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Every Man Is an Island (of Bacteria)
Shipud writes "There are ten times more bacterial cells in our body than our own cells. Most of them are located in our guts, and they affect our well-being in many ways. A group at Washington University has recently reported that although our gut microbes perform similar functions, it appears that different people have completely different compositions of gut bacteria: every man is an island, a unique microbial ecosystem composed of completely different species. One conclusion is that the whole division of bacteria into species may well be over-used in biomedicine."
overrated? That doesn't even make sense. Even if the features of most colonies bacteria are completely unique, that would only indicate a requirement even deeper seperation by individual feature. (i.e. metabolization of a particular substance into sugar by using a particular amino acid reaction)
If video games influenced behavior the Pac Man generation would be eating pills and running away from their problems.
I already learned this from an episode of House last year.
Each of your cells takes up 100-1000x more space than bacteria.
Prokayrotic (most bacteria) cells are much much smaller than Eukaryotic (your body) cells. Therefore event though you have less cells, those cells you do have weigh much more.
I can't believe the summary got "affect" vs. "effect" right, and "than" vs. "then" correct, but whiffed on "our" vs. "are." That's a new one for me.
Light the blue touch-paper and retire immediately.
Well, Im a user here, but im going anony because of my topic.
Every man is an island: Bacteria.
I could tell. How? Every person has a certain scent profile about them, even if they cannot smell it most of the time. I know mine when I work outside on a hot day. Some people at work also sometimes have a pronounced smell.. Perhaps its pheromones or something, I dont know. My GF also has one (and no, I dont mean vaginal smell). Like I said, this is one of the reasons why Im being a coward.
Now, why do I know? I had a diarrhea about 2.5 months ago, from being food-poisoned at our local Subway (friend at same, same sickness, assumed food). Standard food poison is vomiting and diarrhea, neither are which are fun in the least. Along with that are heavy sweats. However, I smelled something weird: when I went to #2, I smelled an acrid smell of the faint "pheromone" I normally smell.. It was like whatever bad food I had was killing off all my good bacteria, and I was smelling it.
So yes, I can understand Island of bacteria comment. I could also see linking the specific bacteria to weight gain/loss, BO factor, and other things. It would be neat to see a culture test of healthiness based upon non-self cultures, and perhaps inoculate yourself with other bacteria to aid in true digestion.
Back in the 80's in OMNI, there was a toothpaste on the market for about 1 month before being pulled, that had a plaque bacteria that could not digest teeth (made no cavities). Of course, gross factor was high and was summarily pulled from market...Perhaps they were right, just 20 years too early.
Bacteria are a tiny fraction of the size of your cells.
http://www.cellsalive.com/howbig.htm has a nifty little flash movie demonstrating the size difference.
If I have been able to see further than others, it is because I bought a pair of binoculars.
No bacterium is an island, entire of itself; every bacterium is a piece of the intestine, a part of the main. If a Lactobacillus be washed away by the sea, the colon is the less, as well as if an Escherichia were, as well as if a colony of thy friend's or of thine own were: any bacterium's death diminishes me, because I am involved in the gut biota, and therefore never send to know for whom the bell tolls; it tolls for thee.
"FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
Many /. readers never took biology, or if they did they were drunk or stoned when they came to class.
I heard about it in the radio (assuming it was the same research, I heard it about 2 weeks ago), and what I found interesting was the caloric intake for different foods was dramatically different for different people (based on stomach biology).
Wow, sent an e-mail as suggested when clicking on "use classic" banner, and got a fast response that addressed my msg
I'll have to remember that next time I get pulled over for driving "alone" in the high-occupancy vehicle lane.
Welcome to the Panopticon. Used to be a prison, now it's your home.
I heard a piece about this on NPR about a month ago. What I found very interesting was that the bacteria help you to digest foods, so one person's personal bacteria may allow her to receive more energy from say a piece of pizza than another person with different bacteria. Also very interesting was that by traveling and eating food from different regions you can pick up different bacteria and possibly gain even more energy from the foods you eat.
This is my sig, there are many like it, but this one is mine...
In terms of the animal kingdom, the concept of 'species' may easily be understood in terms of the concept of breeding. When two organisms cannot produce fertile offspring, they are separate species. This is a well defined barrier. A population does not become a new species overnight.
In terms of bacteria, they can become what might be termed a new species overnight. In the case of this article, they're noting that though the bacteria may be dissimilar at a genetic level, at a morphological level they are essentially the same, hence the question of the value of the species idea. We all have different species of bacteria living inside of us, but they all do the same basic things.
Common knowledge you can find in most microbiology or immunology textbooks.
Quite the opposite. What you would find in most textbooks is the assumption that there is a core human gut microbiome common to whole human populations. The Nature article refutes this. There are millions of $ being put into sequencing the human core gut microbes, but apparently there are no core gut microbes, and this human microbiome sequencing strategy needs rethinking.
Yes: Frrrrrrp.
Indeed, and this is an understatement. I've been told that the reason dogs can track you by smell is not so much that your OWN cells produce a unique smell, it's more that they're actually smelling your unique bacterial garden growing on your body. Which is also why they need fairly fresh clothing or scent, it changes over time. Another interesting tidbit I was told in microbiology class: every time you made out with someone, you probably picked up new SPECIES of bacteria in your mouth. Of course, he was talking to a classroom of college students, maybe that's not true for dating in a senior center.
Note that I'm not saying that I myself have so much as wiki'd this information. But if this is new knowledge, I've been massively lied to.
And so the legend of torso boy continues... He may only be .4 of a boy, but he's 110% heroic, in this weeks episode... Sorry that made me chuckle.
You are probably right, although in the context of test scores I'm not convinced. My stats are right even if my knowledge of what people are thinking when they say stuff sucks.
Sure, it's possible: We know that Crohn's / Ulcerative Colitis have genetic predisposition - it's certainly possible that a susceptible person's immune system sees a particular bacterium or portion thereof or byproduct thereof and starts down the pathway of an autoimmune phenomenon.
from Feldman: Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 8th ed.
So sure, maybe. Stay tuned.
Faster! Faster! Faster would be better!
There are millions of $ being put into sequencing the human core gut microbes, but apparently there are no core gut microbes, and this human microbiome sequencing strategy needs rethinking.
What this paper means is that you can spend billions of dollars sequencing the gut bacteria of thousands of different people and never get the same Nature paper twice. It also means that the number of boring "we sequenced everything we could find" papers in Nature and Science is going to skyrocket from what is already too many.
Just callin' it like I see it.
Another interesting tidbit I was told in microbiology class: every time you made out with someone, you probably picked up new SPECIES of bacteria in your mouth. Of course, he was talking to a classroom of college students, maybe that's not true for dating in a senior center.
You have obviously never dipped your pen in senior center ink, my friend.
Just callin' it like I see it.
Let's hope so...
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Every man is an island
and obviously, the summary was written in the 40s, before feminist criticism of language became familiar to the mainstream.
Obviously, you did not recognize the John Donne reference.
This is an incredible oversimplification, especially when you realise that asexual reproduction is very common in the animal kingdom. The idea you quote is often cited but is, in itself, an insufficient criterion. For example, there are organisms which can interbreed and can produce fertile offspring that are clearly considered separate species by any objective measure. In many species, lots of individuals are incapable of interbreeding with lots of individuals of the same species. Interbreeding is a complex thing that synthesises anatomical, behavioural, geographical and genetic components. A failure in any of these can cause a failure to interbreed which does not necessarily equate to a different species. There are also complexes of closely related species that interbreed frequently and produce fertile offspring but they are still distinct species.
In any case, TFA is about bacteria and not animals. The principle of using inability to interbreed as a definition of species in animals is even more removed from reality in bacteria which often share genetic material across species, even species that are not closely related.
Finally, the postulate that two creatures that are functionally similar within a diverse community, despite genetic dissimilarity, might not be considered different species is simply ludicrous. For example, in fish community assemblages, there are normally planktivores and piscivores. From a broad community perspective, the top-level piscivores all perform precisely the same function. No one, however, would argue that that makes them the same species. By way of illustration, the lake trout in a salmonid/coregonid community fulfills the same functional role as the northern pike in an esocid/coregonid community. That doesn't make lake trout and northern pike the same species.
Give a man a match: warm him for an instant. Douse him in petrol and set him aflame: warm him for the rest of his life.
I would say the fact that you keep vomitting might be what's making you skinny, not the bacteria in your gut.
Since most of the useful bacteria likely live lower in the digestive system, eating your shit might be more productive for those unfortunate people.
How amazed would you be to suddenly find that you just forgot what I wrote and you needed to reread my post.... again.
What does it even mean to break bacteria up into species? They don't reproduce sexually. They take up new genetic material from their environment. It's a bit of a misnomer.
>>I heard about it in the radio
What kind of radio do you have? Sadly, I can't fit into mine.
Um, most of your body weight is water. And water is not cells :)
Actually, the vast majority of the water in your body is found inside your cells, so in fact water IS cells (or rather cells ARE water)
Um, no, it is not. One simple initial example to get the ball running: there are hybrids where the males are sterile, but the females are fecund; for example, hybrids of domestic cats with the African serval (the resulting hybrid is called a Savannah cat). Since a housecat and a serval can produce fertile offspring, your test fails to establish them as separate species. (Note that I was careful not to say that the fertile offspring proves that they are the same species, "If A then B" doesn't entail "If B, then A.")
Now, you may be thinking of ways of strengthening your definition against examples like this one, but that was only the starting point. The broader problem is that as you try to come up with more and more precise definitions of "species," all you will do is set yourself up for ever more elaborate examples of intermediate cases that either pose a problem for your definition, or just suggest that your definition makes arbitrary, unprincipled decisions about where the line should lie. (E.g., what if there are two types of organisms that produce infertile offspring 25% of the time? 12.5%? 7.25%? How low must the percentage get to prove a species barrier? Must that number be the same for every pair of organisms, or does it make sense to measure it differently for different pairs because of some fact about genetics? What about pairs of organisms that would produce fertile offspring often enough, but are reproductively isolated by geographical boundaries? Etc.)
The deeper point is that evolution doesn't care about "species"; it cares about populations whose members interbreed, and in the real world, such populations may easily have very vague boundaries, because "X can breed with Y" isn't a yes/no matter.
Are you adequate?
"Common knowledge you can find in most microbiology or immunology textbooks" doesn't generally get a publication in Nature.
I've worked with one of the authors (Rob Knight) of the most recent paper, so I have some idea of what their research entails. Basically they were expecting to find some diversity in bacterial populations between individuals, but the amount they found was the big surprise -- there is more genetic diversity between the gut bacteria population of any two randomly selected people than there is between two soil bacteria populations in a deep sea trench and on a mountaintop! How strongly the bacterial populations predict leanness vs. obesity was also far beyond any previously published result.
The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
A couple years ago I got very, very sick--nastiness coming out of both ends to the point of hospitalization for dehydration. It took a week for my abdominal muscles to get over the soreness from the heaving. Before that sickness, I had a very tolerant digestive system--spicy, rich, or strange foods did not bother me at all. Since the sickness, certain foods upset my digestive system, causing gas, bloating, etc. And it's weirdly specific--I used to love Progresso canned soup, but since the sickness any Progresso soup with chicken in it gives me terrible gas.
This article is really interesting because I was just speculating the other day with my wife about this--that maybe my sickness cleaned out my GI system so thoroughly that I've lost certain gut bacteria that I had collected over the course of my life, and thus I'm not able to digest certain foods as easily as I once could.
Build a man a fire, he's warm for one night. Set him on fire, and he's warm for the rest of his life.
Something doesn't make sense:
There are ten times more bacterial cells in our body than our own cells. Most of them are located in our guts
That means that over 50% of 90% of our body mass in in our guts? Well, the researchers are Americans...
It's because microbial cells are much smaller then eukaryote cells. Imagine a bunch of basket balls surrounded by BBs.
By mass its probably about two pounds.
Human tissue cells routinely outweigh bacterial cells by more than 100 to 1.
DRM: Terminator crops for your mind!
You have obviously never dipped your pen in senior center ink, my friend.
Only seniors and calligraphers use pens that you need to dip into ink. The rest of us use ball points or cartridge driven quills. Quick to use, they are ready at a moment's notice. They are far less messy and less prone to leakage. They have greater "staying power", as there is no need to go back to the well for a refill.
When our name is on the back of your car, we're behind you all the way!
And by volume it's about 3 grams.