Bone Hormone Linked to Obesity and Diabetes
grrlscientist writes "New research has shown that the skeletal system may be an important player in preventing obesity and type-2 diabetes in animals. This may also be true for humans, and thus represents an important development for the treatment of these health conditions. From the article: 'Not only do bones produce a protein hormone, osteocalcin (pictured), that regulates bone formation, but this hormone also protects against obesity and glucose intolerance by increasing proliferation of pancreatic beta cells and their subsequent secretion of insulin. Osteocalcin was also found to increase the body's sensitivity to insulin and as well as reducing its fat stores ... "The skeleton used to be thought of as just a structural support system. This opens the door to a new way of seeing the bones," said Dr. Gerard Karsenty, chairman of the department of genetics and development at Columbia University Medical Center in NYC, who headed the team that made the discovery.'"
It still seems that not eating massive amounts of sugar (as most Americans do) might help prevent diabetes, too.
I thought that was Einstein pictured...
By what name do you wish to be mourned?
that old nice way of saying "she's fat": "she's just big boned", might actually be true?
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
Y'know what else prevents obesity and type-2 diabetes? Eating less!
Bone Hormone Linked to Obesity and Diabetes
Come on, we all know that fat people and diabetics find themselves unable to bone even when they get a rare opportunity.
You mean viagra? (Or as we scientists call it, \/1@gr@ )
At the bottom of the
By far the best method of combatting obesity is exercise and "eating right". That means cut out the fats and sugars as much as possible.
But people don't want to hear that, any more than they want to hear that credit cards don't magically pay themselves off, or that blowing the trust fund on film school won't automatically get them an Oscar-winning gig in Hollywood.
We have become soft. People aren't chasing their food anymore.
To the "quit blaming it on Americans" person, I AM American, so I blame Americans for their own health. Instead of blaming the European Union, the United Nations, the World Health Organization, or some other random company or government for Americans' bad health. I don't expect the government to make me eat right, nor make companies feed me right. If I can't think enough to look at the ingredients of something before eating it, I apparently am rather stupid. Furthermore, if I expect to be healthy AND eat at MacDonald's all day... well, I may as well believe that Windows ME is by far the best operating system ever produced. It'd be just as logical... :)
In fact, looksie at these links. http://www.mercola.com/2004/may/26/corn_syrup_diab etes.htm
- Corn syrup linked to diabetes.
http://www.washingtonpost.com/ac2/wp-dyn/A8003-200 3Mar10?language=printer
- Average American consumes, in 2001! ... about 62 pounds of corn syrup per year... no wonder we don't have that much real sugar, we replaced it with a chemical :)
Firstly, this isn't Digg, can we please not link to blogs? The original paper from Cell is here: http://download.cell.com/pdfs/0092-8674/PIIS009286 7407007015.pdf.
Secondly, this is exciting news, but not exactly surprising. The differentiation of cells starts in the bone marrow, and there are biochemical signals that start that process. It's not surprising that some of these would be in bone marrow.
Finally, must these articles always make a point to imply that obesity is cause by some random genetic/biochemical "magic bullet," instead of eating poorly and not exercising? I understand that they need funding, and implying you may be able to "cure" obesity is a great way to get it. Even so, I think there's something rather disingenious about it.
Also, you cannot eat pure protein; if you are eating low carb, you must eat fat. My blood pressure and cholesterol have confirmed that this isn't unhealthy as long as you aren't poisoning yourself with too much sugar and corn syrup (which is in a lot of foods you'd normally consider healthy, unfortunately.)
Brackets contain world's first nanosig, highly magnified:[.]
Actually, if I got that right, it sounds more like the absence of a protein that would get you "big bones" makes you obese.
We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
I've repeatedly heard it said that you would have to run for an insane amount of time to burn off the extra calories from just one cookie, so it isn't in that fashion that exercise helps with weight problems. The only alternative explanation I've heard involves endorphins and whatnot. I've suspected that it may be due to the fact that repairing the damage done to one's body during exercise is metabolically more expensive than just doing the motions, but had no idea whether this was true or not. This possibility, however, is far more interesting and direct - exercise puts stresses on the bones that may stimulate the production of a hormone that aids in the proper regulation of energy metabolism.
Kind of like how certain immune functions cease working in the absence of a gravitational field.
Granted, the root of the problem is energy intake exceeding energy expended, but until one understands better the reasons why a person would eat more than they need it is futile to tell people to just stop.
I've also wondered if part of the problem isn't that the modern, refined, carbohydrates are so concentrated. I mean, I would imagine that the human digestive system is capable of absorbing nutrients down to a certain concentration in the digestive fluids. If the calories are more concentrated, eg the food lacks fiber to give it indigestible bulk, then the body will absorb a larger fraction of the calories. So, another question I have is if it is significant to not just consider calories ingested, but calories ingested minus calories expelled.
Sugar (all the different sugars) are chemicals. All life is composed of chemicals. What you mean is, we replaced one chemical in our diets that was unnecessary and very unhealthy with another one that is just as unnecessary but even more unhealthy.
The higher the technology, the sharper that two-edged sword.
was corn-based byproducts (corn syrup?). Most cookies, like most snacks (in box listed portions of course) are around 180 calories. I run about 1 mile at a 10% grade for just over 10 minutes to burn that. My treadmill has on of those digital counters. Changes the way I think about having a beer or buying that bag of potato chips. But I wouldn't call 1 mile insane, just a bit of a disincentive.
Quack, quack.
No, HFCS and cane sugar are equally unhealthy. Both are essentially poisonous to your liver and their effects on your body are the same since they are effectively identical once they hit your mouth.
Claiming the two are somehow different, while popular here, is absurd. HFCS is processed so that is specifically the same as cane sugar; it's fructose content is not higher and its health ramifications are not different.
But, I think in modern slang, "chemical" refers to an unnatural or synthetic (whether synthetically produced/processed or manufactured) substance...
*shrugs*
I'm not fat, I'm big boned!
I know this from personal experience.
Refined carbohydrates put me to sleep and give me headaches.
Unrefined carbohydrates give me gas.
Engineering tradeoffs?
How many "lazy, overeating fat people" have personally told you that they set out to be fat? How many of them would not choose to be lean if given the choice? Why do you assume that fatness is a reflection of their lack of character? Have you ever been fat?
> A level between 40 and 80 is healthy, anything above 80 is unhealthy
40?! You're nuts. If you're below 50, you need to get some orange juice in your body ASAP. Between 80-110 is normal (closer to 80 is better, though). In fact, from the article you linked to, "A measurement of 40 is grounds for an immediate trip to the hospital." Really low glucose levels are more immediately dangerous (easily fatal) than high ones. Consistently high ones will destroy your body in ways you don't want to think about (blindness and limb amputation is common, among many other things).
If you go above, I think, 245 or so, your body goes into 'ketoacidosis' and starts eating itself and the chemical Acetone (nail polish remover) winds up in your bloodstream. I can tell you from personal experience that this feels about as good as it sounds.
Yeah, I know. Sorry to be so pedantic. But it irks me when people refer to food products as "natural" or "real" as if such things don't involve chemistry, but are made of some magically pure unadulterated goodness that no mere chemicals can hope to match.
The higher the technology, the sharper that two-edged sword.
I know some people who are legitimately "big-boned".
A girl I knew in junior high and high school had about 20 inch waist, but wore a size 10 jeans and women's large or extra large shirts. Her pants were baggy at the waist, but just barely fit over her hips. Her shirts hung, but anything smaller wouldn't fit over her very broad shoulders. She's never been fat or flabby.
I have a friend who has to do pull-ups with his hands about 2 or 3 inches apart at the most, because any farther apart and his shoulder blades touch. His chest after being in Kuwait and Iraq in the desert heat wearing boy armor for months was still over 50 inches. Even when he's got nearly an fat on him, the guy's much bigger around than most people his height. He does sometimes carry some extra weight, but he's big even when he doesn't.
While it can be used as an excuse by the overweight, there really does appear to b a difference between slightly built people and people with larger frames. Keeping the muscles toned and the fat down to a healthy level is what matters. Height/weight guides and the body mass index are not a true replacement for body fat percentage. They are much easier to get data to compare against, and they work pretty well for most people, which is why they are so popular. The BMI at least gives someone an idea of the range they should be close to, even if they might end up being a little above or below that and be perfectly healthy.
I have been fat. Over 300lbs twice in my life. It's because I ate too much and sat on my ass too much. Fat people eat too much, and don't burn enough off. Saying anything else is a damn lie. It's easier for some people to eat less or burn those pounds off, but that doesn't change the basic equation.
Dude, it is a simple as that. Eat what you need, not what you want.
The parent to your comment is more right than wrong. Fat people need to stop passing the blame for their 'condition'. Hell, most of the time just being overweight is the lead cause of degrading health - e.g. Diabetes.
"You obviously don't know a thing about the subject."
You obviously don't like being told it is your fault.
Dan. -- So what if it's spelt wrong, nobody's perfect
When I visited the doctor the last time they measured my waist, and said (to my great surprise) that 92 cm (36 in) is the recommended measure for men of ANY length.
More feel-good junk science to feed the rightfully low self-esteem of the Buffet Buffalo population. Many years ago a doctor candidly revealed to me that chronic pathological causes for acute Lardus Assimus account for about 2% of all cases. The rest of the up-right walking hog population is just lazy and eats too much, but doctors can't say that, at least not in public. Life experience tends to confirm this. If you want to be a pig, that's fine, but don't expect any sympathy from the healthy population.
Scruting the inscrutable for over 50 years.
"Fat people eat too much, and don't burn enough off. Saying anything else is a damn lie."
Whoever said otherwise? The fact is, though, that it doesn't have to be much food to be "too much". There are plenty of thin people that vastly overeat fat ones and yet are totally sedentary. If it were as simple as you say, then that wouldn't exist. There is something biologically complicated afoot.
"It's easier for some people to eat less or burn those pounds off, but that doesn't change the basic equation."
Yes, and perhaps it was easier for you to lose your weight than it is for others. Not every fat person is diabetic, though it's likely they will all eventually be. Some people get fat young and find it easier, particularly males, to lose excess weight. When I was in my 20's I weighed 260 and eventually dropped that to 190. I'm now 20 years older, weigh 210, work out at least three days a week, and have a body fat percentage of about 12%, yet controlling my weight now is much more difficult than ever.
What is interesting is why some people have so much easier time naturally controlling how much they eat than others. This is how naturally everyone should be and willpower has nothing to do with it. If a body degenerates into obesity we should naturally assume it is not working properly, not that the person has weak character. Instead, we assume the opposite and many feel inclined to post messages on the matter. It is not just sloth that causes obesity.
Actually, you are wrong but it doesn't surprise me that you said that. I'm in my mid-40's and have 12% body fat. I constantly work with my weight but few that know me consider me to be fat. My family, however, has a history of obesity and diabetes, my mother has it, my father died from it, and my siblings are becoming severely overweight. I have a great deal of experience in the matter and I see a doctor 4 times a year to do blood work.
"Dude, it is a simple as that. Eat what you need, not what you want."
When you grow up, maybe you'll have enough experience to offer and educated comment on the matter.
"You obviously don't like being told it is your fault."
Tell me it's my fault all you want. In 20 years you'll be fatter than me and the attitude will change.
i worked in a supermarket, yes it is sloth and gluttony causing the excess weight in >95% of cases. take a field trip to your local supermarket and observe the produce, bakery, meat, bread, and frozen foods aisles.
i'll tell you right now where you will see the fewest fatties; the produce aisle.
Snowden and Manning are heroes.
and I seem to have problems with candida albicans.
(Yes, I have been tested for diabetes. Inconclusive results.)
I've been living with this more than twenty years. I don't mind the gas. My wife and kids sometimes complain. Living without simple sugars is fine with me, but the hour and a quarter workout every day to kick me into gear before work is sometimes a frustration when I would prefer spending the time on some project.
I'm not as old as you (upper 30s), but I come from a family where everyone has a "weight problem", there is late-onset diabetes, high blood pressure, etc. I've been 40lbs overweight before. It's clear to me as anything in this life is that for the vast majority of people, being fat is a choice. Just like being stupid is a choice, or having a shitty job is a choice, or working hard is a choice, or saving money, or doing drugs, or blah blah blah.
Sure, there are mitigating factors, medical conditions, people need help, people need support, etc.
Here's my support for you: Working out 3 days a week is not enough. Ride your bike to work every day of the year. Every day. Too far? Move or change jobs. Reduce stress. Do you want to be healthy or dead? Run / bike at lunch before you eat at least 3 days a week. Train for a marathon, triathlon or century. Get off your fat ass and walk around at work for 5 minutes at least once an hour. When you get home, don't plant your 12% fat in front of the TV. Eat some vegetables for Christ-Sake. Stop drinking so much alcohol. Quit making excuses, you sound pathetic.
XML causes global warming.
Your work experience qualifies you for nothing. You have no idea whether obese people are that way because of what they eat or they eat the way they do because of their obesity. All you are observing is a connection.
"Maybe it's just that some people naturally have more willpower than others? Maybe some people genetically have more motivation than others? Maybe some people are bred to work hard and achieve goals? It's genetics I tell you, which is why the obesity rate in the USA increasing, obviously. Our genes are getting fat."
That is a nonsense explanation driven out of pure ego.
"It's clear to me as anything in this life is that for the vast majority of people, being fat is a choice."
Sure, just as living is a "choice". Doesn't mean there isn't an overwhelming biological drive to choose obesity. There are obese people with unbelievable appetites. It is absurd to think they choose to overeat. The problem is that they are constantly hungry; far more so than healthy people. Saying that their problem is a lack of willpower, that they are choosing to be fat, is bullshit. They do not face the same choice as you; theirs is far harder.
"Here's my support for you..."
I'm way ahead of you and don't need your condescending "support". I'm 10-15 pound overweight for a 45 year old man of 210 pounds. I work out WITH A TRAINER 3 times a week. I do cardio on my days off. I'm on hormone supplementation and am carefully monitored medically. I bet I could not only teach you a thing or two but run circles around you as well. You are not only ignorant; you're a prick to boot.
i worked in a supermarket, yes it is sloth and gluttony causing the excess weight in >95% of cases. take a field trip to your local supermarket and observe the produce, bakery, meat, bread, and frozen foods aisles.
I was recently diagnosed with a liver tumor, while the liver is 'functioning' correctly as far as medical tests go, one of the side effects of the tumor is a sweet tooth - a craving for sugar. I've been concious of the cravings for a long time and have discussed them with the trainer I see, we've tried a variety of strategies to try and address them. It was in some ways a relief to find out there was a medical reason why I was experiencing those cravings - it gives me more ammunition in how to cope with them.
And before you suggest it, the tumor wasn't cased by sugar - it's a known but rare side effect from taking birth control pills.
Sara
Designer, Gamer, Macgrrl in an XP World
I easily have the biggest chest of any male on either side of the family. However, I used to be tiny like the guys on my mom's side until I was about 7. Around the same time, I was diagnosed with chronic asthma and was on a constant regimen of various steroids (regularly until I was 18, sporadically since because my asthma doesn't kick in as often) to try to control it (likely cause is both parents were smokers). I've always wondered whether there was a connection there regarding my sudden change in metabolism, bone growth and the steroids. My chest definitely started growing beyond my peers pre-puberty. There used to be a gap between the gym lockers and the wall and most of the guys could fit back there but not me, even though I was still thinner than them in the gut.
Also factor in that my dad has a hypothyroid condition. My sister was also diagnosed with it after having a baby and seeing an endocrinologist. My dad's mom's mom had goiters the size of baseballs too. There is obviously a genetic connection in the family, though to my knowledge nobody else has been tested for it. It might, however, explain our metabolic problems with stomach weight and could be the reason why I plateau on weight loss despite sticking to my diet.
Fact is, weight isn't simply a matter of calories in. I was eating about 1000 calories a day for three months while continuing to walk 5-6 miles a day and I couldn't drop any more weight. According to various calculators, I require 2200-2500 calories to maintain my weight. Given the difference, I still should have been losing at least 1200 calories (or a third of a pound) per day.
Don't leave your mind so open that your brain falls out. Don't close it so much that you cut off the blood.
Humans only use up a small amount of energy by moving around. The problem isn't the lack of movement it's the junk which typically goes into the mouth while watching TV.
No sig today...
No, she/he is both fat and big boned.
My other SIG is a Sauer.
I'm slim, strong, BMI of 21, and an accomplished rockclimber.
Guess what, I'm 44 years old!
Grandparent is absolutely right!
I've been asked several times if I'm on a diet. Well bullshit, It's just that I don't overeat. I don't count calories, but am aware of what I eat, and don't stuff myself. Oh by the way, apart from the climbing, I also use an exercise bike about 30 minutes every day.
I will not allow myself to become like most of my age group, flabby, unhealthy whiners. I'd rather be dead!
Well now you can go back to the fridge and the couch.
Bart
I'm guessing you've stopped taking birth control pills? That could have the side effect losing some weight as well, I noticed this with my girlfriend. As for the sugar cravings, you might be able to fool your brain by buying a can of sweetener and a sack of lemons. Add the juice and the sweetener to water and you've got great sugarfree lemonade.
8 of 13 people found this answer helpful. Did you?
I have always said that GH levels that control not only muscle and hormone levels, they also
affect bone....as per our early bodybuilders would show us due to the use of organic GH
as opposed to the synthetic used today. Organic made their bones grow, hence the big gap in their teeth, so because of this, also I would have to agree with this article as I knopw myself from personal experience using insulin, that everything is related at the molecular level to the gh our bodies produce, and which is why they give hormone therapy to obese people and also to aids victims.
...and since you've never experienced metabolic syndrome, no one has. Furthermore, you never will!
You may claim to be 44 years old, but you think and brag like a teenager.
You've demonstrated that you're a prick, now demonstrate that you're not ignorant.
Where did I say anything about "good enough"?
I don't give a shit whether I'm "way ahead" of you or anyone else. My health is my concern, it's not a contest. I could give a shit about the bragging of someone in their early 20's. They have no idea what they face 20 years down the road.
I am also not an "old fart", I am only old compared to those who have no living experience as an adult yet. Once again, you are barely and adult. Who gives a shit what you think?
Lastly, I don't care what the parent was "telling me to do". He knew nothing of my personal situation, his purpose was to make condescending remarks me just as you are.
Well maybe I'm just irritated by all these people that seem to think that its inevitable that you get fat when you get older, or that tell me that with my metabolism I can eat anything.
If I look at the amount of food that those commentators stuff into their body, they always out-eat me by a large amount. Also, the kind of stuff, the deepfried foodoid they seem to prefer is definitely not part of my diet. The funny thing; I am generally taller, and probably more muscular also, so I would need more food to keep those muscles, no ?
I don't brag, I have no reason to brag, this is my life, my body, and I like it this way. Just stop whining when you're overweight, and do something about it.
And lastly, don't sit on top of me in the bus, when you're attempting to sit NEXT to me.
Yes, I read what you wrote the first time. I'm a prick. And ignorant. Yeah, good for you. What about that little bit of bragging bullshit you posted? Ready to respond to the other half of my post yet - or are you too busy "teaching me a thing or two" and "running cicles" around me in you mind?
XML causes global warming.
Carrying excess weight primarily around the midsection is a strong indicator of risk for type 2 diabetes. My doctor keeps telling me that focusing on losing weight there in particular will help keep me from ever becoming insulin dependent like my dad.
There are over 2 dozen non-overeating causes known for obesity, yet bigots like yourself continue to spout your bile. It has been shown that obesity is one of the last acceptable prejudices, because it allows the well-off to look down on the poor who cannot afford gym memberships and healthy food, but have to eat the much cheaper starches, which creates insulin resistance.
Yes, yes I have been. Last August, I weighed nearly 280 pounds. My waist line was approaching 46 inches, and I was sick of it. I then decided to start eating "better." I cut out high calorie, high junk foods, and by January I had dropped to 260. I decided that wasn't enough, and in February began making myself be more active. Not "ZOMG, Run 3 miles a day!" active, but simple, working more exercise into my life (parking at the far en d of the parking lot, walking to the library instead of driving, riding my bike 2 miles to work, hitting the gym 2x a week, playing softball) I now weigh 215, fit comfortably into 38 waist pants, and am quite happy with myself. So yes, I can say that (the majority of) people who are fat, choose to be fat. The choice *not* to do something about it is as much of a choice as the choice *to* do something about it. The fact that it's far easier to simply choose not to do something doesn't absolve people from their own responsibility.
This one made me smile, good one, proves that fat people can be funny: "I've never sat on a person while getting on the bus but I might make and exception in your case." Unless you're not fat ofcourse, in which case it just proves that you can be funny.
:-) I once earned some dollars, but that was in the nineties somewhere. I mostly earn guilders and euros :-)
As for your arguments; maybe my body craves less food than that of an overweight person, that still does mean one HAS to put the food in. I know my wife eats less than she would like to, and doesn't eat some of the things she'd want to, because she likes to be slender more than she likes the food. She used to be chubby by the way, and proves that being overweight can be fixed by lifestyle changes. Same for my father in law by the way.
The other thing: the obesity epidemic is worse in the U.S than anywhere else. This country at the same time has: a very sedentary carloving lifestyle; little free time; lots of eating out at fastfood places; not enough sleep for most of the population! There is obviously no genetics involved since the Americans were not overweight only 50 years ago. The connection seems obvious. Add to this the fact "low fat yoghurt" in the U.S. supermarket would be called normal yoghurt here in Holland shows that supermarkets food labelling doesn't help. Oh one more thing: have you ever considered the meaning of the "Health Food" section in the supermarket? What are they selling in the rest of the place???
As for me personally: I eat no meat, I eat no fried food, I eat no butter or margarine. I eat no candy. No fast food. If there is a low-fat variety of something, I eat that. I exercise, a lot. I sleep enough. Ofcourse I'm at a healthy weight. You won't find anyone with my lifestyle that's overweight. Simple.
Greeting and no hard feelings
Oh, I made 75kEuro last year by the way
We often view bones as the skeltons of the dead, but bones are amazing alive and active organs in body. The American who won then lost Tour de France last year had a dead hip joint during the race. Its was supposed to have been excruciatingly painful and most pain drugs were banned by the Tour.
The trainer recommended have a small chunk of cheese - slow release energy and protein. The other recommened option is raw fruit - the fructose (not from corn syrup - from real fruit) is slightly better than sucrose, and the vitamins are good. Apple, Orange and Ginger freshly squeezd juice for example - the ginger accellerates the metabolism.
Heading out to buy a juicer after the next pay packet.
Sara
Designer, Gamer, Macgrrl in an XP World