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Stem Cells Generated From Adult Cells

DrJay writes "Scientist report that introducing only four genes to adult cells is sufficient to convert them to something that looks and acts remarkably like an embryonic stem cell. Although some of the details need to be worked out, if this technique is generally applicable, it may allow the production of an essentially unlimited supply of stem cells. There is a subscription-only report, and Ars Technica's science journal describes the results in some detail for those without subscriptions."

34 of 190 comments (clear)

  1. Cells have rights too by macadamia_harold · · Score: 3, Funny

    What about the rights of the innocent human cells killed in this process? Have these scientists no moral fiber whatsoever?

    1. Re:Cells have rights too by buswolley · · Score: 2, Insightful
      Got to call the line somewhere... Besides.. we kill our cells all the time in daily activities. I think the idea is that embryonic stem cells are the embryo's, and not the parents..

      In any case, this is great news. Adult stem cells do not get rejected by the body, unlike the other stem cells that come from a genetically different embryo.

      If this technology pans out, then this would both alleviates moral questions, and make for better treatments in one punch.

      --

      A Good Troll is better than a Bad Human.

  2. Fantastic! by Rik+Sweeney · · Score: 3, Funny

    I can finally grow myself a twin!

    Oh wait, I already am one.

    Quads it is then...

    1. Re:Fantastic! by krell · · Score: 2, Funny

      "I can finally grow myself a twin!"

      If it is the fifth (or later) season of the show, rest assured that this twin will be evil.

      --
      Where were you when the voynix came?
  3. Something that turns you into an embryo by krell · · Score: 4, Funny

    Didn't "Star Trek" have an episode about a guy who had this condition?

    --
    Where were you when the voynix came?
    1. Re:Something that turns you into an embryo by IAmTheDave · · Score: 2, Funny

      If Star Trek had had stem cells, they may have been able to give Jordi true-color vision. You know, on top of his X-Ray, heat, infared, and gamma-ray vision.

      But, you know, ethics and Bible beaters all got in Jordi's way...

      --
      Excuse my speling.
      Making The Bar Project
    2. Re:Something that turns you into an embryo by palindromic · · Score: 2, Funny

      You know, I never did understand that.. 300 years into the future, warp drives, replication, matter-energy transport.. little beam things you can heal peoples wounds with perfectly, and they still couldn't figure out how to give a black man some eyes? Geordi went around looking like he was headed to a 90's gay club for what, seven seasons? And I like how when he finally was able to have eyes in Star Trek: Whatever he had red LED lights on his temples and whited out pupils. Way to go RACE-Trek

  4. Of course this only works on mice so far by the_humeister · · Score: 4, Funny

    So if you're a mouse, we have so many cures for you. We even have cures for most cancers. Wake me up when scientists figure out how to do this with human cells.

  5. Cool. by daeg · · Score: 4, Insightful

    This will help kill some of the controversy if it actually works, but many in America still have an irrational fear of sciences that they do not, and can not, understand. People can understand that taking a pill makes you better even if they do not understand the "how" of the pill. They can understand that cutting into your leg to repair a bone with metal rods makes sense. Very few people, however, understand how stem cells may help medical science. Without helping them understand (politicians included), we still have a long way to go before the public openly accepts stem cell research and is comfortable in pumping large amounts of tax money into the research system.

    1. Re:Cool. by RyanFenton · · Score: 4, Insightful

      Exactly - there were never any scientists with a burning need to tear apart embryos just because they seemed like nice spare parts to use. Embryos have unique properties as far as the way their cells can morph into other cells that just don't occur in adult stem cells. If these same properties can be reproduced otherwise, then embryonic research isn't an issue - but until that happens, banning the study of embryos is an important obstacle to scientific progress.

      The irony in all this is that if more embryos that were eventually destroyed without being studied, were instead studied, then these same properties that are important to medical research may have been discovered, allowing us to save more children from more horrible diseases.

      To me, the bans that are in place are the equivalent to old laws banning the study of dead bodies, because doing so reduces the sanctity of life.

      Ryan Fenton (I am not a lab scientist, just a computer guy who loves following science news)

    2. Re:Cool. by Marxist+Hacker+42 · · Score: 2, Insightful

      I understand how stem cells may help medical science in general. But I'm the type of American Bigot who fails to see how embryonic stem cells unrelated to the patient would help anybody at all. Add to that the fact that I've yet to see a single news story of embyronic stem cells curing any disease, but almost bimonthly now we have stories about adult patient donated stem cells curing that patient of something or another, I'd say the value of adult stem cells is well proven- and embryonic stem cell research appears to be an almost useless dead end.

      --
      SJW: a person who perceives an injustice, and while correcting it, commits a greater injustice.
  6. Will this lead to... by Anonymous Coward · · Score: 2, Funny

    Will this lead to our eventual ability to grow brainless human meat in vats, the most ethical meat we can cook up?

  7. Human being by Tracer_Bullet82 · · Score: 4, Insightful

    but.. but.. but.. that cell can turn into a living breathing human being.

    --


    Timang tinggi tinggi
    parang sudah asah
    alang alang mandi
    biar sampai basah
    1. Re:Human being by GundamFan · · Score: 4, Insightful

      If that is true... then this is human cloning... and that is even more of a no no.

      --
      I don't give a damn for a man that can only spell a word one way.
      Mark Twain
  8. Re:now that we've solved that problem by smooth+wombat · · Score: 2, Insightful

    How about someone adopt the thousands of kids who are already living and breathing before we go and create more kids.

    How about instead of people going to China and Peru to adopt kids, they adopt the ones that are here in this country.

    How many kids have you adopted? Until you've adopted at least one, you have no basis to tell women what they can and can't do with their own bodies or prevent them from destroying their own eggs.

    --
    We will bankrupt ourselves in the vain search for absolute security. -- Dwight D. Eisenhower
  9. Gattaca by LilGuy · · Score: 3, Insightful

    See you can't even READ about it unless you've got money... so it starts...

    --

    You're nothing; like me.
  10. The US never banned stem cell research. by chopper749 · · Score: 2, Informative

    Where did you get that info? The government just isn't providing any funding.

  11. Storage issue by Itninja · · Score: 4, Funny

    But won't the bodies start to stack up fast? I mean, there are only so many hobos that one can kill for their stem cells. They could fit like 1000 embreyos in one Tupperware bowl. Now they will have to have an entire U-Haul truck rented to store all the hobo corpses.

    --
    I judt got a nre Kinesis keybiartf so please excusr ant egregiou typos.
  12. Removes the moral problem with stem cells by Parallax+Blue · · Score: 3, Insightful

    The main problem with stem cell research (in the US, mostly) is the moral dimension. This method removes that, and may allow stem cell research to move ahead in the US, although it may be too late. Other countries are less concerned with the moral implications of embryonic stem cells (I believe The Economist had an article about stem cell research in Singapore recently) and are ahead of the US as a result. Can the US catch up fast enough using this method?

    There is also the possibility that any stem cell research will be very limited in the US for some time to come, regardless of the method. This is due to the current administration's attitude towards stem cell research, although the attitude may shift with a new administration in '08.

    1. Re:Removes the moral problem with stem cells by Parallax+Blue · · Score: 2, Informative

      True, but federal funding is usually extremely important to any major scientific research project. As long as the federal government withholds that funding, stem cell research in the US will be limited at best.

      The problem lies in the fact that it has become a political issue, and private investment is scared away as a result. There may be individuals that have enough money, but there's too much risk involved.

      -Parallax

  13. Dunno about this... by Chaffar · · Score: 3, Interesting

    All I know is that this is gonna be used by the religious fr^H^H supporters to say "Aha ! We told you that killing embryos was wrong ! All we needed to do is to give this problem a little bit more thought ... Countless embryos have now been saved from your murderous hands !" Well if the news turns out to be true, then they'd be right :(...

  14. Re:now that we've solved that problem by Bryansix · · Score: 3, Insightful

    Slow down there. Did you read the link? I am not telling any woman what to do. The website promotes adoption of embryos as a way for infertile couples to still have a child that the woman gave birth to. I agree that there are babies that are already born that need adoption. This is not meant to take the place of that. This is for couples who only wish to have a baby if they can give birth to it themselves.

  15. This is good by MobyDisk · · Score: 2, Interesting

    The pie-in-the-sky type of results that people expect from stem cells may only be possible if we can produce these things in mass. This type of research may be the real key to viable stem cell treatments. If you want to grow back another limb, the only way to get enough genetic material is if your own body provides it.

    It would be very ironic if the fear of stem cell research is what yields its ultimate success.

    1. Re:This is good by thule · · Score: 2, Interesting

      And this is exactly why there has been much more success with adult stem cells than there ever has been with embryonic ones. There have been real cures with adult stem cells because the body will accept something that it "knows," otherwise there are problems with rejection. I have my doubts that the embryonic cells can overcome this problem (but you never know).

  16. Three statements and a query. by TheDreadSlashdotterD · · Score: 2, Insightful

    Your body is made of lots of little parts. Most of your parts are screwed up. These can help make new parts to replace those broken parts. Any questions?

    --
    I have nothing to say.
    1. Re:Three statements and a query. by Frymaster · · Score: 2, Funny
      Your body is made of lots of little parts. Most of your parts are screwed up. These can help make new parts to replace those broken parts. Any questions?

      yes. what about the unborn babies??

  17. Biological scientific breakthroughs by MECC · · Score: 2, Funny

    But the key test came when they labeled these ESCs with a fluorescent tag and injected then into recently fertilized mouse embryos at a time when the embryos were a small cluster of cells. The progeny of the engineered ESCs glowed green, and were found in every tissue in these embryos as they developed, as well as throughout adults. There seems to be little that's different between regular ESCs and the engineered ESCs.

    How is it that so often scientific biological breakthroughs are accomplished by making something glow green?

    --
    "We are all geniuses when we dream"
    - E.M. Cioran
    1. Re:Biological scientific breakthroughs by lazybratsche · · Score: 4, Informative

      Basically, it's a standard tool in molecular biology. GFP (an acronym for the creatively named Green Flourescent Protein) is a simple protein that's used as an indicator for all sorts of activity. Biologists, for example, will insert the gfp gene into an organism; if the organism glows, then that bit of gene splicing was successful. In other cases, GFP is tied into various genetic regulatory circuits again as a very convenient indicator.

      In this case, the researchers added these "induced pluripotent stem cells" (tagged with the GFP gene) to a very early mouse embryo. Since the mouse had green glowing cells throughout its tissues, and the only grene glowing genes were introduced with the induced stem cells, the stem cells were clearly able to differentiate into many kinds of mature cells.

      This research is more significant in that it shows the (apparently) minimal set of factors required to make cells revert to pluripotent forms. If only people would shut up about the politics and let scientists do the research...

      Too bad I posted, and won't be able to moderate what looks to be a sparkling and witty discussion...

  18. Scientist! Awesome! by radarsat1 · · Score: 4, Funny

    Wicked, I had no idea Scientist could do this kind of stuff. And he's a great musician.

    Strange though that he doesn't mention this kind of research on his myspace page.

  19. Re:Singularity? by WarpSnotTheDark · · Score: 2, Informative

    Transhumanist is simply someone who advocates transhumanism. Transhumanism; an intellectual and cultural movement supporting the use of new sciences and technologies to enhance human capacities and improve the human condition. Transhuman would be a human more evolved than other humans. (Thanks to Wikipedia.org) I don't find Trahshumanism to be arrogant in any way. Someone claiming to be a Transhuman, however, would have to be one arrogant prick.

  20. This is a GOOD THING! by neatfoote · · Score: 3, Insightful

    I find it amazing that many of the comments here are relatively negative in tone-- that people are still more interested in grousing about the religious right and their ridiculous ethics than they are in celebrating (however cautiously) an advance that may make it possible to reap the benefits of stem-cell research without compromising morals or sacrificing what some consider to be human lives.
     
      This development might offer a way for both sides to win. Should we really be feeling disheartened about that, like "Ugh, what if embryonic stem cells really aren't necessary, and they turn out to have been right all along?"? My impression was that supporting stem cell research was about being pro-science, not anti-religion.

  21. Knew someone in that situation by TimTucker · · Score: 2, Funny

    I knew someone whose parents had tried to abort them (and would remind them of it) -- definitely not the happiest of situations to be in.

  22. 92% the same.. by not-admin · · Score: 2, Informative

    Mice share around 92% of their DNA code with humans, and much of that is realted to shared functions...
    Why should nature re-invent the wheel?

    Something that works in mice is likely to work in humans as well.

  23. Re:Nice Dream by Rostin · · Score: 2, Informative

    Source, please. Most of the Christians I know or have read support research on stem cells from other sources, like umbilical cord blood. See for instance this article, which has nothing but good things to say about it: http://www.worldmag.com/articles/10284