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Scientist Says Most Scientific Papers Are Wrong

An anonymous reader writes "According to epidemiologist John Ioannidis, the majority of published scientific papers are wrong. If Ioannidis's own paper is right, a randomly chosen scientific paper has less than a 50% chance of being true. He also says that many papers may only be accurate measures of the prevailing bias among scientists. However, a senior editor of a scientific journal says that scientists are already aware of this: 'When I read the literature, I'm not reading it to find proof like a textbook. I'm reading to get ideas. So even if something is wrong with the paper, if they have the kernel of a novel idea, that's something to think about.'"

30 of 656 comments (clear)

  1. Lamarck and Darwin were wrong too by geomon · · Score: 4, Informative

    Wow! Science can be wrong.

    That is how the system works.

    But just because these two scientists were wrong about the precise mechanics of evolution doesn't mean that they were wrong about how the data should be interpreted. The data shows that life has progressed to meet the demands of its environment. Survival of the fittest is correct, but there is no straight-line progression of lifeforms leading one from another as was supposed when these authors first penned their ideas.

    Scientific ideas may come and go, but the data set just gets larger. That is why this guy can claim the others are wrong: he has a better data set.

    --
    "Rocky Rococo, at your cervix!"
    1. Re:Lamarck and Darwin were wrong too by superyanthrax · · Score: 4, Insightful

      It is well known that science can be wrong. For example, before about 1900 the model of the universe was based on Galilean relativity, which was proven wrong by Einstein and friends. Those results were based on well-conceived and performed experiments, all of which confirmed their hypothesis (b/c they couldn't get close to light-speed so they couldn't tell).

      But if the creationists/intelligent design advocates/Christian fundamentalists want to use this to say that they're right, they're relying on a logical fallacy. Just because a few papers are wrong doesn't mean that their view is correct. Their view of creationism is not the only alternative to the view of evolution present in a few possibly flawed papers. Evolution may work in a way that we aren't sure about, but this doesn't prove that intelligent design is correct.

    2. Re:Lamarck and Darwin were wrong too by Anonymous Coward · · Score: 5, Funny

      If atoms aren't billard balls, how can you be sure we're monkeys?

      If fish aren't landmines, how can you be sure we're really elk?

      But, more to the point, should you be really drawing any conclusions?

      No. Not until the smoke clears, and I can once again tell the difference between billiard balls, atoms, monkeys, landmines, and elk. And neither should you.

    3. Re:Lamarck and Darwin were wrong too by Dausha · · Score: 4, Insightful

      Scientists publish papers to get tenure and paid.

      --
      What those who want activist courts fear is rule by the people.
    4. Re:Lamarck and Darwin were wrong too by jc42 · · Score: 4, Interesting

      ... Galilean relativity, which was proven wrong by Einstein and friends.

      Actually, strictly speaking, Einstein (and friends) didn't prove Galileo or anyone else wrong. That had already been done by others. Thus, precise measurements of the orbit of Mercury and turned up discrepancies with Newton's and others' laws of orbital mechanics. The Michaelson-Morley experiments produced the apparently-absurd result that light moved at the same speed relative to all observers, even if those observers were moving relative to each other or the light source. Etc.

      What Einstein did was develop a new theoretic approach that could explain a number of these anomalies. It was then up to the scientific community to viciously attack Einstein's theories, and attempt to prove him wrong. They've been at this for a century now, and all of their tests so far have end up with results consistent with Einstein's theories, to within the error bounds of the measurements. In scientific circles, this constitutes "proof" that Einstein's theories are either correct, or are very close to correct.

      Even then, the earlier theories hadn't really been proven wrong. Rather, they were shown to be merely good approximations. After all, if your instruments can measure something to 12 places, but Einstein's and Newton's equations predict a difference in the 20th place, you can't show either set of equations to be wrong. This is why those earlier "disproved" theories are still taught in science and engineering schools. Newton's equations are a lot simpler than Einstein's, and in situations where you can't measure the difference, you might as well use the simplest equations. You just have to be careful not to apply the simpler equations in situations where they aren't good enough.

      But note that Einstein himself didn't disprove those earlier theories; that had been done by the others that found the anomalies. And Einstein didn't prove his own theories; that has been done by a century of tests by the entire scientific community. He did the really hard job: He came up with his wild new theories of a universe that behaved rather differently than anyone thought. But his theories were consistent with those strange observations. And his theories included equations that could be tested against the real universe. And his theories keep passing every test that anyone comes up with.

      Now if we could get some other would-be scientists to present us with versions of their theories that can be tested against the real universe ...

      --
      Those who do study history are doomed to stand helplessly by while everyone else repeats it.
    5. Re:Lamarck and Darwin were wrong too by vanka · · Score: 4, Informative

      If you received a PhD in 2003 and were taught that natural selection is the driving force of evolution, then I am sorry that you wasted your money.

      Darwin's original theory of evolution was based on two very obvious things; variations among organisms and natural selection. Natural selection was not something that Darwin "discovered", the idea had been around for a bit and is quite intuitive - those that are better adapted to their environment will survive; rather he proposed a mechanism through which beneficial changes in a population are preserved in the offspring. But he did not do a good job of how these changes are brought about. We all know that the offspring of an organism will not be identical to the parent (unless it is a clone); so that children are taller, stronger, lighter/darker (you get the idea) than their parents. What Darwin proposed was that those variations were unfavorable to an organism were weeded out by natural selection (i.e. the organism was killed by predators, could not feed, etc); while the advantageous were preserved. Darwin assumed that the variation that he saw in a species (or between closely related species) would continue indefinitely; that if an organism that can run 40 mph has offspring that can run 1 mph faster and the offspring's offspring continue the trend, this will continue until in several generations these organisms will be able to reach speeds of 100 mph.

      This is where Darwin went wrong, although we must not be too hard on him because he had no knowledge of genetics. The genetic code of an organism puts an upper limit on the variation that is possible. Mendel demonstrated this in his famous experiments with peas; which incidentally took place a little after Darwin wrote "Origin". He crossed peas with red and white flowers and was able to get red, white, and pink flowers; but he never got orange, blue, or yellow flowers. Mendel could only select for those traits that were encoded in the genes. So if the population as a whole did not already have the genes for 100 mph speed (recessive or otherwise) there is no way that natural selection can select those genes. A good rule of thumb to remember is that natural selection cannot select what does not exist. So natural selection cannot drive evolution by itself as it cannot produce new traits, and the traits of an organism are determined by its' genes. So there needs to be a mechanism or process that can create new genes; and this is where mutations come in. Mutations by definition are copying mistakes that change the genes. So if there are new genes, natural selection can do its' job of weeding out the bad traits and leaving the good ones. This is known as Neo-Darwinism as the primary idea of primitive organisms evolving into complex ones remains but the process driving it is not natural selection but mutations. In Neo-Darwinism, natural selection is seen as just an obvious footnote.

  2. Well by Neil+Blender · · Score: 4, Funny

    Their is a 50% chance that that's not true.

  3. Blinded by Science by Jhon · · Score: 5, Insightful

    "Science" is NOT the same as "fact" or "truth". It is a METHOD -- a PROCEDURE one follows in an attempt explain some event or phenomenon. It should hardly be surprising that "Scientific" papers are mostly wrong. There may be only one "right" or "correct" theory for a given phenomenon -- but there are countless wrong ones.

    1. Re:Blinded by Science by blamanj · · Score: 4, Interesting

      And, as the article mentions (but doesn't go into detail on), this is why reproducibility is so important.

      Let's say a scientist comes up with a new idea, does the research, and publishes a result. OK, assuming we buy the article's premise, there's a 0.5 chance s/he's made a mistake. Now another scientist and then a third duplicate the experiment and get the same result. The odds that the original proposition is in error drops to 0.25, then to 0.125. The odds are now 8:1 the result is valid.

      See cold fusion for an example of the converse.

  4. Studies, Papers, Research by fembots · · Score: 5, Funny

    Wow, I thought Study Shows One Third of All Studies Are Nonsense is bad enough, who knows scientific papers are worse!

    I patiently await the next article: "Research Shows Three-Quarters of All Researches Are Bullshit".

  5. Re:groan by geomon · · Score: 4, Insightful

    "See? Scientists don't know what they're doing! All your answers are in Teh Bile-Balllllllll! Praise JEEEEEEE-zussssssssss!"

    Yes, but unlike religious dogma, scientific theories are meant to be falsifiable.

    Unless someone in the ID camp is willing to admit that God is falsifiable, their theory will not be considered science.

    --
    "Rocky Rococo, at your cervix!"
  6. Bad research==dangerous. by FireFlie · · Score: 5, Insightful
    I tend to agree with the findings simply because of the inordinate amount of bad scientific papers that I have read. I have also found this to be more true in the field of psychology than most others (I would say more than 50% are bad which brings up the average for all sciences), but that is entirely beside the point.

    What I do see as harmful is the attitude towards bad papers. To many academics try to accumulate more and more published papers the same way that slash-dotters try to build up karma. I understand that having papers published can reflect well on someone, but we need more accountability. Journals need to create a more strict system for reviewing papers that are to be published to weed out more of the crap plain and simple. If the evidence does not reflect the claims throw it away. If the research was conducted on a population that was too small or specific for a grand generalized claim about the topic as a whole, throw it out.

    I understand that you will always have people just trying to throw their names around, but this needs to be looked at from the grander perspective.

    "When I read the literature, I'm not reading it to find proof like a textbook.

    Sure there are probably many scientists that think of it this way. But the problem is that bad research (or a bad paper) rarely dies after being published. They are often cited as evidence for years to come in other papers until enough evidence to the contrary comes out to raise questions. Plus, you have crazy professors giving this bad research for their classes to read, and often they don't explain to their classes where research is possibly flawed--so we find ourselves training generations of new scientific minds that run around spouting out bad research. I understand that we all need to take research with a grain of salt when we read it, however bad scientists trying to become famous with their bad ideas or bad papers can be very detrimental to any field.

    1. Re:Bad research==dangerous. by Arker · · Score: 4, Insightful

      All that is true. But you left out possibly the worst effect of false papers - the effect they can have on the funding gatekeepers. A handful of just BAD research papers, all claiming to show what those that hold the pursestrings want to hear, and suddenly that false conclusion is a 'scientific fact' and anyone that wants their studies to be funded in the future had damn well better agree with that. Which becomes a self-perpetuating cycle.

      --
      =-=-=-=-=-=-=-=-=-=-=-=-=-=-
      Friends don't let friends enable ecmascript.
  7. Comment removed by account_deleted · · Score: 4, Insightful

    Comment removed based on user account deletion

  8. WRONG can still be SOUND and USEFUL by davidwr · · Score: 4, Insightful

    If a submitted paper is scientifically unsound, it should be rejected.

    If a scientific paper is useless to the readership, that publication should reject it and recommend a different journal.

    If a paper is wrong and the reviewers KNOW IT then they should send it back for corrections.

    If it's WRONG but the reviewers don't or more typically can't know it because it is novel, then publish it. The rightness or wrongness will be sorted out soon enough.

    Ever heard of Isaac Newton? Turns out his theories were incomplete in some very fundamental ways, but his theories regarding the motion of objects were the best approximations we had for hundreds of years and are still very useful for macroscopic objects traveling way below c.

    --
    Knowledge is how to play a game, intelligence is how to win, wisdom is knowing what game to play.
  9. Quote by BenjyD · · Score: 5, Insightful

    "If we knew what we were doing, it wouldn't be research"

    That's what my supervisor used to say to me when I got depressed about lack of progress.

  10. Re:Reach by cahiha · · Score: 5, Informative

    Whether anything anyone says is right or wrong, it's a matter of opinion first and foremost.

    No, it's not.

    Our biology does not provide us

    Our biology provides us with excellent truth detectors: throughout most of primate evolution, if you were wrong about whether your food was poisonous or whether there was a lion hiding in the bushes, you didn't get to pass on your genes. You didn't get to debate social relativism with the lion before he made a tasty meal out of you.

    Most of science is still ultimately about matters like that, matters that have good answers, at least in principle.

    Some science has veered off course, however. Every major scientific discipline (physics, biology, chemistry, etc.) has subareas where people start conflating experimental facts with opinion, aesthetics, and prejudice.

    So, scientific truth is not a matter of opinion, but a lot of what is published in science is not about scientific truth.

  11. Re:Reach by Jamu · · Score: 5, Funny

    Therefore anything that anyone says is simply an opinion.

    That's just your opinion.

    --
    Who ordered that?
  12. Re: Peer review by poszi · · Score: 4, Insightful

    I didn't read the article but I don't believe the conclusions of the summary. Maybe in epidemiology it is true but not in physics where usually the results are reproducible and I very rarely find papers that are just wrong. I might agree that most of the papers are not 100% right (small mistakes in formulas happen quite frequently) but it does not impair the usability of a paper.

    However, peer review does not solve all the problems. Most of the research takes a lot of time and effort and referees just read the papers. They do not reproduce the experiments or calculations. So peer review can weed out only obviously bad papers but not papers that looks OK but are wrong.

    --

    Save the bandwidth. Don't use sigs!

  13. Half empty, or half full? by DrCode · · Score: 4, Funny

    If 50% are wrong, then 50% are right. So if I write a scientific paper, the chance of it being right is 1/2. And if I write the same paper, say, 8 times, the chance of it being right at least once is 255/256.

    I think I'll write that paper on statistics.

  14. Re:groan by WiFiBro · · Score: 4, Insightful

    Your missing the point: ID-ers are claiming their theory is falsifiable. Which made others come up with equally falsifiable theories :)
    e.g. Flying Spaghetti Monsterism
    http://en.wikipedia.org/wiki/Spaghetti_%26_Pulsar_ Activating_Meatballs

  15. Wrong in a non-scientific sense by erice · · Score: 5, Insightful

    Science progresses when well thought out hypothothies based on a good data are replaced by more inciteful reasoning based on more complete data. Lamarck wasn't guilty of faulty reasoning. He just didn't have a complete enough data set.

    But the article at hand, isn't talking about that kind of "wrong". He is talking about conclusions that can not be supported by the data presented. Either the reasoning is faulty or the data collection methods are so faulty that no meaningful conclusions can be drawn.

    When a theory is proven wrong in the scientific sense, it is a good thing. We learn something new and that be the basis for further developments. But if a theory is proven "wrong" in the mechanical sense, we have no new insights, just a relief from further time wasting.

  16. Re:groan by Moofie · · Score: 4, Insightful

    I don't dispute for a moment that intelligence can create new forms of life.

    I do dispute the scientific validity of the claim that ONLY intelligence can create new forms of life.

    Your straw man is now on fire.

    --
    Why yes, I AM a rocket scientist!
  17. This is a model by lelitsch · · Score: 5, Insightful

    Did anyone actually RTFP? It's one of the most spurious pieces of "research" I've ever read. And with a biophysics degree, I have read quite a few. The author actually didn't investigate any actual papers, but he builds a mathematical model out of his own biases, statistical projections, and some back of the envelope computation. Even then, his conclusions are much less stringent than the submitter makes them out to be. He "proves" that under all his assumptions, half the research papers *might* be wrong, but shows not even statistical evidence that they are.

    I think PLoS is peer reviewed, but that paper should never have survived peer review. Occasionally, bad papers slip through, even in the so called hard sciences. This one seems to be one of them. Since PLoS Medicine is pretty well respected for an open access publication, lets assume that this was a lark and more on.

    But it makes me curious what the fraction of bad papers looks like in an open access publication like PloS versus a traditional journal like, say, Nature, The Lancet, or New England Journal of Medicine. One reservation people have about open access (or author pays) models was that since PLoS gets paid about $1500 from they authors, they might be accepting vanity papers, or don't triage as well as traditional journals. I don't think they are, but if this paper is any indication, PLoS might take a second look at their peer review process.

  18. I wonder if Global Warming isn't approaching by Shivetya · · Score: 4, Insightful

    the level of religous dogma in some camps.

    The only question is, who decides which science is wrong? I doubt very seriously any big money areas will have a published high rate of error. After the high money science the next protected type would be whatever is en vogue for the time.

    Scientific integrity took a big dive in the late 80s as special interest groups suddenly realized that marketing, confusion, and intimidation were far better at advancing agenda than honest science.

    --
    * Winners compare their achievements to their goals, losers compare theirs to that of others.
  19. Re:groan by syzler · · Score: 5, Insightful

    After reading the summary, I was under the impression that this artical was about a high rate misleading papers published by scientists.

    Based on all of the anti-creationalist comments I thought maybe I had misread the summary, so I looked at the article itself.

    Not once did I see mention of the universe's creation in the summary or in the linked artical, in fact the example stated was "such as whether a particular gene influences a particular disease."

    It seems to me that lately a lot of comments on slashdot have been trying to start a witch hunt for advocates of ID. Can we please knock it off and stop screaming wolf every time some thing that is related to science is mentioned on slashdot.

  20. Sadly, they did publish by edremy · · Score: 4, Interesting
    Stephen Meyer got an ID paper published in the peer-reviewed Proceedings of the Biological Society of Washington last year.

    Skeptic had their take on it in the last issue. In a nutshell

    • The journal is in the bottom 20% of all journals for impact, but it is a legit peer-reviewed journal with a long history
    • The current head editor is a noted creationist who's on the editorial board of another journal that only publishes papers that are in agreement with a literal interpretation of Genesis.
    • The editor won't say who the reviewers were, only that they were biologists at well known institutions.
    • The paper's sponsoring society was not happy, and put out a press release saying that none of them would have agreed to publish if they had known.
    --
    "Seven Deadly Sins? I thought it was a to-do list!"
  21. Re:Why listen to them if they are always wrong? by geomon · · Score: 5, Insightful

    If science can be wrong, then why trust it?

    It is the only objective process for assessing facts from fiction.

    In other words, if the best a scientist can tell you today is that, he might be wrong tomorrow, why even bother listening to him?

    No one is forcing you to listen. You ignore the information provided by science at your peril.

    So you can use science for real things, like physics and design of military weapons and consumer goods, but the rest of it is so much speculative nonsense.

    Quantum physics is speculative, but you don't seem to be throwing your computer out the window.

    The consequences of guessing wrong about the origin of humanity are completely immaterial to most people's lives.

    Dead wrong.

    Stalin believed that Darwinian evolution was just a bouguoise concept. He believed in Lamarckian evolution and directed his agricultural ministry to ignore studies that supported Darwinain evolution. Their agricultural industry suffered and people went hungry in the process.

    You can't show people evolving any more than someone else can show God making something.

    I can show a progression of hominid fossils leading to homo sapien sapien. The Bible is silent about these fossils.

    It's immaterial, unprovable, and so why fight over it?

    It may be immaterial to you, but the theory is consistent with the evidence we possess. You may not choose to believe it, but that the only thing immaterial about this discussion.

    Yeah you can roll out the eliptical argument that evolution is somehow necessary for medicine but most doctors are concerned with the human species, here and now, and now plants and people are related.

    Why bother? You obviously believe that the scientific method works differently for investigations related to the origin of humanity than it does when applied to chemistry.

    To wit, you can get a Chem E degree and still get into Med School.

    You are correct.

    Just don't whine to me when you have difficulty making sense of the data you gather without using evolutionary theory.

    You will never amount to anything more than a glorified technician.

    I can live with that.

    --
    "Rocky Rococo, at your cervix!"
  22. Re:groan by Kohath · · Score: 4, Funny

    It seems to me that lately a lot of comments on slashdot have been trying to start a witch hunt for advocates of ID. Can we please knock it off and stop screaming wolf every time some thing that is related to science is mentioned on slashdot.

    You realize you're talking to zealots, right? I don't think "please" is going to cover it.

  23. Engineer says: Most papers are never read! by xtal · · Score: 4, Insightful

    Universities have failed a lot of scientists in that a) those papers are the result of stupid tenure policies and b) universities often do little to promote their researchers.

    Engineers often read papers to solve problems. When they know about them! (Google Scholar might fix this)

    A worse problem than them often being wrong is that:

    a) there is frequently no way to determine if a given paper is accurate, has mistakes, is partially accurate, is laughable, was accurate at one point but is outdated, etc etc. At least from an outsider's perspective.

    b) there is no good way to stay abreast of current interesting developments - hell, there's no way to see interesting things from 20 years ago easily! Again, this is from an interested outsider's perspective.

    Once or twice a year I have the luxury of spending a week or two in an engineering library for the express purpose of finding out new and interesting things in my field. I'm SHOCKED at the amount of material that is being duplicated (often badly) in industry, material that is inaccurate or poor quality, and VERY GOOD material that never sees the light of day again.

    --
    ..don't panic