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Longevity Gene Found

quixote9 writes "Calorie restriction while maintaining nutrient levels has long been known to dramatically increase life spans. Very different lab animals, from worms to mice, live up to 50% longer (or even more) on the restricted diets. However, so far, nobody has been able to figure out how this works. Scientists at the Salk Institute have found a specific gene in worms (there's a very similar one in people) that is directly involved in the longevity effect. That opens up the interesting possibility that doctors may someday be able to activate that gene directly and we can live long and prosper . . . without giving up chocolate."

9 of 358 comments (clear)

  1. People demand it by ch-chuck · · Score: 5, Funny

    Give me immortality, or give me death!

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    try { do() || do_not(); } catch (JediException err) { yoda(err); }
  2. Gene sequence in hex is... by Bob54321 · · Score: 5, Funny

    09 F9 11 02 9D 74 E3 5B D8 41 56 C5 63 56 88 C0

    (That is going to hurt my karma but I am still no bored of that joke...)

    (OK, maybe a little over it)

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    :(){ :|:& };:
  3. Ponce de León still searching... by Door+in+Cart · · Score: 5, Insightful

    Our current life expectancy is already putting such a burden on our social security system. When will people realize that quality of life != quantity of life? How is our great-grandkids' generation supposed to support millions of supercentenarians?

  4. tinfoil response by u-bend · · Score: 5, Funny

    How long do we really want these worms to live? Till they become sentient long-lived invertebrate overlords?

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    u-bend
  5. Re:OTOH by vidarh · · Score: 5, Insightful
    Birth rates are already well below maintenance levels in most industrialized countries, and even China is set to see it's population peak soon due to the one child policy. The solution to the problem of too high growth is helping developing countries out of poverty.

    We're maybe as little as a century away from actually seeing the worlds population shrinking unless we start increasing lifespans a lot faster than we have.

  6. Who Doesn't Wan't More Time? by knapper_tech · · Score: 5, Insightful

    If I could get a few more years earlier in life while I still have gobs of energy and relatively no responsibilities... Suddenly four years for a degree wouldn't seem like a huge investment. A year of study abroad in Japan wouldn't be an issue. I might have two hobbies. Long term investments would make more sense. I would take more time to learn more things, aquire more skills, and experience a broader life.

    In short, I think living longer would make it a lot easier to live sensibly. As it is, if I have to weight the risks of investing time or taking something I can do now, I end up taking the most courageous and risky courses possible.

    I don't think it's a relative thing either. Not in the sense that, regardless of whatever time-span I had, I would always wish, "Wow, if only I had twice as much." In an absolute sense, I just don't think I'll ever have the years to do all the things I want to. It makes it seem really pointless to invest eight years into something (for instance, undergrad + med-school) when it's such a large investment that, by the time I get done, I will have lost many opportunities of youth, but I couldn't put such a thing off because, who wants to invest eight years in something that will only pay off for twenty?

    Humanity is robbed. People live crazy lives because we are going to die too soon to live fully, so life is futile. Damn whatever you recognize as the determining factor of our longevity. The light is green to research like this.

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  7. They all got it wrong by aadvancedGIR · · Score: 5, Funny

    Healthy food does not prolonge life, it just make it seem so long and boring you want to die.

  8. Interesting similarities by mapkinase · · Score: 5, Informative
    BBC article has a link to another BBC article about an example of a man who followed this diet:

    On a typical day, I will eat an oatmeal-based recipe for breakfast, which is about 455 calories and it gives me about half of my daily nutrients.

    I don't eat lunch - after this breakfast I just don't feel hungry - so that leaves me about 1,350 calories for my evening meal, which is a lot.
    This is very close to the dieting of the Muslims when they fast (obligatory fast during Ramadhan or voluntary fast during the month of Sha'ban, on Mondays and Thursdays, on 13,14 and 15th of each Islamic month or other recommended days).

    We have a breakfast (Suhur) before dawn and do not eat or drink until sunset. After sunset we have a usual meal (Iftar). The only difference to the diet described in this BBC article is that we do not drink while Mr. Cavanaugh does.
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  9. worms and caloric restriction: the dauer effect by sbruinsma · · Score: 5, Interesting

    Interesting study, but I'm always a bit leery of aging studies done in these worms (C. elegans), especially those which involve caloric restriction. Worms have the ability to follow an entirely different developmental path under certain conditions. Thus, normally, worms progress to adulthood and live a couple weeks. But if they are STARVED, at a young stage they shift into what is called a "dauer" state--they stop growing and can live for months and months. This is totally different than just living longer or stopping aging at a normal state--they are entering an entirely different developmental stage, which they normally would never see. Humans, of course, have no such developmental path. So with aging studies dealing with caloric restriction in worms, you have to wonder if they're studying something relevant to mammals, or if they are manipulating this worm-specific dauer pathway. It almost seems more likely to me that they would be affecting something to do with this dauer state. It will be interesting to see what happens when they follow up in mice.