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First Genetically Modified Human Embryo Under Review

Wired is reporting that Cornell University researchers genetically modified a human embryo in 2007, but have only recently been gaining publicity as their work is being reviewed. "The research raises a number of thorny ethical questions. Though adding a fluorescent protein was merely a proof-of-principle step, scientists say that modified embryos could be used to research human diseases. They say embryos wouldn't be allowed to develop for more than a few weeks, much less implanted in a woman and brought to term."

49 of 509 comments (clear)

  1. Re:WHAT HAS SCIENCE DONE? by Datamonstar · · Score: 3, Funny

    Quiche?

    --
    The eternal struggle of good vs. evil begins within one's self.
  2. Re:WHAT HAS SCIENCE DONE? by Teresita · · Score: 5, Funny

    A fluorescent protein? Did they want to make a baby that you can find under the black lights in a night club?

  3. fluorescent protein? by Anonymous Coward · · Score: 5, Funny

    Does that mean the kid would have an annoying hum if born?

    1. Re:fluorescent protein? by John3 · · Score: 4, Funny

      Only until he learns the words.

      --
      "We make our world significant by the courage of our questions and by the depth of our answers." Carl Sagan
  4. wouldn't be allowed to develop? by nurb432 · · Score: 3, Insightful

    Wouldn't that mean they were murdered? That is if you accept the religious side of the house...

    --
    ---- Booth was a patriot ----
    1. Re:wouldn't be allowed to develop? by vertinox · · Score: 4, Funny

      Wouldn't that mean they were murdered? That is if you accept the religious side of the house...

      As much as you murder millions of children every night with bottle of lotion and a box of kleenex...

      --
      "I am the king of the Romans, and am superior to rules of grammar!"
      -Sigismund, Holy Roman Emperor (1368-1437)
    2. Re:wouldn't be allowed to develop? by Bryansix · · Score: 4, Insightful

      www.m-w.com defines it as " the crime of unlawfully killing a person especially with malice aforethought". Therefore the morality of the act is pre-determined by the ruling authority and THAT defines murder. This isn't a religious debate, it is an ethical one. To even bring religion into it is a Straw-Man argument. The point is that these organisms are definitely human and they are definitely alive. So is killing them wrong?

    3. Re:wouldn't be allowed to develop? by kc8apf · · Score: 5, Insightful

      You are presenting one side of an issue as the only side. You've chosen the side that embryos are human and alive and thus this is murder. From the other side, these are not humans and/or not alive. Religion seems to come in on this since one of the most vocal religious groups (christians) tend to side with you. It isn't really a religious debate, but many people view it as one due to that.

      --
      kc8apf
    4. Re:wouldn't be allowed to develop? by 2nd+Post! · · Score: 4, Insightful

      Except what helps an 80 year old billionaire will help an 70 year old millionaire, 60 year old white collar worker, etc, down to 20 year olds with pulmonary hypertension.

      So what IS the cost if an 80 year old billionaire is funding the research for treatment that will benefit everyone else, except a billionaire's money?

    5. Re:wouldn't be allowed to develop? by Bryansix · · Score: 4, Insightful

      I think not. Most people can differentiate between the potential for life (semen and eggs) and actual life itself (autonomous life including self-replicating cells that may or may not have certain dependencies for life; don't we all?).

    6. Re:wouldn't be allowed to develop? by johnlcallaway · · Score: 5, Insightful

      You had me until the last sentence.

      They are a mass of cells that one day could become human. My sperm one day could also become human, does that make masturbation a crime if I don't make every attempt possible to fertilize an egg?? Is a woman committing murder because she doesn't attempt to get pregnant every period??

      Oh .. I know. Some chose an arbitrary point when an egg and sperm meet to decide what is human.

      OK .. I chose the arbitrary point when a fetus emerges from a woman as the point a fetus becomes human. I have just as much basis for that statement as anyone who chooses fertilization. It's all arbitrary depending on your beliefs, since there are no scientific or legal definitions for a soul. Religious definitions don't count, as you just said. As far as the law is concerned, a soul doesn't exist.

      I've noticed it also depends on whether or not the person arguing is the one that has to support it. Seems that people are more than willing to argue against abortion when they don't have to support the child in the end. I agree with the semi-serious argument that all anti-abortion advocates should have to sign up to adopt all the children that their cause prevents being aborted.

      That flimsy argument aside, the US recognizes 90 days of development as to when an abortion can occur, so any embryo that is not developed past that point should be able to be terminated in the US without receiving any permission from a legal authority. The US does not define what methods are acceptable for creating embryos, both natural and artificial means are accepted. So whether or not an embryo is in a placenta or a petri dish should also be irrelevant. Since embryos can be frozen for years, it should be based on physical development, not length of time.

      --
      I rarely read replies, it's my opinion and if you thought about your opinion a little more, I'm OK with that.
    7. Re:wouldn't be allowed to develop? by Toonol · · Score: 4, Insightful

      Just to nitpick, you don't need to be religious to view abortion as murder. Just as some religious people are ok with it.

    8. Re:wouldn't be allowed to develop? by Toonol · · Score: 4, Insightful

      Oh .. I know. Some chose an arbitrary point when an egg and sperm meet to decide what is human.

      I think that point is often chosen because it's not arbitrary. It's a significant developmental event. Twelve hours before, three weeks later; those are arbitrary points. Your second example of an arbitrary point, when the baby is born, isn't arbitrary either. A true arbitrary point would be something like "after the first trimester."

      There's a few other significant points in the development of a baby, such as first mental activity, first heartbeat, and so on. Those aren't arbitrary either. They may not be the correct basis to distinguish a human from a fetus, but they aren't purely subjective.

    9. Re:wouldn't be allowed to develop? by jmorris42 · · Score: 5, Interesting

      > OK .. I chose the arbitrary point when a fetus emerges from a woman
      > as the point a fetus becomes human. I have just as much basis for that
      > statement as anyone who chooses fertilization.

      Lots of logic problems here.

      Fertilization is the only logical point to draw a line ans say HERE is where a seperate entity begins. Sperm is just a part of you, the egg is just a part of her. When they meet something is created that isn't either of you. Consult a basic biology text is this isn't clear; The parts about immune system issues between the fetus and mother should be especially instructive.

      Time of birth is unsuitable for a multitude of reasons. First off, a child a few days from delivery would have an almost 100% chance of independent survival with modern medical science. Happens all the time, some trauma forces an early delivery, etc. But the current legal regime, and your stated position, would allow the same baby who could equally be delivered and have an almost normal chance of a productive life to be aborted instead. Fairly major ethical problem.

      Of course we (in the US) live in a Republic that clearly has birth as the legal definition of citizenship. Says so right in the Constituition. The legal problem can be fixed of course.

      > I've noticed it also depends on whether or not the person arguing
      > is the one that has to support it.

      This is a popular straw man argument. First off, once you conclude you are dealing with a child and not a tissue mass support is a given. After all you can't legally kill off a two week old by denying it basic life support. If you accept the child argument it is totally consistent. Besides, there are long waiting lists to adopt so the argument fails anyway.

      > That flimsy argument aside, the US recognizes 90 days of
      > development as to when an abortion can occur,

      It is getting harder and harder by the year to find a legal scholar who won't admit Roe v Wade wasn't one of the worst cases of legislation from the bench in the 20th Century. Depending on such a dubious 'ruling' isn't exactly an appeal to reason. Besides, medical science has advanced a lot since the 1970s and will only continue. Arbitrary 'viability' cutoffs are dangerous ground to stake out firm moral or even legal positions.

      --
      Democrat delenda est
  5. what's with the link by slig · · Score: 5, Informative

    I'm sure it can't have been slashdotted already. Alternate source here

  6. Re:WHAT HAS SCIENCE DONE? by CowboyNealOption · · Score: 3, Funny

    Seriously though, how many people here would love to be fluorescent green?

  7. Re:WHAT HAS SCIENCE DONE? by Dallas+Caley · · Score: 5, Funny

    I'd be a hit at the next rave i can tell you that for sure!

  8. Why not allow them to be implanted? by the_humeister · · Score: 4, Insightful

    We have glowing mice and they're doing fine. Why not a glowing human? I think that would be pretty nifty. I really don't see why there would be people who are against such things. This has other implications too. Imagine if we could remove the defect that causes Huntington disease in an embryo. Would people have ethical issues with that?

    1. Re:Why not allow them to be implanted? by eln · · Score: 5, Funny

      We can't have glowing humans because they would piss everyone off at movie theatres.

    2. Re:Why not allow them to be implanted? by gdog05 · · Score: 5, Funny

      But at least you could easily corner them in a dark alley afterward.

    3. Re:Why not allow them to be implanted? by Bryansix · · Score: 4, Insightful

      I know this is funny but the root problem here is how would YOU feel if you knew you were born out of a scientific experiment?

    4. Re:Why not allow them to be implanted? by dustman · · Score: 5, Funny

      I know this is funny but the root problem here is how would YOU feel if you knew you were born out of a scientific experiment? awesome
    5. Re:Why not allow them to be implanted? by $0.02 · · Score: 3, Insightful

      Ask the first in vitro conceived human.

      --
      If enithin kan gow rong it whil. (Murfey)
    6. Re:Why not allow them to be implanted? by couchslug · · Score: 4, Insightful

      "I know this is funny but the root problem here is how would YOU feel if you knew you were born out of a scientific experiment?"

      That would depend on how I turned out.

      --
      "This post is an artistic work of fiction and falsehood. Only a fool would take anything posted here as fact."
    7. Re:Why not allow them to be implanted? by compro01 · · Score: 4, Informative

      for those wondering who that was

      http://en.wikipedia.org/wiki/Louise_Brown (first in the world)
      http://en.wikipedia.org/wiki/Elizabeth_Jordan_Carr (first in the US)

      --
      upon the advice of my lawyer, i have no sig at this time
    8. Re:Why not allow them to be implanted? by tsm_sf · · Score: 4, Funny

      I don't know, I have the feeling that

      scientific experiment > mommy was drunk

      for a lot of people. YMMV.

      --
      Literalism isn't a form of humor, it's you being irritating.
  9. Cool! I have a list of human mods already! by farbles · · Score: 5, Funny

    Number 1: More intelligence. Hoo boy do we need this one implemented ASAP.

    Number 2: Respiratory bypass system. No more choking to death on pretzels.

    Number 3: Two hearts. Works for the Time Lords, howzabout it working for us?

    Number 4: Reinforced cerebral circulatory system. No more strokes.

    Number 5: Smarter immune system. Get rid of cancer and AIDS before they start, no more auto-immune diseases.

    Number 6: Smart metabolism. Good-bye unwanted pounds, save your ass if you crash in the Andes without making your co-survivors menu items.

    And so on. Look, we can stand some species improving. Save the default in the genes as a backup and let's get splicing here.

    1. Re:Cool! I have a list of human mods already! by Afecks · · Score: 3, Funny

      Save the default in the genes as a backup and let's get splicing here. Goddamn sploicers!
    2. Re:Cool! I have a list of human mods already! by TheNarrator · · Score: 4, Funny

      Why do "rogue nations" pursue boring 60 year old nuclear weapons technologies when they could instead have armies of super intelligent, pretzel proof, two-hearted, stroke proof, aids proof, super-metabolic super warriors?

  10. Could Be Worse by Anonymous Coward · · Score: 5, Insightful

    Children are born to parents who don't want them, they neglect them, abuse them, and even kill them.

    There are parents who know they have medical problems related to their genetics, and yet are still selfish enough to "try for one" instead of adopting one of the 50,000+ or so that die of starvation somewhere in the world.

    There are people out there who believe that having a baby can help save their relationship / marriage, and so create a whole human being just so they don't have to face up to the fact that they don't belong with somebody.

    There are a host of ethical issues about this genetically modified human embryo, but nothing worse than already exists in the world today.

  11. If they are not self aware, why not? by Bragador · · Score: 5, Interesting

    At this age they are not self aware. Basically they don't know they exist. I don't see the difference between studying an embryo of that age and studyng plants.

    We are already using animals that are aware of their existance in labs. Apes can recognise themselves in front of a mirror and we are using them so I feel this is really not a big issue and we should let science go ahead.

    Now I'm going to start a very heated debate. We know that babies start to be self aware around the age of 2 so if you really want to test my logic I'll tell you my opinion. We could logically use babies to make tests. Why this horrifies people is because they are attached to their own babies but since these newborns are not sentient yet, where is the harm in using "lab babies"? They would have to be grown in artificial wombs and all that to dehumanize them but logically it shouldn't be stopped.

    I might be modded down for opening a can of worms but try to have fun with this ethical puzzle.

  12. Re:Dunno how I feel about this. by flaming+error · · Score: 3, Insightful

    are the ethical questions ... actual issues of right and wrong, or are they ... my own philosophical prejudices? Great question, but aren't "right and wrong" culturally defined? Or is there some objective cosmic value system we can mathematically derive?
  13. Invalid arguement by Nerdposeur · · Score: 3, Insightful

    First, you lump all religious people (hint: this is most of the planet) into the category of "people who cause genocide." Second, you offhandedly pronounce that, on the whole, the effects of religion are evil. Then, you conclude that religious viewpoints should not be heard. I say that you can't back up any of those statements.

    It would be just as easy to out-of-hand dismiss Slashdot users (the only group I can knowingly lump you into) as incapable of reasonable political debate.

    The fact is, this is an ethical question. It presumes that human life is valuable, and asks whether embryos qualify, and then asks how their interests balance against the other considerations.

    The idea that human life IS valuable is just as much a belief as the idea that embryos do or don't qualify as humans. Whether you call that belief "religious" or not, it's still a belief.

    I happen to believe that human life is valuable because we "are endowed by our Creator with certain unalienable rights." I make no argument about the faith of the Founding Fathers, but they did start with that premise. If you toss out the Creator, I assume you have some alternate rationale, but I don't think it's reasonable to say that any religious basis for valuing human life is irrelevant.

    1. Re:Invalid arguement by aztektum · · Score: 3, Insightful
      The effects of religion have proven time and again to be more than overwhelmingly negative. They're only competition for motivation to reap atrocities on mankind is lust for money.

      Point out where I said this wasn't an ethically ambiguous question? Granted my comment was made hastily; I was splitting my attention between 3 things. Given the detailed history of religious followers to shoot first and refuse to ask/answer questions later, I personally give little value to their opinions.

      It would be just as easy to out-of-hand dismiss Slashdot users (the only group I can knowingly lump you into) as incapable of reasonable political debate. I'm not here to have reasonable political debate. This isn't a political forum. I'm not running for office. I want nothing to do with "politics".

      What I'm saying is, I tire of religious rhetoric impacting the lives of those who do not follow a religious association. If to you this has ethical implications along religious principles, fine. To me it does not, to many others it does not. I have no desire to see science and the future of humanities advancement marginalized because somethings make people feel icky.

      My beliefs are not your beliefs. Yours are not mine. Science should always recognize this accordingly and avoid being influenced by either.
      --
      :: aztek ::
      No sig for you!!
  14. What is "human" to you? by Anonymous Coward · · Score: 4, Insightful

    > You are presenting one side of an issue as the only side. You've chosen the side that embryos are human and alive and thus this is murder.

    Forget whether it's "murder" or not for a second (that's an emotive word that will only derail discussion) and focus on the "human" aspect of things, please.

    Fertilized embryos and zygotes are living homo sapien organisms--not some other species, right? They're becoming something we all recognize as human, or would given food and shelter?

    So what's the other side of that (and ONLY that--no "murder" discussion, please)? They can't feel or understand pain so it's speciesist to give them special treatment merely because they're homo sapiens. Or perhaps, "What's the difference between them and cell cultures removed from your body? Especially if we could clone those?", ignoring that fertilized embryos are becoming human and samples are not?

    I merely want to understand, so no flames please. I would like to hear your reasoning and your philosophy, not your anger.

    1. Re:What is "human" to you? by MMC+Monster · · Score: 4, Insightful

      How about Humanity being defined as having brain activity that allows them to respond to stimuli in a non-reflexive manner?

      If someone has no brain activity, they are often declared dead. That being said, they may still have some nerve reflexed (as do detached muscle cells).

      --
      Help! I'm a slashdot refugee.
    2. Re:What is "human" to you? by Straker+Skunk · · Score: 4, Interesting

      An embryo is human (Homo sapiens) and living (not dead tissue), in the technical sense. That has nothing to do with whether it is "a person who { is, should be } granted societal protection from being killed." After all, a brainless vegetable is also human and living, and most folks don't see a problem with pulling the plug on one. (The Terry Schiavo case hinged on whether she really was "brainless," in the public consciousness.)

      --
      iSKUNK!
    3. Re:What is "human" to you? by Spy+der+Mann · · Score: 4, Interesting

      Effectively, by accepting that if they don't feel pain (or anything for that matter) they can be disposed, opens the door to euthanasia in case of people in coma - and also to abortion and to extract embryos from pregnant women to do experiments on them. But also it opens the door to murder, just by giving anesthesics to people before they die. But that opens the door to ethnical cleansing. Later it won't make any difference if the people murdered died a quick painless death (i.e. a gunshot in the head, or even a nuke quick enough to guarantee they won't feel pain), or even a pleasureable death (i.e. drugs).

      When that happens, good bye, humanism.... good morning, Soylent Green!

    4. Re:What is "human" to you? by BungaDunga · · Score: 3, Insightful

      That scoops up most animal life though, doesn't it? Your average chimpanzee isn't working on reflex, arguably neither is your average starfish.

    5. Re:What is "human" to you? by Anonymous Coward · · Score: 4, Insightful

      The obvious difficulty with that standard is its application to human infants. Most people are not willing to take it that far, and so for them it fails (or ought to fail) as a standard.

    6. Re:What is "human" to you? by ArcherB · · Score: 3, Funny

      > You are presenting one side of an issue as the only side. You've chosen the side that embryos are human and alive and thus this is murder.

      Forget whether it's "murder" or not for a second (that's an emotive word that will only derail discussion) and focus on the "human" aspect of things, please.

      Fertilized embryos and zygotes are living homo sapien organisms--not some other species, right? They're becoming something we all recognize as human, or would given food and shelter?

      So what's the other side of that (and ONLY that--no "murder" discussion, please)? They can't feel or understand pain so it's speciesist to give them special treatment merely because they're homo sapiens. Or perhaps, "What's the difference between them and cell cultures removed from your body? Especially if we could clone those?", ignoring that fertilized embryos are becoming human and samples are not?

      I merely want to understand, so no flames please. I would like to hear your reasoning and your philosophy, not your anger. Human tissue is a part of a human. Tissue, by design will not naturally form a new human being.

      An embryo is the whole human, although just very young. In its natural state, it WILL grow, form a personality and wreck daddy's car in about 17 years.

      That help?

      --
      There is no "I disagree" mod for a reason. Flamebait, Troll, and Overrated are not substitutes.
    7. Re:What is "human" to you? by Epistax · · Score: 5, Insightful

      I don't think the parent was suggesting that humans aren't hypocritical dumbasses. That said, I do like my steak medium-rare.

      We make the decision every day as to what deserves to live and die in the animal kingdom. Being a part of the animal kingdom means that we are not above that, unless there is really no logic behind it. If the argument is intelligence, I submit that a one-year-old pig is more sentient than a one-year-old baby (humans develop more slowly), and would therefore have a stronger "right" to live. If the argument is potential intelligence, then what of mentally handicapped?

      Not making an argument, this is just what goes through my head. Again, I like my steak medium rare.

  15. Just because you can doesn't mean you should by BearRanger · · Score: 3, Interesting

    In the long run the Cornell scientists have probably done a good thing, as I'm sure this will be a milestone in manipulating our genome. A great proof of concept. But you have to wonder if, as a species, we're ready for this.

    Few people would object to using genetic manipulation to eliminate diseases or birth defects. What about homosexuality? Or dark skin? Or some other socially marginalized trait that has no bearing on the genetic fitness of the individual? What effect would "enhanced humans" have on a society built by "mundane" humans?

    I personally believe we don't yet have the wisdom or foresight necessary to manipulate our genes. Until we can reach some sort of ethical consensus on the how, why and when of human genome manipulation we should collectively say no.

  16. I am sick and tired of the word "embryo" by jdb2 · · Score: 5, Informative
    First, I haven't RTFA due to the /. effect but I can tell you that the "thorny moral questions" being raised are caused by the media's incorrect use of the word "embryo" -- either to cater to a dumbed down audience or to be "politically (in)correct" such as to not anger the fundies too much.

    There are *2* stages of development before the blob of a few hundred cells is considered an "embryo". First, there's the formation of the zygote after fertilization, and then there's the formation of the blastocyst. The blastocyst is basically a hollow fluid filled sphere consisting of an outer layer of trophoblast cells which eventually become the placenta and an inner blob of cells called the embryoblast which eventually forms the embryo after the blastocyst phase.

    When talking of "embryos", scientists are usually talking about the extracted embryoblast cells which are pluripotent stem cells. These cells are *NOT* viable and are just that : cells -- they're not going to grow into a baby, or an "embryo" for that matter. Even I would be upset if it were found out that the real embryo, after the start of cell differentiation, had been tampered with.

    To conclude, stem cells are not embryos -- they're just a multiplying blob of undifferentiated pluripotent Human cells and as such, they should be put in the same class as pond scum, although pond scum is actually far more highly developed -- the aforementioned stem cells cannot survive outside of a Petri dish (unless they're implanted into another nutrient source, such as the Human body for purposes of healing)

    jdb2

    1. Re:I am sick and tired of the word "embryo" by Crazy+Taco · · Score: 4, Insightful

      Many would accuse you of dodging the issue with that definition. The problem is that to get those stem cells, a fertilized human egg is, at some point, stopped from developing farther. If life begins at conception, trying to tell people you only killed a blastocyst, not an embryo, isn't going to do much for you.

      --
      Beware of bugs in the above code; I have only proved it correct, not tried it.
    2. Re:I am sick and tired of the word "embryo" by Toonol · · Score: 3, Insightful

      And the ethics of a particular matter can sometimes really hinge on nitty-gritty specific details. Thanks for your post.

      I would be against genetically modifying a viable human fetus, or even something that would normally develop into one. However, I wouldn't be against culturing human cells, and would love to hear that they're growing kidneys in a lab someday.

      But when you're doing experiments on individual stem cells, it becomes hard to tell those two situations apart, and our common-sense notions of morality get befuddled. It's like an ethical version of quantum mechanics.

  17. Right and wrong are not cultural by Nerdposeur · · Score: 5, Interesting

    Great question, but aren't "right and wrong" culturally defined?

    If right and wrong are culturally defined (not just specific application, but the general principles), I would argue that they don't exist. There is a big difference between "I/we prefer you don't do X" and "X is wrong."

    Imagine that you're walking down the street and trip on someone's foot. You're annoyed, right? Now imagine that you realize the person tripped you on purpose, and is laughing. Now you're indigent. Tripping people is wrong!

    Clearly your anger has less to do with the pain of falling than with your deep-seated feeling that "it's wrong to harm others." You would not describe this as a preference.

    Whatever we say about the source of morality, I think everyone feels that certain things are simply wrong. To deny this removes an important aspect of what it means to be human.

    I know that someone will say that different cultures have different concepts of morality, but I don't buy it. There are different applications, yes; but no culture values cowardice and treason and murder. Some cultures defend their genocide and slavery by arguing that the victims aren't human, for example, but they do this because they must justify their actions against the standard that genocide and slavery are wrong. Our instinct to make excuses shows that we agree with the standard.

  18. Re:WHAT HAS SCIENCE DONE? by clem · · Score: 3, Funny

    You think it's easy being green?

    --
    Your courageous and selfless spelling corrections have made me a better person.
  19. Re:'Ethical Issues' by cdrguru · · Score: 4, Insightful

    I don't believe there is necessarily a religious connection to saying "this is wrong." Why is it wrong? For starters, do you actually believe no such creations will be allowed to come to term? If you were offered, secretly, to have a "superior, genetically enhanced" child would you not take the offer? Don't you want your offspring to be the very best they could possibly be?

    Genetic modification holds the promise and the threat of changing the face of humanity. Literally in some ways. But the real problem isn't just making green people but people that are not human and do not share humanity with the rest of the people on the planet. This is a fundamental point; we can have a society because of a shared heritage. Messing around with things that at this point we have little knowledge of is an open invitation to creating a branch of the human species which shares no common heritage.

    What would we, meaning the current humans on the planet, do with someone that was both human and not human? Not human because they, for example, believed and acted like they were a superior form of life and that all others were placed within their view for their own amusement? OK, one such being would be a curiosity. 100 would be a threat and 1000 would be a war. What part of the Star Trek episode "Botany Bay" did you not understand?

    I'm not sure I would say this is an "ethical" problem, but it certainly is a problem that we do not have to address. We can choose not to go down this road. We, as the humans on the planet, must not go down this road as it stands a really good chance of leading to disaster, potentially on a global scale.