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Ever-Happy Mouse Sheds Light on Depression

An anonymous reader writes "Scientists have bred a strain of mouse that's permanently cheerful, in hopes of better understanding and treating depression in people. By breeding mice lacking the TREK-1 gene, which is involved in serotonin transmission, researchers were able create a depression-resistant strain. They say it's the first time depression has been eliminated through genetic alteration of an organism."

41 of 452 comments (clear)

  1. Lets call him by mathi · · Score: 5, Funny

    Pinky

  2. Extremely Happy Mice? by Anonymous Coward · · Score: 3, Funny

    Grow an ear on his back, that'll teach 'em!

  3. Obligatory by Dial-Up · · Score: 2, Funny

    I'd like the be the first to welcome our cheerful overlords...

    1. Re:Obligatory by Anonymous Coward · · Score: 1, Funny

      I'd like the be the first to welcome our cheerful overlords...

      They're not the overlords. These are. I bet one of those would ruin their day.

  4. May not generalize to humans by Beryllium+Sphere(tm) · · Score: 5, Funny

    Deactivate a mouse's TREK-1 and it acts like it's on antidepressants.

    Take my Trek away from me and I get depressed.

  5. Re:How the hell... by Frogbert · · Score: 4, Funny

    There toning it down for the kids. By "Happy" they mean the mice are randy.

  6. Kill the damn things by DAldredge · · Score: 4, Funny

    Kill the damn things before they escape, learn to talk, and start asking us if "we are having a case of the Mondays"

    NO GOOD CAN COME OF THIS

  7. Re:How the hell... by TheDugong · · Score: 2, Funny

    By taking away their cheese.

  8. Re:How the hell... by QuantumG · · Score: 3, Funny

    Not taking away, just strategically moving it daily.

    --
    How we know is more important than what we know.
  9. Exciting Applications! by Selanit · · Score: 5, Funny

    Hey, maybe the scientists can use this to their advantage. Something like this:

    PETA spokesman: You're abusing animals in your lab, you fiend.

    Scientist: But they're happy!

    PETA spokesman: How can they be happy with you jabbing them with needles every half hour? Among OTHER things.

    Scientist: Easy - they're permanently cheerful, no matter what we do to 'em. We engineered 'em that way.

    PETA spokesman: >.

  10. Re:Today's Philosphical question... by OrangeTide · · Score: 3, Funny

    Most people are happy without poetry or music. (the "music" that is promoted with millions of dollars isn't really music, it's more like soft core pornography).

    So he can't write songs anymore, he can still be a shoe salemen, CEO or a Senator.

    --
    “Common sense is not so common.” — Voltaire
  11. Re:a similar effect in humansth by kfg · · Score: 5, Funny

    . . .just quit work and start smoking pot, eating magic mushrooms and dancing on the streets in the nude.

    Oh, wow man, you've seen me, huh?

    KFG

  12. It's a start by starling · · Score: 4, Funny

    If they can breed a Goth that's permanently cheerful *then* I'll be impressed.

    1. Re:It's a start by Tomfrh · · Score: 4, Funny

      "You don't know many goths, do you?"

      You say that like it's a bad thing...

  13. Oblig H2G2 by wannabgeek · · Score: 3, Funny

    Let's get Marvin to talk to the mouse and see if it still remains cheerful.

    --
    I'm much more funny, interesting and insightful than the moderators think
  14. Re:a similar effect in humans by Scareduck · · Score: 2, Funny
    start smoking pot, eating magic mushrooms and dancing on the streets in the nude.

    Seeing Rosanne Barr naked in the streets would sober my ass right up, and depress me, all in one shot.

    --

    Dog is my co-pilot.

  15. Re:How the hell... by RsG · · Score: 4, Funny

    So, like office workers and deadlines?

    --
    Erotic is when you use a feather. Exotic is when you use the whole chicken.
  16. Re:People are not Mice by kfg · · Score: 5, Funny

    Mice don't feel taunted by the universe, to figure out it's secrets.

    42, Dude. 42.

    KFG

  17. Comment removed by account_deleted · · Score: 4, Funny

    Comment removed based on user account deletion

  18. Re:So let me get this straight by andersa · · Score: 4, Funny

    Hmm..And on top of that, they are all features normally associated with overlords... .. I, for one, welcome them..

  19. Re:New breakthough != new cure. by cdavies · · Score: 2, Funny

    Jesus, be a little more enthusiastic, would you?

    Can't you see that this brings us closer to the laudable goal of making both goth and emo extinct over the next 200 years?

  20. Re:Today's Philosphical question... by Hal_Porter · · Score: 2, Funny

    Have you read Interview with the Fountainhead by Ayn Rice?

    --
    echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  21. Re:Today's Philosphical question... by kfg · · Score: 5, Funny

    Have you read Interview with the Fountainhead by Ayn Rice?

    Radical capitalist vampires? No, I haven't, but I think I might like to.

    KFG

  22. Re:So let me get this straight by Anonymous Coward · · Score: 1, Funny

    This reminds me of
    1. a Tom and Jerry cartoon where some superdangerous white mouse escapes from a lab and Tom mistakes it for Jerry who just fell into a bowl of flower
    2. Hitchhiker's guide to the galaxy!

    (off to buy cheese stock)

  23. Re:How the hell... by geminidomino · · Score: 2, Funny

    That's putting it mildly...

    Minnie's unconsious, Daisy is limping, and Goofy is hiding in a tree...

    What have we done!? We should never have played god!

  24. Re:So let me get this straight by Stripsurge · · Score: 5, Funny

    Scientists finally clued into what you're saying and decided they sure as hell didn't want any variety those "super mice" angry. All new "super mouse" models will now be forced to comply to the new industry standard in happiness.

  25. Re:Makes you not care? by sporkme · · Score: 2, Funny

    Is your specific disease "inflamatory political statement syndrome" or are you just baiting? Maybe "enlarged vocabulary disorder" is a side-effect of your meds.

  26. First (mis)read by HangingChad · · Score: 3, Funny

    The first time I read the last line I thought it said They say it's the first time depression has been eliminated through genetic alteration of an orgasm

    I thought no shit it's going to be happy. A happy little boinker. Boinky, boinky, boinky.

    --
    That's our life, the big wheel of shit. - The Fat Man, Blue Tango Salvage
  27. Re:So let me get this straight by kasparov · · Score: 4, Funny

    It is truly an exciting time to be alive...as a mouse.

    --
    There's no place I can be, since I found Serenity.
  28. Miranda anyone? by Ambush · · Score: 4, Funny
    So these scientists haven't yet seen Serenity?

    Wait till they get a look at the mice that end up like the Reavers!

    --
    There are 10 kinds of people; those who know ternary, those who don't, and those now hunting for a dictionary.
  29. Re:So let me get this straight by twistedsymphony · · Score: 2, Funny

    exciting? maybe.. happy? ..with out a doubt.

  30. Re:So let me get this straight by HarmlessScenery · · Score: 5, Funny
    It was on the cirriculum for my english class in high school. And I did read it.

    So, did that English course go well? ;)
  31. Re:How the hell... by Walt+Dismal · · Score: 2, Funny
    And how exactly do they induce depression in the mice?

    I assume it starts with exposure to Form 1040, then Schedules A, C, asset depreciation rules, and a lot of coffee. It's all downhill from there.

  32. Re:So let me get this straight by andersa · · Score: 2, Funny

    You know, the funny thing is, I even looked up 'curriculum' on google before I posted, and still managed to mistype it..

  33. Re:Today's Philosphical question... by Stormwatch · · Score: 3, Funny
    Have you read Interview with the Fountainhead by Ayn Rice?
    No, but I've read the sequel, "Lestat Shrugged".
  34. Re:So let me get this straight by CrazyJim1 · · Score: 4, Funny

    Scientists can now produce singing, fearless , cancer resistant, super strong , plague-infected, mice with human brain cells from artificical sperm. On top of that these mice are now happy?!

    Said mice were last over heard singing Monty Python's,"Always look on the bright side of life."

  35. Re:Today's Philosphical question... by Anonymous Coward · · Score: 5, Funny
    Thank goodness I had family/friends to point me towards medical care. Lexapro changed that like a light switch, and the depression (and anti-depressants) are just a memory. But for some the depression is chronic and the treatment will probably need to be permanent.


    And Lexapro can change your life too! Call 800-678-1605 or visit lexapro.com today!

    Lexapro can cause nausea, insomnia, problems with ejaculation, somnolence, increased sweating, fatigue, decreased libido, and anorgasmia. Most of the side effects experienced by patients taking Lexapro are mild to moderate and go away with continued treatment, and usually do not cause patients to stop taking Lexapro.
  36. Obligatory Futurama Quote by pizza_milkshake · · Score: 2, Funny

    Robots don't have any emotions, and sometimes that makes me very sad. -- Bender

  37. Re:So let me get this straight by Pollardito · · Score: 2, Funny

    sounds to me like those mice have a case of the Mondays

  38. Re:Today's Philosphical question... by jafac · · Score: 3, Funny

    I dunno.

    I was depressed because I sucked as an artist.

    Then I quit art, and started fixing computers for a living.

    I'm much happier now.

    And I'm told my code is sheer poetry. (damn groupies)

    --

    These are my friends, See how they glisten. See this one shine, how he smiles in the light.
  39. Re:Today's Philosphical question... by wobblie · · Score: 2, Funny

    Man, it's strange to see someone with such literary tastes on slashdot.