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Bone Hormone Linked to Obesity and Diabetes
grrlscientist writes "New research has shown that the skeletal system may be an important player in preventing obesity and type-2 diabetes in animals. This may also be true for humans, and thus represents an important development for the treatment of these health conditions. From the article: 'Not only do bones produce a protein hormone, osteocalcin (pictured), that regulates bone formation, but this hormone also protects against obesity and glucose intolerance by increasing proliferation of pancreatic beta cells and their subsequent secretion of insulin. Osteocalcin was also found to increase the body's sensitivity to insulin and as well as reducing its fat stores ... "The skeleton used to be thought of as just a structural support system. This opens the door to a new way of seeing the bones," said Dr. Gerard Karsenty, chairman of the department of genetics and development at Columbia University Medical Center in NYC, who headed the team that made the discovery.'"
You mean viagra? (Or as we scientists call it, \/1@gr@ )
At the bottom of the
This is true on the most primitive level. However, for a significant number of people "eating correctly" will mean a 1000 calorie-a-day diet of pure protein and in addition to not being obese they will be constantly hungry and lethargic, lose muscle mass and suffer from various diseases associated with malnutrition. They really need medication as well as medically designed diet/exercise program to take care of those genes and hormones.
Yes, 90% of fat people just need to lay off McDonald and other heavily processed food and throw away TVs.
Firstly, this isn't Digg, can we please not link to blogs? The original paper from Cell is here: http://download.cell.com/pdfs/0092-8674/PIIS009286 7407007015.pdf.
Secondly, this is exciting news, but not exactly surprising. The differentiation of cells starts in the bone marrow, and there are biochemical signals that start that process. It's not surprising that some of these would be in bone marrow.
Finally, must these articles always make a point to imply that obesity is cause by some random genetic/biochemical "magic bullet," instead of eating poorly and not exercising? I understand that they need funding, and implying you may be able to "cure" obesity is a great way to get it. Even so, I think there's something rather disingenious about it.
Informative? What the devil are you thinking? A blood glucose between 80-100 is NORMAL. A NORMAL person will bump up to MAYBE 120 after even a bad meal, but rapidly come back to the 80-100 level. If you get below 70, you're running into HYPOGLYCEMIA territory, enjoy your seizures.
800 is indeed a "nuke for your brain" but unless you're a Type I diabetic without ANY endogenous insulin production, or a horribly controlled type II, you're not gonna see that. Hell, I'm not sure I've even seen a fingerstick capable of registering above 550-600!
Respectfully, parent is full of hockey. I'm sure you're an excellent CS student, but you've not had biology for a long time, friend. Don't check your own Fingerstick blood glucose unless you have reason to (ie: a medical condition), but if you're suspicious, then GO TO YOUR DOCTOR. Get a Fasting Blood glucose drawn, not those crap fingersticks. And if you're not satisfied, push for a glucose tolerance test, where you drink RAW glucose, then follow your venous blood sugar levels to see how your body reacts. If it can't keep up with the load, then welcome to the wonderful world of Diabetes. If it DOES, count your lucky stars, go home, and throw out your ho-ho's, Oreo's and Jolt Colas, and try a lovely dose of Moderation In All Things for a change.
Jebus help me...
Hehe, code was "criteria."
Ketoacidosis is when your body, which creates acetones naturally, can't clean those acetones out of the blood. So, you get nail-polish breath, which, if medical personnel aren't careful, can smell like booze. That's bad because hyperglycemia can produce mental symptoms similar to drunkenness.
P.S. I'm a NJ EMT-B, and we frequently get calls where policemen want us to check out a drunk, with booze breath and all the mental signs like belligerence. They were really a diabetic at least 10% of the time.
Sorry for the OT
I have developed a truly marvelous proof of this comment, which this signature is too narrow to contain.