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Three University of Wisconsin Stem Cell Patents Rejected

eldavojohn writes "A non-profit alumni group from the University of Wisconsin (WARF) has suffered a preliminary ruling against three of their recent patents regarding stem cells. Given that these patents have been upheld in prior rulings, there is a lot of speculation that they will be upheld in a future court case. From the PhysOrg article: 'The patents, which cover virtually all stem cell research in the country, have brought in at least $3.2 million and could net much more money before they expire in 2015, the newspaper said. Companies wanting to study the cells must buy licenses costing $75,000 to $400,000. The newspaper said WARF recently started waiving the fees if the research is conducted at universities or by non-profit groups.' Should universities (or groups within universities) be allowed to hold patents and intellectual property while at the same time gaining donations and grants as an educational institution — or for that matter government funds?"

25 of 92 comments (clear)

  1. Research Exemption? by jakosc · · Score: 4, Interesting

    It's not clear to me that they ever had a case for charging Universities or Non-profit groups, so it's odd that they mention that they have "started waiving the fees"

    IANAL, but doesn't the Patent Research Exemption specifically mean that research does *not* require a license. Even companies can work on research and clinical trials and they don't need a licence as long as they don't begin commercial manufacture of the product within the patent term?

    1. Re:Research Exemption? by rhombic · · Score: 4, Insightful

      IANAL, but doesn't the Patent Research Exemption specifically mean that research does *not* require a license. Even companies can work on research and clinical trials and they don't need a licence as long as they don't begin commercial manufacture of the product within the patent term?


      There is no such thing as non-profit research at a university today, at least not in the life sciences. The reasons that non-profits are licensing these things is because THEY want to patent their inventions, and sell them to industry. If they don't have a license for the original research they did, they won't be able to sell it in turn. When the federal government started to encourage universities to patent the results of research off of NIH and NSF grants, and charge licensing fees, the whole idea of non-profit basic research died a sad death. Uni's are just for-profit research entities today, teaching is nearly irrelevant (most faculty consider it a burden & waste of their time), the junior faculty don't get paid much, & the post-docs and grad students are essentially slave labor, but the Profs that bring in big grants & patents are paid as much if not more than an industry.

      --
      1984 was supposed to be a warning, not an instruction manual.
    2. Re:Research Exemption? by Have+Brain+Will+Rent · · Score: 2, Interesting

      I have a lot of the same concerns. And frankly since I paid for the research through my taxes I think I should own it through the agency of my government. The research results should belong to either the appropriate level of government or the university that employs the researcher, or some mix of the two. The exact mix could depend on where the money for constructing and maintaining the university, providing grants etc. came from. Hopefully those entities make the results available to others at no charge.

      The argument that is frequently made is that the best and brightest will go to industry if they don't get something extra. Fine, pay them industry level wages. Why not? The added perks of tenure, relative freedom etc. should be more than enough to tip the balance towards the academic life. But the results of that work should belong to all of us. Whether or not the results should be freely available to industry is debatable and I can see good arguments for either side of that debate.

      It should also be remembered that different places have different ways of supporting university research. Some make it very competitive, with universities requiring researchers to pay for the facilities they use and government grants only going to the cream of the crop. Others tend to provide basic infrastructure as part of being hired while government research funding is spread around as much as possible so that most researchers get some funding for their work.

      --
      The tyrant will always find a pretext for his tyranny - Aesop
  2. Why not? by E+IS+mC(Square) · · Score: 4, Insightful

    "Should universities (or groups within universities) be allowed to hold patents and intellectual property while at the same time gaining donations and grants as an educational institution -- or for that matter government funds?"

    Why not? I would prefer a university to hold a pattern any day than any corporate - at least, they are letting other NPOs and universities use it without charging.

    In fact, give them more funding to do more research. Let them grab patterns before corporates get there first.

    1. Re:Why not? by mpapet · · Score: 2, Insightful

      I would prefer a university to hold a pattern any day than any corporate

      You are operating under the assumption that a university will act differently (better) than the average corporation.

      As this example points out, there is a direct link between patents and revenue generation for most universities. Why would a university miss an opportunity to generate revenue?

      --
      http://www.maxineudall.com/2010/02/should-economists-be-sued-for-malpractice.html
    2. Re:Why not? by oni · · Score: 4, Informative

      I would prefer a university to hold a pattern any day than any corporate

      I think we will all agree on this point. The real issue is the university charging license fees. I actually work at a university and we recently had a big seminar on intellectual property. You can really tell that the administration is salivating at the thought of an extra revenue stream.

      And I really can't blame them - everybody is strapped for cash these days. I'm just concerned that it's a slippery slope. I would hate to see the day that universities pass up on research because they don't see the ability to make money from it. "oh sorry professor Jones, we aren't going to allow you to research that. We really need you to focus on things that we can license. Thanks."

      So the point of this seminar they made us attend was that everything we do belongs to the university (and I agree) and that we can't release anything without their permission. They want first stab at it so that they can decide if it's a money-maker. Now in the past, I have come up with a neat little algorithm or something and I've just posted it on usenet, or I've answered a technical question on usenet. Theoretically, I'm no longer allowed to do that. My expertise has value and theoretically the university has the right to charge for it.

      So the concern is that there is a chilling effect.

      Look at what has happened to college sports teams. They are no longer about having fun or enriching students' educations by giving them experience with a team dynamic. College sports teams are about making money for the university - which is kind of strange because every part of a university should be dedicated to education. Sports could be an important component, but it's like they have been spun off into something else.

    3. Re:Why not? by john82 · · Score: 3, Insightful

      GP: I would prefer a university to hold a pattern any day than any corporate

      P: You are operating under the assumption that a university will act differently (better) than the average corporation.

      Both of you hold the assumption that a university is not a corporation. Whether or not it has such a status in the legal sense is immaterial. In every other respect, universities are corporations. There are for-profit and not-for-profit examples. Some are good "corporate" citizens, and others are not. They produce product(s) and attempt to generate value for their stakeholders. But to think of universities (as a class) to be a less corruptible entity than corporations is delusional.

      Corporations vs universities strikes me as a "distinction without a difference".

    4. Re:Why not? by doktor-hladnjak · · Score: 2

      Grant money is the life blood of scientific research at major universities (at least in the US). The money for equipment, graduate student stipends/tuition, supporting research and facilites staff simply has to come from somewhere else since endowments and state funding (in the case of public universities) are not enough on their own. It's not uncommon today for less than a third of the total budget of a public university to come from state or local government sources. Any academic department that wants to be successful at research needs to get those grants so that they can compete for the graduate students who do the real work down in the trenches of that business.

    5. Re:Why not? by sdjc · · Score: 4, Informative

      I think there might have been a confusion here. In most cases, you are right, the university owns the intellectual property. That is, once it has become codified IP (i.e., embodied in a patent, copyright, etc.). The researchers (i.e., inventors) are all named on the patent and usually obtain a share of potential revenues once initial costs are cleared. However, part of academic freedom stipulates that the university researcher has the right to bring his findings in the public domain without seeking to protect it - unlike typical employers where the employee must disclose any findings and cannot usually 'give away' advice or product of their work away independantly. The cooling effect is usually do to misinterpretations and the perceived threat that university will force researchers to seek patents (something that is, to this date, against most universities' mission statements). I recommend Benkler's The Wealth of Networks (freely available) and Krimsky's 'Science in the Private Interest' for a good analysis of the current situation.

  3. Reasons by Stooshie · · Score: 3, Insightful

    The reasons given were that the patents were:

    ... obvious to one of ordinary skill ...

    It seems to me that some business model patents and computer patents that were accepted should have been rejected for the same reasons.

    --
    America, Home of the Brave. ... .and the Squaw.
    1. Re:Reasons by theantipop · · Score: 2, Insightful

      The level of ordinary skill varies depending on the art in question. You cannot make a fair judgment between these fields as the level of skill in biotech research is much higher than your standard fair programmer or business manager. The education levels and average expertise are leagues apart.

      I apologize if you weren't trying to make this assumption, but it bears repeating regardless.

  4. Gov't Funded Research Should Be Non-Patentable by Skjellifetti · · Score: 4, Insightful

    I'm not too interested in the ethics or legality of obtaining patents from research funded by grants from non-governmental funding sources. That should be a contract item between the granter and grantee. But research results funded by government sources should be open and non-patentable. I've paid for the research once through my taxes. I should not have to pay for it again. Software developed using government funds should be open sourced using a BSD style license so that anyone can include it in either closed source or open source apps.

    1. Re:Gov't Funded Research Should Be Non-Patentable by Cheapy · · Score: 4, Insightful

      These patents bring money in to the university so they can continue to do research. This supports the research, and lets more research get done. The government doesn't give nearly enough money for all this research to happen without the help of money from patents.

      --
      Would you kindly mod me +1 insightful?
    2. Re:Gov't Funded Research Should Be Non-Patentable by fimbulvetr · · Score: 2, Insightful

      Are you saying then that you don't need the governments support? If you don't, then decline it.

    3. Re:Gov't Funded Research Should Be Non-Patentable by Tilzs · · Score: 2, Insightful

      The government already funds all sorts of research in the form of defense contracts to corporate bidders. Those corporations can patent their innovations. You aren't going to see open source DoD funded missile guidance systems up on sourceforge any time soon.

    4. Re:Gov't Funded Research Should Be Non-Patentable by Checkmait · · Score: 2, Insightful

      I understand your point of view but I object to my tax dollars going to an organization which is collecting money through patent licenses. I have no problem with government-funded research or an increase in government funding for research, but if a research organization is going to patent their research (certainly not a very ethical practice [remember the genome patents]), then they lose their government funding and have to make their own money for research with their licensing.

      p>It's the same with large companies such as MS or IBM (or smaller companies as in this case). We don't want the government handing out money to a corporation, such as one which engages in a lot of R&D, simply because they are doing research.
      --
      "All you need is ignorance and confidence; then success is sure." -- Mark Twain
    5. Re:Gov't Funded Research Should Be Non-Patentable by Hoplite3 · · Score: 2, Insightful

      Sure, they can make money this way, but what you're talking about is essentially a government granted monopoly on an idea used to subsidize research. This sort of monopoly has lots of hidden costs for the economy and an unknown benefit for the patent holder. Why not keep everything clear and open? Don't allow the patent. If they idea is really great, it should be easy for the research group that discovered it to get big grants in the future.

      This is the Adam Smith warning all over again. Government granted monopolies seem like cheap ways of subsidizing desired activities (research, in this case), but they end up costing a fortune. It's like funding things on bond issuance. The government regularly gives money to the NSF and the NIH because science has a solid track record of providing big returns on the investment.

      Locking up ideas in patetents like this is, to me, morally reprehensible too. It inhibits the free flow of ideas by regulating techniques, knowledge, and even the conclusions one can draw from data. I believe that the cost to society of the patent is too high. People invented things before they were granted monopolies, and they will continue to do so after those monopolies are removed. As the pace of innovation accelerates, more people encounter roadblocks caused by this unwise funding. And its exactly that they are paying for the discoveries of a past era through royalties now.

      Intellectual property of all sorts is absurd. The idea could sink our culture.

      --
      Use the Firehose to mod down Second Life stories!
    6. Re:Gov't Funded Research Should Be Non-Patentable by Frumious+Wombat · · Score: 2, Insightful

      Or, my cynical, university-employed, side says, allows administrators to indulge their Edifice complexes with a pot of money lacking strings, while still demanding the science/engineering departments bring in more grant money so they can skim it for overhead. Stanford is not the only university that's been using "overhead" to panel and decorate the administrators' offices.

      (disclaimer: TIME chosen because more authoritative publications are behind subscription firewalls; disclaimer 2: sour grapes due to working in facilities deemed "unsafe by modern standards for both teaching and research")

      --
      the more accurate the calculations became, the more the concepts tended to vanish into thin air. R. S. Mulliken
  5. Warf has had patents since the 1930's I believe by markk · · Score: 4, Informative

    WARF is independent legally from U. Wisconsin, and it has held patents for at least 60 years. Warfarin (Coumadin) was originally patented by Warf long ago. A lot of vitamin technology (producing them, etc.) was also. They are basically the research trust fund of the University. That is, they get a piece of the patents from researchers at Un. of Wisconsin and then distribute the money as grants to UW researchers. I think virtually all big Universities have similar structures.

    Whether these patents were good is another thing, I'm kind of hoping they go on obviousness or previous technology, because if they go the only software patent that would even match them might have been RSA. If I had any trust in the patent system to be consistent I would be for this rejection (speaking as a Wisc graduate) and as a principle I guess I still am.

  6. Why not? by Jonny+do+good · · Score: 3, Informative

    Should universities (or groups within universities) be allowed to hold patents and intellectual property while at the same time gaining donations and grants as an educational institution -- or for that matter government funds?

    If non-profits (particularly universities) hold patents that are funded by donantions and grants they can, in theory, reduce their need for these sources of funds. The Bayh-Dole Act provided an avenue for this and actually encourages universities to license their technologies.

    I am currently a research assitant for the Technology Commercialization Lab (a group that works closely with the Office of Technology Commercialization which governs patent rights for research conducted at the university) at my university and this is part of what we are supposed to do. We try to help professors in either starting a new company based on their research in order to develop a commercial product or to license it to a third party. The university gets 33% of the proceeds, the department gets 33%, and the professor gets 33% of any licensing fees paid to the university. In a research orinted university these proceeds have the ability to add up to a lot of cash to help fund further research, new facilities, and pay salaries. At my university we haven't produced many "killer techs" that have turned into large sums of money, but it can happen. Stanford and MIT (along with others) have both recieved significant sums of money from licensing patents.

  7. Who pays? by Hittite+Creosote · · Score: 2, Informative
    "Should universities (or groups within universities) be allowed to hold patents and intellectual property while at the same time gaining donations and grants as an educational institution -- or for that matter government funds?"

    If the government isn't going to pay 100% of the cost of the research, yes. My last research project was funded at 80% of cost. Where do they expect the other 20% to come from if we can't profit from our research?

  8. Should universities...be allowed to hold patents by l3v1 · · Score: 2, Interesting

    Should universities (or groups within universities) be allowed to hold patents

    Well, if anyone should, then better the universities than companies. Apart from that, I would _not_ ever allow _anyone_ to hold _any_ patent in _any_ way related to human health and cure. Yes, I know what that would mean to "health" and drug companies.
     

    --
    I am putting myself to the fullest possible use, which is all I can think that any conscious entity can ever hope to do.
  9. This isn't just about Stem Cells by Puls4r · · Score: 3, Informative

    Several years ago, a particular big 3 company *accidently* donated a patent regarding a certain coating to a university.

    That university then, 1 year later, turned around and sued the company that had donated the patent for violating it. I'm not kidding. To the order of $300,000 a month. I happen to be involved in the change getting rid of the old coating and moving to the new - just to get away from the litigation.

    Don't fool yourself. Universities are not about being institutions of higher learning. They are businesses, out to advertise and make money just like any other business. Their sports programs, their research programs, even the ranking in the grad and undergrad programs is ALL about attracting talent so they can attract more money.

  10. Re:Should universities...be allowed to hold patent by OakLEE · · Score: 2, Insightful

    I would _not_ ever allow _anyone_ to hold _any_ patent in _any_ way related to human health and cure. Yes, I know what that would mean to "health" and drug companies. Drug Research is one of the few areas where I would support a strong patent regime. Your average drug today costs hundreds of millions, if not billions of dollars to develop. There is simply no way for a company to recoup that money unless it gets exclusive rights to the manufacture and sale of that drug. In pharmaceutical discoveries were unpatentable, drug companies would have no incentive to invest in research. What's the point of spending a but load of cash to find the cure for cancer, when there are hundreds of generic producers waiting to copy your drug and undercut your margins?

    As far as alternatives to the current patent regime, the only other solutions are either government directed research or large government prize rewards. Both of these have drawbacks that far outweigh the benefit of their implementation.

    The problem with direct 100% government funding is that it creates an incentive to never actually finish work. Researchers would be loathed to find a cure if that cure meant that they were no longer needed and their funding would be cut off. As an illustration, look at the War on Drugs. Do you think the DEA and FBI would actually benefit if all illegal drugs were to suddenly stop entering the US? No, they would have their funding either capped or cut.

    Direct prizes are problematic b/c they are inherently hard to value. At a proper prize would have to cover the cost of research plus a "healthy" profit to get companies to compete for it. The hard part here comes in determining the valuation. If the prize amount is set too low, no one will do research. If it is set too high, you effectively have society overpaying for the drug, the excess being the prize amount minus the minimum amount the winning company would have accepted. All of this guessing is eliminated in a patent regime, as the market will determine the amount spent on research, while the patent will effectively serve as "the carrot" for which the drug company will be awarded.

    --
    The sun beams down on a brand new day, No more welfare tax to pay, Unsightly slums gone up in flashing light...
  11. Re:Should universities...be allowed to hold patent by OakLEE · · Score: 2, Interesting

    Would you - honestly - trust a pharmaceutical corporation to support research for a cheap and effective cure to ANY of the billion-dollar-revenue generating illnesses out there? This isn't conspiracy-theory 'They're sitting on an AIDS vaccine!' shit either, this is a simple and likely 'Why fund that? It'd just hurt our bottom line.' Yes, I would trust the pharmaceutical company. The first pharmco to cure cancer or AIDS is going to make hundreds of billions of dollars off the cure, and severely hurt their competitor's bottom line.

    If anything completely government funded research would be worse, because the researchers have no incentive to complete their work. What's going to happen when these researchers find a cure? Their funding is going to be cut and they'll be out of work. If anything, they have incentive to string the government along because, unlike a pharmco Congress would not dare cut their funding. No Congressman wants to have to explain to his constituents how he is hindering their only hope of a cure by reducing funding.

    The other benefit to pharmcos is competition. As I alluded to, if there is only one entity researching a cure, its only going to take one approach at a time to finding it. Contrast this with having several companies doing research. Each company is going to develop its own road map and take varied avenues to the research, effectively speeding up research as a whole. It's like the idea behind distributed computing. Why have one processor repeat same task 10 times when you can have 10 processors do each task once?
    --
    The sun beams down on a brand new day, No more welfare tax to pay, Unsightly slums gone up in flashing light...