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'Bionic' Nerve To Repair Damaged Limbs and Organs

University of Manchester researchers have transformed fat tissue stem cells into nerve cells -- and now plan to develop an artificial nerve that will bring damaged limbs and organs back to life. In a study published in October's Experimental Neurology, Dr Paul Kingham and his team at the UK Centre for Tissue Regeneration (UKCTR) isolated the stem cells from the fat tissue of adult animals and differentiated them into nerve cells to be used for repair and regeneration of injured nerves. They are now about to start a trial extracting stem cells from fat tissue of volunteer adult patients, in order to compare in the laboratory human and animal stem cells.

24 of 107 comments (clear)

  1. To alloplasty before transplants by Anonymous Coward · · Score: 2, Interesting

    It's interesting to think that in Larry Niven's "Gil 'The Arm' Hamilton" stories (collected in Flatlander ) and other Known Space books organ transplants were supposed to be the rage, before eventually being supplanted by alloplasty, "gadgets instead of organs", long after. At the rate science is progressing, viable artificial solutions are going to be found for many things before transplantation would be possible.

    What I wonder, though, is whether these artificial solutions will be allowed to be so much better than the original human part. If you have to replace someone's arm, why not do it with a space-age fiber that would allow him to lift hundreds of pounds single-handedly?

  2. steve austin approves by User+956 · · Score: 5, Funny

    'Bionic' Nerve To Repair Damaged Limbs and Organs

    Unfortunately, it costs 6 million dollars, and makes a very distinctive sound when in use.

    --
    The theory of relativity doesn't work right in Arkansas.
    1. Re:steve austin approves by jamesh · · Score: 2, Funny

      Obviously the whole '6 million dollar man' project would be shelved in todays world. There is far more money to be made by selling penis enhancements. Imagine the spam "Impress your woman with your gigantic bionic dong".

      Of course... if there's a problem with it, do you go to a doctor or a mechanic?

    2. Re:steve austin approves by u-235-sentinel · · Score: 2, Funny

      'Bionic' Nerve To Repair Damaged Limbs and Organs

      Unfortunately, it costs 6 million dollars, and makes a very distinctive sound when in use.


      Only 6 million? Dang, we should have invested when it was cheap. I've been watching the new "Bionic Woman" and heard it's now 50 million for the Bionic parts. Inflation no doubt ;D

      --
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  3. Re:Possible Hope For My Favorite Hobby by speaker+of+the+truth · · Score: 3, Funny

    If you can afford whatever this will cost once its patented you can afford a hooker to simply jack you off once an hour, every hour for the rest of your life.

    --
    Using openSUSE instead of Windows since 9th of October, 2007 and liking it.
  4. You would have to do more to lift 100's of pound by aepervius · · Score: 5, Informative

    Your spine would long give in if it is not muscled/solid enough to lift those hundreds of pound. Sure some people do lift as much , but they are trained for it, and as far as I know are not adverse to accident. Then also there is the center of gravity, unless you lift your 100's of pound like an those alter-lifting pros do, you could have serious problem when your gravity center is suddenly out of the body. Which naturally limit what you can take on, although the second one is probably a detail in comparison to the first one.

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  5. ALS/MND by emjoi_gently · · Score: 3, Insightful

    I'd be interested to know if this would be helpful for people with ALS, where nerves slowly degenerate.
    It might not be a cure to the fundamental problem, but might extend a life.

    1. Re:ALS/MND by yog · · Score: 5, Informative

      Nerves are complicated. To splice a regrown nerve into a particular spot will require some mighty fine tools, and it's got to be the right type of neuron. Also, if an axon has been cut, the body will have reabsorbed it and there's nothing to splice. You'd have to thread your replacement axon from a ganglion next to the spine all the way out to the muscle or organ that is to be innervated.

      Unfortunately this is probably beyond the abilities of current medical science. The problem is that the nervous system grows with the limbs and organs starting from early embryonic stage; it's not something that you can entice to regrow from scratch. Probably the long term solution will be nanomachines that are injected into the body and rebuild nerves along preplanned routes, molecule by molecule. This is very appealing and also probably about 50 years away from reality.

      Also, axons (the long part of the nerve cell) usually require a myelin cell wrapping along its length to boost its ability to depolarize quickly. It's not clear that these folks in Manchester were able to grow a nerve cell along with its myelin. If we knew how to do that, we could also help people with multiple sclerosis, a disease that attacks myelin specifically.

      As for ALS, it's an agent or group of agents that attacks motor neurons; these agents are not fully understood. It might be possible to splice in healthy neurons here and there but you still have the myelin problem.

      This kind of research announcement should not be taken as a big step forward in fixing nerve damage until they can demonstrate it in vivo. Until then, it's just another cold fusion type story.

      --
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  6. Re:You would have to do more to lift 100's of poun by Anonymous Coward · · Score: 2, Interesting

    What about the possibility of enhanced limbs - not so much that they could LIFT hundreds of pounds but perhaps they were more dexterous? Able to move faster or with more precision? Wrists that could literally rotate 360 degrees? Sensors embedded in your fingers to detect certain things.

    This is more entering the bionic range and is not really the topic of the article, which I have not read yet but once you open the flood gates to "new" ideas that are not organic in nature, you have a huge world of things to choose from. The downside may be that they are not all that great in the first place. There are millions of ways TO evolve. But not all of them are very good, as Spore should point out.

    Other issues: interfacing with the body. A deer's antlers are great at this. Catheters are not. Infection is hard to keep at bay. Rejection / encapsulation. The body DOES NOT LIKE stuff inside it that it doesn't recognize. It will either encapsulate it or attack it. Either way, it causes irritation and could leach out into the body. Not something you really want to have happen.

    Also, MRIs will be harder to take.

    Another thing that people don't realize is that limbs, while not essential for life do support the body. Bones, aside from producing red blood cells, also excrete hormones, as we are also learning about adipose (fat) tissue as well. So just because a human limb may appear inferior at first glance, we still have a ways to go before we are actually able to replace human limbs with something truly superior.

  7. genetic memory by n3tcat · · Score: 3, Interesting

    Something that's always intrigued me about stem cell research is the concept of genetic memory. Considering the implications that this theory has on the theory of evolution, I wonder if mixing and matching stem cells, and thereby mixing genetic memories, would fuck the evolutionary process. It's the type of result that we probably wouldn't see for thousands (or tens of thousands) of years.

    Eventually though, I would imagine that it would be like the episode of Star Trek Enterprise when they find the race of people who are basically falling apart genetically and they have no idea why.

    And then of course the old addage "Overspecialize and you breed in weakness" has many powerful implications in this as well.

    Maybe I wouldn't be so scared if we weren't still completely reversing our dietary ideals every 3 years. If we can't even nail down a healthy diet (pyramid points up or down now?!), how the hell can we figure out what the ramifications of stem cell research would be on our evolutionary process?

    1. Re:genetic memory by maxume · · Score: 2, Informative
      --
      Nerd rage is the funniest rage.
    2. Re:genetic memory by riffzifnab · · Score: 3, Insightful

      Wait, what? We are talking about taking stem cells from fat and turning them into nerve cells. Where does tinkering with the DNA we are passing on to our offspring come into the picture? If it doesn't affect that, its not doing anything to our future generations.

      On the lighter side, at least the US has plenty of these stem cells. McDonald's is the savior of the world! [gag]

    3. Re:genetic memory by jollyreaper · · Score: 2, Interesting

      Something that's always intrigued me about stem cell research is the concept of genetic memory. Considering the implications that this theory has on the theory of evolution, I wonder if mixing and matching stem cells, and thereby mixing genetic memories, would fuck the evolutionary process. It's the type of result that we probably wouldn't see for thousands (or tens of thousands) of years. What I find interesting are the genetic atavisms that you get with certain species. The classic examples are cetaceans born with hind legs or humans with true tails, complete with muscles, bones, and nerves. These are throwbacks to previous points in the evolution of that species.

      There was a Trek episode that had a virus do that kind of thing, Worf became a predalien and some humans became bugs. That's a bit silly since bugs aren't in our history. But it makes me wonder, are the genes still there to turn a modern horse into one of those funny-looking mini-horses that were hunted by the giant terror-beak birds? Could you knock a human embryo back 100k years and end up with a modern caveman? It makes me wonder how much information is tied up in the genes. Based on some of the rapid adaptations and speciations shown in the fossil record, it almost seems like there's a physiological playbook in the genes. "In case of this environmental pressure, turn on these genes."

      I'm still blown away by the examples of convergent evolution we've seen. Dolphins and ichtyosaurs, pteradons and bats, triceratops and rhinos, etc. It's fascinating how you can take critters whose last common ancestor had to umpty million years ago and they'll develop the same sorts of adaptations, just like the Russians cribbing off America in the Cold War.
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  8. Re:You would have to do more to lift 100's of poun by pipatron · · Score: 4, Funny

    Sensors embedded in your fingers to detect certain things.

    Would be awesome to have some heat/cold sensors to be able to somehow "detect" if something is too hot or cold!

    Maybe some sort of "tactile feedback" mechanism as well so you could feel some kind of "force" if you for example come into contact with a physical object.

    --
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  9. Re:You would have to do more to lift 100's of poun by jamesh · · Score: 4, Funny

    It would also be awesome to have a device for people to detect if someone is trying to make a joke on slashdot.

    Maybe you could browse in 'humour impaired' mode (or just 'really really tired' mode), where jokes could by highlighted for users benefit...

  10. If Only... by brunes69 · · Score: 2, Funny

    If only they could come up with a Bionic Scriptwriter and Bionic Actress With Personality to save the god-awful Bionic Woman series....

    Had some high hopes for that one... what a waste.

  11. Embryonic vs. adult stem cells by dcobra · · Score: 3, Insightful

    It seems all the successful new treatments with stem cells that we keep hearing about use the adult type, which also have the great advantage of not causing rejection. It makes me wonder why there is so much pressure to use embryonic stem cells, when the research with the adult type is so promising and is far from being exhausted. Perhaps it is because the adult cells, being collected from the patient him/herself, don't need to be bought, so there is no profit incentive, while embryonic stem cells hold the promise of a very lucrative new pharmaceutical/medical market?

    1. Re:Embryonic vs. adult stem cells by Smordnys+s'regrepsA · · Score: 2, Informative

      More likely, because they wouldn't have to waste money and time learning how to trick the adult stem-cells into reverting into unspecialized stem-cells.

      It doesn't take much effort to pump their study animals (be they sentient or not) full of immunosuppressant drugs, so the researchers can test the boundaries of science.

      Everything they can now try with this *still limited* stem-cell, they could have been doing years ago with embryonic-stem-cells.

      --
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    2. Re:Embryonic vs. adult stem cells by ShadowBot · · Score: 2, Interesting
      It's a simple law of averages.

      Currently much more work is being done with adult stem cells than with embryonic stem cells. Therefore you will get much more results from the adult cell research than the embryonic one.

      It says nohing about the usefulness or morality of the research one way or another.

      Actually, your point about rejection and cancer tends to point to the solution of using cloned embryonic stem cells. Which will combine the advantages of both techniques.

      The moral issue is exactly that, a moral issue. A Nazi scientist experimenting on a Jew is exactly the same. a moral issue.
      Looking for scientific backing for a moral arguement actually weakens it. An immoral act is an immoral act, irrespective of whether it adds to the scietific body of knowledge or not!

      --
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    3. Re:Embryonic vs. adult stem cells by foniksonik · · Score: 2, Insightful

      There's billions of dollars that go into embryonic stem cell research around the world. If there were amazing results being found with their use we'd be hearing about it. The US is not like some super advanced technological society that other countries and their scientists dream of becoming in centuries to come... they are just as advanced in medical science... and yet we rarely hear of break-throughs in ESCs...

      So reality check. Just because you'd like it to be so, doesn't make it so. Adult stem cell research is decades ahead of embryonic stem cell research because it is easier, cheaper and works better for the patient and will probably always do so. The parent poster is correct.... ESCs are the more lucrative line of research as if/when they do solve the rejection problem it will enable mass-production of general purpose therapies.

      --
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    4. Re:Embryonic vs. adult stem cells by pQueue · · Score: 2, Insightful

      Honestly I can't see how any reasonable person can see the destruction of microscopic cells as an ethical issue, when they are otherwise thrown away in the trash. Yes, they can become humans but so can sperm.

  12. Bionic? by Aladrin · · Score: 3, Insightful

    There's nothing bionic about it. They are using a man-made tube to help a real nerve grow from stem cells. There's no electronics, not even any moving parts. It doesn't augment or affect the nerve in any artificial way. The end result is... A normal nerve.

    --
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  13. Its the sound track to our lives but by crovira · · Score: 2, Interesting

    I'd put up with it if my MS was alleviated. (And don't worry too much about the cost, I'll find a way to pay for it. [I'll be able to work. {Insert rant about insurance companies that will let you die before they pay and gu'mint agencies that won't help you until you're destitute from having to sell off EVERYTHING, (your house, your car, your furniture, your jewelry, your computers, your retirement savings, your grave [I'm not fuckin' kidding!]) ... right here.}])

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  14. Re:You would have to do more to lift 100's of poun by Paradigma11 · · Score: 2, Informative

    I do some weightlifting and read up on this very topic some years ago (so take this info with a grain of salt). As far as i can remember the dorsal spine can take about 700kg and the ventral about 500kg. if you do squats or deadlifts it is very important to stress only the dorsal part of the spine, no hunching. here is a good link about squats: hhttp://www.exrx.net/Kinesiology/Squats.html , it's pretty hard to get the technique right.