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Capsaicin Tested On Surgical Wounds

Ponca City, We Love You writes "Bite a hot pepper, and after the burn your tongue goes numb. The Baltimore Sun reports that Capsaicin, the chemical that gives chili peppers their fire, is being dripped directly into open wounds during highly painful operations, bathing surgically exposed nerves in a high enough dose to numb them for weeks. As a result patients suffer less pain and require fewer narcotic painkillers as they heal. 'We wanted to exploit this numbness,' says Dr. Eske Aasvang, a pain specialist who is testing the substance. Capsaicin works by binding to C fibers called TRPV1, the nerve endings responsible for long-lasting aching and throbbing pain. Experiments are under way involving several hundred patients undergoing various surgeries, including knee and hip replacements using an ultra-purified version of Capsaicin to avoid infection. Volunteers are under anesthesia so they don't feel the initial burn."

21 of 227 comments (clear)

  1. anesthetic prevents horrible pain by wizardforce · · Score: 3, Informative

    they use a mix of anesthetic and the capsaicin so that you'r not in horrible pain. The nerves are over-stimulated in a way, this leads to them being numbed [like after eating too many spicy peppers] and it has already been used as a topical treatment for pain, I think there's even one pain treatment available to the public already based on this.

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    1. Re:anesthetic prevents horrible pain by mrbluze · · Score: 3, Informative

      I think there's even one pain treatment available to the public already based on this. Yes, an ointment/cream for neuralgia due to shingles.
      --
      Do it yourself, because no one else will do it yourself. [beta blockade 10-17 Feb]
  2. In other news worlds hottest pepper "discovered" by psyclone · · Score: 5, Informative

    The hottest pepper record has been broken.

    In the Scoville Organoleptic Test, the Bhut Jolokia pepper scores over 1,000,000

  3. Burning thing of fire by dbIII · · Score: 4, Informative

    For several years Capsaicin has been used to treat a type of male incontinence. Squirting a bit of it up a catheter apparently is enough to force some of the nerves in the bladder into the right state to stop the muscles being over-relaxed.

  4. Re:old? by Propaganda13 · · Score: 4, Informative

    "LIFE'S LITTLE QUESTIONS"
    SHOW 904
    http://www.pbs.org/saf/transcripts/transcript904.htm

  5. SiChuan pepper works on my mouth by dwater · · Score: 4, Informative

    I've found that this :

    http://en.wikipedia.org/wiki/Sichuan_pepper

    works well as an anesthetic. It's commonly use in Gong Bao Ji Ding (US:Kung Pao Chicken) in China, and, along with ginger, makes it way more tasty than the poor imitation available in the west.

    --
    Max.
  6. Re:Haven't I seen this before? by Ibag · · Score: 2, Informative

    Except you're not. This is about how capsaicin can be used to prevent long term pain in the weeks after surgery, while that one was about how it can be used to deliver new anesthetics that won't leave you numb. You don't even have to have read the articles to know this, just the summary. Why people post when they only read titles is entirely beyond me.

  7. Re:Anesthesia notes by Puff+of+Logic · · Score: 5, Informative

    Of note, capsaicin is also used in "pepper spray" self-defense products advertised to women in particular. I wonder if one could become numb to this after repeated sprayings. Hmmm, anybody on slashdot may be able to answer this from experience? :) Speaking as an ex-law enforcement officer, I can say that there are numerous reports of frequent fliers (if you get my meaning) being relatively insensitive to the effects of being sprayed. Although I can't cite personal experience with such a phenomenon, that it was included in official training sessions suggests at least a modicum of truth. Rather more anecdotally, I've heard some officers claim that individuals who habitually consume large quantities of spicy foods are also less susceptible to the effects of OC spray, although the blinding/irritation effect seemed unchanged. I'm not sure I give much credence to the latter notion, however.

    cheers.
    --
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  8. Re:Haven't I seen this before? by swillden · · Score: 5, Informative

    Oh yeah! I'm experiencing dupe-ja-vu!

    Nope, you haven't seen it before. That non-dupe is about a completely different anesthesia-related use of capsaicin. The purpose there is to enable the distribution of an anesthetic that only works from the inside into the cells.

    The purpose here is to give the nerve endings such an intense blast of pain that they go numb for days or weeks. This would be horrendously agonizing to the patient, but they're already under anesthetic and so don't notice it. Then, those nerve endings being numb for a few weeks reduces the need for post-surgery narcotics.

    Same drug, same general area of research (anesthetics), completely different usage.

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  9. Re:Numb for weeks?!? by RasputinAXP · · Score: 5, Informative

    Except if they're using medical-grade extract of capsaicin, you're talking a Scoville Rating of 100K-300K for a Habanero pepper. Nordihydrocapsaicin is 9.1 million Scovilles, and pure capsaicin is at least 15 million.

    In short, I think the doctors and chemists know more than you do.

  10. Re:Volunteers by slickwillie · · Score: 4, Informative

    I had a mild case of Poison Oak this past summer. I wasn't getting any relief from the normal treatments, so I poured some Cayenne pepper powder on the rash. It almost immediately relieved the itching and the area felt cool. I think it also sped up the healing. The powder was too messy so I got some capsaicin cream that was intended for arthritis. It worked almost as well.

  11. Re:Jalapenos by p!ngu · · Score: 1, Informative

    Trust me, you'll be fine:

    Scoville rating Type of pepper
    15,000,00017,000,000 Pure capsaicin[4]
    9,100,000 Nordihydrocapsaicin
    2,000,0005,300,000 Standard US Grade pepper spray [5]
    855,0001,041,427 Naga Jolokia [6][7][8][9]
    350,000577,000 Red Savina Habanero
    100,000350,000 Habanero Chile [10], Scotch Bonnet [10]

    (http://en.wikipedia.org/wiki/Scoville_scale)

  12. Peppers used for centuries for treating wounds by JunoonX · · Score: 2, Informative

    As I grew up, I heard stories of how my parent, especially, my father, was treated or has seen treatment of wounds using home grown peppers on their farm. This isn't something that comes as a surprise, since most hot peppers have some/varying levels of Capsaicin in their composition. Anyone from a developing country can attest to this, in fact, many American Indians can also attest to this, tobacco and coal as a means of treatment. Fairly interesting seeing its use by modern medicine as well.

  13. Re:Jalapenos by p00pyd00py · · Score: 5, Informative

    If a Jalapeno hurts you then you better not eat a 'hot' pepper. On the Scoville scale a Jalapeno is only about 5000 scoville units. A Cayenne is about 30,000. A Habanero is rougly 350,000. And the new record holder is the Naga Jookla at around 1,000,000. Go eat a Naga and see how you feel afterwards, wimp. :)

  14. Re:Burning mouth pain by arcade · · Score: 2, Informative

    Drink milk.

    Seriously. Drink a nice glass of milk if you want to get rid of the burning. Water does not help. Milk does (due to the fat). Drinking pure olive oil should also help (but taste like shit:).

    Capsaicin is soluble in oil, not water, or something.

    --
    "Rune Kristian Viken" - http://www.nwo.no - arca
  15. Re:Jalapenos by NighthawkFoo · · Score: 3, Informative
    --
    "I disapprove of what you say, but I will defend to the death your right to say it."
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  16. Useful advice. by niktemadur · · Score: 4, Informative

    There's a lot of posters writing about their experiences after eating habaneros and the like, either out of curiosity or on a dare.
    Well, here's a great tip next time you're on a dare, or in a thai or mexican restaurant: Keep a piece of candy nearby. If the burning sensation becomes too much to bear, unwrap the candy and pop it in your mouth, the sudden sugar coating on the tongue will overwhelm the taste buds with a near-opposite sensation, canceling most of the pain.

    --
    Lil' Thindime, lilting a lacrimose lament, krashes the kwaint konfines of Kokonino Kounty
  17. Re:But that's the best part! by Anonymous Coward · · Score: 3, Informative

    I've been taking morphine everyday for about 6 years. People all think you get a buzz from it, but you don't. They have controlled release stuff nowadays too. I think I had a slight buzz once (maybe twice) during the first day I took it. And I'm not on low doses (hell, I already OD'ed on it, and I wasn't buzzed at all, I just struggled to keep breathing).

    It just makes you not wanna kill yourself so the pain ends (chronic pain is like being tortured 24/7 with no relief, you eventually want it to stop, no matter what it takes). That's pretty much it.

  18. Re:Jalapenos by Soporific · · Score: 2, Informative

    As all hot pepper eaters should know, it's not the heat in the pepper, it's the juice. Habanero's are fine the next day, but the Jalapeno has quite a bit of juice that doesn't seem to go away. :)

    ~S

  19. Re:Jalapenos by Luyseyal · · Score: 2, Informative

    Speaking of...why doesn't taco bell every bring back the 'Wild' Sauce they used to wheel out every summer or so awhile back.

    It was cheaper and faster to switch to prepackaged sauce versus the warmed-up sauce in the back (which frankly tasted better... not that Taco Bell is "good"). The preparers don't have to manage the sauce in the back any more and can crank out however many items they need faster.

    Eliminating the old-style green sauce is what stopped my parents going to Taco Bell.

    -l

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  20. Re:Jalapenos by Mister+Whirly · · Score: 3, Informative

    Actually, it is the membranes that hold the seeds that contain most of the "heat".

    "Capsaicin (pronounced cap-SAY-iss-in) is a powerful chemical present in hot peppers that irritates certain nerves in the human nose and mouth. It is most highly concentrated in a hot pepper's central membrane, which holds the seeds."
    http://query.nytimes.com/gst/fullpage.html?res=950DE3DD1E39F93BA35752C1A96F948260

    "The hotter the pepper, the more capsaicin it contains, most of it concentrated in the membrane or rib. Removing both this membrane and the seeds can significantly reduce the overall heat level"
    http://www.sallys-place.com/food/columns/ferray_fiszer/peppers.htm

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