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Brains Work Best At Age of 39

Scientists at the University of California Los Angeles are reporting that while some people may think "life begins at 40," all it seems to do is slow down. According to recent research, at age 39 our brain reaches its peak speed, and it's all downhill after that. "The loss of a fatty skin that coats the nerve cells, called neurons, during middle age causes the slowdown, experts say. The coating acts as insulation, similar to the plastic covering on an electrical cable, and allows for fast bursts of signals around the body and brain. When the sheath deteriorates, signals passing along the neurons in the brain slow down. This means reaction times in the body are slower too."

36 of 267 comments (clear)

  1. Not a First Post by Farmer+Tim · · Score: 4, Funny

    I'm getting old...

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    1. Re:Not a First Post by SpaceLifeForm · · Score: 3, Funny

      You have plenty of time, that '39' is in hexadecimal!

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  2. Dick works best... by bloodninja · · Score: 5, Funny

    ...at age 18.

    I can't wait for the spam that will advertise me an 18 year old dick, a 39 year old brain, and a 65 year old bank account.

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    1. Re:Dick works best... by bloodninja · · Score: 4, Funny

      "Unfortunately the penis is optimally functional at age 18 ... if only we could somehow align these two."

      Obviously not, we are capable of thinking with one and not with the other at any given moment!

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    2. Re:Dick works best... by Yetihehe · · Score: 4, Funny

      Obviously not, we are capable of thinking with one and not with the other at any given moment!

      This explains why slashdoters are so smart.

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  3. Relates to neurological disease as well by Max+Romantschuk · · Score: 5, Interesting

    Interestingly, AFAIK, myelin breakdown due to a malfunctioning immune system is very much related to diseases like MS and ALS, among others.

    Which begs the question, if we could fix those disorders including restoring the myelin around the nerve fibers, could we keep people's brains working better for longer?

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    1. Re:Relates to neurological disease as well by yttrstein · · Score: 4, Interesting

      We can, and the substances that have been shown to be effective on this have been around for quite a while, the most modern ones being things like phenylpiracetam and pramiracetam, whos alkaloids are a suitable replacement in myelin sheath generation in aging human brains.

      I expect this to suddenly be "news" in about five years.

    2. Re:Relates to neurological disease as well by Darkman,+Walkin+Dude · · Score: 4, Insightful

      could we keep people's brains working better for longer?

      To be honest, given that we have no real definition of what "intelligence" is, to say that people get less intelligent in some way once they get past 40 is reaching a bit. Granted there is a physical effect being observed, but people have lost significant hunks of their brains with little detrimental effect.

    3. Re:Relates to neurological disease as well by mcgrew · · Score: 3, Insightful

      Interestingly, AFAIK, myelin breakdown due to a malfunctioning immune system is very much related to diseases like MS and ALS, among others.

      Which brings up a point - no two people are alike. No two people age the same way. I know guys fifteen years younger than me who look older than I am.

      My uncle died of ALS (Lou Gherig's Disease). Most people are dead of this disease before age 65, he didn't even show symptoms until his eighties.

      Spme people's brains peak at age 30, some people's brains peak at 50. To say everyone's brains are the same at any given age is stupidly ludicrous.

    4. Re:Relates to neurological disease as well by yttrstein · · Score: 5, Interesting

      First, I have to say, take the following with a grain of salt, since it's anecdotal:

      Most of the research on the 'racetam family of bioactives has been done in Russia, and because of this there are both mistrusts and language barriers to overcome, but in doing so I discovered some pretty massively interesting studies all about specifically myelin sheath issues. So, since these substances are freely available in the US without any kind of prescription (unlike Russia, interestingly), I purchased a few and fed them to my mother, who is in the last couple of stages of post polio syndrome, which among other things (to put it in a nutshell) severely inhibits myelin effectiveness in nerve sheath maintenance. When she started the regimen a year ago, she couldn't walk at all and had great difficulty grasping things with her left hand, and was also in tremdous pain.

      Just a week ago she and I walked about six blocks to a restaurant, and then back. She can grasp things in her left hand fairly well at this point, and is in very little pain.

      I don't know myelin "helping" nootropics are the holy grail of neurological disorders, but they appear to have helped at least one person tremendously.

    5. Re:Relates to neurological disease as well by thepotoo · · Score: 3, Interesting

      but they appear to have helped at least one person

      I'm not dissing you or your mother, but that could have been the placebo effect. Without a control group, we'll never know. I'm happy for you in any case, and I would say that if nothing else we need more research here.

      Interesting article. This drug "reboots" the immune system, allowing myelin sheathes to reform. I'm waiting to see if these results can be duplicated; if so this stuff might actually be the holy grail you speak of.

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    6. Re:Relates to neurological disease as well by thepotoo · · Score: 3, Interesting
      Hmmm, I can't find the statistics right now, but for stroke victims, the amount you tell them they will get better makes much more difference than any administration of drugs.

      The placebo effect on brain development/neurogenesis/related is huge. IIRC the research I read was comparing "you will get perfect again", both with and without some drug (Valium?) to "you might get better, but you won't be as good as before" with and without the drug.

      No one ever got completely perfect again, but people who were told that they would fared better. These were reproduced a couple of times, and MRIs showed significant (yes, statistically significant) neurogenesis difference, although not by a wide margin.

      Note: I'm now completely offtopic, talking about loss of blood supply and permanent brain damage while TFA is talking about myelination.

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  4. Midlife crisis by bloodninja · · Score: 4, Funny

    This is probably what leads to a midlife crisis. One day you wake up smarter than you've ever been and go "holy shit, I've been a jackass all these years". Then you go and do something about it.

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  5. With three weeks to go until my 39th birthday.... by pez · · Score: 4, Funny

    ...I have to say I expected a little more ;-)

  6. Speed of life and life itself are different things by tftp · · Score: 4, Insightful

    some people may think "life begins at 40," all it seems to do is slow down

    There is no contradiction, IMO. I know people who are so fast they don't have time to live, they are always five minutes late for something. Life begins when you can slow down, relax and think.

  7. speed isn't that important by thermian · · Score: 4, Insightful

    Once, over a period of a week when I was in my twenties, I got repeatedly destroyed at chess by a guy in his eighties. Seriously, I have never been so utterly unable to outthink anyone in my life, and I'm a pretty good chess player.

    He started playing chess as a boy, and while he did tend to ramble on a bit, if his mind wasn't as sharp as it used to be, it must have once been able to cut diamonds...

    --
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  8. Oh no! by T.E.D. · · Score: 4, Funny

    Being 41, I was rather dismayed to see this article. Even more upsetting was the fact that I then proceeded to left click on it, rather than my ususal middle-click to open it in a tab.

    Oh no! It's starting already!

  9. Ahem ... by foobsr · · Score: 4, Insightful

    ... they base their result on a sample of 72 persons within an age range from 23 to 80.

    Science at its best.

    CC.

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    1. Re:Ahem ... by Rakshasa+Taisab · · Score: 3, Insightful

      It's still _BAD_ science.

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    2. Re:Ahem ... by Chapter80 · · Score: 4, Funny

      ... they base their result on a sample of 72 persons within an age range from 23 to 80.

      What do you expect? The researcher was in his 40's. He was much better a few years back...

  10. What about exercise? by rrohbeck · · Score: 4, Interesting

    It is well known that regular intense exercise has a profound impact on aging and brain performance.
    I can't take a report serious that doesn't take the effect of exercise into consideration and doesn't even mention it.
    So does 39 apply to complete couch potatoes? Average Americans with little exercise? Athletes?

  11. Re:...and they said.... by theaveng · · Score: 5, Interesting

    There is No "one" point where the body stops working. Different systems age at different rates:

    - the reproductive system peaks somewhere around age 16 or 17 (lowest risk of birth defects)
    - the *desire* for sex peaks just prior to menopause for women (circa age 35) and apparently never ends for men ;-)
    - flexibility (ala gymanasts and skaters) peaks at 15 and ends around 25
    - reaction time peaks at 30
    - and now it's revealed that the human brain peaks just prior to 40 - after which the neurons' tendrils start falling apart (like an old rubber hose).

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  12. Fatty skin? by Comboman · · Score: 3, Funny

    "The loss of a fatty skin that coats the nerve cells, called neurons, during middle age causes the slowdown, experts say.

    Loss of fatty skin? When I hit middle age, that's when I started getting fatty skin.

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  13. Re:Just the speed of reaction by Life2Short · · Score: 4, Insightful

    As a wise man once said to me: "A new broom sweeps like hell, but the old broom knows where the dirt is..."

  14. FRAUD ALERT -- Slashdot pseudo-science by Futurepower(R) · · Score: 5, Interesting

    Fraud Alert: The results are wildly over-interpreted. The conclusions are guessing, not science.

    Maybe older people don't take finger-tapping seriously. Maybe younger people are far more likely to have played computer games.

    I met a man who was 55 who told me that he didn't get a good score on a computer pinball game he had just begun playing because he was old. Two weeks later, when I saw him again, he said his score had tripled.

    Quote from the article linked by Slashdot: "Significantly, the research suggests that the myelin breakdown process should also reduce all other brain functions for which performance speed is dependent on higher AP frequencies, including memory; ..."

    That's wild over-interpretation. There is no "should" in science. There is only theory, and it is necessary to emphasize that theories are only that, theories.

    1. Re:FRAUD ALERT -- Slashdot pseudo-science by Farmer+Tim · · Score: 3, Funny

      So in a nutshell you're saying I'm not too old and slow to get a first post.

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    2. Re:FRAUD ALERT -- Slashdot pseudo-science by Bloodoflethe · · Score: 5, Informative

      I think that the word you seek with regard to their interpretation of the results is "hypothesis". Were it a Theory, then a claim of over-interpretation would need citation.

      This is besides the fact that the "word" over-interpretation doesn't make sense. Try "wild speculation" or "gross misinterpretation" next time.

      As to the There is no "should" in science thing: try learning about science one day. Any scientific hypothesis must be able to make certain predictions. Predictions are worded in the subjunctive or conditional, depending on the subject matter and placement of the word. The use of the word "should" in relation to science is quite appropriate for the purposes of prediction.

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  15. Bad reporting, more like by Sockatume · · Score: 5, Insightful

    The fuck it is. It's bad reporting. The actual research is all about how motor response speed correlates extremely well with myelin degradation, and discusses how this backs up the idea that myelin degradation is important in the aging of the brain and the resulting reduced physical ability. Even the press release, entitled "Physical decline caused by slow decay of brain's myelin" only mentions the 39-year figure once, and only in the context of this particular sample group, two-thirds of the way down the web page. 39 is the age at which finger tapping speed and myelin integrity both peak and begin to decline. At no point do the researchers claim that this has anything to do with cognative performance, let alone extrapolate it to say that there's some magic age at which mental function begins to decline.

    That story is a creation of the media which have decided to run with "brains work best at age of 39" for no readily appreciable fucking reason. Next time, hacks, save some effort and just put a bunch of words in a hat and make up the story based on those.

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  16. Coding too by EmbeddedJanitor · · Score: 3, Insightful
    Sure the young 'uns can sit up all night and crank out code fast, but quite often the older guys will be relaxing and thinking a bit more and come up with better code.

    But that might also be because by age 40 you'd probably have diverted into management if you were no good at coding.

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    Engineering is the art of compromise.
  17. Fastest != Best by Doc+Ruby · · Score: 3, Insightful

    Just because older brains don't necessarily work as fast as younger ones doesn't mean they don't work better. Plenty of better thinking is slower than the fastest stuff, like jumping to conclusions. And the older brains have lots more information and habits that can be more powerful than the newer ones. This is known to humans as "wisdom".

    Besides, just getting to the wrong answer faster is not "better".

    Just some more reasons people say "age and guile will beat youth and talent any day". Even if younger people just zip around without realizing it.

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  18. Noise by Reality+Master+101 · · Score: 3, Interesting

    Being 44 years old now, I have noticed that I'm not able to think as clearly as I did in my early thirties. In my self analysis, however, I find the biggest culprit is "brain noise." When I think about something, irrelevant associations will pop in with much greater frequency, distracting me from "pure" concentration. Which makes me wonder if it's simply a natural consequence of life: more and more detail is stored away in my head. A younger person with a relatively "empty" head isn't as distracted by all the useless dreck and is able to form thoughts more cleanly.

    Even as I type this post, my lifetime of experience keep popping in with tangentially relevant information, not to mention songs triggered by phrases, movie quotes and other useless crapola. :D

    I've actually wondered if there are mental exercises such as meditation that might help to quiet all the noise.

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    1. Re:Noise by FooGoo · · Score: 3, Informative

      Vipassana or insight meditation is what you are looking for.

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  19. Re:Guess I should quit playing Brain Age by Cornflake917 · · Score: 3, Funny

    Not necessarily. It is more reason to NOT vote for McCain (as if there aren't enough already). Obama is also older than 39. We need to have a candidate who is exactly the minimum age of 35, that way we can vote him out his second term before his brain slows down!

  20. Re:...and they said.... by Bob-taro · · Score: 3, Funny

    - flexibility (ala gymanasts and skaters) peaks at 15 and ends around 25

    Flexiblity ENDS at 25? Is that some sort of pun? I never was very limber, but I'm over 40 and it's not like rigor mortis has set in yet.

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  21. If true, how do you explain mathematicians? by haruchai · · Score: 3, Insightful

    Historically, their most significant work is done before age 30.

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  22. Re:Speed versus flexibility by Knara · · Score: 3, Interesting

    The New Yorker had an interesting article a few weeks back about young vs old geniuses, that your post made me think of. Let me see if I can find it....

    Ah, here it is

    From reading various things, I've come to the conclusion that brains are hard to generalize. Even assuming one of the million things that can go wrong with them doesn't, in fact, happen, they still develop differently from individual to individual, and that what we presume to be the normal way that people's brains "age" isn't necessarily so.