Slashdot Mirror


Testing Drugs on India's Poor

theodp writes to tell us Wired is reporting that a lot of medical research firms are using India's poor as a hot test bed. From the article: "The sudden influx of drug companies to India resembles the gold rush frontier, according to Sean Philpott, managing editor of The American Journal of Bioethics. 'Not only are research costs low, but there is a skilled work force to conduct the trials'"

26 of 531 comments (clear)

  1. Ethics by Winckle · · Score: 5, Insightful

    "Doctors are easier to recruit for trials because they don't have to go through the same ethics procedures as their Western colleagues," Ecks said. "And patients ask fewer questions about what is going on."
    I can't tell if he's being serious, but if he truly does have no moral qualms about that last statement, then he frightens me.

    1. Re:Ethics by Anonymous Coward · · Score: 4, Insightful

      The sad part is, it doesn't really matter. That's the way things are, when you're poor and sick you're willing to try nearly anything. Even experimental drugs. If for no other reason than you can't afford anything else.

      We like to talk about how it sucks our jobs get outsourced to India (and rightfully so, in my eyes), but we have to realize that India is still an incredibly poor country.

  2. No Surprise by ben_white · · Score: 4, Insightful
    I find this quite disturbing. I, however, am not surprised. I have been in academic medicine for 15 years, and have seen the requirements for human research change to the point that many clinicians have just given up any hope of being able to practice and participate in meaningful clinical trials due to the exploding amount of red tape. Of course the red tape does serve a purpose; from the article:
    In another incident, Sun Pharmaceuticals convinced doctors to prescribe Letrozole, a breast cancer drug, to more than 400 women as a fertility treatment in a covert clinical trial -- and used the results to promote the drug for the unapproved use.
    This type of problem was not terribly uncommon in the past in the US (and I assume other industrialized nations), but is not common now, due to the oversight of clinical trials we have now.
    --
    cheers, ben

    Never miss a good chance to shut up -- Will Rogers
    1. Re:No Surprise by advocate_one · · Score: 3, Insightful
      Seems to me I remember a fertility treatment called thalidomide....and a bunch of babies born without arms and legs being the reason for that.

      IT was not a fertility treatment... it was prescribed to reduce morning sickness...

      Isn't it amazing how profit creates short memories?

      NOT for me... my brother is one of the victims

      --
      Donald 'Duck' Dunn: We had a band powerful enough to turn goat piss into gasoline.
  3. Generic versions of patented drugs by op12 · · Score: 5, Insightful

    FTA: "But in March, everything changed when India submitted to pressure from the World Trade Organization to stop the practice and implement rules that prohibit local companies from creating generic versions of patented drugs."

    WHy do they want to prevent that? What about in the U.S. where we have things like Walgreen's Wal-tussin to compete with Robitussin (same ingredients, cheaper cost for the consumer)? (same with Sudafed, etc.) Does this fall under the kind of thing WTO wants to stop?

    1. Re:Generic versions of patented drugs by slavemowgli · · Score: 5, Insightful

      Non-cynical answer: the difference is "patented". Robitussin's active ingredient was patented in the 1950s, so the patent has long since run out, and everyone's free to recreate it.

      Cynical answer: the difference is that the USA doesn't want Indian companies to hurt the sales of US-American companies. If it's two US-American companies fighting, the USA as a whole don't lose anything, but if it's foreign companies...

      I think there's some truth in both answers.

      --
      quidquid latine dictum sit altum videtur.
  4. Re:I'm Fine With It by Marxist+Hacker+42 · · Score: 4, Insightful

    They are getting paid for it, a nice enough sum that it's worth their health and life. They aren't being forced or coerced into it.

    Some would say the difference between life as a dahlit and life as a dahlit after being paid for it is most certainly a form of force and coercion.

    Besides, these people don't have much use in society or a future, especially in India's caste society. This is an excellent opportunity for them to contribute something to better mankind and benefit the rest of us. We should be applauding and congratulating them for their sacrifice. We shouldn't try to take this away from them.

    So you agree- givent he caste system they don't have any real choice at all.

    --
    SJW: a person who perceives an injustice, and while correcting it, commits a greater injustice.
  5. One case where less regulation will help! by ErichTheRed · · Score: 3, Insightful

    I'm not sure what kind of FDA-equivalent the Indian government has, but there's definitely an advantage to conducting your human trials in places where people aren't breathing down your neck.

    I'll bet that India and the rest of the "developing" world will be the next scientific powers given their highly educated and motivated workforce, and the fact that they're a little less backward when it comes to science. Example: South Korea is taking on a cloning project while we're still fighting over teaching evolution in school, abortion and stem cell research.

    Sometimes it makes me wish we'd let the South win the civil war. They could live in backward redneck-land and the rest of the country could get on with evolving the species.

    1. Re:One case where less regulation will help! by buhatkj · · Score: 3, Insightful

      Are you honestly trying to say that you think that the US is more "backward" than India??
      Amazing...
      I would have thought that the penchant of people in the USA to question the morality or ethical repercussions of a scientific pursuit show maturity and a lack of willingness to sacrifice our humanity for some megalomaniacal pursuit of "progress".
      I'm sure we can all think of something we wish we could un-invent (weaponized atomic energy, nerve gas, communism). Science is a wonderful thing, but in order to benefit from it we need ethics and morality to direct our pursuits. If all we do is come up with better ways to kill each other and perpetuate the devaluation of human life we have accomplished nothing of value.

      Somehow I think if they were grabbing homeless people off the streets of your town and testing drugs on them without regulatory protections (which is what this amounts to...) that you would sing a different tune. Especially if you were one of those people.

      --
      sometimes, i wonder if i'm the only conservative on teh intarweb. ah well, back to mah hogs and warmongerin'....
  6. Re:I'm Fine With It by Anonymous Coward · · Score: 5, Insightful

    If you have seen the film "Constant Gardener", you can see the problems associated with this practice. The main problem is lack of accountability. So what if a couple people die from these drug tests. They are poor, no one is going to miss them. No one will fight for them.

  7. Okay by joemawlma · · Score: 3, Insightful

    How is this any different than the poor people here who get paid to test drugs? Just because it's happening in India now as well it's news? Yes India is another developed country just like ours with people who want to get paid to pop pills. As well as get paid to do all the same things we do. It's not like they're an alien race or something.

    1. Re:Okay by voice_of_all_reason · · Score: 3, Insightful

      Because the companies are likely taking advantage of less severe (or nonexistent) legal protection for the people risking their lives with untested drugs in another country.

  8. Straight from the movies ... by cpn2000 · · Score: 4, Insightful
    --
    All you touch and all you see is all your life will ever be ... Dark side of the moon
  9. $$$ greater than Human life? by Ostien · · Score: 4, Insightful

    This isin't about saving a few bucks (yes I know its more then a few bucks) on medical testing its about not respecting human life in an equal manner.

    "Third World lives are worth much less than the European lives. That is what colonialism was all about," said Srirupa Prasad, a visiting assistant professor of medical history and bioethics at the University of Wisconsin-Madison.

    hits the nail on the head. unfortunatly.

    --
    Reality is a big nasty dragon. Fortunately I don't believe in dragons.
  10. Re:Wait by advocate_one · · Score: 4, Insightful
    it's as big a scandal as the ships being dissassembled by hand on the beaches of India... and all the surplus PCs being shipped off to be stripped down by hand...

    Corporate pigs shipping work out to places that have NO health and safety laws... all in the name of short term shareholder profits. These bastards have NO ethics... how would they feel if they themselves were on the breadline with no job protection and the only work available being dirty, shit jobs exported from countries that should know better

    --
    Donald 'Duck' Dunn: We had a band powerful enough to turn goat piss into gasoline.
  11. Testing Drugs on America's Poor. Different? by Kunta+Kinte · · Score: 5, Insightful

    For years people right here in the US have been selling body fluids and enrolling in drug trials to make extra cash.

    But there's a moral issue when it is done in some other country?

    Can we quite patronizing the people? They're poor not retarded.

    --
    Based on upvotes, Ageism is the only "-ism" Slashdotters care about and think isn't SJW
  12. Re:I'm Fine With It by Anonymous Coward · · Score: 3, Insightful

    You are the most callous person I have seen among the ./ crowd.

    Sure, let the street girls turn the tricks. They are getting paid for it. Otherwise they might end up on welfare and we will have to share the burden of assisting them through taxes.

  13. The perils of genetic variations by G4from128k · · Score: 4, Insightful

    This sounds like a recipe for disaster. I, personally, would avoid drugs that had not been tested on people genetically similar to myself. People are not identical in their ability to absorb, metabolize, respond to, or excrete medications. A drug that works well in one population can easily fail to help (or have fatal side effects) in people in a different population.

    --
    Two wrongs don't make a right, but three lefts do.
  14. Re:Wait by IAmTheDave · · Score: 3, Insightful
    Corporate pigs shipping work out to places that have NO health and safety laws... all in the name of short term shareholder profits. These bastards have NO ethics... how would they feel if they themselves were on the breadline with no job protection and the only work available being dirty, shit jobs exported from countries that should know better

    Yeah, you're right. Without question. But someone's gotta be the first to test a drug. The real problem here is that the drug companies are trying to act without the restrictions of the US. Were they operating under the same restrictions over there, then I really wouldn't have much of a problem here at all, since someone, somewhere, has to be the first.

    The US/FDA COULD refuse to accept or deny the right to sale to any drug that is tested without adhering to the same restrictions/rules that they would have to in the US. Test subjects would still be cheaper, but at least there would be incentive for treating these people decently.

    --
    Excuse my speling.
    Making The Bar Project
  15. Re:WWII by rainer_d · · Score: 3, Insightful
    I do recall that a lot of the medical advancements we are enjoying today
    are a result of the many barbaric experiments done by Nazi scientists
    on their prisoners back in WWII.

    I think this is not exactly the case. More to the tune of "...a lot of the medical advancements we enjoyed in the 50s and 60s..."

    So are the insights they gained from their immoral experiements bad enough that we shouldnt use it on moral grounds?

    Back then, the origin of the studies was just conveniently forgotten. Unlike Dr. Mengele, his boss (Adolf Butenandt) managed to continue his career in post-war Germany - mainly by vigorously destroying every evidence of his deeds. Mengele fled to South America but his research was (in parts) considered the de-facto standard until the early sixties - he himself being a good scape-goat, too, taking most of the guilt of the rest of the staff with him.

    The reason, the concentration-camps were so attractive to all kinds of bio-scientist at that time were really two-fold:

    • total lack of regulations
    • the possibility to generate an mind-staggering amount of samples in a very short time
    (previous studies on twins, one of Dr. Mengele's favorite projects, had taken years and were taken on a much smaller sample)
    I must assume, it's the same in India today, again: lot's of samples, little paper-work. If corporations don't apply any ethics, things will run out of control, again. It may even run out of control with more regulation - after all, who can counter the killer-argument of "but it may cure xyz-cancer or AIDS".
    In the current climate of "sacrifice some lives for many/some freedoms for the big-picture", it's only a small step.

    Don't rely on the assumption that scientists will just do "the right thing" - more often than not, the prospect of being able to "advance science" will just open new abysses, which later generations will look down with disgust and horror.

    cheers,
    Rainer

    --
    Windows 2000 - from the guys who brought us edlin
  16. Re:Wait by Surt · · Score: 3, Insightful

    I think as long as the human animals involved can make an informed choice and aren't physically forced or coerced to participate, PeTA will indeed be thrilled.

    --
    "Who is the Journal of Quantum Physics going to believe?" --Stephen Hawking
  17. Re:Wait by Cal+Paterson · · Score: 3, Insightful

    "Their love of profits make them test life-saving drugs on people instead of doing the decent thing and going out of business (giving their drugs to noone). If only they knew that their profits are what make people sick in the world."

    Fool. The issue at hand here is that these people are poor and vulnerable. Testing drugs on them is abusive. Maybe you failed to pick up the point that this is exploitation, and without the dehabilitating poverty, these Indians would never consider being part of the research program.

    The moral here, as I saw very well illustrated in another /. post:
    "If you don't give a fuck when it's not your ass on the line, don't except anyone else to give a fuck when it is"

    The lesson here:
    You're a selfish fuck, who doesn't give a damn about anyone except yourself.

  18. Down the slippery slope we go! by bstarrfield · · Score: 3, Insightful

    Ethics matter; ethics help assure good science.

    There's definitely an advantage to conducting your human trials in places where people aren't breathing down your neck.

    Ever frakkin' wonder why the FDA dares to breath down peoples necks? Do you think that people should be informed of the risks of the test; the potential for long term harm. Do you want pharmaceutical companies to document the positive and the adverse reactions of medical testing?

    Thank God we've found poor, uneducated people living in a country with a rampant caste system - where the poor are of even less spiritual value than the elite! Testing can proceed apace. And don't worry, the ends do justify the means.

    Gee, the South Koreans can have cloning by having one of their lab assistants donate her eggs - amongst numerous other problems with that particular series of experiments.

    --
    /* Dang, I can't type that well. */
  19. Re:Pff.. by elgatozorbas · · Score: 3, Insightful
    ...it is the US poor who volunteer to praticipate in research studies here too.

    This need not even be a Bad Thing. The janitor in the school where I work participates in medical studies three or four times a year (as much as he is allowed to) and he makes more money than I do. He doesn't suffer a bit from it and if I had more spare time I would consider joining him. Clinical studies are not necessarily dangerous. Sometimes they just want to see if a medicine has side effects, makes you sleepy or so. I don't think they want to find out the mortality rate.

  20. Re:Wait by jemenake · · Score: 3, Insightful
    it's as big a scandal as the ships being dissassembled by hand on the beaches of India...
    The only "scandal" I see here is that the living conditions in those areas are so bad that the inhabitants place so little value on their time, health, and life.

    However, when a corporation decides to "shop around" and find the cheapest solution to their problem, I don't see how that's not just a large-scale version of when I go on Froogle to find the cheapest place to get my new DVD burner.

    This whole scenario plays into what economists call "factor price equalization". The idea goes something like this: Let's say you're in the business of manufacturing something (like a car engine or whatnot). You've got all of your manufacturing pieces in place except for one: you need ten thousand washers placed on ten thousand bolts. For doing this job, "Joe American" in Detroit wants $10/hr, plus medical, dental, and vision coverage... and 2 weeks per year paid vacation. Meanwhile, Shankar in India will do the same job for $4/day and requires none of the other benefits.

    Now, if "Joe American" were able to put the washer on the bolt with an expertise, precision, and efficiency that was simply unmatched by Shankar, then there might be a reason to pay him the 20x as much. However, even if there was such a disparity in skill, it would also have to be worth it to you to have the washers put on the bolts with that extra skill.

    Alas, in reality, there is no skill disparity when it comes to tasks as simple as this, so the American worker can offer no advantage to the employer to justify his high price. The "equalization" part of Factor-Price Equalization theory is the observation that, eventually, the prices (in wages and benefits) charged by Joe American and Shankar will equalize. Eventually, increasing competition for Indian labor will drive their price up, while Joe American will finally come to the realization that simply having been born in the USA doesn't make up for the fact that he never finished high-school and he'll face the fact that the value of his labor is much lower than what he was, up until now, able to get away with.

    The lesson is clear: If you want to be well-compensated for your work, you need to be able to do something that... A) few other people can do (ie, low supply), and B) many people want/need done (ie, high demand). This lesson isn't new. It's just that we're now starting to see a decrease in people being able to get away with not heeding it.

    Now, like I said at the outset, the fact that there exist such squalid conditions in India (and countless other parts of the world) might qualify as a travesty (and how is employing these people doing anything but working towards eliminating that?), but... as has been pointed out here numerous times... the hundreds of workers showing up every day don't consider themselves to be exploited. They call it opportunity.
  21. Re:Wait by MickLinux · · Score: 4, Insightful

    Except that though the choice may be semi-informed, it won't be free when the person has a choice between being killed by drugs or killed by starvation (along with their family). There's a reason why India is being targeted. I think I can do without those drugs. Even if not using them shortens my life.

    --
    Correct Horse Battery Staple: 72 bits of entropy. Enter "Correct H" into google. When it generates the phrase, that's