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Prions Observed Jumping Species Barrier
palegray.net writes "Nature is reporting on new findings that prions jump species barriers. Believed to be responsible for ailments such as Creutzfeld-Jakob disease and 'mad cow' disease, prions are thought to disrupt biological processes by causing normal proteins to fold abnormally. Researchers at the University of Texas Medical Branch in Galveston have observed infectious prions from hamsters causing abnormal protein development in mice, along with a range of other observations on prion actions in test tube environments. From the article: '... they also found that when a prion jumps species, it produces a new kind of prion. "This is very worrisome," says Claudio Soto, who led the research, published in Cell. "The universe of possible prions could be much larger than we thought."' Sounds like another good reason to donate your spare CPU cycles to projects like Folding@home."
For those with access to the journal Cell, you can view The Castilla, et al, paper online (this abstract should be available for all). The nature link in the summary goes to a write-up about the article, not the actual article itself.
Those with subscriptions to Cell can also get the full text, Full Text in PDF, and the Supplementary Data.
Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
Instead of donating energy to run Folding on your inefficient PC, where the results have to be triple-checked - consider just donating money directly to the project instead of via your power bill.
Runtime on a trusted supercomputer / local cluster is going to be an order of magnitude more efficient in terms of data crunched per watt-hour.
3laws: No freebies, no backsies, GTFO.
Or do both. I think they'll be glad for any CPU and especially any GPU cycles.
lol: You see no door there!
While I certainly wouldn't want to get any of the prion diseases, they are all rather nasty, I find the existence of prions fascinating. They are arguably even less alive than viruses, though not by much, and yet they multiply(in a sense), and exist in all sorts of variants.
It seems like any sufficiently complex system(biological proteins in this case), is at considerable risk of having something analogous to life spring up and cause trouble.
That's been illegal in the U.S. for cows for many years. I'm not sure about the current law for chickens. From a 2003 USAToday article:
It must have been something you assimilated. . . .
I'm sorry, but Creutzfeld-Jakob disease is a bit more than an "ailment." It's deadly and incurable. I think a slightly stronger word would be in order.
EagerEyes.org: Visualization and Visual Communication
>Runtime on a trusted supercomputer / local cluster is going to be an order of magnitude more efficient in terms of data crunched per watt-hour.
Problem is, there ain't no such thing on this planet.
From Wikipedia: http://en.wikipedia.org/wiki/Folding@home
"On September 16, 2007, the Folding@home project officially attained a performance level higher than one petaFLOPS, becoming the first computing system of any kind to do so, although it had briefly peaked above one petaFLOPS in March 2007.[14][15]. In comparison, the fastest supercomputer in the world (as of June 2008, IBM's Roadrunner) peaks at 1.026 petaFLOPS[16]. In early May 2008 the project attained a sustained performance level higher than two petaFLOPS, again being the first computing system of any kind to do so. Now Folding@home computing cluster operates at above 2 petaFLOPS at all times, with a large majority of the performance coming from PlayStation 3 and GPU clients.[2] On August 20, 2008, the Folding@home project broke the three petaFLOPS milestone, once again being the first computing project of any kind in history to ever do so.[2]"
I couple of years back, I did a lot of reading on Mad Cow. There were so many examples of it jumping the species barrier...and some of them many, many years old.
Here is an example from 18 years ago:
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http://www.highbeam.com/doc/1G1-111779850.html
WASHINGTON -- Eighteen years before last week's first confirmed case of mad cow disease in the United States, investigators concluded that an epidemic of a brain-wasting disease on a Wisconsin mink farm was probably caused by a malady similar to mad cow disease.
The Wisconsin farmer had fed his mink a steady supply of "downer" cows -- too sick or injured to move on their own -- like the one that tested positive for mad cow disease in Washington state last week. On Tuesday, the Department of Agriculture banned such animals for human consumption.
Long before the USDA action, the mink industry began discouraging farmers ..
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It is basically that anyone who did a little study would know that it could jump the species barrier...but it just can't do that until some people in white coats tell us it can do that...then it can.
transporter_ii
Doctors destroy health, lawyers destroy justice, universities destroy knowledge, religion destroys spirituality
Depends on when you run it. Coal plants burn more coal at night than they need for electricity to keep the furnaces hot for peak usage periods. If you run F@H between 9PM and 6AM, you're actually not having much impact on fossil fuel use, pollution or carbon footprint.
That's why electric utilities and some companies are developing programs to make the best use of off-peak power. Electric cars, for example, are exciting because they could engage timers that charge them only during off-peak.
F@H could do the same in principle, with a check-box to run only during late hours. I don't know if they have that feature now.
It made me wonder, if it changes when it jumps species, maybe prion diseases are something new, so I did some quick checking on Wikipedia. I didn't track down more stuff yet, but I plan on following up. I didn't realize this, but it appears that a lot of prion diseases are fairly recent developments. Scrapie showed up in 1732, Bovine Spongiform Encephalopathy in the 1800s, CJD showed up around 1920, Kuru in 1957, Chronic Wasting Disease in 1967, Feline Spongiform Enecephalopathy 1990.
And these are more than half of the diseases caused by prions, I believe. That's more than a bit disconcerting.
... Mark Purdey was, of course, the British beef farmer who had a different theory about Mad Cow. In the 80's the British government required all cattle to be dosed with an Organo-phostate pesticide, to combat a warble fly epidemic (these bugs punch holes in cattle skin, making the hides less suitable for leather seats).
Purdey was an organic farmer, and sued to protect his right to keep synthetic pesticides away from his herd. He won. A few years later Chernobyl went off, and some time after that the first Mad Cow epidemic occured. Purdey's cows were mostly immune. He had a few mad cows, but these were mostly transplants to his herd which had, presumably, been dosed with the pestacide.
As the years went by, Purdey turned into a scientist himself, doing the research that the british government wouldn't do because of their potential liability in having caused the mad-cow epidemic (by require farmers to poison their herds).
Basically, the pesticide used chellated (removed) copper from the treated body. Somehow manganese substitutes for copper, but it isn't a good subsitute. The radioactive fallout from Chernobyl didn't help things either. It's been years since I first read Purdey's site, so I don't remember the details.
He commented that the Mad Cow in Washington (the northwest state) came from a copper-deficient pasture in Canada, into an area where quite a bit of nuclear weapons research had been done in decades past. The mad deer in Colorado also occupy a site with extensive radiologic environmental poisoning.
So basically, Purdey's theory is that prions are an effect of environmental poisoning, not the cause of Mad-Cow-esque disease.
Purdey is deceased now (brain cancer?), but his site's still live. Definitely recommended reading.
Learn the rules so you know how to break them properly.
www.teslabox.com
Sounds like another good reason to donate your spare CPU cycles to projects like Folding@home."
So the public is donating a lot of computing time and electrical energy. What does the public get back?
If Folding@Home goes towards lining the pockets of a university endowment or a drug company's coffers, count me out. If the research product is required to be free from patents, and available for public good...full speed ahead. Somehow, I seriously doubt that any successful results will be freely available.
Please help metamoderate.
That's been illegal in the U.S. for cows for many years.
Not so. The FDA ban on feeding cattle protein to cattle excepts proteins derived from blood products and fat, and beef tallow is still used as a feed supplement at cattle farms. Also, since the bovine meat and bonemeal that used to be fed to cattle are still fed to other food stock like pigs and chickens - whose meal is, in turn, an accepted protein supplement for cattle - there is still a chance that infectious prions could find their way back into cattle (and us). Check out Michael Pollan's book, The Omnivore's Dilemma, for more info.
For this issue Rosetta at home (Boinc) might be a better choice for protein structure. It's already wokring on the prion problem.
Some drink at the fountain of knowledge. Others just gargle.