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Biologist (Almost) Creates Artificial Life

Aditya Malik writes "Wired has an interesting story up about how a lab led by Jack Szostak, a molecular biologist at Harvard Medical School, is building 'protocells' from artificial molecules which are very close to satisfying the conditions for being 'alive.' 'Szostak's protocells are built from fatty molecules that can trap bits of nucleic acids that contain the source code for replication. Combined with a process that harnesses external energy from the sun or chemical reactions, they could form a self-replicating, evolving system that satisfies the conditions of life, but isn't anything like life on earth now, but might represent life as it began or could exist elsewhere in the universe.' This obviously raises some questions about creationism, not to mention some scary bio-research-gone-wild scenarios."

14 of 539 comments (clear)

  1. Questions about Creationism? by thefolkmetal · · Score: 5, Funny

    That seems slightly ironic in this particular case, simply because these protocells were "created" by this Jack fellow. I don't believe in Jack.

  2. Re:What questions exactly? by Chris+Burke · · Score: 5, Insightful

    Since the scientist did the (almost) creating here, what questions would this raise? Now if the (almost) alive protocells had popped into existence by random chance and from a void of nothingness, that would raise some uncomfortable questions.

    Because it would show that life can be created from basic non-living components using simple chemical reactions, and that it didn't require some magical "zap" from heaven to do it? Yes, in this case it would be a scientist doing it intentionally, rather than it occurring by chance in the primordial soup, but it shows that in principle it is possible. At that point you would have a pretty solid theory of abiogenesis if you can show that earth had in the distant past these basic components and sufficient energy to cause the necessary reactions, and then just like with evolution you have millions of years and trillions of molecules to handle the "chance" part.

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    The enemies of Democracy are
  3. Umm. What? by fuzzyfuzzyfungus · · Score: 5, Funny

    Why does this raise any questions about creationism? To the best of my knowledge, there are essentially no creationists who argue that life was created by humans or any other intelligent organisms(unless they are squirming around on the stand, trying to avoid the establishment clause). And nothing in any current evolutionary hypothesis precludes artificially constructed organisms any more than they preclude artificially constructed computers and hammers. The fact that we can, almost, produce simple organism analogs doesn't mean anything one way or the other, though I suspect that it will be a very convenient mechanism for exploring the capabilities of (relatively) low complexity structures, and will provide the opportunity to do evolutionary experiments from well defined baselines.

    As for the bioresearch gone wild scenarios: all advances in knowledge create the potential for trouble; but I suspect that it will be quite some time before any synthetic organism becomes much of a threat. The world outside is an incredible hostile place, crawling with microbes that have been slitting each others' throats in innumerable horrid ways for millennia. The interaction will be something like this:

    [Synthetic wimp organism]:"Hi, I'm synthetic."
    [Hardbitten wild bacterium]:"I fucking killed my own family over a nanogram of glucose."
    [SWO]:*gulp*
    [HWB]:"Hey, look, one of the thousands of antibiotic compounds secreted by fungi as part of the brutal chemical war of all against all."
    [SWO]:*Dies horribly*

  4. Re:Self Replicating? by philspear · · Score: 5, Informative

    All organisms self replicate. Just because something is lab-made doesn't mean it would magically not be subject to evolutionary forces.

    Having not been made by natural evolutionary forces, it's unlikely they would be fit to survive in any natural environment. These things have not been instilled with any defenses against things looking to eat them including bacteria. Didn't read the article, but I would guess they aren't capable of digesting molecules, they probably have to be presented with ready to go "nutrients" to replicate, move or do anything. You don't find that anywhere in the real world, in fact, as I recall you don't even find that in your bloodstream. ATP is what your molecules use for power, but you only get that once your cells import glucose and your mitochondria turn it into ATP.

    In other words, they have absolutely no way to eat anything they would need to survive.

    In evolutionary biology, a major cause of extinction, at least in theory, is called "changing rules." If you're an organism doing well, you're highly adapted to your environment and proliferate. Think of the dinosaurs, they ruled the earth, bigger was better. Mammals were barely hanging on for dear life, small, furry, warm blooded, nocturnal didn't make sense at the time. If the rules suddenly change though through environmental shift, you might not be fit for the new environment. The asteroid hits, an ice age happens, and suddenly cold-blooded huge lizards can't cut it and massively go extinct. The only reason reptiles remain today is that there was significant variation in that clade that allowed some of them to survive in the new game.

    These artificial bugs are barely managing to survive in an environment tailored to them, they can't replicate on their own. They also appear to have no variation. If they get out of their environment, they have no chance of survival. It's precisely because they're subject to evolutionary forces that they have no chance.

  5. Re:What questions exactly? by jfengel · · Score: 5, Insightful

    The trick with uranium dating is that when zircon crystals form, uranium is trapped but lead is excluded. So you know that all of the lead was created AFTER the crystal formed.

    This is cross-checked against other forms of dating, too.

    The disappointing thing is that your science teacher was spreading doubt on the subject when the answers were out there to be found. When a vast number of scientists say it's true, "I don't think it's right" is not a valid answer unless you've got a PhD. He may not have been spreading religion, but he was spreading doubt about a well-founded science, as if the scientists themselves were ignorant of it. They are not, and it's extremely bad form to imply that they are.

  6. Re:What questions exactly? by lawpoop · · Score: 5, Insightful
    Thanks for the answer. I'd always wondered about that one.

    The disappointing thing is that your science teacher was spreading doubt on the subject when the answers were out there to be found. When a vast number of scientists say it's true, "I don't think it's right" is not a valid answer unless you've got a PhD. He may not have been spreading religion, but he was spreading doubt about a well-founded science, as if the scientists themselves were ignorant of it. They are not, and it's extremely bad form to imply that they are.

    I'm a scientifically-minded skeptic, but I gotta say I disagree with you 100% here. I think that the essence of science is doubt, skepticism, and inquiry. These theories are not so fragile that we have to protect them with a shield of awe. If the science is well-founded, then it should be able to clear these hurdles easily. It should be able to withstand the most withering lines of inquiry -- And it does.

    If you teach kids to blindly accept what "the authorities" tell you, whether those authorities are the Bible, or well-respected grey-bearded scientists, then you will get adults who accept whatever the authorities tell them -- in other words, people who can't be scientists, because they don't know how to think for themselves, and therefore can't use the scientific method.

    When we teach science, we shouldn't say "Believe this because a bunch of scientists believe in it!". Instead, we should teach them to ask questions, develop a hypothesis, and think about ways to prove or disprove it. When they're old enough, they should be doing experiements. Think, ask questions, make observations, and do experiments to test your theories. That is science, not the consensus of elites.

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    Computers are useless. They can only give you answers.
    -- Pablo Picasso
  7. Re:Get your own dirt! by arevos · · Score: 5, Insightful

    God just looked at him and said, "No, no, no. You go get your own dirt!"

    I find jokes like this interesting, because they demonstrate quite neatly humanity's obsession with modesty. Humans have relatively little power to alter their surroundings. We have hands and fingers that can manipulate small objects, but nothing much beyond that. We're a creature who's first resume could be summed up with "Skills: Can throw rocks" and "Hobbies: Enthusiastic hooting". We live short lives and die horribly easily. Compared to the vast energies of quasars, or the intricacies of quantum particles, we are powerless and clumsy creatures; small sacks of meat with little more natural skills than the ability to pick up small stones.

    But in a blink of the cosmic eye, our species has constructed, well, this. Technology of unfathomable intricacy, abilities far beyond the dreams of our forebears. When you consider what we started out with, and where we are now, and how much work goes into everything we take for granted, it's too much for a single mind to comprehend. But rather than reflect on our amazing achievements, we exhibit an enviable modesty, making jokes comparing these achievements to a hypothetical perfect being. We ever hold in our minds how far we have to go, almost never considering how far we have come.

    It's akin to leaving a child on a beach, and coming back an hour later to find he's accepting a Nobel Prize for the particle accelerator he build out of sand and seaweed. You might be amazed, but the child would merely shrug depreciatingly, and say something like "Well, it's not as good as the one at CERN."

    Conversely, our concept of God is a entity that is inherently incapable of performing impressive actions. He might make impressive things, or be impressive to behold, but because his power is, by definition, unlimited, there can be no effort, or possibility of failure involved in his manipulations of the Universe. God creating a human being is no more impressive than a human picking a pebble off a beach; both are inherent skills that require no effort or risk of failure. But for a human being to create life, for a being of our meager abilities to succeed in reproducing, even in part, the awesome forces of nature and the cosmos... now that's impressive.

    In summary, that joke makes God look like the asshole parents who try and win races against their 5 year old children. It's not a flattering image.

  8. Re:Self Replicating? by SuperSlug · · Score: 5, Informative

    There is strong evidence that dinosaurs were in fact warm blooded and were not reptiles. Many actually lived in colder climates in the northern regions of the globe.

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    The information wants to be free, I just give it somewhere to go.
  9. Re:Interesting work by draco664 · · Score: 5, Funny

    Male and female humans can rarely interact successfully (or at least satisfactorily).

    Oh boy, are you doing it wrong!

  10. Re:To all worried about "grey goo"... by jeffb+(2.718) · · Score: 5, Informative

    Recall that bacteria have had around 4 billion years to turn Earth into a nanopocalyptic wasteland.

    You mean like the Oxygen Catastrophe, where uncontrollably replicating microbiomachines saturated the atmosphere with a waste product so caustic that it rotted the very rocks out from under them?

  11. Re:Self Replicating? by SuperSlug · · Score: 5, Interesting

    Ok here is some more evidence

    Bone structure and histology
    Growth rates
    Predator/prey ratios
    Speed and agility
    Rate of evolution
    Similarities with birds
    Parental Care
    Bone Isotope Composition
    Insulation
    Arctic Faunas

    Should I go on? There is a ton of evidence for each of these items that indicate that dinosaurs were warm blooded. There speed, growth rates and similarities with birds to the most obvious one.

    --
    The information wants to be free, I just give it somewhere to go.
  12. Re:Self Replicating? by zunicron · · Score: 5, Funny

    Strong evidence? Jurassic Park doesn't count as evidence.

  13. Re:Self Replicating? by Everyone+Is+Seth · · Score: 5, Funny

    Well, there goes about 99% of all the scientific "research" I have done in my life...

  14. Re:Created life vs evolved life? by speculatrix · · Score: 5, Funny

    vote it into office?