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Listening for Cancer Cells

Posted by ryuzaki0 on from the sorry-to-hear-that dept.

Roland Piquepaille writes "According to researchers at the University of Missouri-Columbia, it's now possible to detect skin cancer cells present in blood samples by listening to the sound of melanoma cells. The scientists have used a method named photoacoustic detection, which uses a laser to make cells vibrate and ultrasound techniques to pick the sound of cancerous cells. This technique is so precise that it's possible to identify the spread of cancer even if there are only ten melanoma cells in a blood sample. Still, large clinical tests must be done before this method can be widely used."

57 of 74 comments (clear)

  1. Listening for Roland Piquepaille Crap by Anonymous Coward · · Score: 1, Insightful

    So the editors won't listen to the readers to stop posting Roland's crap, can we at least have a feature to filter him and other annoying submitters out please?
    Suck it Roland. Suck it long, and suck it hard.

    1. Re:Listening for Roland Piquepaille Crap by stinerman · · Score: 1

      Whatever happened to the *beatles-beatles* guy?

  2. This one's go by ackthpt · · Score: 5, Funny

    This one's got the Rockinpneumonia and the Boogie Woogie Flue

    --

    A feeling of having made the same mistake before: Deja Foobar
    1. Re:This one's go by thewiz · · Score: 3, Funny

      Actually, I'd bet cancer cells play the Imperial March from Star Wars.

      Plus Darth Vader breathing noises.

      --
      If "disco" means "I learn" in Latin, does "discothèque" mean "I learn technology"?
    2. Re:This one's go by ackthpt · · Score: 1

      Actually, I'd bet cancer cells play the Imperial March from Star Wars. Plus Darth Vader breathing noises.

      It would be nice if they did, then they'd really stand out. You'd know it was time to visit your oncologist if George Lucas sent you a C&D letter or showed up on your front step with a hammer

      It's great to detect the stuff spreading, but the real trick is to catch it before it does. Santa Cruz is littered with memorials to young people who've died from malinoma. Too bad some didn't take a little better care with waterproof sunscreen, a few less days in the sun and giving up that infectious feeling youth have of immortality. Get your skin checked now and then. It doesn't hurt.

      --

      A feeling of having made the same mistake before: Deja Foobar
    3. Re:This one's go by Kesch · · Score: 1

      Thank God, it wasn't Disco Fever.

      --
      If this signature is witty enough, maybe somebody will like me.
    4. Re:This one's go by Hogwash+McFly · · Score: 1

      Nah, that's for Type 2 Diabetes.

      --
      Mother, do you think they'll like this sig?
    5. Re:This one's go by LiquidCoooled · · Score: 1

      or showed up on your front step with a hammer

      Actually sir, you are mistaken - I believe he is holding a walkie-talkie.

      --
      liqbase :: faster than paper
  3. They also found a new way to kill the cells too by antifoidulus · · Score: 3, Funny

    they just tell the RIAA that they are infringing on their copyrighted "sound of cancer" Clean them up real quick :P

    --
    Monstar L
    1. Re:They also found a new way to kill the cells too by Chacham · · Score: 1

      they just tell the RIAA that they are infringing on their copyrighted "sound of cancer" Clean them up real quick :P

      Originally, they asked the RIAA to "shoo" them away. The RIAA told them to get the H out of there, and they decided to "sue" them out of there.

      Talk about celling out.... (or is that shelling out?)

      --
      Have you read my journal today?
    2. Re:They also found a new way to kill the cells too by Chacham · · Score: 1

      "sound of cancer"

      The cells are a-dead with the sound of ca-a-a-ancer.

      --
      Have you read my journal today?
    3. Re:They also found a new way to kill the cells too by 8ball629 · · Score: 1

      Why do I suspect a Weird Al song coming?

      Perhaps "The Sound of Cancer" instead of "The Sound of Silence".

    4. Re:They also found a new way to kill the cells too by stunt_penguin · · Score: 4, Funny

      And in the naked light I saw
      Ten rounds of chemo, maybe more

      Tumor growing without shrinking
      Pack a day, what was I thinking?

      Things are going wroooong,
      I'm loosing all my hair....
      It's not fair

      This is the sound... of Cancerrr

      --
      When the posters fear their moderators, there is tyranny; when the moderators fears the posters, there is liberty.
  4. Moo by Chacham · · Score: 1

    I don't like the sound of this; making light of an otherwise dead issue.

    --
    Have you read my journal today?
    1. Re:Moo by Rob+T+Firefly · · Score: 1
      I don't like the sound of this; making light of an otherwise dead issue.
      Light causes melanoma, you insensitive clod!
      --
      Slashdot Burying Stories About Slashdot Media Owned
    2. Re:Moo by SnoopJeDi · · Score: 1

      I think you mean otherwise dead tissue

      Thank you, I'll be here all week.

    3. Re:Moo by ultracool · · Score: 1

      Not all light. Only ultraviolet.

  5. Checkup by Raynor · · Score: 1, Insightful
    "In fact, the blood-test procedure could be performed regularly such as in screenings for high-risk patients, requiring just a small sample of blood, and its results would be almost immediate. "It could take just 30 minutes to find out if there are any circulating cancer cells," Viator said."
    With how long many medical tests take, this should have definately made it into the brief...
    --
    "Dictator Flakes. They WILL be delicious."
    1. Re:Checkup by From+A+Far+Away+Land · · Score: 1

      "The scientists have used a method named photoacoustic detection, which uses a laser to make cells vibrate and ultrasound techniques to pick the sound of cancerous cells." ...I wonder if that's how medical tricorders work...

      And if not, let's get this down to a portable size soon. The 23rd Century isn't far off.

      --
      Oh You POS
    2. Re:Checkup by From+A+Far+Away+Land · · Score: 1

      "Medical tricorders don't work."
      Next you'll tell me that Bones wasn't a real doctor. :-(

      --
      Oh You POS
  6. For those of you wondering by $RANDOMLUSER · · Score: 2, Informative

    It only works on melanoma (skin cancer) cells, which answers the question of "How do they know where to shine the laser?".

    --
    No folly is more costly than the folly of intolerant idealism. - Winston Churchill
    1. Re:For those of you wondering by Stile+65 · · Score: 2, Informative

      They shine a laser at a blood sample, actually. This is only useful for detecting melanoma at an early stage of metastasis, where it's made it into the blood, but hasn't yet formed any noticeable tumors in areas of the body other than the skin.

      --
      I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
    2. Re:For those of you wondering by TheMeuge · · Score: 1

      I guess it's important to know... but the overall implications of such a detection method are almost nil, given the fatality rate of malignant melanoma. The idea is to catch it before the metastasis.

    3. Re:For those of you wondering by javiator · · Score: 2, Informative

      This test can determine the relative number of circulating melanoma cells, so it can indicate response to treatment, remission, or relapse, so it may have value to the oncologist managing treatment of Stage IV melanoma patients. You are right, catching melanoma before metastasis is key, but for the advanced cases, this could be an important test. There's lots of work to do, but I think this is a promising technique. There certainly is a lot of clinical interest in my work. John Viator Assistant Professor, Biological Engineering and Dermatology University of Missouri, Columbia

    4. Re:For those of you wondering by TheMeuge · · Score: 1

      Thank you for your reply. It's both surprising, as well as encouraging to see the originators of the work here on Slashdot.

      I did not mean to diminish the significance of this work. Certainly, it's a revolutionary technique... one that is likely to have an even wider impact in the future.

      And certainly any additional test is welcome in an oncologist's arsenal. I am considering specializing in Oncology, and I am anxiously watching every development... because with every new test and treatment, Oncology steps further away from end-of-life management and towards being able to conclusively affect the final outcome... which makes it more likely to become my final choice.

    5. Re:For those of you wondering by TheLink · · Score: 1

      Just curious - have you heard about people using dogs to detect cancer (by smelling)? How effective is that method?

      --
    6. Re:For those of you wondering by fastgood · · Score: 1
      Couldn't another searchpoint for cancer cells be
      that they are the only cell types that do not die
      off regularly and naturally in the human body?

      No death, grow endlessly without aim or purpose:
      it also seems like a good definition of nihilism.

  7. Applicable to other cells? by TubeSteak · · Score: 1, Insightful
    The sound waves produced by melanin are high-frequency ultrasounds, meaning that they cannot be heard by the human ear, even if amplified. However, researchers can pick them up with special microphones and analyze them with a computer. Other human cells do not contain pigments with the same color as melanin, so the melanin signature is easy to tell apart from other noises, said John Viator, a biomedical engineer at Missouri-Columbia and a coauthor of the Optics Letters paper.
    You know how they tag cancer cells with a (radioactive) dye injection?

    Well, what if they could find a dye that responded in the same fashion.

    Suddenly, the technique could apply to a range of cancers.
    --
    [Fuck Beta]
    o0t!
    1. Re:Applicable to other cells? by Stile+65 · · Score: 2, Informative

      TFA talks about gold nanoparticles being attached to cancer cells and used the same way. It's fairly standard for the new nanotech-based imaging modes (attach a magneto- or photo-responsive molecule to a ligand that attaches itself to a surface protein that's overexpressed in cancer cells, and see where the molecule attaches). Targeted drug delivery is being done the same way.

      --
      I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
    2. Re:Applicable to other cells? by ackthpt · · Score: 1

      You know how they tag cancer cells with a (radioactive) dye injection? Well, what if they could find a dye that responded in the same fashion. Suddenly, the technique could apply to a range of cancers.

      It isn't really cells responding to dye, it's that many cancers when they spread are transported by the lymphatics system. I had a Lymphangiogram, back in June 1986 and it wasn't a very fun experience, but they made insicions in the tops of both feet after injecting some coloured dye between my toes (a very effective means of torture, I assure you) to make tiny lymphatic capilaries stand out. They picked one in each foot and inserted tiny needles in and pumped, for about 45 minutes, an iodine dye into them with a very patient little pump. Cancer cells consume disproportionate amounts of 'food', which may be one way to have them stand out, but this dye was to light up the entire lymphatic system, like a big ol' neon light sign and look for anomolies, which could indicate tumours.

      --

      A feeling of having made the same mistake before: Deja Foobar
  8. The sound.... of cancer by MBCook · · Score: 1

    Hello darkness my old friend,
    I've come to hear from you again.
    Because a paitent softly weeping,
    Wants to know if cancer is creeping.
    Is the sound of the cancer coming from her brain?
    Will it remain?
    As we listen... to the sounds... of cancer.

    I've got to say, this is a pretty amazing idea. Plus it would make detecting some cancers an easy part of your yearly physical.

    --
    Comment forecast: Bits of genius surrounded by a sea of mediocrity.
    1. Re:The sound.... of cancer by LordPhantom · · Score: 2, Funny

      Uh, yeah, like if they were detecting prostate cancer.....
      "You want me to stick the speaker WHERE????"

    2. Re:The sound.... of cancer by mobby_6kl · · Score: 1

      Uh, yeah, like if they were detecting prostate cancer.....
      "You want me to stick the speaker WHERE????"

      Reminds me of this cat
  9. Hrm... by Stile+65 · · Score: 3, Interesting

    From TFA:

    Because of melanin, melanoma is the only type of cancer whose cells will strongly absorb all wavelengths of light, emitting ultrasounds that stand out from those of other cells.

    How difficult would it be to modify melanin to produce electricity (or even sugar) from light? It sounds like it has a much wider absorption spectrum than chlorophyll, which could make things very interesting for genetic engineering and/or solar power!

    --
    I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
    1. Re:Hrm... by Stile+65 · · Score: 1

      And of course, that's what I get for not hitting "Preview" before "Submit." Imagine a after "cells."

      --
      I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
    2. Re:Hrm... by modecx · · Score: 1

      How difficult would it be to modify melanin to produce electricity (or even sugar) from light? It sounds like it has a much wider absorption spectrum than chlorophyll, which could make things very interesting for genetic engineering and/or solar power!

      Damnit, Jim, this must be how the Breatharians do it!

      Their ability to live without eating must be offset by the fact that they will die of skin cancer before they starve!

      --
      Constitutional rights may be respected, repealed, or modified; but they must never be ignored.
    3. Re:Hrm... by F�an�ro · · Score: 1

      organic substances that absorb light are a dime a dozen. Generating electricity from this light is a *lot* harder

  10. One must wonder by nizo · · Score: 3, Funny

    Do they make little screaming noises or evil laughing noises?

    --
    I Am My Own Worst Enemy
  11. lasers? by aaronots · · Score: 2, Funny

    unfortunalely the lasers used actually cause skin cancer in the process

    1. Re:lasers? by javiator · · Score: 2, Informative

      We actually used an optical parametric oscillator pumped by the third harmonic of an Nd:YAG laser...meaning the laser wavelength range was from 410-710 nanometers. You'd only get mutagenesis from a UV light source so we couldn't cause cancer in the sample. Besides, the laser irradiates a portion of cells separated from the blood sample. So the patient would never be exposed to the laser light. John Viator Assistant Professor, Biological Engineering and Dermatology University of Missouri, Columbia

  12. Shhh be werwy werwy kwiet by Anonymous Coward · · Score: 1, Funny

    I'm melanoma hunting hehehehe

  13. G*D-damned anonymous nimrods! by mmell · · Score: 3, Insightful
    Did you even read the article? It seemed to be from a reputable source, reporting current, important information of interest not only to /.'ers but to the world community. The article was concise, reasonably well written and dealt not with some incredibly distant possible technology but rather with a technology which could very soon be in routine use in oncology centers around the world.

    I don't care if Roland Piquepaille is a shameless whore, trying to drive hits and business to his website (although I didn't see any of that in this article). In this instance, he has posted an article which is reasonably intelligent, reasonably presented (clicked through thirty pages of NYT to read thirty paragraphs of a story lately?), and likely to be of interest to /.'s target audience. What's your major malfunction, maggot?

    Then again, I suppose the name "anonymous coward" says it all, eh?

  14. what do they sound like? by revery · · Score: 4, Funny

    Apparently cancer cells sound very much like the Starland Vocal Band and can frequently be heard singing "Afternoon Delight" while carrying out their destructive task.

    Which is just one more good reason to eradicate cancer once and for all...

  15. Luke, use photoacoustic detection... by fahrbot-bot · · Score: 4, Funny
    • Luke: How was your chemotherapy treatment?
    • Obi-Wan: It's as if millions of cancer cells suddenly cried out in terror and were suddenly silenced.
    --
    It must have been something you assimilated. . . .
  16. Roland Piquepaille Blocker by brendandonhue · · Score: 1

    I realize that the summary doesn't link to Roland's blog this time, but any Firefox users that want to hide his submissions can use this Greasemonkey script: http://userscripts.org/scripts/show/5738

  17. Melanoma cells required by flyingfsck · · Score: 1

    You'll need to use cancer cells for your photolysis tank. Ordinary cells will die.

    --
    Excuse me, but please get off my Pennisetum Clandestinum, eh!
    1. Re:Melanoma cells required by Stile+65 · · Score: 1

      I was thinking about engineering plants or algae to use a derivative of melanin instead of chlorophyll... or using a derivative of melanin grown with genetically engineered yeast or bacteria and extracted and purified as something to print on thin-film solar cells or something.

      --
      I claim first use of "Error No. 0B" - or "No. 0B error." It'll be the new ID 10T!
  18. Good news for us Basal Cell Pxs too. by fuego451 · · Score: 1

    As a basal cell carcinoma patient I stand a greater risk of developing a melanoma in the future. It is nice to hear that new tests and treatments are being developed which could save lives.

    I am paying for a lifetime of fun in the sun. This month I had Mohs surgery for a deep rooted basal cell cancer on my nose, which left a nice crater, and will receive skin grafts in a few weeks to make me handsome again. But this is a cake walk compared to melanoma.

    Protect your skin.

    1. Re:Good news for us Basal Cell Pxs too. by javiator · · Score: 1

      I'm glad you're doing well. We are also working on a method to more precisely define basal cell carcinoma borders so that when a patient needs such a lesion removed, we can preserve as much healthy skin as possible.
      John Viator
      Assistant Professor
      Biological Engineering and Dermatology
      University of Missouri, Columbia

    2. Re:Good news for us Basal Cell Pxs too. by fuego451 · · Score: 1
      We are also working on a method to more precisely define basal cell carcinoma borders.

      Well, this is good news as well. I have some pretty gnarly scars on both shoulders from excision, burn and scrape removals of BCC. Not a big deal to most men, probably, but I can see where many women and some men might be upset with the result of EBS. On the other hand, not even I can see the scar from the excision of the basal cell cyst under my right eye.

      Being a neighbor, you may have heard of my doctor for the Mohs surgery; Carlos A. Garcia, M.D.(plus long credentials) from the University of Oklahoma, Department of Dermatology. Great guy.

      Thank you for the reply and please keep up your great work which so many of us appreciate. Oh, and please don't move to a coast. You would probably receive more fame and I know you would reap much more fortune but we really need you here in the central US.

      ~robin

    3. Re:Good news for us Basal Cell Pxs too. by javiator · · Score: 1

      I moved here two years ago from nearly a lifetime on the west coast, most recently Portland, Oregon. I love Missouri and the midwest. In fact, I don't think I would have come upon this area of research if I hadn't been at the University of Missouri. The spirit of collaboration is so great here, I routinely work with people in the College of Agriculture, Engineering, Arts and Sciences, Veterinary Medicine, and School of Medicine. It's a great environment and I think the openness and friendliness of the people of the midwest has a lot to do with it.

      Haven't heard of Dr. Garcia, but I hope to cross paths with him as I continue my work in Dermatology.
      John

  19. Kill em... by suv4x4 · · Score: 1

    If it can make cancer cells vibrate and the rest not.. can a vibration strong enough kill them?

    There was an allegedly "quack" treatment of cancer and bacteria revolving around this technique several decades ago.

    Now it suddenly resurfaces... You can't stop science with misinformation and lawyers can you...

  20. Prediction by Anonymous Coward · · Score: 1, Insightful

    We will find that almost everyone over forty has enough cancer cells that the detection is meaningless. The real question is, "why do some people's cancer cells replicate at high rates, causing what we call cancer?'

    1. Re:Prediction by Ginger+Unicorn · · Score: 1

      why is that modded insightful? how do we know it's an insight? the tone of the statement strikes me as being plucked out of his ass.

      --
      (1.21 gigawatts) / (88 miles per hour) = 30 757 874 newtons
  21. TOOTH FOR SALE by punchwhilecube · · Score: 1

    http://cgi.ebay.com/ws/eBayISAPI.dll?ViewItem&item =200038011808

  22. Pssffft... by nanoakron · · Score: 1

    That's the sound of vapour-ware my friend!

  23. That's going to be in the Matrix prequals by trigggl · · Score: 1

    That's why we took out the sun. Whole batches were lost. On a serious note, cancer is no joke in any of it's variations. I had a year of chemo to treat a brain tumor. I was one of the lucky ones. Most people that get a brain tumor are only treated for 3 months. A brain tumor is a death sentence most of the time and even when the treatment works the first time, there is a 98% chance of a recurance. Tick, tick, tick,... Way to go Mizzou! Don't let all the jokesters dampen your spirits.

    --
    Ops, I shuld have usd the prevuwe but in.