Slashdot Mirror


Mitochondria and the Prevention of Death

H_Fisher writes "Research into mitochondria — small structures within a cell that have their own DNA — suggests that they may be a cause of cellular death, according to Newsweek. The article The Science of Death: Reviving the Dead reports on people who have recovered from sudden death due to cardiac arrest through the use of medically induced hypothermia. The cooling process may help stop the death of brain and heart cells initiated by the mitochondria once they are deprived of oxygen. The article goes on to probe delicately at the question of where a person's personality 'is' between death and later revival, and describes several ongoing scientific studies of near-death experiences."

9 of 453 comments (clear)

  1. It's not exactly mysterious. by ScentCone · · Score: 5, Funny

    A person's personality goes off to Digg when they are Mostly Dead.

    --
    Don't disappoint your bird dog. Go to the range.
    1. Re:It's not exactly mysterious. by ozphx · · Score: 5, Funny

      Mod parent: +5 Hippy Ownage

      --
      3laws: No freebies, no backsies, GTFO.
    2. Re:It's not exactly mysterious. by Anonymous Coward · · Score: 5, Funny
      personally my game hunting weapon of choice is a stick of dynamite. i sneak up on my prey and insert it quickly and silently into it's anus then light it.

      the skill is in lighting it without them knowing.

    3. Re:It's not exactly mysterious. by Dahamma · · Score: 5, Interesting

      Um, no....
      Sorry, I don't read "arguments" that begin with "um".


      I was so tempted just to reply "I don't read 'arguments' that begin with 'um' *or* 'sorry'" - but I decided that it was only slightly wittier than either of the originals, and witty they were not.

      I find it hilarious that an article mentioning (focused on is too strong - despite the title it was about 4 paragraphs) an extremely low level process (ie possible mitochondrial-related rapid apoptosis of neurons after oxygen short-term deprivation as a leading cause of death in cardiac arrest) has resulted in some moronic moral battle between "keep what you kill" and "meat is murder".

      Your argument is stupidly off-topic for this article. So, here are two fun trains of thought to get you guys back on track:

      1) Your mitochondria, after millions of years, have not realized that we can usually revive the rest of your body after 10 minutes of cardiac arrest. Don't we wish they could figure that out. Maybe we could rise above other base "evolutionary" traits as well and learn to be more ethical to other living beings. Meat is murder!

      2) Your mitochondria, after millions of years, are the result of an amazing evolutionary process likely descended from symbiotic prokaryotes that now constitute the major energy-producing components of our bodies. Thanks to said little helpers and many other evolutionary advantages, we can enjoy a higher standard of living, often grow over 6' tall with the plentiful supply of meat and dairy, and even entertain the luxury of pondering ethics and morality on slashdot. Meat, it's what's for dinner!

      Pick your pseudo-religious viewpoint, and go at it!

  2. Thanks, but... by Icarus1919 · · Score: 5, Insightful

    I don't want to troll, but I prefer not to get my science from MSNBC and other mainstream media sources.

  3. Ob. Princess Bride by PresidentEnder · · Score: 5, Funny

    Miracle Max: See, there's a big difference between mostly dead, and all dead. Now, mostly dead: he's slightly alive. All dead, well, with all dead, there's usually only one thing that you can do.
    Inigo: What's that?
    Miracle Max: Go through his clothes and look for loose change.

    --
    I used to carry a bottle of whiskey for snake bite. And two snakes. -Nefarious Wheel
  4. Been there, done that. by RiffRafff · · Score: 5, Interesting

    I was diagnosed with "sick sinus syndrome." Well, not until I had basically died a few times. The electrical impulses that cause the heart to fire, ceased. I flat-lined, and was essentially "dead." The first few times (twice at home, 2 or 3 times at the hospital) I came back on my own. There was no "where am I?" questions upon regaining consciousness; I knew where I was, and I knew _something_ had happened, but I didn't know what. It wasn't until the last "episode," after they had attached a heart monitor with the little sticky-pads that the doctors actually knew, for sure, that I was flat-lining. They immediately ran a catheter up my groin, into my heart, and attached to an external pace-maker. A day later they implanted a pace-maker. Now, almost three years later, the pace-maker's computer says it has never "paced." In other words, I haven't really needed it. :-/

    My point is this: when I was "dead," I never "left my body," I never saw myself and the doctors in the hospital from "above," I never experienced anything. It was like a light-switch was simply flipped. I was just gone. No angels, no bright light, nothing. So. My advice, for what it's worth, is that you should do whatever you need to do. Whatever you need to accomplish. If my experience is any indication, there is no second chance. Do it now. Don't expect anything else after you're gone. When you're gone, you're gone. There appears to be nothing else. And while that may not be what you wanted to hear, that was my reality.

    Don't live your life in fear of death, but don't take anything for granted, either. As Warren Zevon said, "enjoy every sandwich."

    (Of course, Zevon also said, "I think I made a tactical error by not going to the doctor earlier." So don't do that.)

    --
    "I might have made a tactical error in not going to a physician for 20 years." -- Warren Zevon
  5. Just to deconfuse things by goombah99 · · Score: 5, Insightful

    Programmed cell death (apoptosis) is normally considered a good thing. Cell death is the front line against Viruses, toxins, and other pathogens. When a cell is hopelessly invaded it will immediately try to kill itself or be told to kill itself by it's neighbors? Why? Well first single cells by themselves don't have much defense against stuff so when the jig is up there's no point in trying to live on. An inveded cell is a danger to it's neighbors since the virus will use it's machinery to replicate. Thus it's a mutually assured destruction strategy. And the first thing most bugs do on entering a host is attack the signals for apoptosis. Indeed Cancer is dangerous because it's immortal.

    Thus it's interesting to find a way to override perhaps the most important response shared by cells in the body.

    --
    Some drink at the fountain of knowledge. Others just gargle.
    1. Re:Just to deconfuse things by MillionthMonkey · · Score: 5, Informative

      Cancer is immortal because the tumor cells have lost their chromosomal integrity; some of them are missing parts of chromosome arms that have the genes for triggering apoptosis. Part of an arm of chromosome 3 in particular seems to confer certain superpowers of cancer on cells that lose it; without it the cells can't recognize intercellular signals, but in general these genes do not aid cancer cells in their competition with one another. So as the population starts to evolve as a gene pool of individuals with distinct genotypes (variations on your original) that compete with each other to dominate the tumor, the cells that survive are the ones that lose the ability to control themselves for the greater good of the entire population (i.e. you).

      If taken care of, cancer cell populations can easily be kept alive for decades. HeLa cells were first cultured from a cervical tumor in a patient named Henrietta Lacks. There must be tons of HeLa cells in labs all over the world; all together they probably weigh hundreds of times as much as Henrietta ever did.