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Objections Over Antibiotic Approved for Use in Cattle

An anonymous reader writes "The Washington post reports that the FDA is expected to approve the marketing of the new antibiotic called Cefquinome for use in cattle. This is over objections of the American medical association, the FDA advisory board and the World Health Organization. Cefquinome is from a class of highly potent 'last line of defense' antibiotics for several serious human infections. It is feared that large scale use in cattle will allow bacteria to develop a resistance to these drugs. This news follows complaints from the FDA that it is no longer getting the funds needed to do the research required for the desired level of food safety."

26 of 253 comments (clear)

  1. This goes beyond idiocy by dsanfte · · Score: 5, Insightful

    This goes beyond idiocy... This is blatant pandering to the cattle lobby at the expense of our health. Everyone of us who might one day get MRSA, or flesh-eating disease...

    Any increased use of these drugs, especially on bacteria present in the food supply, is asking for disaster. When a federal agency start making bad decisions for corporate lobbyists that will cost real lives, it's time for heads to roll.

    --
    occultae nullus est respectus musicae - originally a Greek proverb
    1. Re:This goes beyond idiocy by miskatonic+alumnus · · Score: 4, Insightful

      But, but, what you propose would interfere with that most holy of holies --- the Free Market. Please, won't someone think of the stockholders? A few million lives is a small price to pay for corporate megabucks and a strong economy. Fnord.

    2. Re:This goes beyond idiocy by Chandon+Seldon · · Score: 4, Insightful

      The free market fails in the face of uncompensated externalities.

      "A few million lives" for "megabucks" won't produce a strong economy anyway. In an economic analysis, you *can* put a price on human lives - but that price is well over the couple hundred bucks each this statement implies at maximum.

      --
      -- The act of censorship is always worse than whatever is being censored. Always.
    3. Re:This goes beyond idiocy by Frumious+Wombat · · Score: 5, Insightful

      Or, we could try a free-market approach: We charge ranchers market-rates for grazing lands and water, we stop propping up corn-states with subsidies so that dirt-cheap corn isn't available for feedlot use as clearance prices, and we treat feedlots as the industrial polluters they are, and regulate them accordingly. While we're at it, label beef openly. You should be able to pick up a package of beef, look at the label, and see "feedlot-raised herford routinely injected with the following antibiotics@concentration@interval just in case". Next to it would be, "grass-fed, open-range, dusted for ticks and certified treated only for illness and not within 120 days of slaughter". End result: a whole whack of inefficient cattlemen go under (at least we won't have to list to the whining of rugged individualists who only need continual tax subsidies but no other gub'mint involvement to stay in business), meat prices rise a bit, successful ranchers will go back to open-range grazing like Argentina does, and possibly some of that fertilizer-gulping corn will be plowed under and prarie grass for grazing planted in its place.

      With better animal-husbandry (don't feed a grazing animal expecting a high-fiber diet acidic corn and make it stand in one place all day), you'll get healthier animals, and less need for antibiotics and other promoters to make them grow. And before anyone starts the accusations, I eat meat and look askance at soybean-based alleged food products. These are the same people pushing irradiation of food so that they don't have to slow down slaughterhouses and worry about what bits of cattle-waste end up on or in meat. Sometimes the answer really is, "it's not a machine, and we should not be producing beef as if it was Nikes, so worry about public health first, then about m

      --
      the more accurate the calculations became, the more the concepts tended to vanish into thin air. R. S. Mulliken
  2. Re:OK Dems, the ball is in your court . . . by bill_mcgonigle · · Score: 4, Insightful

    Now that the Dems are back in the saddle, is it really "Bush's fault"?

    It's cute that you think there's a significant difference between the two parties.

    --
    My God, it's Full of Source!
    OUTSIDE_IP=$(dig +short my.ip @outsideip.net)
  3. "guidance document" by Wolfier · · Score: 4, Insightful

    Disgusting. They should understand very well that human health is #1, and animal drugs is #10, period.

    Any "guidance" serves nothing but to make up excuses that tries to justify animal drugs over human health, for pure "economic" reasons (i.e. greed).

  4. Re:Just don't eat meat by Anonymous Coward · · Score: 4, Insightful

    You're missing the point.

    It's not a fear that this antibiotic will have a negative effect on humans. The problem is that, by overusing this drug, it will lose its potency. Many antibiotics have already been rendered useless thanks to careless overuse, and this one has been deliberately set aside as a last resort. If cattle farmers are allowed to use this drug it will no longer be useful for treating human infections.

    The FDA is in every single way destroying a cure for life-threatening diseases in order to fellate a bunch of worthless scum-sucking factory farmers. You should be outraged, not just avoiding meat.

  5. Re:Just don't eat meat by ucblockhead · · Score: 4, Insightful
    Nope. Problem not solved. Vegetarians will also suffer if and when diseases become resistant to these antibiotics because of overuse in the cattle industry.


    Antibiotics should be banned for agricultural uses. It's putting all of us at risk so that a few can make a bigger profit.

    --
    The cake is a pie
  6. Re:"Feared?" by Dunbal · · Score: 5, Informative

    some invincible strain of ecoli

    E. coli is not, and has never been the problem - gram negative bacilli are fairly easy to deal with - we have loads of antibiotic families for them. The BIG problem is the various form of Staphylococci - gram positive cocci - with their built in enzymes that inactivate antibiotics plus all their other enzymes that are just perfect for digesting tissue.

          If I had to choose between a gram negative and gram positive infection, I'd choose the gram negative. Shoot me full of an aminoglucoside or a fluoroquinolone and I'll probably be ok. But gram positives... oops.

          This stuff is a _BIG_ deal. Vets have been using Vancomycin on chicken farms for YEARS. The more antibiotic we put into the environment, the more we encourage resistant strains. There is no doubt that those strains eventually transmit their resistance genes to human pathogens.

    --
    Seven puppies were harmed during the making of this post.
  7. Micotil by vladilinsky · · Score: 5, Interesting

    I'm a farmer/cattle rancher and i actuality get to respond to something on slashdot. I'm so happy. I can say that this really worries me because about 10 years ago we got a new drug Micotil for treating cattle. it would kill anything cattle got (people too if you inadvertently stabbed yourself) now doses for cattle have doubled or even tripled the treatment times need to be increased and the effectiveness, (in my view from my experience ie completely non scientific) is about 1/3 of what it was when Micotil first came out. Maby instead of looking for better antibiotics for the cattle we should be looking at why there are getting sick to begin with, because virtually all cattle that go through the Industrial livestock system get sick.

    1. Re:Micotil by nuzak · · Score: 4, Insightful

      Maby instead of looking for better antibiotics for the cattle we should be looking at why there are getting sick to begin with, because virtually all cattle that go through the Industrial livestock system get sick.

      Density. When you cram that many of the same species into one space, you have rather less of a herd and more of a bacterial growth medium, not unlike a petri dish. Suppressing natural immune responses through minimal culling and artificial antibiotics exacerbates the problem. And once you have really virulent infections going around, they contaminate the environment, so any livestock that merely pass through will pick it up. They can't even decontaminate hospitals completely -- you think a feedlot gets disinfected as much?

      Not to be rude, but how on earth can a rancher not know this sort of thing?

      --
      Done with slashdot, done with nerds, getting a life.
    2. Re:Micotil by WindBourne · · Score: 4, Interesting

      I use to work for Monfort's (Greeley co) back in the late 80's. One of the things that I recall was seeing an internal report of the increase of amount of antibiotics on the lots. These animals are in close proximity and then get intermixed with new cattle all the times. Worse, the lots were 10-20 feet apart. Finally, the workers would move from one site to the next with the same equipment. The above guarantees that all new bugs will be introduced into a yard, and then quickly spread. I remember thinking that it would have been far cheaper in the long term to simply change the set-up, but accountants said too much money. But hey, what did I know? I was just a coder with a micro-bio degree and had minimal farming experience growing up. The accountants HAD to be correct.

      Now, I prefer beef that is ranged. I would be nice to not use anti-biotics, but I consider that inhumane.

      --
      I prefer the "u" in honour as it seems to be missing these days.
    3. Re:Micotil by vladilinsky · · Score: 5, Interesting

      Its not rude, most farmers/ranchers don't know it. and all vets ever do and tell us is pump more antibiotics into animals, so thats what farmers do. I do know it, i moved away from the feedlot system to grass feed antibiotic free cattle about 5 years a go. i just wanted to make other people think

    4. Re:Micotil by vladilinsky · · Score: 5, Interesting

      the rest of the people around here (Alberta Canada) mostly are indifferent, some react offended at the thought that what they are doing could be considered harmful, and a few understand completely.

      the problems come in trying to market the meat independently. It is really hard. If you try to go through a store they tack on a minimum of 30% which forces me to sell it for market price. (how many people go into a store and are willing to pay more for there food) and if I sell it independently there are a whole other set of problems (to much to get into) so basically i can't sell it for more at this time. I do believe though that there is a growing market for antibiotic free meat.

  8. The Big One by DogDude · · Score: 5, Insightful

    The Big Thing that's gonna take humans down a notch won't be nuclear attack. It won't be global warming. It'll be a simple bacteria, maybe a version of something common like strep or staph that doctors just can't kill because of simple resistance. I can't wait.

    --
    I don't respond to AC's.
  9. Avoiding the word "Evolution" again by DrJay · · Score: 4, Insightful

    It's ironic that in light of the recent analysis of the use of the term "evolution" covered here on slashdot that the summary would suggest that the bacteria will "develop a resistance to these drugs." Resistance to the drugs will will evolve, if we're to use the proper term for the process.

    As the original article in that earlier discussion noted, if we'd use the appropriate term when discussing these issues, it's more likely that people will realize that understanding evolution is essential to understand this and a variety of other public health issues, such as emerging diseases, cancer, etc. And maybe, just maybe, science classes would be a touch more likely to teach science without winding up in the court system.

    --
    ______ This mind intentionally left blank.
  10. UK Policy by mr-mafoo · · Score: 4, Interesting

    In the UK we dont immunise animals that are going to end up down the food chain to prevent antibodies from passing down the food chain. And ofcorse to prevent resistant strains of the desieses from forming.

    This is why at the last foot and mouth outbreak we (UK) killed off all the infected stock. France etc treated their animals.

  11. "Industrial" by Svartalf · · Score: 4, Insightful

    Anywhere I see "industrial" I see unsustainable practices for maximal profits being done.

    Doesn't matter WHERE I see it. It just is.

    Pack a bunch of dumb animals into a tight space, something that isn't natural- you're going to get problems.
    The industry's answer, drug them animals up to offset the problem. Which isn't really an answer.

    As the Poultry industry seems to be figuring out- raising chickens and harvesting eggs more akin to the way
    one would do in the old days on a farm is actually better than the other way, costs only a little more to
    do, and produces much more desirable results (The eggs are more nutritious, as is the chicken meat- and they
    taste oh, so much better...) for only slightly more retail cost. The same goes for bread, etc. We've improved
    our ways of doing things such that doing things sustainably is more valuable than doing them for the lowest
    costs- and for each and every "cost saving" thing, we damage our health, etc.

    High Fructose Corn Syrup - while it's cheaper than cane sugar and other sweeteners, HFCS makes type II diabetics
    out of people. And we've adulterated the food supply with the damn stuff.

    Nutrasweet - I won't even begin to start on THAT stuff.

    Antibiotics given to animals indescriminately - antibiotic resistant bacteria that cause problems worse than the
    the expense of food would be if you'd back off a little on production.

    When will the food industry wise up? When will someone cashier the FDA as it currently is because
    it doesn't do ANYTHING of what it's supposed to do. It doesn't allow good drugs to be. It doesn't
    allow good food to happen. It doesn't prevent bad drugs from getting on the market. It doesn't
    prevent bad food production practices and additives from getting on the market. But it is the final
    arbiter on things for this country.

    --
    I am not merely a "consumer" or a "taxpayer". I am a Citizen of the State of Texas
  12. Re:OK Dems, the ball is in your court . . . by The+Good+Reverend · · Score: 4, Insightful

    It's cute that you think there's a significant difference between the two parties.

    It's cuter that people get modded up for repeating this nonsense whenever there's a political discussion. The differences aren't as remarkable as larger party differences in other countries, but to say there's no "significant difference" is absurd, unless you don't consider things such as rights to abortion, rights to marry who you want and freedom from religion important.

    (Yes, I realize there are democrats against the above things. But the party's platforms spell out clear differences).

  13. Can't teach an old cow new tricks by novus+ordo · · Score: 5, Interesting

    What's in that milk?

    "The sale of Posilac is illegal in virtually every developed country with the exception of the United States. Recent studies have shown that lab rats absorbed IGF-1 during the digestive process, which subsequently caused cysts and other cancerous growths to form in the test animals flesh. Despite numerous official requests for the FDA to revoke the approval for Monsanto's product, no such action has been taken thus far."

    Don't try and tell people though.

    As for FDA, I can't even begin to tell you how badly it's managed. Thankfully they thought about a perfect side dish to our Dolly steaks. Maybe we shouldn't wonder why health care costs are skyrocketing and people are getting fatter...

    --
    "You're everywhere. You're omnivorous."
  14. Huh? by Xenographic · · Score: 4, Informative

    BSE ("mad cow" disease) is thought to be caused by prions, not bacteria, last I knew. In other words, this antibiotic has nothing to do with it.

    That said, this is positively horrible that we're wasting a potent, last-line-of-defense antibiotic on cows. Why can't they use the antibiotics to which there's already a lot of resistance, anyhow, instead of wasting this one? I mean, you can just shoot a sick cow and dispose of it. I sincerely hope they're not suggesting we do that with sick people.

    When that many doctor's organizations are opposing this, it makes you wonder how the hell they can be expected to approve it. Well, okay, I admit to not wondering that much. In the end, I have to think that it all has everything to do with little slips of paper with green ink on them and not very much to do with medicine.

  15. Re:"Feared?" by puck01 · · Score: 4, Interesting

    E. coli is not, and has never been the problem - gram negative bacilli are fairly easy to deal with - we have loads of antibiotic families for them

    If I had to choose between a gram negative and gram positive infection, I'd choose the gram negative.

    I'm a physician and my friend who is an infectious disease doc happened to be next to me when I read your comment. We both aggreed, this comment is just plain wrong. I'm not sure where to start. Its wrong on many levels mostly because its just too simplistic. My time is limited unfortunatly, so I'm going to be brief. Gram negative infections are common and they can be serious, especially if they make there way into the blood. There are a number of highly resistant gram negative bacteria that are incredably difficult to treat as they are pan-resistant in some cases to every antibiotic avaiable so combinations have to be used for any effectiveness. It is not uncommon to do synergy studies for gram negative bacteria so that we can find combinations of antibiotics that will work because one will not. I personally have never heard of (nor has my friend) needing synergy studies in a gram positives bacteria - please correct me if we are wrong. Every gram positive I've treated or heard of has been at least susceptible to one antibiotic, either vanc or linezolid, usually both. Of course, gram positive infections can be very serious, but so are gram negative infections. I'm not sure at all where you are coming from in your statement. I apologize for the brevity...I wish I had more time.

  16. This is criminal... by dtjohnson · · Score: 4, Insightful

    Every gram of antibiotics administered is one more gram released into the environment where it will create resistant microbes. The microbes do not care if the antibiotic was administered in tiny doses to a 2-year-old with an ear infection or in massive doses to a 600 pound cow as a feed supplement to make it grow faster and bigger. EVERY antibiotic given to cattle in massive doses has quickly lost its effectiveness in the human population to the point that resistant microbes are now very common. The cow excretes most of the antibiotics into the environment where they create new resistant microbe populations that then migrate worldwide. The public health people hector doctors to avoid giving antibiotic prescriptions unless absolutely necessary and then the FDA does something like this. This is criminally negligent and irresponsible and some people at the FDA need to be brought to trial and thrown into prison.

  17. Follow the money by Scrameustache · · Score: 5, Informative

    Just don't approve anything. In about 6 months you'll get the funds you need. I don't think that would work:

    September 30, 1980-- The Public Board of Inquiry concludes NutraSweet should not be approved pending further investigations of brain tumors in animals. The board states it "has not been presented with proof of reasonable certainty that aspartame is safe for use as a food additive."

    January 1981-- Donald Rumsfeld, CEO of Searle, states in a sales meeting that he is going to make a big push to get aspartame approved within the year. Rumsfeld says he will use his political pull in Washington, rather than scientific means, to make sure it gets approved.

    January 21, 1981-- Ronald Reagan is sworn in as President of the United States. Reagan's transition team, which includes Donald Rumsfeld, CEO of G. D. Searle, hand picks Dr. Arthur Hull Hayes Jr. to be the new FDA Commissioner.

    [...]
    July 15, 1981-- In one of his first official acts, Dr. Arthur Hayes Jr., the new FDA commissioner, overrules the Public Board of Inquiry, ignores the recommendations of his own internal FDA team and approves NutraSweet for dry products.

    [...]
    September, 1983-- FDA Commissioner Hayes resigns under a cloud of controversy about his taking unauthorized rides aboard a General Foods jet. (General foods is a major customer of NutraSweet) Burson-Marsteller, Searle's public relation firm (which also represented several of NutraSweet's major users), immediately hires Hayes as senior scientific consultant.
    --

    You can't take the sky from me...

  18. Re:"Feared?" by Dunbal · · Score: 5, Interesting

    I'm a physician and my friend who is an infectious disease doc happened to be next to me when I read your comment.

          I'm a GP - so I won't argue with an infectologist. I'm also in the 3rd world. We barely have access to vanco in our (poor) public healthcare system - much less linezolid and the other new anti-staph drugs. If you have access to linezolid - great, I agree with you.

          For us if we run into MRSA that patient is pretty much screwed, whereas with a gram negative - despite having to use two or more drugs like genta/clinda, we can usually do something for the patient. I'm by no means an infectologist however ;)

    --
    Seven puppies were harmed during the making of this post.
  19. 30% becomes far more by r00t · · Score: 4, Insightful

    With 30% dead, lots of regular jobs are going undone, and regular things aren't being bought.

    The music store only has employees for a few days of the week. They have to shut down on the other days. Nobody wants to be out buying music anyway though. The rent doesn't get paid. The store closes. The landlord now has an empty storefront. That hurts business for his other tenents. Also, he still has to pay his taxes. The Burger King can't staff their place. Do they just close up shop?

    Businesses find themselves needing to shrink and consolidate, fast. That is majorly disruptive. Facilities must be closed. Employees may need to move; some will refuse.

    Everything becomes inefficient as businesses collapse. Shortages come and go, interspersed with surplusses that get wasted.

    Whole towns need to be abandoned. When a small place loses the only food store, the people have to move elsewhere.

    The police are in disarray, just like every other organization. The now-idle masses are starving, bored, irrational, and willing to take great risks because death appears likely anyway. The New Orleans looting was nothing, really. Imagine something like that accross the whole world. There will be no help coming from outside.

    Eventually, the farms aren't tended. The cattle aren't fed. Transportation is unreliable. Fuel may be mostly unavailable. Real food shortages set in.

    Way more than 30% die. Maybe 99% or more. Very few of us have a backyard garden that can completely feed the family.

    People fall back on idiotic superstitions, as they have done since the very first humans.

    Welcome to the Dark Ages II. (this time, Protestant and Islamic)