more than one way to do me.
  4. Big Deal by Anonymous Coward · · Score: 5, Funny

    I've heard stories of Keith Richards doing this sort of thing since the '70s.

    1. Re:Big Deal by JordanH · · Score: 5, Funny
      • I've heard stories of Keith Richards doing this sort of thing since the '70s.

      Oh, so that's what happened. Do you know when the plan to revive him?

  5. Russians were doing this in 1940 by Anonymous Coward · · Score: 5, Informative
    1. Re:Russians were doing this in 1940 by Anonymous Coward · · Score: 5, Funny

      If I remember the old joke right* :

      Monday: U.S. scientists announce a new discovery.
      Tuesday: Pravda reports that Soviet scientists discovered it 20 years ago.
      Thursday: German engineers invent a device that puts the discovery to use.
      Friday: Japan exports the device to the U.S.

      If only I could remember what happened on Wednesday...

      * Last heard this one back in the early 1980's, if that helps put the stereotypes in context.

    2. Re:Russians were doing this in 1940 by Rude+Turnip · · Score: 5, Funny

      Right, but in 1940 they were still the Soviet Union. So, technically, dogs created zombie scientists.

  6. Re:Not On Me. by fdrake76 · · Score: 5, Funny
    This seems too far fetched to be real.

    From what I understand, the dogs can't fetch very far either.

  7. Brains!? by Zediker · · Score: 5, Funny

    BRA.... errr... BONES!!!

    --
    I love to slaughter the english language.
  8. Attn: Postal Workers... by sl8763 · · Score: 5, Funny

    The Good: Zombie dogs are much slower than the normal kind.

    The Bad: Normal dogs will not attempt to eat your juicy, delicious brain.

  9. I can't wait by nizo · · Score: 5, Funny

    The picture that comes with the article sure makes this whole process look really appealing. It reminds me of the picture that the local news station shows when there is any asteroid in the news (a huge moon-sized rock hitting the earth). Aren't stock pictures great?

  10. Volunteers by Hoi+Polloi · · Score: 5, Funny

    I think this explains a lot about Dick Cheney.

    --
    It is by the juice of the coffee bean that thoughts acquire speed, the teeth acquire stains. The stains become a warning
  11. Has to do with the oxygen level by DanielMarkham · · Score: 5, Informative

    This is a follow-on to an article in Scientific American this month. Interestingly enough, the article concluded that cells stay viable just fine in very high or very low oxygen environments. It's the transition stage that causes all the damage.
    Hence the reason for injecting saline -- it takes the oxygen-carrying blood out of the tisses almost immediately, which is what you want to do. The SA article authors said this seems a little extreme to use in humans, and I agree. They've had some success with mice using Hydrogen Sulfide, I think, mixed in with air. Also, surgery for animals that are "dead" brings in a whole new line of specialties that we haven't developed yet. This is going to be a fascinating area to watch, imo.

  12. Not just ER Patients... by cnelzie · · Score: 5, Interesting

    ...they could use this for the next set of Skull Sharing Conjoined Twins in an operation to split them apart.

    --
    If you ignore the other uses of a tool, does that make the tool less useful, or you less useful?
  13. But don't call it godless necromancy! by PCM2 · · Score: 5, Funny

    Nothing these scientists have done defies the laws of nature. Got that? No laws were broken! The scientists have merely "time shifted" the animals, which is perfectly permissible under Fair Use.

    --
    Breakfast served all day!
    1. Re:But don't call it godless necromancy! by mooingyak · · Score: 5, Funny

      Repairing broken animals has never been an issue, it's just when you try to make copies without written authorization from the copyright holder that people get all upset.

      --
      William of Ockham had no beard. The most likely explanation is that it was chewed off by squirrels every morning.
  14. Re:No brain damage by ScentCone · · Score: 5, Interesting

    You'd have to really know a dog well (and observe its sensory and motor skills, note its emotional stability, and have a sense of its habits) before subjecting it to this sort of process. And then you'd have to pursue the dog's regular activities afterwards and note the changes. Anyone who has lived with a bright, energetic dog can tell you instantly if the animal is "off" in some way. Just like you'd notice it in your child. Now, longer-term issues, who knows. Like, would some degenerative, trauma-induced thing (something Alzheimers-ish) kick in later? No way to know. But no matter how good your brain scans or other imaging techniques may be, these are complex animals, and long-time handler/owner could tell you if you'd dropped a couple of circuits along the way.

    Why would you want to freeze someone indefinately? Let's go for a Sci-Fi answer since we're dealing with a near-Sci-Fi topic. Let's say that you've got the aging examples of some really prize breedings from a particular bloodline (I'm talking dogs here). And then, something ugly not unlike hoof-and-mouth, or bird flu starts turning in a species-specific pandemic. If I were a breeder that had been perfecting a bloodline for 50 years, I'd seriously consider taking a couple of those dogs and letting them have A Big Nap.

    For a lot of breeders, they love the individual dogs, but their truly beloved "pet" is the bloodline out of which they spring. Generations (of human lives) go into creating something as unique as a specialized dog (or bull, or chicken), so ways to put them on ice for later revival once a viral or other threat has been understood (or a vaccine developed) could be very compelling.

    I'd say all the same things about humans, but I'd be very Politically Incorrect at that point, so of course I won't.

    --
    Don't disappoint your bird dog. Go to the range.
  15. ObNethack by cswiii · · Score: 5, Funny


    What do you want to #rub?
    (w) - saline liquid
    What do you want to rub the vial of saline liquid with?
    (Q) - wand of cold
    The vial glows briefly.
    What do you want to wield?
    (w) - saline liquid (cold)
    You break the vial over the little dog's head. --more--
    The little dog yelps! --more--
    The little dog falls asleep.
    The zombie dog awakens! The zombie dog bites! --more--
    The zombie dog bites!

  16. This hits home... by Anonymous Coward · · Score: 5, Interesting

    On Sunday morning I was playing tennis with an older man I met in an online league. He was turning around to pick up a ball and he suffered a major heart attack and collapsed. His heart stopped for about 10 minutes on the tennis court while a girl from the court next to us performed CPR. He's in a coma in an ICU right now. The doctors said that stabilizing his heart is a primary concern right now, but that in the coming days discerning any damage done to his brain due to oxygen loss will become a primary concern.

    One of the things the doctor told us was that they were going to actually induce hypothermia in him while he is in the ICU. Recent studies have provided evidence that doing so may limit the brain damage caused by the loss of oxygen to the brain. Of course, in his case, it was extremely important (and fortunate) that CPR was started soon after his heart stopped, thus limiting the loss of oxygen to his brain.

    Hopefully studies like this will lead to more treatments which help people recover from heart failure.

  17. brains.... brains.... by Thud457 · · Score: 5, Funny

    Sweet zombie Jesus, how can you tell if a dog has brain-damage anyhow? They already eat their own shit if you don't stop them.

    --

    the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff

  18. Re:I call "bullshit" on this article. by Anonymous Coward · · Score: 5, Informative
  19. High Quality News Source by BuckaBooBob · · Score: 5, Insightful

    Just look at a list of other stories they are currently covering

    12-year-old girl gets divorce
    Goats recruited to fight bushfires
    Scientists create robot lobster
    The most dangerous day of the week
    Cookie trail leads to suspects
    Soldiers steal tank to buy vodka
    Bonking, brawls and booze
    Man gets $2600 for plaster Jesus
    New shop to turn away the rich
    Sticky stunt's disastrous end

    Drop the story and move on :)

    --
    Who needs WiFi when we can have Packet Over Sheep! http://datacomm.org/PoS-InternetDraft.txt