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Implant Raises Cellular Army To Attack Cancer
holy_calamity writes "New Scientist reports on a sneaky new approach to getting the immune system to fight cancer. An implant releases a 'molecular perfume' irresistible to messenger immune cells, which enter the implant where they are given a sample of the cancer's 'scent' and a disperse signal that sends them scurrying to the nearest lymph node. There they convince other immune cells to start attacking anything that matches the sample they picked up."
this is pretty amazing to a layman such as myself..
You're nothing; like me.
Incorporate this in bullets and you get 100% lethality.
"cellular army bullet" enters body, tip takes sample of nearby healthy cells, programs immune system to attack own body, person dies horrible death to both his own immune system and the pathogens which are now left alone by the distracted immune system.
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The human immune system is a pretty potent beast to unleash. Getting it to attack cancer cells is genius. I would be worried about side effects, specifically the immune system getting confused or over-stimulated and attacking other things, but that's just speculation and surely for highly aggressive cancers like the ones they tested in the mice the risk would be more than worth it. We already use 'cures as bad as the disease' to treat cancer.
On the same note, though, I was encouraged by the teaser at the end where they suggest using similar techniques to 'reprogram' the immune system to correct auto-immune disorders. Learning how to put the immune system back in its cage could be just as useful as being able to send it after a target.
The enemies of Democracy are
If watching three seasons of Dexter has taught me anything, it's that once someone gets a taste for killing, they have a need to kill again. What happens with this army after it kills the cancer? Who does it kill next? You're going to have a mercenary army running loose in your system desperate for another kill....
Bah, linked wrong article. Meant this one: http://science.slashdot.org/article.pl?sid=03/11/04/1816227&tid=191
My understanding of the immune system is that class I MHC molecules present certain antigens produced inside host cells ("self").
So yes, MHC is exactly this system you conjecture!
However after RTA I did see that all of the control group died and the mice with the implant 90% were cured.
I hate to say it, but that's over-interpreting. This appears to have warded off imminent death in the mice, which is a result that is very encouraging. Unfortunately, it likely did not -cure- the mice. When we see data indicating these mice have a 5-year survival which is greater than the control (uh... or whatever the equivalent is since even healthy mice maybe don't live 5 years) then I too will be celebrating.
The immune system would sort of be vaccinated against markers on the cancer cells, but there's no guarantee that every cancer cell will have the marker and will keep it. You can imagine that if 99% of the cells in a tumor do have it, the tumor may be killed by the primed cells, but that 1% that doesn't will repopulate a while later.
Of course, this may have a feedback effect. I'm no immunologist, but I would hazard a guess that if a tumor were being attacked in this manner, the increased activity in the area may start targeting that 1% too. Maybe. That could also be a downside, as you can imagine if the immune system is primed but learns the wrong marker, you suddenly have an autoimmune disease on top of the cancer. Once again, I'm not an immunologist, so I don't know whether that's pure crap or not.
So it's another good finding, and of course a way to fight tumors is a miracle to a patient even if it's not a complete cure. It might be a total cure, but let's not set ourselves up for dissapointment.
Psst, they weren't using viruses or anything contagious. Hard to see how small plastic inserts and protein could spread from person to person. Even if it did, it would cause an autoimmune disease, not reprogram you to be a vampire/zombie. And there are worse apocalypse scenarios than Will Smith hitting on mannequins.
As opposed to the nonmolecular kind?
Yo dawg, I heard you like the Ackermann function, so OH GOD OH GOD OH GOD
When my father had lung cancer, I did a lot of research on cancer treatments and came to believe that the best possible treatment for cancer was to get the body's immune system to attack it. Especially for cancer that has spread, you need a systemic treatment that targets the cancer cells while not damaging the healthy ones and nothing will ever be as effective at doing that as the body's own immune system. This treatment is very encouraging and is on the right track. There are also several cancer vaccines under development that train the immune system to fight cancer before it takes hold. In the future, you may be able to get vaccinated against the kind of cancers that you are genetically vulnerable to.
I know, right? The Visitors would have given us their cancer cure ages ago, if it wasn't for that stupid Donovan guy.
Did anyone else think of the latest movie version of /I AM LEGEND/ when reading about this miracle cure for cancer?
I'll begin hording food and guns now.
Background info....Think of these antigens the article is referring to as extremely unique binding sites ("locks"). A cell can have a variety of locks on the cell surface. Some exist to bind to only one other molecule or binding site of another specific cell. So for anything to bind this lock, it must work like an incredibly precise lock and key mechanism. Our immune's adaptive systems (that is, T cells) go around with their "set of keys"** to every cell they come across and see if they fit into the "cell's lock" (remember, that's the antigen). These T cells have keys to fit the "locks" of bacteria, viruses, tumors, or any foreign, non-human cells that's there. That is why when you come across the same flu virus you were immunized against, the T cells, already having the right "key" made, can bind to the cell and cause cell death. But if it's a new flu virus, with the lock even slightly modified by a few DNA mutations, the T-cell's keys must be made to fit once again (this takes ~2 weeks and requires B cells, antibody production, etc).
Now to get to the tumor part....Tumors with tumor-specific antigens (TSAs) will fit the keys of T-cells once the keys are made. I recall someone asking "what if the immune cells kill healthy tissue?" There are "locks" called TAAs (tumor associated antigens) that are present on normal and tumor cells...they will all be destroyed. (Thankfully you can regenerate most of your healthy tissue--the rationale behind using toxic chemotherapeutics that target healthy and cancer tissue).
Now to actually explain the article's research....So effectively what this research is trying to accomplish IS THIS: release a barrel of locks around the tumor that will ONLY bind to the tumor. ALLOW your T-cells and other immune cells to use their "keys" to BIND the huge number of locks and activate cell death of the tumor cells. Currently, most research of biologic cancer drug development is focused on producing the right "key" for the naturally occurring "locks" that are present on cancer cells. Let me say that this research is a great approach--why not make and put the locks there?
Side note and extra info for fun....It's easy to think that one method of research is going to replace another. But the new trend is hitting cancer cells with EVERYTHING at once. That is, chemotherapy + biologic + barrel of "locks" + whatever else is out there. In addition, another trend that may occur is treating cancer like a CHRONIC illness, like diabetes. You've all seen how at best we can only kill 90-99% of tumor cells (at least, our imaging technology can only pick up small malignancy, not individual tumor cells)....so imagine getting cancer treatment intermittently every 2-5 years, but never experiencing symptoms of cancer (ie sickness, death)...I just thought I'd share that extra stuff. Now that I'm done with my essay I guess I should get back to my cancer research. Thanks for reading all the way through, and please comment.
**For the science geek: Yes Yes, I know the role antibodies play as the "set of keys" T-cells use...I think it would compromise the easy of explanation if I got into all that
"Engineering. Where the noble, semi-skilled laborers execute the vision of those who think and dream." -Sheldon
welcome our new cellular overlords.
Fascism starts when the efficiency of the government becomes more important than the rights of the people.
There's a good reason they have to implant the device before injecting the cancer cells. The immune response isn't instantaneous, it takes some time, 2 weeks or so, for the immune system to reach it's full response. But this particular cancer kills untreated mice in about 20 days, which doesn't really leave the immune system much time to really do it's job. Fortunately, most types of cancer aren't lethal in 20 days, and for a more "normal" cancer that could take months or years to be fatal, the immune system would have more than enough time to fully respond. But, it's not really practical to use a slowly growing tumor for this kind of basic research. If you use a tumor that would kill the mouse in 6 months, it would just take too long.
It'll be interesting to see how human trials go. The last time I saw cytokines referenced, it was in relation to this drug:
http://en.wikipedia.org/wiki/TGN1412
Looked great in animal studies; not so great for the humans involved.