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Ever-Happy Mouse Sheds Light on Depression
An anonymous reader writes "Scientists have bred a strain of mouse that's permanently cheerful, in hopes of better understanding and treating depression in people. By breeding mice lacking the TREK-1 gene, which is involved in serotonin transmission, researchers were able create a depression-resistant strain. They say it's the first time depression has been eliminated through genetic alteration of an organism."
TREK-1 has an important role in neuroprotection against epilepsy and brain and spinal chord ischemia. So there are some very adverse side effects to this.
The article seems very light. There's lots of interesting stuff to be found if you google for "trek-1 gene".
Australian running a company that does C# / C++ / Java / SQL / Python / Mathematica
One way is the 'forced swim test'. They put the mouse in a water tank from which it can't escape. The animal will normaly swim around trying to find a way out. If it is depressed it will tend to give up on swiming and spend long periods of time without moving. Another way is the 'tail suspension test'. It is prety much the same thing. The mouse is suspended on its tail. If it is depressed it won't give a shit about life and will just hang there. Give it some antidepresenats and it will move and try to escape a lot more actively.
Anybody saw/remember Serenity (movie of Sci-Fi series Firefly)? Can it happen if we get rid of stress? Spoiler Alert! -------------- In the movie, somehow they took people's aggressiveness, and people simply stopped doing anything (they literally stopped moving), and they died while they are sitting/lying down like dolls. --------------
People on anti-depressants are not "non-challant" about everything so long as they take their pills. This statement shows a profound misunderstanding of what modern anti-depressents are like. As someone who been taking anti-depressents for most of my life (very long family history of it, suicides everywhere on my family tree), I would like to point out that these are not happy pills, mothers little helpers that makes you stop caring about the world. This is a common belief and one that is simply not true. I feel a full range of emotions like any other person, and the emotional side effects aside from the alteration of the depression is quite small. In fact, I feel MORE emotion that I would off my medication becuase depression tends to overpower other emotions. This was not as true with older varieties of anti-depressents, but the modern SSRI's http://en.wikipedia.org/wiki/SSRI have a minimal inhibitive effect on the range, duration, and power of my negative emotions aside from depression. Even more, I actually CAN get depressed even with the medications if the circumstances of my life dictate it. The ending of a relationship, loss of a loved one or whatever else might get a normal person depressed have the same effect on me. However, it is now short term and recoverable, that is, normal.
Society should think of modern anti-depressents as you would a prosthetic for a person born without a leg. Although unnatural, it corrects a problem, bringing sufferers closer to "normal". Of course, becuase you cannot SEE my handicap, people assume that it is not there, and my condition is a character flaw or choice. This is not true, I have no control over it just as a schizophrenic has no choice in the perception of their hallucinations. Not everyone who is depressed needs these aids, but for sufferers of long term, chronic depression these medications are lifesavers, quite literally. Research and discoveries like those in the article bolster my confidence that future treatments will bring me even closer to normal.
I am surpremely grateful that I live in the age of modern psychopharmacology, I am quite positive that I would not be here if it did not exist.
Sorry, yes I know a dirty word around here, but it stops depression dead. Our body is designed to do physical work on a daily basis, if it doesn't get exercise all sorts of things start to go wrong, depression is just one of them, and not a minor one.
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Your first link is incorrect. Just in case someone want's to find them, here are the singing mice.
What's wrong with 'And'?
I am a depression immune person who lives with and dates a bipolar woman. I swear that almost every single friend of mine through my girlfriend has some form of depression or another. The biggest difference between me and them is that I don't get irrationally depressed for long periods of time. Everyone gets sad when their dog dies. Resistance to depression doesn't mean that you don't get frustrated or sad. If you take away these emotions you would probably cease to be a truly functional human. You need a little sadness and regret now and then to keep you functional in society and able to maintain human relationships. The big difference is the duration of the depression, the depth of the depression, and the level of tragedy it takes to invoke it.
A truly depressed person can be provoked into a feeling of uselessness over trivial or simply non-existent events. The depression can result in more then just a little remorse or sadness. They can want to kill themselves or refuse to do anything. Further, such depression can last far longer then is appropriate. If you are depression resistant on the other hand, you keep on pushing forward. You never get the "lay down and die" feeling. You can still be sad, frustrated, or remorseful, but such feelings are not so over powering that you can't do anything else
Personally, I applaud any good research into depression. Despite arguments to the contrary, depression IS an illness that is completely worthy of treatment. While depression can be invoked through events in one's life, some times (if not most of the time) it is a purely physical problem in the brain that deserves treatment like any other disease. That is not to imply that psychotherapy does not have its uses, but the belief that a depressed person can simply be talked out of a depression is utterly insane and down right dangerous for some. If all that is standing between happiness in a depressed person is a flipped chemical switch in the brain, they should have the option of getting that switch flipped. I appreciate the work of tortured artists as much as anyone, but I don't want to see my loved ones suffer or pull a Kurt Cobain just to keep my MP3 player filled.
The parent post and a number of other posts in this thread showcase the lack of understanding people have of depression and the medication used to treat it.
Depression is not sadness. It a serious mental illness that has very detrimental effects on a person's well being and livelyhood. There is no relationship between depression or its treatment and ones ability to feel emotions like outrage and regret.
Antidepressants are used to treat clinical depression. They are not "happy pills." I personally suffered from depression combined with panic disorder that set in approximately two years ago. Since then I have been taking Lexapro which effectively treated my depression and continues to treat my panic disorder. I don't run around feeling happy all day and I still very much posess the ability to feel sad, happy, angry, outraged and regretful.
I especially can't believe the parent's comment about people being non-chalant while on antidepressants. People who make the decision to take antidepressants don't just pop them like tylenol. They take antidepressants because of a mental illness. Did you consider that it could be the depression that is making these people non-chalant? When you're consumed by your own depression it's a little bit difficult not to be non-chalant about what's going on around you. You have bigger things to worry about.
If your brain chemistry is sufficiently fucked up, nothing makes you happy. That's what depression is - the inability to take joy from anything.
Forget magic. Any technology distinguishable from divine power is insufficiently advanced.
Actually, they are toning it down for the article. By happy depression resistant mice researchers generally mean it takes them longer time to give up and decide to let themselves drown in a forced swim experiment. There are some other measures of depression but this is the one I am most familar with and have seen used most often for depression studies.
Well, those mice are. They also produced miserable mice in the process of doing so. Which isn't funny.
P.S. Your singing mice link points to the plague-infected story?
From first hand experience, my time spent on Welbutrin and Zoloft was profoundly helpful in treating my depression. I have been off all medication for over four months now and my brain functions are working well.
My personal growth has been in leaps and bounds over the course of my therapy and I've never been happier in my life.
BUT, I've also experienced the depths of sadness and anger (and all their variations). I am now able to experience those feelings without being drawn down to the depths of depression nor am I compelled to perpetuate dysfunctional behavior.
I think it's hard for people with healthy emotional and physical upbringings to relate to the distorted thinking and perceptions of depressed people. I'm not talking "sad" depressed. I'm talking about "clinically" depressed. There's a huge difference.
In my experience, my clinical depression stemmed from a number of factors including upbringing, genetics (possibly), miseducation (or lack of education), and the effects of personal decisions from that framework (poor choice of marriage, poor choice of lifestyle, etc...). I also know that my experience was my own, no one else's, and that I don't have the capability of knowing what is best for some one else, nor can I fully comprehend another person's experience.
In other words, as a dear friend put it, "who the fuck am I to think I know better than you..." as to what is best for your life? We're not talking parent-child relations, we're talking peer-to-peer.
I see this research as significant from the perspective of learning about biological mechanism. It's research, period. The applications will come later and I can make my decisions on those at that time.
Aside from that, I welcome our Ever Happy Furry Little Rodent Overlords.