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Nicotine Is the New Wonder Drug

Fantastic Lad sends us to Wired for a story on the upside of nicotine. Researchers are developing drugs based on nicotine that may prove beneficial for brains, bowels, blood vessels and immune systems. "Nicotine acts on the acetylcholine receptors in the brain, stimulating and regulating the release of a slew of brain chemicals, including seratonin, dopamine and norepinephrine. Now drugs derived from nicotine and the research on nicotine receptors are in clinical trials for everything from helping to heal wounds, to depression, schizophrenia, Alzheimer's, Tourette Syndrome, ADHD, anger management and anxiety." A separate story talks about nicotine warding off Parkinson's disease.

9 of 439 comments (clear)

  1. Re:Suspicious at best. by canUbeleiveIT · · Score: 5, Insightful

    I guess that you're intimating that the cigarette companies are pushing this.

    I'm sure that it won't be administered via a cigarette because the delivery system is important too. In the case of cigarettes, the delivery mechanism causes more harm than the nicotine helps. After all, antibiotics are good medicine but you wouldn't administer them by putting them on the tip of a knitting needle and jamming it into your eyeball.

  2. Nicotine and bowels by LordBafford · · Score: 4, Insightful

    I can kind of vouch for this. Usually when I have my first smoke of the day I have to use the can soon after. I always thought they just put laxatives in cigarettes..

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    Today's Tomorrow is Yesterday's Future! --- "Where Ever You Go, There You Are" -- Diablo 1
  3. Re:'medicine' by TheLink · · Score: 4, Insightful

    You're overreacting. It's all about the dosage and usage.

    Lots of people go for botox treatments, and allegedly some of them end up looking better ;).

    People consume poisons all the time - capsaicin (in spicy foods), cyanide (in almonds), caffeine, and nicotine. Chrysanthemum is often made into a tea, but it contains pyrethrum which is a "natural pesticide".

    In fact, it may be that a lot of smokers are dying more due to the radioactivity than the nicotine or tar.

    wiki: "One study found that tobacco grown in India averaged only 0.09 pCi per gram of polonium 210, whereas tobacco grown in the United States averaged 0.516 pCi per gram."

    "In support of this hypothetical link between radioactive elements in tobacco and cancer is the observation that bladder cancer incidence is also proportional to the amount of tobacco smoked, even though nonradioactive carcinogens have not been detected in the urine of even heavy smokers; however, urine of smokers contains about six times more polonium 210 than that of nonsmokers, suggesting strongly that the polonium 210 is the cause of the bladder carcinogenicity, and would be expected to act similarly in the lungs and other tissue."

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  4. Re:Suspicious at best. by LS · · Score: 4, Insightful

    Who said that cigarettes had to be the delivery mechanism? I'm sure cigarette companies have a large stake in tobacco farms, and may even own them. Seeing the heavy legislation and the decline in smoking, they are doing what any well-run company would do, which is to pursue other markets. The nicotine has to come from somewhere.

    LS

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    There is a fine line between being a cultivated citizen and being someone else's crop. - A. J. Patrick Liszkie
  5. You have to love corporate pharma... by tjstork · · Score: 4, Insightful

    We're going to replace a $2.50 pack of cigarettes with a $400 bottle of pills, and declare victory! I would be more than willing to bet that even if you factor in the eventual risk cost of cancer and other smoking related diseases, it might still come in cheaper than the cost of exotic drugs based on nicotine. The moral of the story is, smoke up to avoid depression, and hope science comes up with a cheaper pill to cure cancer.

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    This is my sig.
  6. Re:Oh great by BluBrick · · Score: 4, Insightful

    You gave up smoking? There's half your problem!

    It's in your language - you see not smoking as a sacrifice. Every time you mention to anyone that you're giving up, you subtly reinforce to yourself the idea that you are depriving yourself of something pleasurable.

    I stopped smoking instead of giving up. I made a point of referring to it in that fashion. The thing is, because of that attitude, I made sure I didn't feel like I was missing out on anything.

    Giving up smoking is hard - I tried it several times. Stopping smoking is much easier.

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    Ahh - My eye!
    The doctor said I'm not supposed to get Slashdot in it!
  7. Re:Suspicious at best. by asliarun · · Score: 5, Insightful

    Not exclusively nicotine. They sell an image. Nicotine is just a nice side effect that keeps people physically addicted to their stuff. Sure, but so does alcohol or any other legally addictive substance. My point here is not to start a comparison war or a flame on which drug is healthier/less addictive etc. I'm just trying to point out that there is a LOT of hypocrisy surrounding cigarettes and smoking. My guess is that this hypocrisy mainly arises because smoking has now become socially unfashionable and even a taboo, at least in the US. Let me put it another way: If the same study was done about say, the beneficial effect of wines or alcohol in general, i bet you would see a tiny fraction of comments making snide remarks about the validity of the test and about the funding agency. Yes yes, I know, the tobacco industry is evil and has a history of funding shady science, but I still feel that the scorn being shown on /. is disproportionate. Heck, even a hard drug like cocaine or LSD wouldn't get this much opposition and sarcasm.
  8. Re:Suspicious at best. by cayenne8 · · Score: 4, Insightful
    "Not exclusively nicotine. They sell an image. Nicotine is just a nice side effect that keeps people physically addicted to their stuff."

    It isn't just that...for many of us, smoking is FUN. I wish to hell it wasn't bad for you...if it weren't, I'd go back to it. It just was so natural to be in a bar, have a drink in one hand...smoke in the other. It also appeals to the 'firebug' in many people. Half the fun to me was the lighting up part.

    Also, was a neat way to introduce yourself to a woman...even not smoking any more, I often carry a lighter to light a smoke for her when she pulls one out.

    I'm sure some people...many in fact...are very hooked to nicotine..but, not everyone. Whenever I quit (and I've gone for years at a time)..the first 2 days are a PITA...but, not that big a deal after than. I didn't really smoke 'cause I NEEDED ONE....I did it because it was fun and an enjoyable activity for me.

    I don't think anyone is smoking because it "looks cool" or promotes an image. Most people I think smoke because they enjoy it and it is fun. If they came out with a harmless cigarette....I'd start smoking again immediately.

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    Light travels faster than sound. This is why some people appear bright until you hear them speak.........
  9. Not Sure Why... by severoon · · Score: 4, Insightful

    I'm not sure why this is so hard for some people to swallow. Most drugs that have such an obvious and strong effect on people and have been tested on millions with few adverse effects (all the bad effects of smoking come mostly from the smoke + chronic use—the nicotine merely makes it addictive) usually yield other valuable research output.

    I don't see any reason to let emotional value judgments get in the way of potentially valuable medical applications. Let's turn that frown upside down and make a negative into a positive!

    Disclaimer: No I'm not a drug company representative nor a smoking advocate.

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    but have you considered the following argument: shut up.