Slashdot Mirror


Drug Reverses Retardation In Mice

snydeq writes "Rapamycin, a medication doctors prescribe to transplant patients to prevent organ rejection, has been used to reverse learning disorders and mild retardation associated with TSC (tuberous sclerosis complex) in mice. Because the condition is linked to autism, scientists believe the drug may be used to treat learning disabilities and short-term memory deficits in all kinds of autism as well. The scientists chose rapamycin after they realized the drug regulates one of the same proteins that the TSC gene does, just in different parts of the body. 'What was surprising is that we could give rapamycin to adult mice and reverse their condition,' said neurobiologist Alcino Silva of the David Geffen School of Medicine at UCLA. 'We did not know ... that this drug would be equally effective for the learning disabilities as it is for tissue rejection.' Rapamycin treatment leveled the playing field between normal and TSC mice in as little as three days."

12 of 318 comments (clear)

  1. flowers for algernon by stoolpigeon · · Score: 5, Interesting

    make sure it doesn't wear off after a little while

    --
    It's hard to believe that's how Micronians are made. Why don't we see it right now by having you both kiss one another?
    1. Re:flowers for algernon by MyLongNickName · · Score: 5, Funny

      Seriously. I read that book 15 years ago and it still stands out in my mind how sad the degradation is. It is one of my worst nightmare to eventually lose my reasoning capacities.

      LOL! ME 2!!!!!!!!!!!!!!!!!!!!

      --
      See my journal for slashdot ID's by year. Mine created in 2005. http://slashdot.org/journal/289875/slashdot-ids-by-year
  2. Cool! by morgan_greywolf · · Score: 5, Funny

    Great!!! Now how can we get this drug out to 80% of the population quickly enough?

    1. Re:Cool! by lena_10326 · · Score: 5, Funny

      Great!!! Now how can we get this drug out to 80% of the population quickly enough?

      Your estimate is high. Only 50.7% require it.

      http://en.wikipedia.org/wiki/2004_US_presidential_election

      --
      Camping on quad since 1996.
    2. Re:Cool! by Thelasko · · Score: 5, Funny

      Great!!! Now how can we get this drug out to 80% of the population quickly enough?

      Put it in expensive bottled water.

      --
      One of our competitors trademarked the term "hypothesis". From now on, we will call them "boneheaded ideas".
    3. Re:Cool! by Neeperando · · Score: 5, Funny
      Maybe we can use that to our advantage. We should have nominated a puppy for president instead of Obama.

      Press: What's your plan to make health care affordable for all Americans?

      Candidate Puppy (chews on tennis ball, chases tail): Woof!

      Voters: Awwwwww!

      --
      Being a computer scientist means you tell people how computers should work, not that you know how they actually work.
  3. Finally a cure by gijoel · · Score: 5, Funny

    NARF!!!!!

  4. Re:$1k per month by east+coast · · Score: 5, Insightful

    1K to turn someone into a productive member of society and lead a meaningful life? It's a bargain. We're paying more than that to keep rapists alive in jails. Not to mention that as technology moves on it will either cost less or new drug will take it's place being either more effective or less expensive.

    --
    Dedicated Cthulhu Cultist since 4523 BC.
  5. Autism Affects 1 in 160 Children in the US by FurtiveGlancer · · Score: 5, Informative

    Having studied the autistic spectrum to some degree, this provides hope for only a few of the range of autistic symptoms. To learn more, check out Autism Speaks.

    --
    Invenio via vel creo
  6. As a parent of an Autistic... by BobMcD · · Score: 5, Insightful

    ...let me say that any hope is a good hope. This condition is a far, far greater burden than you probably realize, and to date most of medical science is still groping in the dark.

    My son's neurologist actually prescribed an anti-psychotic to a three-year-old boy. One that, by the way, had NEVER been tested on children and was not FDA approved for that purpose.

    There are some voodoo-science options as well. Some work all the time for certain cases, while others do not work at all. Gluten-free/Casen-free diet, Omega3's, Anti-Fungals etc, etc, etc. If you take information like this to a practicing MD they are quite likely to either roll their eyes our laugh outright. Still, there are those that swear by them.

    This is where we presently sit.

    Imagine having a young man, totally dependent on you, who is struggling not only to fit in, but to avoid punishment for perfectly natural behaviors. Now imagine the feeling when the realization sets in that you simply will not ever be able to 'fix' him, no matter how much parenting you may apply. In fact, try though you do, at the end of the day it feels like no one has helped him at all.

    Any hope is a good hope.

  7. Should Mod to Funny... by tjstork · · Score: 5, Insightful

    Your estimate is high. Only 50.7% require it.

    http://en.wikipedia.org/wiki/2004_US_presidential_election [wikipedia.org]

    I'm a Republican, a Bush and now McCain supporter, and have more troll points on slashdot to prove my right wing cred, and I don't find this offensive at all. Come on people, lighten up. This was -funny-. If I would have been first to the joke, I would have made the same crack going the other way. The more seriously we take our political affiliations, the more we are trapped into the political parties that really don't represent us!

    After all, can't we say: "Christ, Bush is such a great oil man, that he goes and invades the world's largest untapped source of oil, and now gas is $5 / gallon."

    --
    This is my sig.
  8. Oh, Please by encoderer · · Score: 5, Insightful

    Look at you. Sitting there, presumably in full control of your faculties, able to socialize, to date, to start and raise a family, to use your time as you wish, to banter back and forth on websites, or read a book, to build a career and take pride in your accomplishments, to further your education and expand your horizons.

    Do you even KNOW anybody who suffers from any of these mild-to-mid-grade mental deficiencies? And I don't mean know OF, I mean KNOW and care for?

    If you did, you'd see very clearly the tragedy that is a person who much of the time seems completely healthy and normal.

    Wouldn't it be GREAT if pharma would give these things away for free? Sure. But this world today is not perfect. And you can't expect just a single industry to "disarm" and go socialized. Even if it WOULD benefit us all.

    There's a test you can apply here: When a pharma company spends $1bn researching a drug that ends-up a flop, should we as taxpayers refund that cash to them? If the answer is "no," then you can't begrudge them for taking profits where they can.

    And as much as I hate paying $4 for gas, I could say the same about oil: I don't know about you, but 8, 9 years ago when gas was $0.85/gallon, I never decided to pay $1.50 just to help out. Oil companies collapsed and consolodated when Oil was $20/barrel and now, I can't begrudge them for taking profits where they can.

    Remember, nearly all of us are shareholders in these companies, whether directly, thru a 401k, thru a pension, thru a union, thru your local government which often invests a portion of its cash-on-hand, etc.

    So the drug costs $1k. That's the reality of it. To suggest that being a "slave to the pharma industry" is as bad as being a prisoner of your own reduced faculties shows an abject lack of understanding, not to mention, a serious empathy deficit.