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Towards an Exercise Pill

aztektum among many other readers sent us news that medical researchers have developed two drugs that can build muscle tone in mice without exercise. While such an advance may inspire dreams of a "couch potato pill," the article mostly talks about other medical uses, should the drugs prove safe and effective in humans. The doctor in charge of the research is working with sports authorities to develop a test to detect the drugs in athletes. "Researchers at the Salk Institute in San Diego reported that they had found two drugs that did wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice's endurance on a treadmill by 44 percent after just four weeks of treatment. A second drug, GW1516, supercharged the mice to a 75 percent increase in endurance but had to be combined with exercise to have any effect. 'It's a little bit like a free lunch without the calories,' said Dr. Ronald M. Evans, leader of the Salk group."

15 of 362 comments (clear)

  1. Re:Nerd Decisions... by Thiez · · Score: 5, Funny

    Take the pill, and then beat up a nerd who bought the new iPhone and steal it.

    Or don't get the new iPhone at all. Who needs that thing?

  2. Better Living Through Chemistry by Jaysyn · · Score: 5, Insightful

    If this drug works as advertised & has no dangerous side effects, why wouldn't *everyone* including athletes take it? I realize that this would be an unfair advantage in the present, but I'm talking about after 20+ years of testing.

    --
    There is a war going on for your mind.
    1. Re:Better Living Through Chemistry by mattpm · · Score: 5, Insightful

      If this drug works as advertised & has no dangerous side effects

      That's a big IF

    2. Re:Better Living Through Chemistry by Your.Master · · Score: 5, Insightful

      This argument has many forms, and I dislike all of them (although I admit your last line made it funny, and maybe the argument was intended to be subordinate to that).

      If that's the reason we shouldn't have this, then the problem to solve is "poor people can't have this pill", not "rich people can have this pill". The solution to social inequity is not to drag everybody down to the level of the poorest person, it's to build up the little guy. Somebody living well is not a problem; somebody living poorly is a problem.

      Now, if there's a separate reason that we shouldn't have this pill, then we can piss and moan about the rich getting it anyway.

  3. The heart muscle? by Anonymous Coward · · Score: 5, Interesting

    What about the type of muscle tissue found in the heart? Could this be used to help rebuild a heart that's been weakened by a heart attack?

  4. Re:How Much Does the Pill Weigh? by Mordok-DestroyerOfWo · · Score: 5, Funny

    Good news! It's a suppository.

    --
    "Never let your sense of morals prevent you from doing what is right" - Salvor Hardin
  5. Wow! by Anonymous Coward · · Score: 5, Funny

    I've said it before, but I'll say it again: Never in history has there ever been a better time to be a mouse!

  6. Uh oh by larry+bagina · · Score: 5, Funny

    Once they develop pills for big dicks, fashion sense, personality, and odor elimination, Linux development will cease!

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    Do you even lift?

    These aren't the 'roids you're looking for.

  7. Re:But...? by ColdWetDog · · Score: 5, Funny

    How do you get the couch potatoes to the pharmacy in the first place?

    Don't you ever look at your email? The answer should be obvious.

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    Faster! Faster! Faster would be better!
  8. Space Exploration Applications? by halsver · · Score: 5, Interesting

    Presuming that this will be safe for use in humans, could this be one of the missing keys for space exploration? I'm imagining Joe Astronaut wakes from his month-long slumber on route to Planet X. His muscles have atrophied over this time, but by using these pills and doing some remedial exercise, he is ready to face the perils of the alien planet in days!

    I 3 the future.

         

    --
    Roughly half my comments are never submitted. You may be reading the better half...
  9. Give me my smart pill by Anonymous Coward · · Score: 5, Funny

    I want a pill that will improve critical thinking skills! And logical reasoning ability!

    And while we are at it, lets make it inhance one's capacity for impartial objectivity when making important decisions.

    I would spend my entire life savings on this stuff just to dump it in my city's tap water.

    One can dream...

  10. Re:How Much Does the Pill Weigh? by larry+bagina · · Score: 5, Funny

    the pill or the mouse?

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    Do you even lift?

    These aren't the 'roids you're looking for.

  11. Not necessarily by Moraelin · · Score: 5, Insightful

    Well, you have to realize that everything in your body is chemistry. No more, no less. All the feedback loops in your body, including "oi, we're doing lots of contracting here, we need more muscle fibers!" or "oi, we're suffocating here, let's have some more blood vessels!" are based on chemical signals. Some chemicals are produced, whether solely as a dedicated hormone/signal, or as a by-product of the cell's normal functions (e.g., CO2.) Some protein binds to them, and does something else. A lot of them regulate the expression of some genes to produce more or less of some other protein, or trigger cell division.

    So, yes, if you just force a bunch of cells to divide, you'll get what you wrote.

    On the other hand, if you fake the signal which says, basically, "oi, we're doing lots of contracting here, we need more muscle fibers!", you'll get just that. The body doesn't and can't distinguish between the real thing and a faked substance which binds with the same proteins. (Which is why tobacco, marijuana, etc, work, for example. They too bind to some proteins which were meant for something else, but the body can't differentiate between its own canabinoid signals and the THC from hemp.)

    Mind you, it doesn't need to be perfect. If the other signals aren't perturbed, the body will still use its other feedback loops for stuff like building blood vessels there or for how many mitochondria it needs there. So you may have some thick muscles, but without the thick veins of real body builders, since they only have to feed those muscles in an unused state. Which isn't a problem, since, well, they do get as much oxygen there as they actually need. You might get faster tired than a real athlete, as a result, though.

    But anyway, to cut this rant short and actually answer your question: yes. It would very much help with that.

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    A polar bear is a cartesian bear after a coordinate transform.
  12. Muscle tone or muscle mass? by beanlover · · Score: 5, Informative

    TFA doesn't say the word "tone" unfortunately and there is a difference. My son was born with Hypotonia which is low muscle tone. When I read the summary I got a little excited thinking this could help him out going forward.

    Basically the tone of the muscle is the elasticity of the muscle (this is from memory when the Dr.'s were explaining this to us after he had been diagnosed). It has little to nothing to do with strength and, due to his condition, makes him more prone to hernias and similar problems (he was born with a hernia which was hidden by a communicating hydrocele).

    Those with low muscle tone are more flexible (so add that to your GF requirement list :)). My son can touch his shin bone with the top of his foot (try it) as well as do complete splits, etc.

    We had to get him orthotics to help his ankles support his weight as he grew. This, fortunately (for him...not for us parental units), has NOT slowed him down. He's currently five and very active...loves to be outdoors and catch bugs...but I digress.

    Anyway...thought I'd point that difference out.

  13. Re:Nerd Decisions... by Crazy+Taco · · Score: 5, Funny

    Or don't get the new iPhone at all. Who needs that thing?

    Agreed. I'm not standing in line for a phone until Microsoft makes one. Then I might, though, because MS products are 1337. Or at least better than their Apple counterparts. Microsoft only needed 2 generations to make a Zune MP3 player that is better and has more features than a 7th generation iPod.

    --
    Beware of bugs in the above code; I have only proved it correct, not tried it.