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Mice Created With Human Brain Cells

pin_gween writes "Scientists have added 100,000 human brain cells to mice in an effort to create realistic models of disorders like Parkinson's Disease. Although mice are 97.5 percent genetically identical to humans and it sounds like a large number, 100,000 only represents 0.1% of the number of cells in mice brains. FTA: 'It's true that there is a huge amount of similarity, but the differences are huge,' Snyder said. 'You will never ever have a little human trapped inside a mouse or monkey's body. [...] Researchers are nevertheless beginning to bump up against what bioethicists call the "yuck factor." 'The worry is if you humanize them too much you cross certain boundaries,' said David Magnus, director of the Stanford Medical Center for Biomedical Ethics. 'But I don't think this research comes even close to that.'"

15 of 339 comments (clear)

  1. NARF! by Noctopus · · Score: 5, Funny

    I for one welcome our new Pinky and the Brain overlords. NARF!

  2. 42 by Anonymous Coward · · Score: 5, Funny

    The mice were furious.

    1. Re:42 by Hognoxious · · Score: 5, Funny

      What, both of them?

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  3. WTF? by Tune · · Score: 5, Funny

    I thought mice - being pan dimensional beings - were far more advanced than humans (ranked 3, just after dolphins).
    This is like modding an xbox 360/ps3/whatever with a Z80 - why whould you want to do that?

  4. I for one welcome... by ocelotbob · · Score: 5, Funny

    Yay, human-brained mice. This means that once they escape and start rampaging, scientists will have no choice but to create a race of catpeople to counter them. Of course, this will lead to revolts creating a need for dogpeople, but for a short time, I shall have my catboy! Vengance shall be mine!

    --

    Marxism is the opiate of dumbasses

  5. Re:97.5% genetically identical by kfg · · Score: 5, Insightful

    so is all this 97.5% like generic organ, dna stuff?

    You're about 50% banana.

    i dont see the similarities between humans and mice

    You obviously haven't even looked at a banana very closely, let alone a mouse. About the only difference a lifeform from the proverbial Mars would see between a human and a mouse would be scale. We are virtually identical to mice in every detail but stature.

    If you want learn human anatomy, disect a chicken, and a chicken isn't even a mammal.

    KFG

  6. The "yuck factor" by TripMaster+Monkey · · Score: 5, Funny

    Researchers are nevertheless beginning to bump up against what bioethicists call the "yuck factor."
    Everyone wants to save Hitler's brain...
    but when you put it in the body of a Great White Shark,
    suddenly, you've gone too far.
    Professor Farnsworth
    --
    ____

    ~ |rip/\/\aster /\/\onkey

  7. The conscious neuron? by jtangen · · Score: 5, Interesting

    Remind me what's so unique about human neurons that cause people to fear that mice will somehow become conscious, thinking organisms?

  8. Keeping a tally... by Metasquares · · Score: 5, Insightful

    So far we have super-strong, long-lived, regenerating mice with human brain cells. We're getting pretty close to "the mice of NIMH".

  9. brain simulation? by Anonymous Coward · · Score: 4, Interesting

    If 100.000 brain cells is 0.1% then a mouse has 100.000.000 brain cells. How many bytes does it take to describe a brain cell? How many connections are there from a single brain cell to other brain cells? Say it takes 4 bytes to address the connections. Then 10 connections per cell make 4GByte in total. Who is going to write the software to simulate a mouse?

    1. Re:brain simulation? by penguinoid · · Score: 5, Interesting

      Neurons have several thousand connections, not "about 10". Furthermore, these connections are analog (have a range of strengths), say 1 byte to address the strenghts. Given about 100,000,000 brain cells, you would need almost 30 bits per connection as well, but call it 3 bytes. At 1000 connections, you need 4 kb per neuron, or 400 Gb of memory for 1 rat brain. Barely doable, but the processor power to handle all of that will not be easy to find...

      --
      Don't waste your vote! Vote for whoever you want, unless you live in a swing state it won't matter anyways
  10. Re:well i think by PakProtector · · Score: 4, Interesting
    "'The worry is if you humanize them too much you cross certain boundaries,' said David Magnus, director of the Stanford Medical Center for Biomedical Ethics. 'But I don't think this research comes even close to that.'"

    Yes, certain boundaries. F#%$# you. Using other animals to experiences already is "certain boundaries".

    At least, they wont be too "human" and so, they will not destroy and kill other species only for fun. This right, we cannot give to any other animal, because we can easily lost our "superiority".

    Woah, there! Easy now, fellah! We've already lost that one to Chimps, at the very least, who have been seen to actively seek out and kill Chimps that don't belong to their own group, going so far as, when finding a lone 'other,' to head back, round up a posse, and then go 'curb stomp' their 'ass.' Chimps will also kill babies of any female they meet that they have not had sex with. Hence Chimp promiscuity.

    And dolphins also commit gang-rape.

    We humans aren't so special after all.

    --

    Edward@Tomato - /home/Edward/ man woman
    man: no entry for woman in the manual.
    "Qua!?"

  11. "Boundaries" by base_chakra · · Score: 4, Insightful

    The worry is if you humanize them too much you cross certain boundaries

    How about if we cross a different barrier and drop the anthropocentric bullshit.

  12. so far... by Gravis+Zero · · Score: 5, Funny

    so just for the record, we can make super strong fearless immortal mice that can sing, regenerate body parts, sniff out landmines, and have partial human brains. scientists don't mod their computer cases, they mod their mice!

    --
    Anons need not reply. Questions end with a question mark.
  13. Re:97.5% genetically identical by OldManAndTheC++ · · Score: 4, Funny
    We are virtually identical to mice in every detail but stature.

    Well I don't know about you, but speaking for myself, I find significant differences:

    • A mouse cannot use tools. I can use tools, or at least I could, if I could ever find my toolbox.
    • A mouse cannot do the New York Times Crossword Puzzle. I can, except the Sunday one - that one's pretty hard.
    • Mice love cheese. I don't - it really f*cks me up.

    Of course, there are also similarities:

    • We are both covered with soft, downy fur.
    • We are both thicker around the waist than the shoulders.
    • We both scurry away in fear at the least sign of danger.
    • We both get cancer if we consume 10,000 servings of NutraSweet.

    You're about 50% banana.

    I like to think of myself as mostly fruitcake.

    --
    Soylent Green is peoplicious!